Clinical trials: Cardiovascular Disease, Obesity
Overweight, Obesity
Cardiovascular Risk Factors in Overweight Adolescents
The aim of the present study was to determine the effects of either a multidisciplinary approach or intensity-controlled interval training on cardiovascular risk factors in overweight adolescents.
- Trial name
- NCT00184236
- Testing
- Multitreatment approach, Aerobic interval training
- Where
- Norway
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Obesity
BLOSSOM: Behavioral Modification and Lorcaserin Second Study for Obesity Management
The purpose of this study is to assess the weight loss effect of lorcaserin during and at the end of 1 year of treatment in overweight and obese patients.
- Trial name
- NCT00603902
- Testing
- Lorcaserin 10 mg once daily (QD), Lorcaserin 10 mg twice a day (BID)
- Where
- United States
- Volunteers
- 4,008 people
- Sponsor
- Eisai Inc.
Heart Failure
Dietary Prevention of Heart Failure in Hypertensive Metabolic Syndrome
Tens of thousands of Veterans have heart failure with preserved ejection fraction (HFpEF), and suffer poor quality of life, frequent hospitalizations, and high death rates.
- Trial name
- NCT03170375
- Testing
- Performance of WHEELS-I in promoting DASH/SRD adoption
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- VA Office of Research and Development
Hypertension, Obesity & Overweight
A Trial Within Cohort Feasibility Study Design Comparing Standard of Care Versus Weight Loss (Achieved Through Tirzepatide) for Obesity-related Hypertension in Young Adults
Hypertension is the leading risk factor for death globally, affecting approximately 30% of adults in the United Kingdom. Obesity is also a serious and ongoing epidemic, with global obesity rates having more than tripled in men…
- Trial name
- SOLUTION-Pilot (NCT07364175)
- Testing
- Tirzepatide, Anti-Hypertensive medications
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Cardiovascular Disease, Obesity
Heart Health Study in Washington D.C. to Develop a Community-Based Behavioral Weight Loss Intervention
Background: Past studies suggest that the best way to improve heart health in the Black community is through community-based programs. Researchers will partner with DC community leaders.
- Trial name
- NCT01927783
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Pediatric Obesity
Cardiovascular Alterations in Obese Children
This cross-sectional study aims to assess cardiovascular structural and electrophysiological alterations in obese children attending Assiut University Children's Hospital.
- Trial name
- NCT07859657
- Volunteers
- 150 people
- Sponsor
- Assiut University
Obesity, Cardiovascular Risk Factors
Planned CORR: Planned Care for Obesity and Risk Reduction
The researchers propose a randomized controlled trial to evaluate how well an intervention, Planned Care for Obesity \& Risk Reduction (Planned CORR), supports primary care treatment of obesity in adults with at least one…
- Trial name
- Planned CORR (NCT01134029)
- Testing
- Stepped Care
- Where
- United States
- Volunteers
- 262 people
- Sponsor
- University of California, San Diego
Adolescent Obesity, Hypertension,Essential
Treatment and Handling Severe Obesity-Related Comorbidities in Adolescents Through Exercise
The main objective of this project is to analyze the effect of a tailor-made, one-to-one, exercise program (aiming to treat and handle obesity-related comorbidities in adolescents with severe obesity at high risk of…
- Conditions
- Adolescent Obesity, Hypertension,Essential, Non-Alcoholic Fatty Liver Disease, Dyslipidemias
- Trial name
- THOR-X (NCT06520800)
- Testing
- Treatment and handling obesity-related comorbidities in adolescents through exercise
- Volunteers
- 24 people
- Sponsor
- University of Lisbon
Obesity, Morbid, Type 2 Diabetes Mellitus (T2DM)
Comparative Outcomes of One-Anastomosis Gastric Bypass and Roux-en-Y Gastric Bypass As Revisional Procedures Following Failed Restrictive Bariatric Surgery
Study Description This prospective, multicenter study aims to compare the outcomes of One-Anastomosis Gastric Bypass (OAGB) and Roux-en-Y Gastric Bypass (RYGB) as revisional procedures for patients experiencing insufficient…
- Conditions
- Obesity, Morbid, Type 2 Diabetes Mellitus (T2DM), Hypertension, Dyslipidemia
- Trial name
- COBRA stady (NCT06794892)
- Where
- Italy
- Volunteers
- 328 people
- Sponsor
- Azienda Sanitaria Locale Napoli 2 Nord
Obesity, Cardiovascular Risk Factor
Dietary Sources of Lysophospholipids
This study aims to test the hypothesis that dietary intake of phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) acutely alters plasma lysophosphatidic acid (LPA) levels and autotaxin activity in normal weight and obese…
- Conditions
- Obesity, Cardiovascular Risk Factor, Hyperlipidemia
- Trial name
- NCT02952638
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Susan Smyth
Metabolic Syndrome
Canadian Health Advanced By Nutrition and Graded Exercise
The overall objective of the CHANGE initiative is to change the delivery of care in primary care clinics to treat disease by reducing reliance on drugs and hospitals through the promotion of scientifically validated nutritional…
- Trial name
- CHANGE (NCT01616563)
- Testing
- Dietary Intervention, Exercise Prescription and Fitness Program
- Where
- 3 sites in Canada
- Volunteers
- 305 people
- Sponsor
- Daren K. Heyland
Metabolic Syndrome, Obesity
Prevention of the Metabolic Syndrome by New Lifestyle Intervention Methods
This intervention aims to reduce obesity by using new type of nutritional and lifestyle therapy and in parallel, tailored persuasive information and communications technology (ICT)-technology based application.
