Clinical trials: Cardiovascular Condition
Cardiac Arrest (CA), Extracorporeal Cardiopulmonary Resuscitation
Clinical Application of Low-Field Magnetic Resonance Imaging in Patients on Extracorporeal Cardiopulmonary Resuscitation
Timely identification of acute brain injury (ABI) patterns in patients with extracorporeal cardiopulmonary resuscitation (ECPR) is essential for prognostic assessment and optimization of clinical management, particularly…
- Conditions
- Cardiac Arrest (CA), Extracorporeal Cardiopulmonary Resuscitation, Acute Brain Injury
- Trial name
- NCT07526701
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Capital Medical University
Heart Failure, Heart Diseases
Palliative Care in Heart Failure
The primary aim of the PAL-HF trial is to assess the impact of an interdisciplinary palliative care intervention combined with usual heart failure management on health-related quality of life as measured by the Kansas City…
- Conditions
- Heart Failure, Heart Diseases, Cardiovascular Diseases
- Trial name
- PAL-HF (NCT01589601)
- Testing
- Usual heart failure care, Interdisciplinary palliative care
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Duke University
Post-traumatic Stress Disorder, Prehypertension
Sympathetic Overactivity in Post-traumatic Stress Disorder
Post-traumatic stress disorder (PTSD) is a highly prevalent anxiety disorder that is associated with an increased risk of cardiovascular (CV) disease and hypertension.
- Trial name
- SO-PTSD (NCT01627301)
- Testing
- Device-Guided Breathing (DGB), Transcutaneous Vagal Nerve Stimulation (tVNS)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Emory University
Heart Failure
Influence of Edoxaban on Coagulability and Thrombin Generation: An in Vitro Study Focusing on Thrombelastography
The influence of different doses of edoxaban on physical characteristics of the clot and thrombin generation kinetics in blood samples will be studied by in vitro spiking of blood samples collected from patients treated for heart…
- Trial name
- NCT02448901
- Testing
- Edoxaban
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- LifeBridge Health
Morality, Diabetes
Saturated Fatty Acids Intake and Mortality, Diabetes, Hypertension and Overweight
The role of saturated fatty acids (SFAs) intake in the development of total death, cardiovascular diseases, diabetes, hypertension and overweight are in great controversy but evidence from large population in China is scant.The…
- Conditions
- Morality, Diabetes, Hypertension, Overweight
- Trial name
- NCT03281512
- Volunteers
- 14,383 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Stroke
Urdu Version of National Institutes of Health Stroke Scale: Reliability and Validity Study
The goal of this study was to translate and culturally adapt NIHSS into Urdu language and to evaluate its reliability and validity in Pakistani stroke population.
- Trial name
- NCT05203081
- Where
- Pakistan
- Volunteers
- 225 people
- Sponsor
- Riphah International University
Stroke, Aphasia Following Cerebral Infarction
Combined Aphasia and Robot-Assisted Arm Treatment for Chronic Stroke Survivors
The goal of this clinical trial is to learn if a program that combines language and arm treatment can improve language and movement problems in people with chronic stroke.
- Conditions
- Stroke, Aphasia Following Cerebral Infarction, Hemiparesis After Stroke
- Trial name
- CARAT (NCT07000019)
- Testing
- CARAT: combined aphasia and robot-assisted arm therapy, Robot-assisted arm therapy
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- New York Medical College
Heart Failure
Exercise Training in Heart Failure: Changes in Cardiac Structure and Function
This is a research study being conducted to better understand the impact of exercise training on changes on the structure and function of the heart.
- Trial name
- NCT02275819
- Testing
- Exercise
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- VA Office of Research and Development
Valvular Heart Disease
The Impact of Sleep-disordered Breathing on the Incidence of Postoperative Acute Kidney Injury in Patients Undergoing Valvular Heart Surgery
Sleep-disordered breathing has a prevalence of 30~80% in patients with heart diseases. Various studies have revealed a correlation between the incidence and various diseases such as heart failure, hypertension, diabetes, and…
- Trial name
- NCT04080219
- Where
- South Korea
- Volunteers
- 414 people
- Sponsor
- Yonsei University
Chronic Lymphocytic Leukemia (CLL), Lymphoma, Non-Hodgkin (NHL)
Dose Escalation Study of CAL-101 in Select Relapsed or Refractory Hematologic Malignancies
The purpose of this study is to determine the dose that can be safely given to see what effect it may have on your cancer and to determine how the drug is distributed in the body.
- Conditions
- Chronic Lymphocytic Leukemia (CLL), Lymphoma, Non-Hodgkin (NHL), Acute Myeloid Leukemia (AML), Multiple Myeloma (MM)
- Trial name
- NCT00710528
- Testing
- CAL-101
- Where
- 9 sites in United States
- Volunteers
- 192 people
- Sponsor
- Gilead Sciences
Non-Alcoholic Fatty Liver Disease, Cardiovascular Diseases
EndoNAFLD: Relationship Between Fatty Liver Disease and Cardiovascular Diseases
Management of risk factors is the primary approach to prevent cardiovascular disease (CVD). In this regard the accurate scoring of disease risk is fundamental.
