Clinical trials: Cardiovascular Condition
Relapsed/Refractory Multiple Myeloma
A Study of Subcutaneous (SC) AMG 701 in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
A study to evaluate the safety and tolerability of subcutaneous (SC) AMG 701 in participants with relapsed or refractory multiple myeloma (RRMM) to determine the maximum tolerated dose (MTD) or recommended phase 2 dose (RP2D)
- Trial name
- ProxiMMity-1 (NCT04998747)
- Testing
- AMG 701
- Sponsor
- Amgen
Alzheimer Disease, Dementia
SAFE at Home: A Service to Provide Social Engagement to Community-Dwelling Persons With Dementia
The proposed Phase 1 study will involve initial development and evaluation of a new service called Social Activities For Engagement at Home or SAFE at Home (SaH).
- Conditions
- Alzheimer Disease, Dementia, Dementia, Vascular, Dementia, Mixed
- Trial name
- NCT05516147
- Testing
- SAFE at Home
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Hopeful Aging
Heart Disease, Coagulopathy
Comparison of Three Management Strategies for Post Cardiac Surgery Bleeding
Open-heart surgery frequently results in abnormal clotting, which in turn results in excessive blood loss and the need for transfusion of multiple blood products to patients and leads to adverse outcomes.
- Trial name
- NCT00188747
- Testing
- Thromboelastograph, Point of Care
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- University Health Network, Toronto
Congenital Heart Disease
Impact of a Cardiac and Mental Health Rehab Program on Well-Being and Fitness in Young Adults With Fontan Circulation: A Randomized Trial
Helping Young Adults With Fontan Circulation Feel Better and Stay Active What is the study about? This study looked at how a special program could help young adults with Fontan circulation feel better mentally and physically.
- Trial name
- (NCTXXXXXXXX) (NCT06844149)
- Testing
- CPR; (Cardiac and Psychosocial Rehabilitation) with Cardiac Rehabilitation, CR; Home-Based Cardiac Rehabilitation, Usual Care
- Where
- South Korea
- Volunteers
- 36 people
- Sponsor
- Samsung Medical Center
Diabetic Retinopathy, Depression
Diabetic Retinopathy as a Marker of Cognitive Dysfunction and Depression
In recent years damage to the nerve fibers in the retina has been experienced as an early sign of complications resulting from type 2 diabetes.
- Conditions
- Diabetic Retinopathy, Depression, Cognitive Impairment, Cognitive Dysfunction
- Trial name
- DIRMA (NCT04610749)
- Where
- Denmark
- Volunteers
- 148 people
- Sponsor
- Region of Southern Denmark
Obesity
Supplemental Calcium in Overweight People
This study will examine the health effects of calcium supplements in overweight adults. Overweight adults often eat a diet low in calcium.
- Trial name
- NCT00030238
- Testing
- Calcium supplement
- Where
- United States
- Volunteers
- 540 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Cardiometabolic Disease
Metagenomics and Integrative Systems Medicine of Cardiometabolic Diseases
Supported by state-of-the-art systems medicine competences including integrative computational and functional genomics, the overarching goal of the trial is to investigate the impact of qualitative and quantitative changes in the…
- Trial name
- METACARDIS (NCT02059538)
- Testing
- Adipose tissue biopsies (omental and subcutaneous) liver, CT-scan, Stools sampling
- Where
- 3 sites in Denmark, France and 1 more
- Volunteers
- 2,350 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Myocardial Infarction
Remote Exercise SWEDEHEART Study
The overall aim of the study is to evaluate if remote video exercise-based cardiac rehabilitation (exCR), offered as an alternative to centre-based exCR, can increase participation in exCR sessions post myocardial infarction (MI).
- Trial name
- NCT04260958
- Testing
- Exercise-based cardiac rehabilitation
- Where
- 25 sites in Sweden
- Volunteers
- 1,500 people
- Sponsor
- Sahlgrenska University Hospital
Coronary Artery Disease
Pycnogenol and Endothelial Function in Coronary Artery Disease
Pycnogenol® is a proprietary bark extract of the French maritime pine tree (Pinus pinaster ssp. atlantica). Pycnogenol® has prevented pathologic symptoms such as chronic inflammation and increased platelet aggregation, a risk…
- Trial name
- NCT00641758
- Testing
- Pycnogenol
- Where
- Switzerland
- Volunteers
- 25 people
- Sponsor
- University of Zurich
Stroke, Acute
Hemodynamic Response and Motor Functions Following Transcranial Direct Current Stimulation in Acute Stroke
The aim of the present study is to evaluate the possible effect of using dual-tDCS applied before conventional physical therapy on motor functions and hemodynamic response
- Trial name
- NCT04051658
- Testing
- Transcranial direct current stimulation
- Where
- Thailand
- Volunteers
- 96 people
- Sponsor
- Mahidol University
Moyamoya Disease
Efficacy and Safety of rTMS for Cognitive Rehabilitation in Moyamoya Disease
The purpose of this study is to evaluate the safety and effectiveness of transcranial magnetic stimulation (TMS) therapy in moyamoya patients who received surgical revascularization.
