Clinical trials: Cardiovascular Condition
Breast Cancer
A Trial Assessing Feasibility of Allostatic Load Biomarkers and CVD Risk Among Black Breast Cancer Survivors
This study's overall objective is to test the effects of a culturally tailored gratitude, exercise, and mindfulness/emotional freedom techniques (GEM) psychosocial intervention on allostatic load and atherosclerotic…
- Trial name
- GEM (NCT06852560)
- Testing
- Gratitude, exercise, and mindfulness program
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Hypotension
Influence of Preload Dependence on the Effect of Phenylephrine on Cardiac Output
The perioperative hemodynamic management aims to ensure organ perfusion pressure and an oxygen arterial transport adapted to oxygen consumption.
- Trial name
- NCT01730820
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Caen
Acute Ischemic Stroke
Phase III Clinical Trial of SHPL-49 Injection in the Treatment of Acute Ischemic Stroke
This study is designed to determine the efficacy and safety of SHPL-49 intravenous infusion in acute ischemic stroke patients.
- Trial name
- SAIL (NCT07241520)
- Testing
- SHPL-49 Injection
- Where
- China
- Volunteers
- 1,096 people
- Sponsor
- Shanghai Hutchison Pharmaceuticals Limited
Hypertension
An Intervention to Increase Engagement With Hypertension Care for American Indian Patients
The objective of this study is to reduce the effects of stereotype threat on the adherence of American Indian/Alaska Native patients with hypertension.
- Trial name
- NCT04414982
- Testing
- Intervention Values Affirmation, Control Values Affirmation
- Where
- 2 sites in United States
- Volunteers
- 339 people
- Sponsor
- University of Colorado, Denver
Coronary Artery Disease
Comprehensive Assessment on Diagnostic and Prognostic Performance of Coronary Physiological Indices
The objective of the Zhongshan Hospital CONCORDE Registry is to evaluate utility, diagnostic value, and clinical outcomes of coronary physiological indices in an all-comers population of patients with suspected coronary artery…
- Trial name
- CONCORDE (NCT06127420)
- Testing
- coronary physiological indices
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Shanghai Zhongshan Hospital
Parkinson's Disease, Autonomic Neuropathy
Effects of Feet Mechanical Stimulation on Cardiovascular Autonomic Profile and Inflammation in Parkinson's Disease
In the present study, investigators test the hypothesis that a controlled mechanical pressure applied on specific sites of both fore-feet (ES) can reduce the inflammatory state and arterial blood pressure in patients with…
- Conditions
- Parkinson's Disease, Autonomic Neuropathy, Inflammation, Hypertension
- Trial name
- parkgo-1 (NCT02608424)
- Testing
- Foot Mechanical Stimulation (Gondola®, CE marking n° 0476)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Istituto Clinico Humanitas
Arteriovenous Malformations, Cavernous Angiomas
Influence of MMP on Brain AVM Hemorrhage
Brain vascular malformations, including arteriovenous malformations (AVM), cavernous malformations (CVM) and aneurysms, are a source of life-threatening risk of intracranial hemorrhage. The etiology and pathogenesis are unknown.
- Conditions
- Arteriovenous Malformations, Cavernous Angiomas, Brain Aneurysms
- Trial name
- NCT00783523
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of California, San Francisco
Mitochondrial Encephalopathy, Lactic Acidosis and Stroke-Like Episodes (MELAS Syndrome)
A Phase 2b Study of Zagociguat in Patients With MELAS
PRIZM is a Phase 2b randomized, double-blind, placebo-controlled, 3-treatment, 2-period, crossover study evaluating the efficacy and safety of oral zagociguat 15 and 30 mg vs.
- Trial name
- PRIZM (NCT06402123)
- Testing
- zagociguat 15mg, zagociguat 30mg
- Where
- 20 sites in United States, Australia and 4 more
- Volunteers
- 43 people
- Sponsor
- Tisento Therapeutics
Stroke; Sequelae
Efficacy of Massage in Stroke Spasticity
Stroke is one of the common diseases in the elderly. It is the third ranking cause of death and affects health care system in our country. One of the most important consequences of stroke is spasticity.
- Trial name
- NCT01448980
- Testing
- Thai Traditional Massage (TTM), Physical therapy program
- Where
- Thailand
- Volunteers
- 396 people
- Sponsor
- Mahidol University
MINOCA
Plaque Burden and Ischemia in MINOCA
The goal of this clinical trial is to assess coronary artery plaque burden, perivascular inflammation and extent of myocardial ischemia in patients presenting with acute myocardial infarction and non-obstructive coronary artery…
- Trial name
- NCT05681858
- Testing
- CT coronary angiography and [12N] NH3 PET-MR
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- University of Bergen
Atrial Fibrillation
Minocycline Plus Amiodarone Versus Amiodarone Alone for the Prevention of Atrial Fibrillation After Cardiac Surgery
. New- onset postoperative atrial fibrillation (POAF) is a common complication after cardiac surgery and its occurrence increases with age. POAF can result in clinically significant morbidity and mortality.
