Clinical trials: Cardiovascular Condition
Coagulation Disorder, Cirrhosis, Liver
Heparin Like Effect in Acute Variceal Bleeding
This study attempts to clarify the pathophysiology of haemostasis in relation to the evidence of sepsis in liver disease, and compares the accuracy of various available laboratory tests in assessment of these patients.
- Conditions
- Coagulation Disorder, Cirrhosis, Liver, Variceal Hemorrhage
- Trial name
- NCT04111120
- Testing
- SONOCLOT, coagulation factor assays for VIII/X, XIII, TPA/ PAI
- Where
- India
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Abdominal Obesity, Cardiac Disease
Effects of Different Dietary Interventions on Abdominal Fat Components, Quadriceps Muscles and Cardiometabolic Parameters
The study aims to evaluate the impact of different dietary interventions on body composition (abdominal fat components and quadriceps muscles) and cardiometabolic parameters.
- Conditions
- Abdominal Obesity, Cardiac Disease, Metabolic Disease, Cardiometabolic Syndrome
- Trial name
- NCT06320782
- Testing
- Calorie restriction and balanced distribution of macronutrients, Calorie restriction and low-carbohydrate diet, Calorie restriction and low-fat diet
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pernambuco
Multiple Myeloma
Linvoseltamab in Addition to Lenalidomide (L2) During Maintenance Therapy of NDMM to Deepen Responses or Redrive MRD Negativity After Relapse
The purpose of this study is to determine whether giving linvoseltamab with lenalidomide during maintenance treatment to participants with multiple myeloma will: 1.
- Trial name
- NCT06910124
- Testing
- Linvoseltamab, Lenalidomide
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Dickran Kazandjian, MD
Chronic Obstructive Pulmonary Disease, Interstitial Lung Disease
Move With Air: Physiological Response Assessment
A fan blowing cool air to the face has been shown to alleviate breathlessness in malignant and non-malignant disease at rest and during exercise, however the underlying physiological mechanisms remain unknown.
- Conditions
- Chronic Obstructive Pulmonary Disease, Interstitial Lung Disease, Heart Failure
- Trial name
- NCT05659550
- Testing
- Honeywell HT-900 Turbo Force Air Circulator
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- McGill University
Aortic Stenosis, Altitude
Short-term Exposure to High Altitude in Patients With Asymptomatic Aortic Stenosis
Aortic stenosis is a common disease with increasing prevalence due to an aging population. Aortic valve replacement is indicated for symptomatic severe aortic stenosis.
- Trial name
- ASALT (NCT06894550)
- Testing
- Participants will be escorted to high altitude and undergo a series of test
- Where
- Switzerland
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Ischemic Stroke
Perfusion and Collaterals Imaging With C-arm CT
Single-center, single-arm pilot study to evaluate the ability of C-arm computed tomography imaging to assess perfusion parameters, collateral vessels, recanalization and brain ischemia in patients with suspected or proven…
- Trial name
- NCT03161691
- Testing
- Percutaneous treatment of ischemic stroke
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Coronary Artery Disease
Telemedicine in Cardiac Surgery: A Pilot Study
Telemedicine has been widely used in managing patients with neurologic disorders or mental illness. Telemedicine is defined as the use of medical information exchanged from one site to another via electronic communications for…
- Trial name
- NCT01163474
- Testing
- Evaluate video clinic visit prior to Face-to-Face usual care visit
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- VA Office of Research and Development
Persistent Atrial Fibrillation, Longstanding Persistent Atrial Fibrillation
Medtronic Terminate AF Study
The purpose of this study is to demonstrate the safety and effectiveness of the Cardioblate iRF and CryoFlex hand held devices for the treatment of non-paroxysmal atrial fibrillation (AF).
- Trial name
- NCT03546374
- Testing
- Surgical Ablation, Cardioblate and Cryoflex hand held devices
- Where
- 15 sites in United States
- Volunteers
- 160 people
- Sponsor
- Medtronic Cardiac Surgery
Dynamic Strength Exercise Session, Isometric Strength Exercise Session
Acute and Chronic Effects of Combined Training on BP in Hypertensives
Dynamic strength training (DST) is widely recognized for promoting neuromuscular adaptations such as increased strength and hypertrophy.
- Conditions
- Dynamic Strength Exercise Session, Isometric Strength Exercise Session, Combined Exercise Session, Control Session (CON)
- Trial name
- COMBAT-H (NCT07470450)
- Testing
- Combined strength training, Dynamic strength training, Acute Isometric Exercise Session.
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of Rio Grande do Sul
Hypoxic Preconditioning, Carotid Artery Stenosis
Hypoxic Preconditioning on Patients
The purpose of this study is to study the effects of intermittent whole-body hypoxic preconditioning on patients with carotid artery stenosis.
- Conditions
- Hypoxic Preconditioning, Carotid Artery Stenosis, Ischemic Cerebrovascular Disease
- Trial name
- NCT02966418
- Testing
- Mild Hypoxia Preconditioning
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Hua Yan
Hyperlipidemia, Hypertension
Renal Hemodynamic Effects of the HMG-CoA Reductase Inhibitors in Normal Volunteers and in Patients With Chronic Renal Failure
This study was done to determine whether Simvastatin (a medication commonly used to treat patients with high cholesterol levels in the blood increases blood flow to the kidneys and improves renal function in normal volunteers and…
- Conditions
- Hyperlipidemia, Hypertension, Chronic Renal Failure
- Trial name
- NCT02511418
- Testing
- Simvastatin
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic
Stroke, Acute, Dysphagia
Post Stroke Dysphagia: Effect of Adding rTMS to Conventional Therapy on the Prevalence of Pneumonia.
