Clinical trials: Cardiovascular Disease, Obesity
Childhood Obesity
Role of Carbohydrate Modification in Weight Management Among Obese Children
The purpose of this study is to test the hypothesis that a low-carbohydrate diet and a low-glycemic load diet will improve body mass index and result in more body fat loss than a control diet among overweight children ages 7 to…
- Trial name
- NCT00215111
- Testing
- Low carbohydrate, reduced glycemic load, and a control diet
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Hypertension, Obesity & Overweight
A Trial Within Cohort Feasibility Study Design Comparing Standard of Care Versus Weight Loss (Achieved Through Tirzepatide) for Obesity-related Hypertension in Young Adults
Hypertension is the leading risk factor for death globally, affecting approximately 30% of adults in the United Kingdom. Obesity is also a serious and ongoing epidemic, with global obesity rates having more than tripled in men…
- Trial name
- SOLUTION-Pilot (NCT07364175)
- Testing
- Tirzepatide, Anti-Hypertensive medications
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Obesity, Exercise
Structured Exercise Prescription Program in Obese Children
This controlled clinical trial aims to compare the effects of a multicomponent program that includes structured personalized exercise prescription in children with obesity with a control group that will be enrolled in a…
- Conditions
- Obesity, Exercise, Cardiovascular Risk Factor, Liver Diseases
- Trial name
- NCT03552367
- Testing
- Personalized structured exercise program, Non personalized non-structured exercise program
- Where
- Mexico
- Volunteers
- 140 people
- Sponsor
- Hospital General de México Dr. Eduardo Liceaga
Abdominal Obesity, Metabolic Syndrome
Aldosterone, Microvascular Function and Salt-sensitivity
Currently, the incidence of obesity and obesity-related disorders is reaching epidemic proportions, which entails an increasing burden for health care systems.
- Conditions
- Abdominal Obesity, Metabolic Syndrome, Sodium-sensitivity, Insulin Resistance
- Trial name
- NCT02068781
- Testing
- Low-sodium diet, High-sodium diet
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Obesity & Overweight
Cardiac Function and Biomarkers in Patients With Obesity and Overweight
Obesity is a major public health problem worldwide and an established risk factor for cardiovascular disease. In individuals with obesity or overweight, systemic inflammation and endothelial dysfunction contribute to myocardial…
- Trial name
- BEYOND (NCT07455630)
- Testing
- Weight loss with pharmacotherapy, Weight loss without pharmacotherapy
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- TecSalud Investigación Clínica
Obesity, Hypertension
A Randomized Clinical Trial To Study Losartan On Endothelial Dysfunction and Insulin Resistance In Obese Patients
The main purposes of this study are to find out if the study drug losartan (Cozaar) or placebo ("sugar pill") has an effect on insulin sensitivity (how your body responds to insulin) and to measure the effect of the study drug…
- Conditions
- Obesity, Hypertension, Hyperglycemia
- Trial name
- NCT00675987
- Testing
- losartan
- Where
- 9 sites in United States
- Volunteers
- 53 people
- Sponsor
- Brigham and Women's Hospital
Cognitive Impairment, Dementia
Determinants of Cognitive Impairment Among Geriatrics
This study aims to explore the determinants of cognitive impairment among Indonesian geriatrics in an Old Age Home.
- Conditions
- Cognitive Impairment, Dementia, Hearing Impairment, Vision Impairment and Blindness
- Trial name
- NCT03669536
- Where
- Indonesia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tarumanagara University
Cardiovascular Diseases, Heart Diseases
School- and Home-Based Program to Prevent Obesity in American Indian Children
The purpose of this study is to prevent excessive weight gain among kindergarten and first grade American Indian children using improved diet and increased physical activity at home and at school.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Obesity
- Trial name
- NCT00123032
- Testing
- Diet, Exercise
- Where
- 2 sites in United States
- Sponsor
- University of Minnesota
Physical Activity
Exercise is Medicine at Emory Seavey Internal Medicine Clinic
Implementation of physical activity promotion in routine health care delivery is low because of multiple barriers including insufficient health system support, care team coordination, and scarcity of community resources for…
- Trial name
- EIM (NCT03416634)
- Testing
- App, Wearable Device, Automated Motivational Message
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Emory University
Morbid Obesity, Obesity
A Decade of Sleeve Gastrectomy: Analysis of Short and Long-term Outcome of 562 Patients
Obesity is a chronic disease and its treatment requires close follow-up to accurately assess the efficacy and durability of any treatment strategy.
- Conditions
- Morbid Obesity, Obesity, Diabetes, Dyslipidemia
- Trial name
- SG (NCT02931292)
- Testing
- Laparoscopic sleeve gastrectomy
- Volunteers
- 562 people
- Sponsor
- Medical Park Gaziantep Hospital
Hypertension
Safety and Efficacy Study of BMS-823778 to Treat Uncontrolled High Blood Pressure in Overweight and Obese Patients
The purpose of this study is to determine whether BMS-823778 is safe and effective in the treatment of hypertension in overweight and obese patients.
