Clinical trials: Cardiovascular Disease, Obesity
Type 2 Diabetes Mellitus, Cardiovascular Disease
The Effect of a Traditional Dietary Intervention on Diabetes Mellitus and Cardiovascular Disease Risk Factors in a First Nation Community: A Pilot Study
The purpose of this study is to evaluate whether or not a traditional First Nations diet (high protein) and/or a dietary intervention based upon current Canadian dietary recommendations (high carbohydrate/high fiber) effects risk…
- Conditions
- Type 2 Diabetes Mellitus, Cardiovascular Disease, Obesity
- Trial name
- SLHDP (NCT00707460)
- Testing
- Dietary Intervention (Macronutrient composition)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Heart Diseases, Type2 Diabetes
Psychosocial, Environmental, and Chronic Disease Trends in Puerto Rico
The overall goal is to identify trends and longitudinal associations in psychosocial, food-related, and cardiometabolic risk factors that can guide public health priorities and future research needs aimed at reducing…
- Conditions
- Heart Diseases, Type2 Diabetes, Hypertension, Obesity
- Trial name
- PROSPECT (NCT03794531)
- Where
- Puerto Rico
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Vascular Disease, Peripheral, Physical Inactivity
Inter-individual Physiological Response to a Training and Detraining Period in Cardiometabolic Risk Factors Subjects
Background: Although exercise training is a well described therapy for some cardiometabolic diseases such as obesity, type 2 diabetes, arterial hypertension, and metabolic syndrome, there is scarcity of knowledge about the…
- Conditions
- Vascular Disease, Peripheral, Physical Inactivity, Arterial Hypertension, Endothelial Dysfunction
- Trial name
- VASCU-HEALTH (NCT05710653)
- Testing
- Exercise training intervention
- Where
- Chile
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Cristian Alvarez
Cardiovascular Diseases, Sedentary Behaviors
PATHWAYS--FULL SCALE STUDY
To implement a culturally appropriate school-based, multicenter, randomized trial that promotes healthful eating behaviors and increases physical activity to prevent obesity in pre-adolescent upper elementary American Indian…
- Conditions
- Cardiovascular Diseases, Sedentary Behaviors, Obesity
- Trial name
- NCT00000545
- Testing
- exercise, diet
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Sarcopenia, Obesity
Resistance Exercise, Muscle Mass, Strength and Body Composition
A plethora of trials reported the positive effect of resistance exercise on functional and morphological parameters. Although a large amount of the studies used suboptimum devices and obsolete methods the results of these older…
- Trial name
- NCT01766791
- Testing
- HIT-exercise, low repetition range, HIT-exercise, high repetition range, HIT-exercise with protein
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Hypertension, Overweight and Obesity
Lifestyle Online Re-Intervention On Blood Pressure, BMI, And Physical Activity On Obese Hypertensive Patients
This research will constitute a 3 years follow-up which includes a re-assessment and re-intervention of obese or overweight adults with hypertension, recruited from a hypertension unit of a public hospital, that already…
- Trial name
- IBI-HTA (NCT04571450)
- Testing
- Reintervention
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Cardenal Herrera University
Hypertension, Diabetes
Arts & Health Education to Improve Health, Resilience, and Well-Being
This is an 8-week randomized controlled trial to help address health, resilience, and well-being. Participants are randomized into either a health education group or an arts-based health education group.
- Conditions
- Hypertension, Diabetes, Obesity, COPD
- Trial name
- NCT04154579
- Testing
- HeRe We Arts, HeRe We Ed
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Lisa Gallagher
Hypertension
Metabolic Effects of Antihypertensive Drugs on People With Metabolic Syndrome (The MEAD Study)
High blood pressure, also referred to as hypertension, is a blood pressure level of 140/90 mm Hg or higher. Along with lifestyle changes, various medications are currently used to treat people with hypertension.
- Trial name
- MEAD (NCT00887510)
- Testing
- Hydrochlorothiazide, Trandolapril
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Florida
Hypertension With Complications and Secondary Hypertension, Overweight and Obesity
Study of the Long-term Effects of Exercise on Heath Indicators in Older People
Cardiovascular diseases (CVD) represent the most frequent cause of death among the elderly population. Hypertension, unfavorable lipid profile, obesity and physical inactivity are among the main risk factors for CVD.
- Conditions
- Hypertension With Complications and Secondary Hypertension, Overweight and Obesity, Lipid Metabolism Disorders, Sarcopenia
- Trial name
- NCT01874132
- Testing
- Exercise training
- Where
- Portugal
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Trás-os-Montes and Alto Douro
Insulin Resistance, Obesity
Developing an Adaptive Lifestyle Intervention Program in Family Medicine Clinics
The purpose of this study is to investigate the feasibility of conducting a multicomponent lifestyle intervention research study within the UAB Family Medicine Clinic at Highlands and to obtain preliminary data on the…
- Conditions
- Insulin Resistance, Obesity, Diabetes, Hypertension
- Trial name
- NCT04392284
- Testing
- Diet Counseling, Exercise Counseling
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Obesity, Vascular Diseases
Technique for Successful Ultrasound-guided Peripheral Vascular Access
Obtaining peripheral vascular access in medical patients is a necessary procedure for many healthcare providers. Peripheral vascular access is traditionally performed using palpation or visual inspection to identify appropriate…
- Trial name
- NCT01975974
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Iowa
Morbid Obesity, Anorectal Diseases
GLP-1 Receptor Agonists and Early Proctologic Effects in Morbid Obesity
Prospective observational cohort study evaluating the early proctologic effects of GLP-1 receptor agonist therapy in morbidly obese patients.