- Trial name
- Endo-NAFLD (NCT06392828)
- Where
- 4 sites in Spain
- Volunteers
- 63 people
- Sponsor
- IMDEA Food
Coronary Artery Disease
"JACTAX" Trial Drug Eluting Stent Trial
Prospective, multi-center, non-randomized registry. 100 patients will be enrolled at up to 10 clinical sites in Europe. The results of this study will be compared to the TAXUS™ ATLAS clinical trial to evaluate the safety of the…
- Trial name
- NCT00754728
- Testing
- JACTAX DES
- Where
- 5 sites in Germany, United Kingdom
- Volunteers
- 103 people
- Sponsor
- Boston Scientific Corporation
Percutaneous Coronary Intervention (PCI), Atrial Fibrillation (AF)
Monotherapy With P2Y12 Inhibitors in Patients With Atrial fIbrillation Undergoing Supraflex Stent Implantation
Patients with atrial fibrillation undergoing percutaneous coronary intervention with stent implantation require treatment with different antithrombotic drugs.
- Conditions
- Percutaneous Coronary Intervention (PCI), Atrial Fibrillation (AF), Oral Anticoagulation, P2Y12 Inhibitor
- Trial name
- MATRIX-2 (NCT05955365)
- Testing
- P2Y12 inhibitor, Aspirin, DOAC
- Where
- 15 sites in Belgium, France and 7 more
- Volunteers
- 3,010 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Pericardial Effusion, Inflammatory Response After Surgery
Anesthesia Management, Inflammatory Response and Recovery After Non-intubated VATS Pericardial Window
Non-intubated video-assisted thoracoscopic surgery (NIVATS) is performed under spontaneous ventilation and avoids tracheal intubation and one-lung mechanical ventilation.
- Conditions
- Pericardial Effusion, Inflammatory Response After Surgery, Postoperative Complications, Procedural Sedation and Analgesia
- Trial name
- RNIVATS (NCT07800767)
- Testing
- Systemic opioid-based analgesia during NIVATS, Thoracic regional analgesia during NIVATS
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Koşuyolu Kartal Heart Training and Research Hospital
Covid19, Acute Cardiovascular Disease
Russian Cardiovascular Registry of COVID-19
This is a Russian multicenter observational study aimed to assess the mid-term and long-term prognosis in patients recovered from COVID-19 with the involvement of the cardiovascular system or with baseline severe cardiovascular…
- Conditions
- Covid19, Acute Cardiovascular Disease, Cardiovascular Diseases
- Trial name
- NCT04724707
- Where
- Russia
- Volunteers
- 900 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Pulmonary Embolism
Replication of the EINSTEIN-PE Anticoagulant Trial in Healthcare Claims Data
Investigators are building an empirical evidence base for real world data through large-scale replication of randomized controlled trials.
- Trial name
- NCT04879407
- Testing
- Rivaroxaban, Warfarin
- Where
- United States
- Volunteers
- 98,947 people
- Sponsor
- Brigham and Women's Hospital
Heart Failure, Atrial Fibrillation
Cardiac Contractility Modulation in Patients With Chronic Heart Failure and the Various Forms of Atrial Fibrillation
Chronic heart failure (CHF) is a global pandemic which affects around 26 million people worldwide and develops in 10% of people over 70 years .
- Conditions
- Heart Failure, Atrial Fibrillation, Left Ventricular Ejection Fraction
- Trial name
- NCT05550792
- Testing
- optimizer smart
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
Acute Leukemia, Chronic Leukemia
Fungemia in Hematologic Malignancies
The purpose of this study is to determine the risk factors for fungemia in a population of patients diagnosed with hematologic malignancies and eligible for chemotherapy.
- Conditions
- Acute Leukemia, Chronic Leukemia, Multiple Myeloma, Lymphoma
- Trial name
- NCT02451592
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Sorveglianza Epidemiologica Infezioni Fungine Emopatie Maligne
Atrial Fibrillation
Left Atrial Function After Pulsed Field Ablation of Atrial Fibrillation
Introduction: Pulsed field ablation (PFA) has emerged in routine clinical practice as a new promising technology in catheter-based treatment of atrial fibrillation (AF).
- Trial name
- NCT06478342
- Testing
- ablation
- Volunteers
- 50 people
- Sponsor
- Charles University, Czech Republic
Arterial Hypertension
The Role of Genetic Factors in the Development of Arterial Hypertension in the Kazakh Population
This is a GWAS study that aims to identify possible candidate genes associate to arterial hypertension by exploring single nucleotide polymorphism (SNP) in a group of arterial hypertension, in the Kazakh population.
- Trial name
- NCT05088486
- Testing
- DNA analysis
- Where
- Kazakhstan
- Volunteers
- 1,200 people
- Sponsor
- Asfendiyarov Kazakh National Medical University
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