Clinical trials: Cardiovascular Disease, Obesity
Obesity, Morbid, Obesity (BMI > 35) and Diabetes Mellitus
Pilot Study of an Intervention Involving Cognitive Training and tDCS in Morbidly Obese Subjects
The study aims to: 1) investigate the effects of cognitive training (CT) and combined CT and transcranial direct current stimulation (tDCS) on food intake and 2) to further understand its neuropsychological and neurophysiological…
- Conditions
- Obesity, Morbid, Obesity (BMI > 35) and Diabetes Mellitus, Obesity (BMI > 35) and High Blood Pressure, Obesity (BMI > 35) and Dyslipemia
- Trial name
- NCT03943979
- Testing
- Cognitive Training, transcranial Direct-Current Stimulation (tDCS)
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Parc de Salut Mar
Cardiovascular Diseases, Coronary Disease
Genetics of Atherosclerosis in Mexican Americans
To identify individual genes that contribute to variation in susceptibility to coronary heart disease (CHD) in Mexican Americans.
- Conditions
- Cardiovascular Diseases, Coronary Disease, Obesity, Atherosclerosis
- Trial name
- NCT00005462
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Obesity, Cardiovascular Disease
Effectiveness of Four Popular Diet Strategies for Weight Loss and Cardiac Risk Reduction
A single-center randomized trial at an academic medical center in Boston, Mass, of overweight or obese adults with known hypertension, dyslipidemia, or fasting hyperglycemia.
- Conditions
- Obesity, Cardiovascular Disease, Metabolic Syndrome
- Trial name
- NCT02454127
- Testing
- Atkins Diet, Zone Diet, Weight Watchers Diet
- Volunteers
- 160 people
- Sponsor
- Tufts Medical Center
Hypertension
Clinical Efficacy of Telmisartan in Reducing Cardiac Remodeling Among Obese Patients With Hypertension
Hypertension is closely related to metabolic abnormalities such as obesity, dyslipidemia and diabetes. When hypertension is complicated with metabolic abnormalities, target organ damage is more serious, the risk of cardiovascular…
- Trial name
- NCT03956823
- Testing
- telmisartan, amlodipine
- Where
- China
- Volunteers
- 300 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Type 2 Diabetes Mellitus (T2DM), Hypertension
Eating Window and Sleep Disorders on Glycemic Control, Cardiovascular Risk, and Weight Loss
This project aims to offer a quantitative and qualitative nutritional approach, along with educational nutritional guidelines for participants with Non-Communicable Chronic Diseases.
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Hypertension, Obesity and Type 2 Diabetes, Cardiovascular Diseases
- Trial name
- NCT06735859
- Testing
- Comparison of eating windows intervention
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of São Paulo
Morbid Obesity, Diabetes
Factors Influencing the Positive Outcome of Bariatric Surgery for Morbidly Obese Patients
The purpose of this study is to report data with patients after bariatric surgery.
- Conditions
- Morbid Obesity, Diabetes, Hypertension
- Trial name
- NCT01583790
- Where
- Israel
- Volunteers
- 2,000 people
- Sponsor
- Assuta Hospital Systems
Morbid Obesity, Type2diabetes
Comorbidities Resolution After MGB Surgery and Change in Body Composition
This observational study aims to learn about the correlation between the improving comorbidities associated with obesity after MGB (Mini-Gastric Bypass) surgery and changes in body composition in morbidly obese patients.
- Conditions
- Morbid Obesity, Type2diabetes, Sleep Apnea, Hypothyroidism
- Trial name
- MOGAMBO (NCT06015620)
- Testing
- Mini gastric bypass surgery
- Where
- India
- Volunteers
- 35 people
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Obesity, Food Addiction
Impact of a Phone-based Cognitive and Behavioral Therapy on Food Addiction in Patients With Severe or Morbid Obesity
Morbid or severe obesity is a chronic pathology of multifactorial etiology that affects 4.3% of the French population. In these patients, eating disorders are frequent and must be managed as they are considered risk factors with…
- Trial name
- ADALOB (NCT04626570)
- Testing
- Cognitive and Behavioral Therapy
- Where
- 9 sites in France
- Volunteers
- 154 people
- Sponsor
- University Hospital, Tours
Hypertension, Atherosclerosis
Age-Related Changes in Body Composition
Background: Advancing age is associated with greater risk of heart disease. High blood pressure and hardening of the arteries also have more complications with age.
- Trial name
- NCT01517113
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Cardiovascular Diseases, Hypercholesterolemia
Plant Sterols on Cardiovascular Markers, Microbiota and Sterol Metabolism (Cardiofoodsterol)
Potential cholesterol-lowering effect of a regular intake of a plant sterol (PS)-containing food supplement, in overweight/obese type 1 or 2, normoglycemic/pre-diabetic, with LDL-cholesterol values > 115 mg/dl and not…
- Conditions
- Cardiovascular Diseases, Hypercholesterolemia, Prediabetic State, Overweight and Obesity
- Trial name
- NCT06481020
- Testing
- Plant sterols 2g/day
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- University of Valencia
Atherosclerosis
Lipoic Acid and Prevention of Heart Disease
The purpose of this study is to see if a dietary supplement, R-alpha lipoic acid, is able to reduce risk factors such as body weight and high blood cholesterol levels in overweight or obese participants.
