Clinical trials: Cardiovascular Disease, Obesity
Obesity, Pre-hypertension
Diet and Whole-body Vibration Training on Cardiovascular and Autonomic Function
Obesity is a major risk factor for premature arterial abnormalities including high blood pressure and increased stiffness. Previous studies have shown that weight loss via lifestyle modifications is associated with a decrease in…
- Conditions
- Obesity, Pre-hypertension, Hypertension
- Trial name
- NCT01741779
- Testing
- Whole Body Vibration Training, Hypocaloric diet, Whole body vibration training & diet
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Florida State University
Cardiovascular Disorder, Coronary Artery Disease
A Sugar-Sweetened Beverage Reduction Intervention for Native American Men
This clinical trial develops and tests a culturally-appropriate educational program (Indigenous SIPin) for reducing sugar-sweetened beverage consumption in men affiliated with Native American athletics communities.
- Conditions
- Cardiovascular Disorder, Coronary Artery Disease, Diabetes Mellitus, Obesity-Related Malignant Neoplasm
- Trial name
- NCT06029517
- Testing
- Education Intervention, Observation of Indigenous SIPin Interventon, Discussion
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Obesity, Vitamin D Deficiency
Vitamin D Supplementation Reduces Renin-Angiotensin System Activity in Obesity
Hypothesis: Vitamin D supplementation lower renin-angiotensin system activity in obesity. Specific Aim: To investigate whether Vitamin D supplementation in obesity improves the vascular sensitivity to angiotensin II.
- Conditions
- Obesity, Vitamin D Deficiency, Hypertension
- Trial name
- NCT01068418
- Testing
- Vitamin D (cholecalciferol)
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Brigham and Women's Hospital
Blood Pressure, High Blood Pressure
Remote Dietary Counseling to Promote Healthy Diet and Blood Pressure
American College of Cardiology/American Heart Association (ACC/AHA) hypertension guidelines recommend lifestyle modification for patients with elevated blood pressure.
- Conditions
- Blood Pressure, High Blood Pressure, Dietary Modification, Overweight and Obesity
- Trial name
- NCT03700710
- Testing
- Self-Guided Approach, Dietitian-led Approach
- Where
- 2 sites in United States
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- Geisinger Clinic
Atrial Fibrillation Ablation, Persistent Atrial Fibrillation
Tirzepatide to Reduce rEcurrence And Burden After Ablation of Atrial Fibrillation
The goal of this clinical trial is to determine whether tirzepatide can reduce atrial fibrillation (AF) burden after catheter ablation in overweight or obese patients with persistent AF.
- Conditions
- Atrial Fibrillation Ablation, Persistent Atrial Fibrillation, Obesity & Overweight
- Trial name
- TREAT-AF (NCT07382024)
- Testing
- Tirzepatide, Standard Care (in control arm)
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Cardiovascular Diseases, Obesity Prevention
Mediterranean Diet Education in Shift Nurses: Effects on Sleep, Activity, and Health Parameters
This study aimed to evaluate the effects of Mediterranean diet education on sleep quality, physical activity levels, blood parameters, and anthropometric measurements among shift-working nurses.
- Conditions
- Cardiovascular Diseases, Obesity Prevention, Atheroscleroses, Hypertension
- Trial name
- NCT07123610
- Testing
- Mediterranean Diet Education Program
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Health, Subjective, Healthy
Prevalence of Sedentary Lifestyle, Pre-hypertension, and Obesity
Hypertension has been a serious problem among people from different ages in the last few decades, so by taking this in consideration we decided to search for specific risk factors that cause hypertension in young healthy adults…
- Trial name
- NCT05629351
- Testing
- Observational Group
- Where
- Turkey (Türkiye)
- Volunteers
- 382 people, healthy volunteers welcome
- Sponsor
- Istanbul Saglik Bilimleri University
Lung Diseases, Sleep Apnea Syndromes
Sleep Apnea in a Non-Clinical Population
To investigate the causes, consequences and quantitation of sleep disordered breathing (SDB).
- Conditions
- Lung Diseases, Sleep Apnea Syndromes, Obesity, Cardiovascular Diseases
- Trial name
- NCT00005551
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Obesity, Peripheral Arterial Disease
Lower Extremity Venous Hemodynamics in Obese Patients Without Clinically Significant Venous Disease
This research project is investigating the relationship between body weight and function of the leg veins using a special non-invasive technique known as venous plethysmography.
