Clinical trials: Cardiovascular Condition
Cardiovascular-kidney-metabolic Syndrome, Cardiovascular Diseases
Inspire HER: Inspiring the Heart and Emotions for Radical Health
Poor heart health puts Black women at risk for a shorter life with more illness than people of any other non-indigenous racial group.
- Conditions
- Cardiovascular-kidney-metabolic Syndrome, Cardiovascular Diseases, Hypertension, Diabetes
- Trial name
- NCT06966258
- Testing
- Inspire HER Intervention
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Alabama at Birmingham
Atrial Fibrillation (Permanent), Atrial Fibrillation (AF)
Atrial Fibrillation: In Search for the Optimal Target for Rate Control
A rate control strategy is commonly adopted in the management of patients with Atrial Fibrillation (AF). Controversies remain as regards to what constitutes the optimal target of rate control.
- Trial name
- STRICT-4-FUN (NCT07135258)
- Testing
- Ivabradine + Usual Care
- Where
- Hong Kong
- Volunteers
- 200 people
- Sponsor
- The University of Hong Kong
Cardiovascular Disease
Dietary Intervention and Vascular Function
It is well established that diet plays an important role in both the development and progression of heart disease. Different types of dietary fat have varying effects on heart disease risk factors.
- Trial name
- DIVAS (NCT01478958)
- Testing
- SFA diet, MUFA diet, n-6 PUFA diet
- Where
- 2 sites in United Kingdom
- Volunteers
- 202 people
- Sponsor
- University of Reading
Multiple Myeloma
Tumor-Associated Antigen-Specific Cytotoxic T-Lymphocytes for Multiple Myeloma
This study is for patients that have a cancer called Multiple Myeloma, monoclonal gammopathy of undetermined significance (MGUS) or smoldering myeloma (SM).
- Trial name
- TACTAM (NCT02291848)
- Testing
- TAA-specific CTLs, TAA-specific CTLs- fixed dose
- Where
- 3 sites in United States
- Volunteers
- 36 people
- Sponsor
- Baylor College of Medicine
Coronary Artery Disease, Myocardial Ischemia
The Comparative Effectiveness of Hybrid Revascularization (MIDCAB Then PCI) With DES Versus Multivessel DES PCI or CABG
Minimally invasive revascularization of the left anterior descending artery followed by stent implantation versus percutaneous coronary intervention or coronary artery bypass in patients with multi-vessel coronary disease
- Conditions
- Coronary Artery Disease, Myocardial Ischemia, Coronary Disease, Heart Diseases
- Trial name
- HREVS (NCT01699048)
- Testing
- Hybrid (MIDCAB+PCI), PCI, CABG
- Where
- Russia
- Volunteers
- 150 people
- Sponsor
- Russian Academy of Medical Sciences
Acute Myeloid Leukemia, Adult, Cardiotoxicity
Clinical and Diagnostic Significance of Endothelial Dysfunction and Myocardial Contractility in Patients With AML
Acute myeloid leukemia (AML) is a clonal neoplastic disease of the hematopoietic tissue associated with a mutation in the precursor cell of hematopoiesis, which results in a differentiation block and uncontrolled proliferation of…
- Conditions
- Acute Myeloid Leukemia, Adult, Cardiotoxicity, Endothelial Dysfunction
- Trial name
- NCT05703126
- Testing
- History taking, Anthropometry, Complete blood count
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Samara State Medical University
Acute Kidney Injury
The Effect of Sodium Bicarbonate on Postoperative Renal Function in Infective Endocarditis Patients Undergoing Open Heart Surgery
The purpose of study is to test whether perioperative sodium bicarbonate infusion can prevent acute kidney injury following open heart surgery in infective endocarditis patients.
- Trial name
- NCT01920126
- Testing
- sodium bicarbonate, Saline
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Yonsei University
Vasoplegia Syndrome
Effects of Vitamin C on Shock Duration and Microcirculation in Patients With Vasoplegia Syndrome After Cardiac Surgery
This pilot study intends to observe the effect of intravenous vitamin C on the prognosis and sublingual microcirculation in patients with vasoplegia syndrome after cardiac surgery through a prospective randomized controlled study…
- Trial name
- NCT06723626
- Testing
- Vit C, Standard Preparation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Southeast University, China
Hypertension
The Comparison Between Spironolactone and Indapamide Monotherapy or in Combination With Amlodipine to Reduce the Risk of Heart Failure
1. Study name: The comparison between spironolactone and indapamide monotherapy or in combination with amlodipine to reduce thr risk of heart failure (SIRRHF) 2.
