Clinical trials: Cardiovascular Condition
Deep Vein Thrombosis
Incidence of Venous Thromboembolism in Children Undergoing Elective Neurosurgical Procedures
The purpose of this study is to determine how frequently children undergoing elective neurosurgical procedures develop blood clots in the deep veins of the legs while hospitalized.
- Trial name
- NCT02037607
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Indiana University
Hypertension, Cardiovascular Risk Factor
HIGH Altitude CArdiovascular REsearch Latin America Population Study
High blood pressure (BP) is one of the principal cardiovascular risk factors. While BP levels and hypertension prevalence are well characterized in many populations, information on BP and on cardiovascular risk profile in high…
- Conditions
- Hypertension, Cardiovascular Risk Factor, Altitude Hypoxia, Altitude Sickness
- Trial name
- HIGHCARE-LAPS (NCT04751292)
- Testing
- Exposure to high altitude
- Where
- Peru
- Volunteers
- 937 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Macular Edema, Retinal Vein Occlusion
A Study of the Efficacy and Safety of Ranibizumab Injection in Patients With Macular Edema Secondary to Central Retinal Vein Occlusion (CRUISE)
This was a Phase III, multicenter, randomized, double-masked, sham injection-controlled study of the efficacy and safety of intravitreal ranibizumab compared with sham injections in patients with macular edema secondary to…
- Trial name
- CRUISE (NCT00485836)
- Testing
- Ranibizumab injection 0.3 mg, Ranibizumab injection 0.5 mg
- Volunteers
- 392 people
- Sponsor
- Genentech, Inc.
Non-Hodgkins Lymphoma, B-cell Lymphoma
Study of the Efficacy and Safety of Ublituximab in Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma
The purpose of this study is to determine whether ublituximab is safe and effective in patients with relapsed or refractory B-cell lymphoma who were previously treated with rituximab.
- Conditions
- Non-Hodgkins Lymphoma, B-cell Lymphoma, Waldenstrom's Macroglobulinemia, Marginal Zone Lymphoma
- Trial name
- NCT01647971
- Testing
- Ublituximab
- Where
- 8 sites in United States
- Volunteers
- 39 people
- Sponsor
- TG Therapeutics, Inc.
Atrial Fibrillation
EMOTIon and COgNitive Function After Atrial Fibrillation Catheter Ablation vs. Medical Therapy(EMOTICON Trial)
"Atrial fibrillation (AF) is an arrhythmic disease that increases especially in the elderly, increasing the risk of ischemic stroke by 5 times and is a major cause of dementia and cognitive impairment.
- Trial name
- NCT04942171
- Testing
- Atrial fibrillation catheter ablation group, Medical therapy group
- Where
- South Korea
- Volunteers
- 320 people
- Sponsor
- Yonsei University
Aortic Regurgitation
Performance of Currently Available traNscaTHEter Aortic Valve Platforms in Inoperable Patients With Pure Aortic regurgitatiON of a Native Valve. The PANTHEON International Project.
To investigate the performance of currently available THVs in terms of safety and efficacy To evaluate potential predictors of THV embolization or migration (TVEM) To assess the impact of TVEM on prognosis
- Trial name
- PANTHEON (NCT05319171)
- Testing
- TAVR
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Policlinico S. Donato
Hypertension
Effect of Isometric Handgrip Exercises on Blood Pressure of Hypertensive Adults
This study is designed to determine the effects of isometric handgrip exercises as compared to aerobic exercises in the hypertensive population, specifically in pre-hypertensives and those with hypertension stage I who are not…
- Trial name
- NCT05240144
- Testing
- IHG, Aerobic exercises
- Where
- Pakistan
- Volunteers
- 104 people
- Sponsor
- Riphah International University
Hypertension, Obstructive Sleep Apnea
Prospective National Multi-center Registry of Obstructive Sleep Apnea Syndrome in Hypertensive Patients in China
Study name: Screening, Diagnosis and Treatment of Obstructive Sleep Apnea Syndrome in Hypertensive Patients in China: A Prospective National Multi-center Registry.
- Trial name
- NCT05735444
- Testing
- Continuous positive airway pressure
- Where
- China
- Volunteers
- 633 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Amyloid Cardiomyopathy, Block, AV
Screening of ATTRwt in Patient With Advanced AV-Block Undergoing Pacemaker Implantation
The investigators will nationally investigate the prevalence of Transthyretin Amyloidosis wildtype (ATTRwt) in patients of ≥ 65 years with left ventricular hypertrophy who present with high degree atrioventricular block…
- Trial name
- ATTRAB (NCT05699044)
- Testing
- Amyloidosis screening (bloodtest, DPD-scintigraphy, potentially endomyocardial biopsy)
- Where
- Denmark
- Volunteers
- 170 people
- Sponsor
- Steen Hvitfeldt Poulsen
Chronic Limb-threatening Ischemia, Diabetes Mellitus
Bone Marrow Mononuclear Cells vs Mesenchymal Stem Cells in Diabetic Patients With Chronic Limb Ischemia
Patients in the severe stages of Chronic limb-threatening ischemia (CLTI) are prone to amputation and death, leading to poor quality of life and a great socioeconomic burden.