BACKGROUND: Dysphagia is one of the most life-threatening stroke complications. Dysphagic stroke patients are at increased risk of aspiration pneumonia.
- Conditions
- Stroke, Acute, Dysphagia, Pneumonia
- Trial name
- NCT06123650
- Testing
- Repetitve transcranial magnetic stimulation
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Cairo University
Acute Renal Failure, Kidney Diseases
Biomarker Effectiveness Analysis in Contrast Nephropathy (BEACON)
This study is an observational non-interventional study which will examine a) the accuracy of biomarkers in predicting renal and cardiovascular outcomes after contrast-induced acute kidney injury.
- Conditions
- Acute Renal Failure, Kidney Diseases, Chronic Kidney Disease, Coronary (Artery); Disease
- Trial name
- NCT03004950
- Volunteers
- 922 people
- Sponsor
- University of Pittsburgh
Multiple Myeloma in Relapse, Multiple Myeloma
Study of HPN217 in Participants With Relapsed/Refractory Multiple Myeloma MK-4002 (MK-4002-001)
Researchers want to learn if MK-4002 (also known as HPN217) can treat relapsed or refractory multiple myeloma (RRMM). The goals of this study are to learn about the safety of different doses of MK-4002 and how well people…
- Conditions
- Multiple Myeloma in Relapse, Multiple Myeloma, Multiple Myeloma of Bone, Multiple Myeloma With Failed Remission
- Trial name
- NCT04184050
- Testing
- MK-4002
- Where
- 12 sites in United States, France and 1 more
- Volunteers
- 100 people
- Sponsor
- Harpoon Therapeutics, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Chronic Subdural Hematoma
Middle Meningeal Artery Embolization for the Treatment of Subdural Hematomas With TRUFILL® n-BCA
This is a prospective, multi-center, open-label, randomized controlled study in which subjects can receive standard of care (SOC) alone or SOC and TRUFILL n-BCA MMA embolization for the treatment of chronic subdural hematomas…
- Trial name
- MEMBRANE (NCT04816591)
- Testing
- Experimental: Interventional Cohort: TRUFILL n-Butyl Cyanoacrylate (n-BCA) Liquid Embolic System, Standard of Care Surgery, Experimental: Interventional Cohort: TRUFILL n-BCA Liquid Embolic System
- Where
- 33 sites in United States, China
- Volunteers
- 376 people
- Sponsor
- Cerenovus, Part of DePuy Synthes Products, Inc.
Essential Hypertension
Efficacy and Safety of Olmesartan Medoxomil in Stage 1 and 2 Essential Hypertension
In patients naive to treatment or after a 2-week washout period for patients whose treatment was ineffective, the use of olmesartan was assessed in a 4-phase treatment scheme: monotherapy, addition of hydrochlorothiazide (2…
- Trial name
- Benibest (NCT00890591)
- Testing
- olmesartan medoxomil + hydrochlorothiazide, if necessary + amlodipine, if necessary
- Volunteers
- 144 people
- Sponsor
- Daiichi Sankyo
Arterial Hypertension
Reliable Hypertension Diagnosis Based on 24 ABPM
24 h blood pressure monitoring can help to define which is the optimal timing and frequency of measurements
- Trial name
- NCT03674918
- Testing
- 24 h ambulatory blood pressure measurements
- Where
- Belgium
- Volunteers
- 408 people
- Sponsor
- Hasselt University
Ischemic Heart Disease
Ranolazine for Improving Symptoms of Palpitations
Patients with ischemic heart disease often report multiple symptoms, including angina and palpitations. Ranolazine has antiarrhythmic effects which are largely a result of the drug's effect on multiple ion channels.
- Trial name
- RYPPLE (NCT01495520)
- Testing
- Ranolazine
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
Myocardial Infarction, Stroke
Red Meat, Increased Iron Load and CVD Risk
Increased iron load could be a risk factor for cardiovascular diseases (CVD). Red meat consumption affects iron status and has also been shown to be related to increased CVD risk.
- Conditions
- Myocardial Infarction, Stroke, Cardiovascular Mortality
- Trial name
- NCT03218020
- Testing
- No intervention assigned, this is an observational study.
- Where
- Germany
- Volunteers
- 25,540 people
- Sponsor
- German Cancer Research Center
Atrial Fibrillation, Deep Vein Thrombosis
Randomized Trial of Interventions to Improve Warfarin Adherence
The purpose of this research study is to see if a lottery which provides the opportunity to win money, a reminder system using a "Med-eMonitor", or the combination of both might be useful in helping patients to achieve better…
- Conditions
- Atrial Fibrillation, Deep Vein Thrombosis, Dilated Cardiomyopathies
- Trial name
- WIN3 (NCT00904982)
- Testing
- Financial Incentive and Med-eMonitor, 2Med-eMonitor
- Where
- 2 sites in United States
- Volunteers
- 268 people
- Sponsor
- University of Pennsylvania
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