- Conditions
- Morbid Obesity, Anorectal Diseases, Drug-Related Side Effects and Adverse Reactions, Constipation
- Trial name
- GLP-PROCT (NCT07668765)
- Testing
- GLP-1 receptor agonist therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Gazi University
Obesity (BMI>30), Heart Failure With Preserved Ejection Fraction (HFPEF)
Pilot Study of Endoscopic Sleeve Gastroplasty for Obese Patients With Heart Failure and Preserved Ejection Fraction
This is a small research study to see whether losing weight with a minimally invasive weight-loss procedure called endoscopic sleeve gastroplasty (ESG) can help improve symptoms of a type of heart failure called HFpEF in adults…
- Trial name
- NCT07798219
- Testing
- Endoscopic sleeve gastroplasty (ESG)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center
Obesity, Cardiovascular Disease
Gastric Sleeve Pilot Study in Morbidly Obese Undergoing Liver Transplantation
The rapid rise in obesity (body mass index (BMI) ≥ 30 kg/m2) in the US over the past decade is responsible for more disease and death than any other single factor.
- Conditions
- Obesity, Cardiovascular Disease, Type 2 Diabetes, Hypertension
- Trial name
- NCT02068872
- Testing
- Sleeve Gastrectomy
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Northwestern University
Ischemic Heart Disease, Myocardial Infarction
Polyamine Treatment in Elderly Patients With Coronary Artery Disease
The present study is testing spermidine treatment in elderly patients with coronary artery disease. The study is a randomized, double-blind, placebo-controlled, two-armed, parallel-group, single centre, clinical study.
- Conditions
- Ischemic Heart Disease, Myocardial Infarction, Cardiovascular Diseases, Hypertensive Heart Disease
- Trial name
- PolyCAD (NCT06186102)
- Testing
- Spermidine
- Where
- Denmark
- Volunteers
- 187 people
- Sponsor
- University of Aarhus
Obesity, Overweight
Study of the Effect of Moxonidine and Diet on Sympathetic Functions in Young Adults With Obesity
The prevalence of obesity is increasing rapidly among adults and has more than doubled in the past 10 years. The metabolic syndrome (MS) is often associated with obesity.
- Trial name
- NCT01180231
- Testing
- Moxonidine (Physiotens), Dietary intervention
- Where
- 2 sites in Australia
- Volunteers
- 77 people
- Sponsor
- Baker Heart and Diabetes Institute
Hypercholesterolemia, Cardiovascular Risk Factor
Effect of Totum-070 on Lipid Metabolism in Moderate Hypercholesterolemic Subjects
This clinical study aims to assess the efficacy of TOTUM-070, a mix of 5 plant extracts, on lipid metabolism in moderate hypercholesterolemic subjects.
- Conditions
- Hypercholesterolemia, Cardiovascular Risk Factor, Dyslipidemias, Overweight and Obesity
- Trial name
- HEART (NCT04760951)
- Testing
- TOTUM-070
- Where
- 4 sites in France, Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Valbiotis
Hypertension, Abdominal Obesity
Treatment of Adiposity Related hypErTension (TARGET)
High blood pressure (hypertension) is an important cause of myocardial infarction and stroke. High blood pressure often occurs in people who are overweight. These people frequently also have abnormal fat and sugar metabolism.
- Conditions
- Hypertension, Abdominal Obesity, Metabolic Syndrome
- Trial name
- TARGET (NCT01138423)
- Testing
- Aliskiren, Moxonidine, Hydrochlorothiazide
- Where
- Netherlands
- Volunteers
- 32 people
- Sponsor
- UMC Utrecht
Bariatric Surgery Candidate, Cardiovascular Diseases
Gut Microbiota in Metabolic Surgery
Metabolic surgery is an emerging option to treat obesity-related metabolic diseases (e.g., type 2 diabetes) and prevent cardiovascular disease (CVD).
- Conditions
- Bariatric Surgery Candidate, Cardiovascular Diseases, Type 2 Diabetes, Dyslipidemias
- Trial name
- NCT05000996
- Testing
- Bariatric Surgery
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Vanderbilt University Medical Center
Obesity
Weight Loss Effects on Heart and Blood Vessel Function in Obesity
Obesity is a growing epidemic and is associated with an increased risk of heart attack and stroke. The investigators know that obesity leads to abnormalities in how the blood vessels and the heart function and that these…
- Trial name
- NCT00782262
- Testing
- KicStart™
- Where
- Australia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Adelaide
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