Clinical trials: Cardiovascular Complications
Hypertension, Diabetes Mellitus
Cohort Study on Patient Outcomes, Effectiveness and Cost-effectiveness of Intervention Programmes for DM/HT Patients
Objectives: To determine the outcome trajectories of patients with hypertension (HT) and/or diabetes mellitus (DM), and evaluate the long-term effectiveness and cost-effectiveness of the Risk Assessment and Management Programmes…
- Conditions
- Hypertension, Diabetes Mellitus, Cardiovascular Diseases, Morbidity, Multiple
- Trial name
- TRACC (NCT04302974)
- Testing
- Different structures and processes of primary care management strategies, Multi-disciplinary Risk Factor Assessment and Management Programmes for diabetes (RAMP-DM), Multi-disciplinary Risk Factor Assessment and Management Programmes for hypertension (RAMP-HT)
- Where
- China
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
ST-elevation Myocardial Infarction
Cooling in Myocardial Infarction
The primary goal in the treatment of acute myocardial infarction is to reperfuse the ischemic myocardium to reduce infarct size.
- Trial name
- STATIM (NCT01777750)
- Testing
- EMCOOLS flex pad; Philips Innercool RTx
- Where
- Austria
- Volunteers
- 120 people
- Sponsor
- Medical University of Vienna
Chronic Kidney Disease
Physical Exercise With Flow Restriction of the Forearm in Chronic Kidney Disease
The aim of this study is to analyze the effectiveness of physical exercise with blood flow restriction on the diameter and the flow of vessels, muscle strength and circumference of the forearm in patients with CKD prior to making…
- Trial name
- NCT02619968
- Testing
- experimental group
- Volunteers
- 20 people
- Sponsor
- Universidade Federal de Pernambuco
Foot Ulcer, Diabetes
Improving Diabetic Foot Ulcers With Atorvastatin
Lower limb complications are a substantial matter in the diabetic population and studies show that the annual incidence of foot ulcers ranges from 1.0-4.1% while the cumulative lifetime incidence is approximately 15%.
- Trial name
- NCT00134550
- Testing
- Atorvastatin (10 mg or 80 mg)
- Where
- 2 sites in Norway
- Volunteers
- 13 people
- Sponsor
- Asker & Baerum Hospital
Congestive Heart Failure, Chronic Kidney Diseases
Within Subject Variability Study of ER Torsemide 20 mg Tablet in Healthy Subjects
The study will evaluate the within-subject variability of 20mg ER torsemide as compared to 20mg IR torsemide (Demadex) in fully replicate double-crossover trial in healthy volunteers, who are consuming a high-salt diet (300…
- Trial name
- NCT03214874
- Testing
- Demadex 20mg Tablet, ER Torsemide 20mg Tablet
- Where
- India
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Sarfez Pharmaceuticals, Inc.
Turner Syndrome, Cardiovascular Diseases
Lymphedema, Low-grade Inflammation and the Vasculature in Turner Syndrome
100 women with karyotype verified TS, previously examined at 4 study visits during a 19-year period will be asked to participate in a 5th study visit. Healthy age-matched females will be included as controls in a ratio 2:1.
- Conditions
- Turner Syndrome, Cardiovascular Diseases, Lymphedema, Inflammation
- Trial name
- TSCOR_V (NCT06325618)
- Testing
- No intervention other than obtaining biopsies, Indocyanine green (ICG)
- Where
- Denmark
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Pregnancy, Down Syndrome
Comparison of Aneuploidy Risk Evaluations
This is a prospective, multi-center observational study designed to compare the test results of the Verinata Health Prenatal Aneuploidy Test to results of conventional prenatal screening for fetal chromosome abnormalities in…
- Conditions
- Pregnancy, Down Syndrome, Edwards Syndrome, Patau Syndrome
- Trial name
- CARE (NCT01663350)
- Where
- 26 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- Verinata Health, Inc.
ST-elevation Myocardial Infarction
Effect of Conditioning on Myocardial Damage in STEMI
The LIPSIA-Conditioning trial is an investigater initiated, randomized, single-center study that will assess the effect of different intrahospital conditioning protocols on myocardial damage assessed by MRI in patients with acute…
- Trial name
- LIPSIA-COND (NCT02158468)
- Testing
- Combined intrahospital pre- and postconditioning, Postconditioning
- Where
- Germany
- Volunteers
- 600 people
- Sponsor
- University of Leipzig
Atherosclerosis Cardiovascular Disease, Chronic Kidney Disease
A Study of Orforglipron (LY3502970) on Cardiovascular Outcomes in Adults With Atherosclerotic Cardiovascular Disease and/or Chronic Kidney Disease (ATTAIN-Outcomes)
The purpose of this study is to measure cardiovascular outcomes with orforglipron compared with placebo in participants with atherosclerotic cardiovascular disease (ASCVD) and/or chronic kidney disease (CKD).
- Trial name
- NCT07241390
- Testing
- Orforglipron
- Where
- 566 sites in Argentina, Australia and 36 more
- Volunteers
- 7,140 people
- Sponsor
- Eli Lilly and Company
Chronic Kidney Disease; End-Stage Renal Disease; Hemodialysis; Pain; Anxiety
Deep Breathing Relaxation and Lemongrass Aromatherapy on Pain
This randomized controlled trial aims to evaluate the effect of deep breathing relaxation combined with lemongrass aromatherapy on pain during arteriovenous fistula needle insertion and anxiety in hemodialysis patients.