- Conditions
- Metabolic Syndrome, Obesity, Overweight, Cardiovascular Disease
- Trial name
- PrevMetSyn (NCT01959763)
- Testing
- Weight loss counseling program
- Where
- Finland
- Volunteers
- 574 people
- Sponsor
- University of Oulu
Cardiovascular Diseases, Type 2 Diabetes
HEART Kitchen Pilot
This study is testing a 28-day healthy eating program for adults who live in public housing and are at risk for heart disease. The program helps people eat more whole plant foods, like fruits, vegetables, beans, and whole grains…
- Conditions
- Cardiovascular Diseases, Type 2 Diabetes, Obesity and Obesity-related Medical Conditions
- Trial name
- HEARTKITCHEN (NCT07037121)
- Testing
- Whole Food Plant Based Diet Jumpstart
- Where
- United States
- Sponsor
- Reya Andrews
Obesity
Trial of the MEND Childhood Obesity Treatment Program
The number of children who are obese in the UK is steadily increasing with both short and long term consequences for health. The aim of this study is to determine whether the MEND Programme (a new national initiative for the…
- Trial name
- MEND (NCT00974116)
- Testing
- MEND Childhood Obesity Program, Control Group
- Volunteers
- 300 people
- Sponsor
- Institute of Child Health
Coronary Syndrome, Obesity
Body Composition Estimated by Bioelectrical Impedance Analysis in Patients with Acute Coronary Syndrome.
This study addresses the critical issue of obesity and its impact on patients with acute coronary syndrome (ACS). While obesity is a known risk factor for cardiovascular diseases, emerging evidence suggests that obese patients…
- Trial name
- NCT06561815
- Where
- Argentina
- Volunteers
- 100 people
- Sponsor
- Hospital de Clinicas José de San Martín
Cardiovascular Diseases, Heart Diseases
Physical Fitness and Cardiovascular Mortality in Firefighters
To study prospectively the interrelationships among physical fitness, activity, other measured risk factors, coronary heart disease (CHD) and all-cause mortality in a cohort of 3,403 firefighters.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Hypertension
- Trial name
- NCT00005540
- Volunteers
- 3,403 people
- Sponsor
- University of Southern California
Obesity
A Study of Safety and Efficacy of Topiramate in Male Patients With Abdominal Obesity
The purposes of this study are to compare the effects of Topiramate and placebo on abdominal visceral fat accumulation at 6 months and to evaluate the safety of Topiramate for up to 12 months of continued treatment in male…
- Trial name
- NCT00231608
- Testing
- topiramate
- Volunteers
- 68 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Psoriatic Arthritis, Osteoarthitis
CARTIZ Registry: Cartilage, Arthropathy and Imaging Under Tirzepatide in Zone-stratified Cohorts - A Four-Institute Mexican Observational Registry
CARTIZ is a prospective observational clinical registry of adults in Mexico receiving tirzepatide (a dual GLP-1/GIP receptor agonist) under an independent clinical indication - typically type 2 diabetes, insulin resistance…
- Conditions
- Psoriatic Arthritis, Osteoarthitis, Knee, Diabetes (DM)
- Trial name
- CARTIZ (NCT07567378)
- Testing
- Tirzepatide
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- JULIO GRANADOS MONTIEL
Growth & Development, Obesity
Effects of Infant Egg Consumption on Child Health and Cognition Development
The objective of this study is to examine how infant egg consumption (age of introduction and frequency of intake) influences physical growth, obesity, cardio-metabolic health, risk of food allergy, and cognition development in…
- Conditions
- Growth & Development, Obesity, Cardiovascular Risk Factor, Metabolic Syndrome
- Trial name
- NCT04345185
- Testing
- Infant egg consumption (i.e., age of introduction and frequency of intake)
- Where
- United States
- Volunteers
- 5,374 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Hypertension
A Clinical Study to Compare Combination of Aliskiren+ HCTZ to Irbesartan+ HCTZ or Amlodipine+ HCTZ or HCTZ Alone in Obese Hypertensive Not Responsive to HCTZ 25 mg
To evaluate the blood pressure lowering effects of the combination of aliskiren 300 mg and HCTZ 25 mg in obese patients with essential hypertension inadequately treated with HCTZ 25 mg, compared to irbesartan or amlodipine with…
- Trial name
- NCT00219115
- Testing
- aliskiren
- Where
- 2 sites in United States, Germany
- Volunteers
- 493 people
- Sponsor
- Novartis
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