- Trial name
- NCT05631444
- Testing
- Cell-based therapy
- Where
- Colombia
- Volunteers
- 24 people
- Sponsor
- Fundación Oftalmológica de Santander Clínica Carlos Ardila Lulle
Carotid Atherosclerosis
A Study to Evaluate the Efficacy and Safety of Rosuvastatin in the Treatment of the Carotid Atherosclerotic Plaques
This is a 2-year, open-label, randomized study to evaluate the efficacy of Rosuvastatin dosing adjustment by LDL-C level compared to that of 5mg maintenance dose in chinese patients with Carotid Atherosclerosis.
- Trial name
- NCT02532309
- Testing
- Rosuvastatin (5mg，10mg，20mg), Rosuvastatin 5mg
- Where
- China
- Volunteers
- 308 people
- Sponsor
- Wei Liu
Coronary Heart Disease
China PEACE-Prospective AMI Study
Coronary heart disease (CHD) and heart attacks pose a serious health risk to men and women, however little information is available about how evidence-based therapies are incorporated appropriately into routine clinical practice…
- Trial name
- NCT01624909
- Where
- China
- Volunteers
- 4,286 people
- Sponsor
- China National Center for Cardiovascular Diseases
Right Hemispheric Stroke
Functional Connectivity and Predictors of Affective Aprosodia Intervention in Subacute Right Hemisphere Stroke
This study is an investigation of a behavioral speech and language treatment for emotional prosody recognition and production deficits in subacute right hemisphere stroke.
- Trial name
- NCT04575909
- Testing
- Aprosodia Intervention, No-Intervention
- Where
- United States
- Sponsor
- Johns Hopkins University
Alzheimer s Disease, Vascular Dementia
Predictors of Emergency Department Use in Frail Patients
When admitted to the emergency department (ED), elderly non-autonomous patients show high risk of adverse health outcomes. The prompt identification of ED use risk factors in such population is hence needed.
- Conditions
- Alzheimer s Disease, Vascular Dementia, Frailty, Elderly
- Trial name
- THE-Spoke 10 (NCT07259499)
- Testing
- Plasma phosphorylated Tau 181
- Where
- Italy
- Volunteers
- 110 people
- Sponsor
- University of Pisa
Metabolic Syndrome, Diabetes Mellitus
Biomarkers Derived From Adipose Tissue Useful for Diagnosis and Prognosis of Cardiovascular Risk (CVR) in Obese Patient
This study evaluates the relationship between the adipose tissue, as an active component, which can define metabolic phenotypes linked to cardiovascular risk modification post bariatric surgery.
- Conditions
- Metabolic Syndrome, Diabetes Mellitus, Inflammatory Response
- Trial name
- CROP (NCT03561987)
- Testing
- Bariatric surgery
- Volunteers
- 70 people
- Sponsor
- Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado
Severe Sepsis, Septic Shock
Minimally-Invasive Cardiovascular Hemodynamic Optimization (MiCHO) Versus Early Goal-Directed Therapy (EGDT) in the Management of Septic Shock
Early intervention in the treatment of septic shock, including early goal-directed therapy (EGDT) in the first 6 hours of disease presentation, has been shown to significantly decrease mortality.
- Trial name
- MiCHO (NCT00535821)
- Testing
- Esophageal Doppler monitoring - CardioQ, Deltex Inc, Central line with CVP and continuous ScvO2 monitoring
- Where
- 4 sites in United States
- Volunteers
- 5 people
- Sponsor
- Loma Linda University
Obesity, Adolescent Obesity
Chronotropic Incompetence During Exercise in Obese Adolescents: Clinical Implications and Pathophysiology
A reduction in peak heart rate (HR) and suppressed HR response during exercise is highly prevalent in obese populations. This phenomenon is also known as chronotropic incompetence (CI).
- Trial name
- CICO (NCT03516721)
- Testing
- the prevalence of chronotropic incompetence CI during maximal cardiopulmonary exercise testing, CPET
- Where
- Belgium
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Ehlers-Danlos Syndrome
Vision-based Assessment of Joint Extensibility in Ehlers Danlos Syndrome
Ehlers Danlos Syndrome (EDS) is a heterogenous group of genetic disorders with 13 identified subtypes. Hypermobile EDS (hEDS), although the most common subtype of EDS, does not yet have an identified genetic mutation for…
- Trial name
- NCT05366114
- Testing
- No intervention, additional video data collection only
- Where
- Canada
- Volunteers
- 225 people
- Sponsor
- University Health Network, Toronto
Heart Failure, Cardiac Remodeling, Ventricular
Biological Mechanisms Behind Resynchronization Therapy in Heart Failure
Heart failure is a common disease, affecting 2-3% of the population in the western world. About 30% of patients with heart failure and reduced ejection fraction display signs of electrical dyssynchrony on ECG, usually left bundle…
- Trial name
- NCT06140914
- Testing
- Proteomics, miRNA studies and studies of blood cells from blood samples
- Where
- Sweden
- Volunteers
- 220 people
- Sponsor
- Region Stockholm
Breast Cancer, Cardiotoxicity
The Effects of Two Exercise Interventions on Breast Cancer Patients Undergoing Cardiotoxic Chemotherapies
The purpose of this study is to determine if exercise preconditioning can mitigate the off target effects of chemotherapy treatment on measures of cardiovascular function, inflammatory responses, and quality of life.
- Conditions
- Breast Cancer, Cardiotoxicity, Cardiovascular Diseases
- Trial name
- NCT05786014
- Testing
- High Intensity Interval Exercise, Moderate Intensity Walking
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Virginia
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.