- Trial name
- NCT00554541
- Testing
- Ankle Brachial Index Venous physiologic study
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Hypertension, Obesity
A Randomized Trial of Behaviorally Designed Gamification and Social Incentives to Increase Physical Activity Among Overweight and Obese Veterans
Despite the many associated health benefits, more than half of Veterans do not achieve enough regular physical activity. The investigators' prior work has demonstrated that gamification, a method commonly used for health…
- Trial name
- STEP 4 Vets (NCT05554601)
- Testing
- gamification with collaboration, gamification with competition
- Where
- United States
- Volunteers
- 725 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Obesity, Overweight
Hybridized Three Steps Intervention to Prevent Diabetes in Venezuela
The American Diabetes Association recommends implementing the Diabetes Prevention Program (DPP) in subjects with prediabetes. In the DPP, weight reduction was the main predictor of a lower incidence of type 2 diabetes (T2D), each…
- Conditions
- Obesity, Overweight, PreDiabetes, Diabetes Mellitus, Type 2
- Trial name
- HITS (NCT04927871)
- Testing
- Total Diet Replacement (TDR), Medical Nutritional Therapy (MNT), Diabetes Prevention Program 4 months
- Where
- 2 sites in Venezuela
- Volunteers
- 156 people
- Sponsor
- Foundation for Public Health and Epidemiological Research of Venezuela
Cardiovascular Diseases, Type 2 Diabetes Mellitus in Obese
Implementation of a Peer Leader-facilitated Dyadic Intervention
This Pilot Study Large Application builds upon the results of our prior work to 1) Implement and pilot test a peer leader-facilitated 12-week dyadic intervention (Community Health among Asian Indian immigrants (CHAI) Dyad study)…
- Conditions
- Cardiovascular Diseases, Type 2 Diabetes Mellitus in Obese, Hyperlipidemias
- Trial name
- NCT06643806
- Testing
- CHAI dyad study
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Diabetes, Prediabetes
Meta-Analyses of the Effect of Plant Protein Versus Animal Protein on Cardiometabolic Risk
Vegetarian diets have been associated with a reduced risk of preventable diseases such as type 2 diabetes and cardiovascular disease. These effects may be mediated through direct or indirect pathways.
- Conditions
- Diabetes, Prediabetes, Metabolic Syndrome, Dysglycemia
- Trial name
- NCT02037321
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- John Sievenpiper
Insulin Sensitivity, Obstructive Sleep Apnea
Obesity, Sleep Apnea, and Insulin Resistance
Obstructive sleep apnea (OSA) and type 2 diabetes confer increasing economic, social, and public health burdens in the United States.
- Trial name
- NCT02192684
- Testing
- Pioglitazone
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Stanford University
Obesity
Beige Fat, Energy, and the Natriuretic Peptide System
Obese individuals experience an increased risk of cardiovascular and metabolic diseases. Evidence from genetic studies indicate that the natriuretic peptide (NP) system may protect against these diseases.
- Trial name
- NCT04357964
- Where
- 2 sites in United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Obesity and Type 2 Diabetes, NAFLD - Non-Alcoholic Fatty Liver Disease
OneSTOP (One-Stop Telehealth Obesity Program) for Multidisciplinary Weight Management and Related Comorbidities
The goal of this clinical trial is to learn if the use of a care model including teleconsults and the EMPOWER app can induce clinically significant weight loss and metabolic improvements in obese adults with diabetes and…
- Conditions
- Obesity and Type 2 Diabetes, NAFLD - Non-Alcoholic Fatty Liver Disease, Hypertension, Dyslipidaemia
- Trial name
- OneSTOP (NCT06890169)
- Testing
- OneSTOP program, Standard of care weight management program
- Where
- Singapore
- Volunteers
- 120 people
- Sponsor
- Changi General Hospital
Vascular Disease, Diabetes
A Randomized Controlled Trial of a Novel Community-based Primary and Secondary Cardiovascular Prevention Program
VIP is a demonstration project with a goal to decrease modifiable risk factors for those with a higher risk of having a vascular event such as a heart attack or stroke or of developing vascular disease.
- Conditions
- Vascular Disease, Diabetes, Hypertension, Hyperlipidemia
- Trial name
- NCT00236210
- Testing
- Action Score, VIP program
- Where
- Canada
- Volunteers
- 422 people
- Sponsor
- Group Health Centre
Obesity, Insulin Resistance
Effects of Infliximab on Insulin Sensitivity and Beta Cell Function in Insulin Resistant Human Obesity
The aim of the study is to test whether neutralizing TNF-alpha with infliximab affects insulin resistance and phenotypical manifestations of the metabolic syndrome as fasting plasma insulin, total body fat, plasma lipid profile…
- Conditions
- Obesity, Insulin Resistance, Metabolic Syndrome
- Trial name
- NCT00636142
- Testing
- Infliximab
- Where
- Austria
- Volunteers
- 9 people
- Sponsor
- Medical University of Graz
Acute Coronary Syndrome
Study of the Efficiency of Education About Cardiovascular Risk Factors in Patients After an Acute Coronary Syndrome
The purpose of this study is to determine whether the follow up of patients with acute coronary syndrome and modifiable cardiovascular risk factors is efficient based on outpatients visits in a House of Education, underlining the…
- Trial name
- NCT00337480
- Testing
- education
- Where
- 6 sites in France
- Volunteers
- 504 people
- Sponsor
- Resicard
Coronary Artery Disease, Diabetes Mellitus, Type 2
CArdioMetabolism and Atherosclerotic PlaqUe progreSsion
Systematic metabolic diseases are closely related to prevalence and progression of atherosclerosis. This prospective cohort consecutively enrolls patients with coronary artery disease compliacted with metabolic abnormalities such…
- Conditions
- Coronary Artery Disease, Diabetes Mellitus, Type 2, Dyslipidemias, Obesity
- Trial name
- CAMPUS (NCT05117424)
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Ruijin Hospital
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