- Trial name
- NCT01602367
- Testing
- BMS-823778
- Where
- 35 sites in United States, Colombia and 3 more
- Volunteers
- 7 people
- Sponsor
- Bristol-Myers Squibb
Heart Failure With Preserved Ejection Fraction, Heart Failure, Diastolic
A Randomised, Controlled Trial of a Low-energy Diet for Improving Functional Status in Heart Failure With PRESERVED Ejection Fraction Preserved Ejection Fraction
Heart failure with preserved ejection fraction (HFpEF) is a common and serious complication of obesity and type 2 diabetes (T2D). HFpEF occurs when the heart muscle unable to relax efficiently to pump the blood around the body.
- Conditions
- Heart Failure With Preserved Ejection Fraction, Heart Failure, Diastolic, Diabetes Mellitus, Type 2, Diabetes Mellitus Type 2 in Obese
- Trial name
- AMEND (NCT05887271)
- Testing
- Low calorie meal replacement plan, Cardiovascular magnetic resonance (CMR) imaging and magnetic resonance spectroscopy, Transthoracic echocardiography
- Where
- 3 sites in United Kingdom
- Volunteers
- 66 people
- Sponsor
- University of Leicester
Heart Failure, Systolic, Heart Failure, Diastolic
Associations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness Status
The purpose of the study is to determine associations between fitness status, bacteria in the mouth, and the blood flow to muscle.
- Conditions
- Heart Failure, Systolic, Heart Failure, Diastolic, Peripheral Arterial Disease, Overweight and Obesity
- Trial name
- NCT06009276
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Virginia
Hypertension, Diabetes
Wearable Devices Empowering Active Health Initiatives for High-Risk Stroke Populations
The purpose of this study is to evaluate the control effect of smart wearable devices on key risk factors in the high-risk populations for stroke
- Conditions
- Hypertension, Diabetes, Atrial Fibrillation, Dyslipidemia
- Trial name
- AISP (NCT06935513)
- Testing
- Wearable Devices
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Affiliated Hospital of Nantong University
Obesity, Cardiovascular Disease
IMPACT: Inactivity Monitoring and Physical Activity Controlled Trial
As individuals age, their physical activity decreases and sedentary time increases. Even small changes in these two behaviors can greatly decrease risks for several major health problems, including cardiovascular disease…
- Conditions
- Obesity, Cardiovascular Disease, Cancer, Diabetes
- Trial name
- IMPACT (NCT01869348)
- Testing
- Monitor intervention
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Cardiovascular Disease, Obesity
Cooperative Lifestyle Programs (CLIP-II)
The aim is to study the effects of weight loss and weight loss combined with different types of physical activity on changes in physical functioning of older adults who are at-risk for cardiovascular disease.
- Conditions
- Cardiovascular Disease, Obesity, Physical Disability
- Trial name
- CLIP-II (NCT01547182)
- Testing
- Caloric restriction, Aerobic Training, Resistance Training
- Where
- 3 sites in United States
- Volunteers
- 249 people
- Sponsor
- Wake Forest University Health Sciences
Obesity
High Fat Diet II on Weight Loss
To evaluate two different diets and their effects on weight loss and measurements of several risk factors for cardiovascular disease.
- Trial name
- HFD (NCT00525850)
- Testing
- high fat diet, low saturated fat diet
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Christiana Care Health Services
Obesity, Cardiovascular Diseases
Inflammatory Status of Monocytes in Obesity
The study of the pro-inflammatory activation of circulating monocytes/macrophages in obesity is the main problem of this project.
- Trial name
- NCT05490862
- Testing
- Lifestyle Modification, Traditional Recommendations
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Federal State Budgetary Scientific Institution
Arrhythmia, Sudden Cardiac Death
Electrophysiological Phenotyping Of Patients at Risk of Ventricular Arrhythmia and Sudden Cardiac Death
Obesity, rheumatoid arthritis (RA) and gene-specific dilated cardiomyopathy (DCM) are common medical conditions. Small-scale studies have shown that these are associated with proarrhythmic changes on 12-lead electrocardiogram…
- Conditions
- Arrhythmia, Sudden Cardiac Death, Cardiomyopathy, Dilated, Obesity
- Trial name
- EPORVA (NCT03910725)
- Testing
- Electrocardiographic imaging
- Where
- 2 sites in United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Obesity, Sedentary Lifestyle
The Healthy Options Feasibility Study
The investigators hypothesize that having health care providers other than physicians within a "Groupe de Médecine de Famille" conduct cardiovascular risk assessments and teach lifestyle interventions to primary prevention…
- Conditions
- Obesity, Sedentary Lifestyle, Dyslipidemia, Hypertension
- Trial name
- NCT00746460
- Testing
- CVD risk profile
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McGill University
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