Clinical trials: Cardiovascular Condition
Dysphagia, Stroke
Wearable Biofeedback for Swallowing Disorders Rehabilitation in Stroke and Parkinson Disease
Dysphagia, or difficulty swallowing, is a common symptom of many neurological diseases but its treatment is not well established or easily accessible.
- Conditions
- Dysphagia, Stroke, Parkinson Disease
- Trial name
- NCT06638944
- Testing
- In-person sEMG-biofeedback, Remote sEMG-biofeedback, Standard-of-care treatment
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Illinois at Urbana-Champaign
Critically Ill, Deep Venous Thrombosis
PROphylaxis for ThromboEmbolism in Critical Care Trial (PROTECT Pilot)
PROTECT Pilot objective is to assess: 1) the feasibility of timely enrollment and complete, blinded study drug administration, 2) the bioaccumulation of LMWH in patients with acquired renal insufficiency and its association with…
- Trial name
- NCT00182364
- Testing
- Fragmin (Dalteparin) LMWH verus Unfractionated Heparin (UFH)
- Where
- 16 sites in Australia, Canada
- Volunteers
- 120 people
- Sponsor
- Hamilton Health Sciences Corporation
Peripheral Artery Disease, Peripheral Vascular Disease
BARD® Study of LIFESTREAM™ Balloon Expandable Covered Stent Treating Iliac Arterial Occlusive Disease
Collect confirmatory evidence of the safety and effectiveness of the Balloon LIFESTREAM™ Stent Graft for the treatment of stenoses and occlusion in the iliac arteries.
- Conditions
- Peripheral Artery Disease, Peripheral Vascular Disease, Arterial Occlusive Disease
- Trial name
- BOLSTER (NCT02228564)
- Testing
- Percutaneous transluminal angioplasty (PTA), LIFESTREAM™ covered stent
- Where
- 20 sites in United States, Germany and 1 more
- Volunteers
- 155 people
- Sponsor
- C. R. Bard
Arterial Hypertension
Measurement of Noradrenaline Concentrations Using Different Dilution Methods
Norepinephrine is the vasopressor of choice for the treatment of peri-anesthetic arterial hypotension. The use of this drug at significantly lower concentrations (dilution factor between 40 and 200) than the commercial…
- Trial name
- NCT04772599
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Periodontal Disease, Stroke
PeRiodontal Treatment to Eliminate Minority InEquality and Rural Disparities in Stroke
The PREMIERS study is a proposal for conducting an adequately powered two center phase III randomized controlled trial to test whether intensive periodontal treatment reduces the risk of recurrent vascular events among ischemic…
- Conditions
- Periodontal Disease, Stroke, TIA
- Trial name
- PREMIERS (NCT02541032)
- Testing
- Intensive dental treatment, Standard dental treatment, Arestin
- Where
- 2 sites in United States
- Volunteers
- 400 people
- Sponsor
- University of South Carolina
Multiple Myeloma
Intravenous rhMBL in Patients With Multiple Myeloma Receiving Chemotherapy Followed by Stem Cell Transplant
MBL deficient patients enrolled in this protocol are scheduled to be treated with melphalan-based high-dose chemotherapy followed by autologous hematopoietic stem cell transplant (HSCT) for their multiple myeloma.
- Trial name
- NCT00388999
- Testing
- Intravenous Recombinant Human Mannose-Binding Lectin (rhMBL)
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Enzon Pharmaceuticals, Inc.
Vasoplegic Syndrome, Liver Transplant; Complications
Methylene Blue vs Cyanokit for Intraoperative Vasoplegic Syndrome in Liver Transplant Patients
This study will evaluate if Hydroxocobalamin may be a new and possibly superior treatment for refractory vasoplegic syndrome during liver transplant surgery.
- Trial name
- NCT04054999
- Testing
- Hydroxocobalamin, Methylene Blue
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Mayo Clinic
Venous Thrombosis Deep (Limbs), Post Thrombotic Syndrome
EXERT: Exercise Physiology After Thrombosis
Deep vein thrombosis (DVT) can cause long-term scarring and narrowing of veins. When there is extensive damage to the veins in the legs, groin or abdomen it can affect the way that blood is able to flow back up to the heart.
- Trial name
- NCT05296499
- Testing
- Cardiopulmonary exercise test (CPET), Exercise cardiac MRI, 6 minute walk test
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Aortic Valve Disease
Aortic Valve Diseases RISk facTOr assessmenT and Prognosis modeL Construction
This study is a multicenter cohort study including patients diagnosed with aortic valve disease during hospitalization, including aortic insufficiency and aortic valve stenosis.
- Trial name
- ARISTOTLE (NCT06069232)
- Where
- 7 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Sun Yat-sen University
Stroke Sequelae, Brain Ischemia
EEG Based BCI for Upper Limb Rehabilitation in Stroke
Biomedical and Engineering approaches form a key element to neurological rehabilitation of upper limbs. Brain Computer Interface (BCI) using Motor execution and Motor Imagery are known to aid motor recovery in stroke.