- Trial name
- NCT07825974
- Testing
- Deep Breathing Relaxation, Lemongrass Aromatherapy
- Where
- Iraq
- Volunteers
- 190 people
- Sponsor
- University of Baghdad
Hypertension
Fluid Overload Management and Vascular Stiffness in Chronic Kidney Disease Patients With Hypertension
This study aims to reduce fluid overload in order to control blood pressure of hypertensive CKD patients using bio-impedance assessment of fluid status and using a diuretic therapy algorithm.
- Trial name
- NCT05378750
- Testing
- Diuretic algorithm
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- University of Alberta
Diabetes (DM), Prediabetes
Artificial-Intelligence-based Early Detection of Diabetic Retinopathy (FUNDUS AI)
Examination of individuals with prediabetes and established diabetes for early signs of diabetic retinopathy.
- Trial name
- FUNDUS AI (NCT07378891)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University Hospital Tuebingen
Heart Failure, Cardiomyopathies
Multimodal Physiologic State Intelligence Study
The OMNIPHYS study will investigate whether multimodal ultrasound and other routinely collected clinical and physiologic data can be combined with artificial intelligence to characterize changes in a person's physiologic state…
- Conditions
- Heart Failure, Cardiomyopathies, Pulmonary Hypertension, Myocarditis; Acute or Subacute
- Trial name
- OMNIPHYS (NCT07814118)
- Testing
- OMNIPHYS Multimodal Ultrasound Imaging System
- Where
- United States
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Diabetic Foot Ulcer
The Purpose of This Study is to Assess Clinical Efficacy and Safety of Berovenal® Intended to Promote Treatment and to Expedite Chronic Diabetic Foot Ulcer Healing
The goal of this clinical investigation is to evaluate clinical efficacy of medical device Berovenal® intended to promote treatment and to expedite healing of chronic diabetic foot ulcer in male or female subjects aged 18-85…
- Trial name
- NCT06584617
- Testing
- Berovenal®, NU-GEL Hydrogel with Alginate
- Where
- 9 sites in Germany, Poland
- Volunteers
- 66 people
- Sponsor
- VULM s.r.o.
Blood Pressure
The GUARDIAN Trial
An international randomized trial to test the primary hypothesis that perioperative tight blood pressure management reduces a composite of major perfusion-related complications (myocardial injury, stroke, non-fatal cardiac…
- Trial name
- NCT04884802
- Testing
- Tight blood pressure management, Routine blood pressure management
- Where
- 20 sites in United States, China and 4 more
- Volunteers
- 6,254 people
- Sponsor
- The University of Texas Health Science Center, Houston
Myocardial Infarction
Post-conditioning to Reduce Infarct Size
When angioplasty (PTCA) and stenting of the blood vessels of the heart is the treatment for a Heart Attack, there is damage to the heart muscle that is caused by the sudden opening of the blood vessels.
- Trial name
- NCT00755469
- Testing
- Post-conditioning
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Minneapolis Heart Institute Foundation
Diabetic Foot Ulcers, Hyperbaric Therapy
Hyperbaric Oxygen Therapy and Angiogenesis in Diabetic Patients With Foot Ulcers
Diabetic foot ulcers are a major cause of morbidity and mortality, accounting for approximately two-thirds of all non-traumatic amputations performed in the United States.
- Conditions
- Diabetic Foot Ulcers, Hyperbaric Therapy, Angiogenesis
- Trial name
- NCT00475202
- Where
- Israel
- Sponsor
- Assaf-Harofeh Medical Center
Stroke, Swallowing Disorder
The Effects of Neuromuscular Electrical Stimulation on Swallowing Functions in Stroke Patients With Dysphagia
In our study, our aim is to evaluate the effect of neuromuscular electrical stimulation added to traditional dysphagia therapy in stroke patients with dysphagia, on functional oral intake status, dysphagia-related symptoms…
- Conditions
- Stroke, Swallowing Disorder, Dysphagia, Stroke, Complication
- Trial name
- NCT04421937
- Testing
- Procedure: Traditional Dysphagia Therapy (TDT), Procedure: Neuromuscular Electrical Stimulation with TDT
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Istanbul University
Diabetic Retinopathy
Pilot Assessment of EyeArt as an Automated Diabetic Retinopathy Screening Tool
More than 29 million people in the US are living with diabetes, many of whom will develop diabetic retinopathy (DR) or diabetic eye disease (DED), the leading cause of vision loss and blindness in working-age adults.
- Trial name
- NCT03078231
- Testing
- Color fundus photography, Mydriatic Agent
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Eyenuk, Inc.
Pregnancy
Cardiovascular an Echocardiographic Assessment in Hypertension During Pregnancy
Cardiovascular \& echocardiographic assessment in pregnant women with hypertension during their pregnancy in comparison to Pregnant normotensive women.
- Trial name
- CREATION-P (NCT01068002)
- Where
- Israel
- Volunteers
- 80 people
- Sponsor
- HaEmek Medical Center, Israel
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