- Trial name
- SIRRHF (NCT04455178)
- Testing
- Spironolactone, Indapamide
- Where
- 4 sites in China
- Volunteers
- 200 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Ischemic Stroke
Merci Registry - Real World Use of the Merci Retrieval System in Acute Ischemic Stroke
Post-Market Registry on Use of Merci Retrieval System. Primary data to be collected will include: Post-procedure revascularization success 90-day mRS 0-2 90-day mortality
- Trial name
- NCT00478478
- Testing
- Mechanical Thrombectomy
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Stryker Neurovascular
Lifestyle
Development and Implementation of a Tool for the Evaluation and Monitoring of the Mediterranean Lifestyle in the Clinical Setting
The main goal is to develop a health online app based on a Mediterranean lifestyle score (diet, cooking preferences, rest, physical activity, social habits, conviviality) and its implementation in clinical settings with patients…
- Trial name
- MedLIFE (NCT06601478)
- Testing
- The MedLIFE app
- Where
- Spain
- Volunteers
- 74 people
- Sponsor
- Universidad Autonoma de Madrid
Critical Limb Ischemia
Peri-operative Foot CT Perfusion in CLI Patients
To investigate the clinical value of quantitative analysis of peri-operative foot supply through CT perfusion in patients with critical limb ischemia
- Trial name
- POP-CLI (NCT05575778)
- Testing
- computed tomographic perfusion
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Fudan University
Nephrotic Syndrome, Thromboembolic Disease
Causes and Prevention of Thromboembolic Disease in Nephrotic Syndrome
The study aims to describe the biochemical coagulation profile and investigate the effect of Low molecular weight heparin and Apixaban on this profile in patients with nephrotic syndrome.
- Trial name
- CAPTAIN (NCT04850378)
- Testing
- Dalteparin, Apixaban
- Where
- Denmark
- Volunteers
- 57 people
- Sponsor
- University of Aarhus
Multiple Myeloma
Vorinostat,Lenalinomide and Dexamethasone in Multiple Myeloma Refractory to Previous Lenalinomide Containing Regimens
Phase IIb clinical trial to determine if resistance to a lenalidomide containing regimen can be overcome by the addition of vorinostat, in patients with relapsed and refractory multiple myeloma.
- Trial name
- RZD (NCT01502085)
- Testing
- Vorinostat, Lenalinomide and Dexamethasone
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Hackensack Meridian Health
Hypertension
Sexual Dysfunction in Hypertensive Women
Several studies describe the existence of an association between sexual dysfunction and high blood pressure (hypertension), most often characterized by a decrease in the number of orgasms and the existence of dyspareunia.
- Trial name
- DYSFHO (NCT05156385)
- Testing
- Blood sample for the determination of antihypertensives or their metabolites., Questionnaire on sexual activity, Scale on hospital anxiety and depression
- Where
- France
- Volunteers
- 348 people
- Sponsor
- University Hospital, Toulouse
Stroke, Proprioceptive Disorders
Use of Sensory Substitution to Improve Arm Control After Stroke
Supplementing or augmenting sensory information to those who have lost proprioception after stroke could help improve functional control of the arm.
- Trial name
- NCT03298243
- Testing
- Vibrotactile stimulation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Marquette University
Stroke, Gait, Hemiplegic
A Comparison Between the Exoskeleton Hybrid Assistive Limb and Conventional Gait Training Early After Stroke
Overall aim is to evaluate HAL for gait training early after stroke and the effect of HAL on short- and long-term functioning, disability and health compared to conventional gait training as part of an inpatient rehabilitation…
- Conditions
- Stroke, Gait, Hemiplegic, Ambulation Difficulty, Hemiparesis
- Trial name
- HAL-RCT (NCT02410915)
- Testing
- Hybrid Assistive Limb (HAL); gait training, Control Group; Conventional gait training
- Where
- Sweden
- Volunteers
- 32 people
- Sponsor
- Danderyd Hospital
Stages of Heart Failure
A Cohort Study on Early Stages of Heart Failure
The main goal of this observational study is to learn about the epidemiological characteristics of heart failure among elder population in Beicai community in Shanghai and construct a community-based database and biobank.
- Trial name
- NCT06673615
- Where
- China
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- Shanghai East Hospital
Stroke
Impact of Non-invasive Brain Stimulation on Motor Recuperation
tDCS (transcranial direct current stimulation) will be used in chronic stroke patients to improve a variety of functions with superior or inferior limb.
- Trial name
- NCT01544699
- Testing
- tDCS (ELDITH)
- Where
- Belgium
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital of Mont-Godinne
Spinocerebellar Ataxias, Spinocerebellar Ataxia Type 1
Troriluzole in Adult Participants With Spinocerebellar Ataxia
The purpose of this study is to compare the efficacy of Troriluzole (200 mg once daily) versus placebo after 48 weeks of treatment in subjects with spinocerebellar ataxia (SCA).
- Conditions
- Spinocerebellar Ataxias, Spinocerebellar Ataxia Type 1, Spinocerebellar Ataxia Type 2, Spinocerebellar Ataxia Type 3
- Trial name
- NCT03701399
- Testing
- troriluzole
- Where
- 23 sites in United States, China
- Volunteers
- 299 people
- Sponsor
- Biohaven Pharmaceuticals, Inc.
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