Clinical trials: Cardiovascular Disease, Obesity
Leukemia, Hodgkin's Lymphoma
Abdominal Obesity and Cardiovascular Risk Factors in Women Who Survived Cancer or a Related Illness Following Total Body Irradiation and Stem Cell Transplant
The purpose of this study is to better understand why some women who survived cancer or a related illness later develop diabetes, problems with their cholesterol, or other problems that may lead to heart disease.
- Conditions
- Leukemia, Hodgkin's Lymphoma, Non-Hodgkin's Lymphoma, Myelodysplastic Syndrome
- Trial name
- NCT00510315
- Testing
- Questionnaires, Laboratory tests, Abdominal MRI
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Hypertension, Atherosclerosis
Age-Related Changes in Body Composition
Background: Advancing age is associated with greater risk of heart disease. High blood pressure and hardening of the arteries also have more complications with age.
- Trial name
- NCT01517113
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Microbial Colonization, Cardiovascular Diseases
Influence of Freeze Dried Strawberry Consumption on Gut Microbiota and Cardiovascular Health.
This proposal seeks to build upon studies, including ours, on the favorable effects of California strawberries on vascular health.
- Conditions
- Microbial Colonization, Cardiovascular Diseases, Obesity
- Trial name
- NCT03283969
- Testing
- Freeze Dried Strawberry Powder, Isocaloric powder
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Refractory Hypertension
Study of the Relationships Between Refractory Hypertension, Overweight/Obesity and Sleep Apnea Syndrome
The purpose of the study is to investigate the links between blood pressure (BP), overweight or obesity, and sleep apnea syndrome (SAS), by studying a large cohort of subjects suffering from refractory hypertension.
- Trial name
- RHOOSAS (NCT00746902)
- Testing
- nCPAP
- Where
- France
- Volunteers
- 62 people
- Sponsor
- University Hospital, Grenoble
Obesity, Morbid, Hypertension
Comparison of Extremely Obese Patients Undergoing Gastric Sleeve Surgery
By the comparison of the preoperative and postoperative data of approximately 160 patients undergoing gastric sleeve surgery, we try to draw conclusions about the effectiveness of gastric sleeve surgery, expected complication…
- Conditions
- Obesity, Morbid, Hypertension, Diabetes Mellitus, Type 2
- Trial name
- NCT05929170
- Where
- Hungary
- Volunteers
- 160 people
- Sponsor
- University of Pecs
Hypertension (HTN)
Finerenone and Empagliflozin Combination in Obesity With Hypertension: A 12-Week Prospective, Parallel-design, Double-blind, Randomized, Placebo-controlled Trial
The EFFORT Study (Empagliflozin and Finerenone Combination in Obesity with Hypertension) is a 12-week, randomized, double-blind, placebo-controlled trial that aims to test whether combining empagliflozin (10 mg/day) with…
- Trial name
- NCT07678151
- Testing
- Empagliflozin and Finerenone
- Where
- 2 sites in China
- Volunteers
- 260 people
- Sponsor
- Heart Health Research Center
Weight Loss, Obesity
A Grapefruit Feeding Trial in Healthy, Overweight Adults
Folklore has suggested that consuming grapefruit may promote weight control. Sparse data exist to support this hypothesis, though there is some evidence of health promotional effects regarding blood pressure and lipid profiles.
- Conditions
- Weight Loss, Obesity, Cardiovascular Risk Factors
- Trial name
- NCT01452841
- Testing
- Grapefruit, Control
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Atherosclerotic Cardiovascular Disease, Subclinical Disease and/or Syndrome
Gastric Bypass Versus Best Medical Treatment on Progression of Carotid-intima Media Thickness in Type 2 Diabetes Mellitus (T2DM)
Background: Type 2 Diabetes Mellitus (T2DM) is associated with an increased burden for cardiovascular disease (CVD). Multifactorial interventions are necessary to reduce the CV risk in T2DM.
- Trial name
- EURDSS (NCT01353066)
- Testing
- Intensive Medical Treatment, IMM+Roux-en-Y Gastric Bypass (RYGBP)
- Where
- Spain
- Volunteers
- 240 people
- Sponsor
- Hospital Clinic of Barcelona
Obesity and Obesity-related Medical Conditions, Cardiovascular Risk
Cardiometabolic Risk of Obese Subjects: Cross-sectional Study
experimental study with analysis on tissues. This study aims to study cardiometabolic risk from a genetic, clinical, instrumental and laboratory point of view in a population of subjects with obesity.