- Trial name
- MINA (NCT01422148)
- Testing
- Amiodarone, Minocycline
- Where
- United States
- Sponsor
- Baystate Medical Center
Traumatic Brain Hemorrhage
SAFETY: Stabilization Points to Third Hospital Line Assessment oF the Impact of the usE of Infrascanner Model 2500 to Provide Decision Support for Diagnosis/Screening of Traumatic Brain InjurY in Ukraine
The Infrascanner model 2500 is a handheld, noninvasive device that is FDA-cleared to detect traumatic intracranial hematomas. FDA clearance K200203 was issued in 2020, K211617 added pediatric age group to the IFU in 2022, and…
- Trial name
- SAFETY (NCT07014748)
- Testing
- Handheld brain hematoma detector
- Where
- 4 sites in United States, Ukraine
- Volunteers
- 600 people
- Sponsor
- InfraScan, Inc.
Coronary Artery Disease, Diabetes Mellitus
Reservoir-Based Polymer-Free Amphilimus-Eluting Stent Versus Polymer-Based Everolimus-Eluting Stent in Diabetic Patients
This study is a prospective, randomized controlled, single blind, two-arm, multicenter clinical evaluation. Diabetic patients (n=112) with de novo coronary artery disease will be randomized to one of the 2 treatment arms: 1)…
- Trial name
- RESERVOIR (NCT01710748)
- Testing
- Polymer-Based Everolimus-Eluting Stent, Polymer-Free Amphilimus-Eluting Stent
- Where
- 4 sites in Spain
- Volunteers
- 112 people
- Sponsor
- Spanish Society of Cardiology
Lung Neoplasms, Respiratory Failure
Clearance Of Mucus In Stents (COMIS)
The goal of this clinical research study is to compare the effects of sodium bicarbonate to normal saline when used for clearing mucus blockage in patients with airway stents.
- Conditions
- Lung Neoplasms, Respiratory Failure, Pneumonia, Acute Coronary Syndromes
- Trial name
- NCT01370278
- Testing
- Normal Saline, Sodium Bicarbonate
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Coronary Artery Disease
Personal Genomics for Preventive Cardiology
The purpose of this study is to see if providing information to a person on their inherited (genetic) risk of cardiovascular disease (CVD) helps to motivate that person to change their diet, lifestyle or medication regimen to…
- Trial name
- NCT01406808
- Testing
- genetic risk score for coronary risk factors
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Stanford University
Out-Of-Hospital Cardiac Arrest
REmote COnditioning in Out-of-Hospital Cardiac Arrest
Out-of-Hospital Cardiac Arrest remains a major public health problem, resulting in high mortality largely related to multiple organ failure and poor neurological outcomes due to brain anoxia.
- Trial name
- RECO-OHCA (NCT06306625)
- Testing
- Remote ischemic conditioning, No remote ischemic conditioning
- Where
- 14 sites in France
- Volunteers
- 220 people
- Sponsor
- Hospices Civils de Lyon
Aortic Stenosis, Gender
TAVI and Gender Outcomes Aortic Stenosis Undergoing Transfemoral Transcatheter Aortic Valve Implantation.
Severe aortic stenosis (AS) is the commonest form of valvular abnormality in the developed world and transcatheter aortic valve implantation (TAVI) is now widely practiced as in many cases is the preferred treatment option over…
- Conditions
- Aortic Stenosis, Gender, Surgery
- Trial name
- NCT04915976
- Volunteers
- 14,086 people, healthy volunteers welcome
- Sponsor
- Imperial College Healthcare NHS Trust
Out-Of-Hospital Cardiac Arrest, Cardiac Arrest
Steroid Treatment After Resuscitated Out-of-Hospital Cardiac Arrest
Comatose patients resuscitated from Out-of-Hospital Cardiac Arrest (OHCA) often develop a complicated systemic inflammatory response and have a poor prognosis with neurological damage being the most common cause of death.
- Conditions
- Out-Of-Hospital Cardiac Arrest, Cardiac Arrest, Cardiac Arrest With Successful Resuscitation, Post Cardiac Arrest Syndrome
- Trial name
- STEROHCA (NCT04624776)
- Testing
- Methylprednisolone, Isotonic saline
- Where
- 2 sites in Denmark
- Volunteers
- 158 people
- Sponsor
- Christian Hassager
Paroxysmal Atrial Fibrillation
Cryoballoon Pulmonary Vein Isolation vs. Radiofrequency Pulmonary Vein Isolation With Additional Right Atrial Linear Ablation for Paroxysmal Atrial Fibrillation: Prospective Randomized Trial (CRAPAF Trial)
Cryoballoon ablation is proven to be effective in pulmonary vein isolation in patients with paroxysmal atrial fibrillation, and it can reduce the procedure time compared to conventional radiofrequency (RF) catheter ablation.
- Trial name
- NCT03920917
- Testing
- Cryoballoon Pulmonary Vein isolation, Radiofrequency Pulmonary Vein isolation and Additional Right Atrial linear ablation
- Where
- South Korea
- Volunteers
- 330 people
- Sponsor
- Yonsei University
Atrial Fibrillation
Carotid Artery Implant for Trapping Upstream Emboli for Preventing Stroke in Atrial Fibrillation Patients
Vine™ is a permanent carotid filter designed to provide protection against embolic stroke in people with atrial fibrillation. It is implanted bilaterally in the common carotid arteries from a thin needle under ultrasound…
- Trial name
- CAPTURE (NCT03571789)
- Testing
- Vine™
- Where
- 4 sites in Belgium, Czechia and 1 more
- Volunteers
- 25 people
- Sponsor
- Javelin Medical
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