- Trial name
- NCT00765310
- Testing
- R-alpha lipoic acid
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Oregon State University
Aging, Obesity
Acute Exercise on Brain Insulin Sensitivity
Dementia is a leading cause of death in the United States among aging adults. Brain insulin resistance has emerged as a pathologic factor affecting memory, executive function as well as systemic glucose control.
- Conditions
- Aging, Obesity, Insulin Resistance, Cognition
- Trial name
- NCT05853913
- Testing
- Exercise
- Where
- 4 sites in United States
- Volunteers
- 16 people
- Sponsor
- Rutgers, The State University of New Jersey
Obesity, Diabetes
Effect of Pomegranate Extract Intake on Body Composition and Blood Pressure.
Pomegranate has gained widespread popularity since the health effects of the whole fruit, as well as its juices and extracts, have been studied in relation to a variety of chronic conditions such as hypertension, diabetes…
- Conditions
- Obesity, Diabetes, Cardiovascular Disease
- Trial name
- NCT02017132
- Testing
- Pomegranate extract
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Queen Margaret University
Coronary Artery Disease, Coronary Heart Disease
Gamification to Increase Mobility in the Hospital
Low mobility is a mediator for poor outcomes of hospital care. Wearable devices will be used and 2-way texting via patient smartphones to monitor patients' physical activity during hospitalization with and without gamification to…
- Conditions
- Coronary Artery Disease, Coronary Heart Disease, Hypertension, Diabete Mellitus
- Trial name
- Level Up (NCT04300764)
- Testing
- Gamification Intervention
- Where
- United States
- Sponsor
- University of Pennsylvania
Morbid Obesity
Sevoflurane Versus Intravenous Anaesthetic Agents in Morbid Obese Patients
The objective of this prospective randomized clinical study was to compare anesthesia, in morbidly obese patents (BMI >50) who underwent BPD-RYGBP with either sevoflurane or propofol with remifentanyl.
- Trial name
- NCT01279499
- Testing
- Sevoflurane, Propofol- Remifentanyl, Propofol, Remifentanyl
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- University of Patras
Obesity, Cardiovascular Disease
IMPACT: Inactivity Monitoring and Physical Activity Controlled Trial
As individuals age, their physical activity decreases and sedentary time increases. Even small changes in these two behaviors can greatly decrease risks for several major health problems, including cardiovascular disease…
- Conditions
- Obesity, Cardiovascular Disease, Cancer, Diabetes
- Trial name
- IMPACT (NCT01869348)
- Testing
- Monitor intervention
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Morbid Obesity, Insulin Resistance
Assessment of Insulin Resistance, NAFLD, Predictors of CV Morbidity, and Subcutaneous Adipose and Visceral Adipose Gene Expression in Patients Undergoing Gastric Bypass Surgery
The purpose of this research is to further study the effect weight loss after gastric bypass surgery has on the heart and blood pressure and on how the body uses or metabolizes the sugars, fats and proteins we eat.
- Conditions
- Morbid Obesity, Insulin Resistance, Non-Alcoholic Fatty Liver Disease
- Trial name
- NCT01007955
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- University of Massachusetts, Worcester
Overweight, Obesity
Program of Healthy Lifestyle Promotion in Yaqui Indigenous in Sonora
Obesity has become an epidemic worldwide and is considered one of the main causes related to type 2 diabetes. The World Health Organization reported that in 2016, 39% of adults were overweight, while the percentage of obesity was…
- Trial name
- NCT03599817
- Testing
- Healthy lifestyle promotion program
- Where
- 4 sites in Mexico
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centro de Investigación en Alimentación y Desarrollo A.C.
Cardiovascular Diseases Risk, Adiposity
Dose-effect of HIIT on Cardiovascular Health of Children
An adequate physical activity level has important effects on cardiovascular health of children. However, the scientific literature suggests that few children meet the physical activity recommendations to obtain these…
- Trial name
- NCT03479658
- Testing
- High intensity interval training, Nutritional education
- Where
- Spain
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Universidad Pública de Navarra
Hypertension (HTN), Diabetes (DM)
Team-Based Shared Decision-Making Program in Cardiovascular-Kidney-Metabolic Health (Healthy Heart - CKM)
The investigators are proposing a new team-based shared decision-making (SDM) program. The goal of this study is to see whether this program is practical and whether it may help adults with cardiometabolic risk factors and…
- Conditions
- Hypertension (HTN), Diabetes (DM), Hyperlipidaemia, Kidney Disease
- Trial name
- SDM in CKM (NCT07662616)
- Testing
- Team-based shared decision-making
- Volunteers
- 94 people
- Sponsor
- Johns Hopkins University
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