- Trial name
- NCT03543748
- Testing
- Transcranial Magnetic Stimulation
- Volunteers
- 50 people
- Sponsor
- Huashan Hospital
Coronary Artery Disease
Medtronic RevElution Trial
The purpose of this trial is to evaluate the clinical safety and efficacy of the Polymer-Free Drug-Eluting coronary stent system for the treatment of de novo lesions in native coronary arteries with a reference vessel diameter…
- Trial name
- RevElution (NCT02480348)
- Testing
- Polymer-free DES (Drug Eluting Stent)
- Where
- 15 sites in Australia, Brazil and 1 more
- Volunteers
- 109 people
- Sponsor
- Medtronic Vascular
Renal Artery Stenosis, Aortic Dissection
On-table Renal Perfusion Evaluation Renal Artery Stenosis or Obstruction
1. Evaluate the feasibility for the on-table evaluation of the renal perfusion by using Syngo Dyna Parenchymal Blood Volume(PBV) Body; 2.
- Conditions
- Renal Artery Stenosis, Aortic Dissection, Renal Perfusion, Renal Artery Obstruction
- Trial name
- NCT03530748
- Testing
- Endovascular therapy and Imaging Acquisition
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Zhongshan Hospital
Cardiac Arrest
Measurement of Core Temperatures During Therapeutic Hypothermia
The purpose of this study is to determine that the measurements of rectal and bladder temperature are correctly consistent with core temperature by using the pulmonary artery catheter during therapeutic hypothermia; rapid…
- Trial name
- TH (NCT01292148)
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Seoul National University Hospital
Multiple Myeloma
Safety and Efficacy of Anti-FcRL5 CAR-T Cell Therapy in Treating Relapsed and Refractory Multiple Myeloma (R/R MM)
This is an open label, single-arm, Phase 2 study to evaluate the efficacy and safety of Anti-FcRL5 CAR-T in subjects with relapsed and refractory multiple myeloma. A leukapheresis procedure will be performed to manufacture.
- Trial name
- NCT06196255
- Testing
- anti-FcRL5 CAR-T
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xuzhou Medical University
Hypertension in Pregnancy
Remote Surveillance of Postpartum Hypertension
Women with hypertensive disorders of pregnancy need postpartum blood pressure (BP) surveillance to detect persistent hypertension. Various barriers result in only 30% attendance at postpartum BP visits.
- Trial name
- TextBP (NCT03185455)
- Testing
- Remote (text based) surveillance
- Where
- United States
- Volunteers
- 206 people
- Sponsor
- University of Pennsylvania
Coronary Artery Disease
Sex-related Differences in Outcome After Hybrid Coronary Revascularization
Hybrid coronary revascularization (HCR) has emerged as a favorable technique over traditional coronary artery bypass grafting (CABG) in a select group of patients with multivessel coronary artery disease (CAD).
- Trial name
- SEX-HYBRID (NCT06023355)
- Testing
- HYBRID
- Volunteers
- 1,000 people
- Sponsor
- University of Roma La Sapienza
Hypertension, Coronary Arterial Disease
Comparative Effectiveness of Dual Antihypertensive Regimens in Patients After Percutaneous Coronary Intervention
This prospective randomized open-label study aims to compare the effectiveness of two dual antihypertensive therapy regimens in patients with arterial hypertension and coronary artery disease after elective percutaneous coronary…
- Conditions
- Hypertension, Coronary Arterial Disease, Percutaneous Coronary Intervention
- Trial name
- EDAM (NCT07683585)
- Testing
- Losartan + Hydrochlorothiazide, Amlodipine + Azilsartan
- Where
- Russia
- Volunteers
- 207 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Carotid Stenosis, Hypoperfusion
Physiological Magnetic Resonance Imaging (MRI) to Improve Carotid Endarterectomy Outcomes
The carotid arteries are blood vessels in the neck that supply blood to the brain. Carotid stenosis disease is defined as a narrowing of these arteries due to the build up of plaque.
- Conditions
- Carotid Stenosis, Hypoperfusion, Transient Ischemic Attack
- Trial name
- NCT01272843
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Sunnybrook Health Sciences Centre
Chronic Heart Failure
Impact of a Letter Encouraging Pneumococcal Vaccination on the 1-year Vaccination Rate in Heart Failure Patients With a Primary Care Physician
Heart failure affects more than 1.5 million people in France, resulting in over 70,000 deaths and more than 165,000 hospitalizations each year.
- Trial name
- NCT06360315
- Testing
- Incentive letter for pneumococcal vaccination to the patient and to the GP
- Where
- France
- Volunteers
- 12,000 people
- Sponsor
- University Hospital, Montpellier
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