- Trial name
- NCT04188132
- Testing
- EEG -BCI based Feedback for rehabilitation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Houston
Shoulder Pain, Hemiplegia
Shoulder Passive Range of Motion and Positioning Exercise on Hemiplegic Stroke Patients
Several factors associated with the hemiplegic shoulder pain after stroke includes rotator cuff injury, bicipital tendonitis, impingement, spasticity, limited external rotation of shoulder joint, adhesive capsulitis, shoulder…
- Conditions
- Shoulder Pain, Hemiplegia, Stroke, Rotator Cuff Injury
- Trial name
- NCT03045432
- Testing
- video-teaching, oral-teaching, regular rehabilitation program
- Volunteers
- 104 people
- Sponsor
- Chang Gung Memorial Hospital
mHealth
VR-3D Movie-based Education
Atrial fibrillation (AF), which is the most common cardiac arrhythmia in adults, is associated with a high risk of stroke and other thromboembolic complications.
- Trial name
- NCT03104231
- Testing
- three-dimensional (3D) movie
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Warsaw
Cardiovascular Disorder, Classic Hodgkin Lymphoma
A Study About How Blood Cell Growth Patterns Relate to Heart Health After Treatment for Hodgkin Lymphoma
This study assesses how blood cell growth patterns (clonal hematopoiesis) relate to heart health or cardiovascular disease (CVD) after treatment in patients with Hodgkin lymphoma.
- Conditions
- Cardiovascular Disorder, Classic Hodgkin Lymphoma, Clonal Hematopoiesis
- Trial name
- NCT05705531
- Testing
- Archive Sample Retrieval, Biospecimen Collection, Electronic Health Record Review
- Where
- 36 sites in United States, Canada
- Volunteers
- 190 people
- Sponsor
- Children's Oncology Group
Acute Stroke
The CLOQS Trial - Countdown Lights to Optimize Quality in Stroke
To reduce door-to-needle times in acute stroke treatment. Using an organizational behaviour intervention (a large stopwatch), we will post a visual cue to remind all parties that "time is brain".
- Trial name
- CLOQS (NCT01148602)
- Testing
- LED stopwatch-clock timers
- Where
- 3 sites in Canada
- Volunteers
- 3,452 people
- Sponsor
- Sunnybrook Health Sciences Centre
Suboptimal Health Status
Evaluation of Laser Acupuncture on Health Promotion of Sub-health People
Background: Suboptimal health status (SHS) is a dynamic state wherein people have not been diagnosed with a disease but tend to develop diseases. People with SHS often experience fatigue and other nonspecific symptoms.
- Trial name
- NCT04325945
- Testing
- Low level laser therapy
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Heart Failure
Observation of Clinical Routine Care for Heart Failure Patients Implanted With BIOTRONIK CRT Devices
The registry is primarily designed to assess outcome, efficacy and residual safety aspects of CRT based on long-term data from an unselected, real-life clinical set-up.
- Trial name
- BIO|STREAM HF (NCT03366545)
- Testing
- Cardiac Resynchronization Therapy (CRT)
- Where
- 114 sites in Australia, Austria and 18 more
- Volunteers
- 3,030 people
- Sponsor
- Biotronik SE & Co. KG
Atherosclerotic Cardiovascular Disease
In Silico Study Assessing the Impact of Inclisiran on Major Adverse Cardiovascular Events in Patients With Established Cardiovascular Disease
Study CKJX839B1FR01 in an In silico trial to predict the efficacy of Inclisiran therapy on major adverse cardiovascular events (MACE) and cardiovascular (CV) death in virtual patients with atherosclerotic cardiovascular disease…
- Trial name
- SIRIUS (NCT05974345)
- Testing
- Inclisiran sodium, Ezetimibe, Evolocumab
- Where
- France
- Volunteers
- 204,691 people
- Sponsor
- Novartis Pharmaceuticals
Liver Diseases, Alagille Syndrome
Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis (LOGIC)
Cholestasis is a condition in which bile is not properly transported from the liver to the small intestine. Cholestasis can be caused by an array of childhood diseases, including the genetic diseases Alagille syndrome (ALGS)…
- Conditions
- Liver Diseases, Alagille Syndrome, Alpha 1-Antitrypsin Deficiency
- Trial name
- LOGIC (NCT00571272)
- Where
- 17 sites in United States, Canada
- Volunteers
- 1,675 people
- Sponsor
- Arbor Research Collaborative for Health
Coronary Artery Ectasia
Endothelial Function in Patients With Ectatic Compared to Normal Coronary Arteries
The aim of this study is to show the frequency of endothelial dysfunction in patients suffering from ectatic coronary arteries as compared to those who have normal coronary arteries.
- Trial name
- NCT00548457
- Where
- Israel
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Mitral Regurgitation, Mitral Valve Regurgitation
Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional MR
The COAPT Continued Access Study (CAS) is an extension of the COAPT RCT under the same IDE (G120024). COAPT CAS was a single-arm, prospective, multicenter continued access registry that enrolled heart failure patients with…
- Trial name
- COAPT CAS (NCT07227675)
- Testing
- MitraClip® NT System
- Where
- 32 sites in United States
- Volunteers
- 162 people
- Sponsor
- Abbott Medical Devices
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