- Conditions
- Obesity and Obesity-related Medical Conditions, Cardiovascular Risk, Genetics
- Trial name
- MiRNome (NCT06714058)
- Where
- 2 sites in Italy
- Volunteers
- 240 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Atrial Fibrillation, Obesity
Effect of Complex Weight-reducing Interventions on Rhythm Control in Obese Subjects With Atrial Fibrillation
Obesity is a well-established risk factor for the development of atrial fibrillation (AF), while the reduction of body weight was shown to reduce the risk of AF.
- Trial name
- HOBIT-FS (NCT04560387)
- Testing
- Physician-lead complex program of weight-reducing interventions, Bariatric surgery - sleeve gastrectomy
- Where
- Czechia
- Volunteers
- 160 people
- Sponsor
- Martin Haluzik
Cardiovascular Disease, Childhood Obesity
Exercise and Arterial Modulation in Youth
The project is designed as a large scale, cross-sectional study. The aim of the study is to investigate the association of micro- and macrovascular function with physical fitness and body composition in primary school children.
- Conditions
- Cardiovascular Disease, Childhood Obesity, Hypertension, Endothelial Dysfunction
- Trial name
- ExAMIN YOUTH (NCT02853747)
- Testing
- Physical Activity, 20-meter shuttle run
- Where
- Switzerland
- Volunteers
- 337 people, healthy volunteers welcome
- Sponsor
- University of Basel
Metabolic Disease, Cardiovascular Diseases
HYPERtension Reduction Through WALKing Stairs Versus Brisk Walking
This clinical trial investigates whether incorporating stair walking into daily routines improves physical health in adults at risk of lifestyle-related conditions such as hypertension, type 2 diabetes, and cardiovascular…
- Conditions
- Metabolic Disease, Cardiovascular Diseases, Hypertension, Obesity and Overweight
- Trial name
- HYPERWALK (NCT06952348)
- Testing
- Stair and brisk walking combined, Brisk walking, Standard care
- Where
- 4 sites in Sweden
- Volunteers
- 450 people
- Sponsor
- Karolinska Institutet
Hormone, Cardiovascular
Cardiometabolic and Hormonal Adaptations to 4-Month Zumba Training in Overweight/Obese Women
This study aims to evaluate the effects of a 4 month Zumba training program on cardiometabolic, hormonal, inflammatory, hepatic, renal, and functional parameters in overweight and obese women.
- Conditions
- Hormone, Cardiovascular, Obesity & Overweight
- Trial name
- NCT07264348
- Testing
- Zumba training
- Volunteers
- 73 people
- Sponsor
- High Institute of Sports and Physical Education of Kef
Cardiovascular Diseases, Heart Diseases
Weight Loss Maintenance (WLM)
To determine the effectiveness of continuous patient contact on weight loss maintenance.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Obesity, Diabetes Mellitus, Non-insulin Dependent
- Trial name
- WLM (NCT00054925)
- Testing
- Personal contact (PC), Interactive technology (IT)
- Volunteers
- 1,685 people
- Sponsor
- Duke University
Atherosclerosis, Obesity
Vascular Inflammation Stratified by Body Size Phenotype
Vascular Inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. 18FDG-PET is a promising novel tool for identifying and quantifying vascular inflammation within atherosclerotic plaque Recently…
- Conditions
- Atherosclerosis, Obesity, Metabolic Syndrome
- Trial name
- NCT01979068
- Where
- South Korea
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Korea University
Metabolically Healthy Obesity
Gut, Immune, and Vascular Health in Metabolically Healthy Obesity
The investigators seek to better understand how a single high-fat meal impacts gut, immune, and vascular outcomes in individuals with "metabolically healthy obesity" (obesity and largely normal cardiometabolic profile) and…
- Trial name
- NCT07559227
- Testing
- Inulin Supplementation, High-fat meal
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ball State University
Cardiovascular Disease
Comprehensive Rimonabant Evaluation Study of Cardiovascular ENDpoints and Outcomes
The primary objective is to show whether rimonabant reduces the risk of a heart attack (MI), stroke, or death from an MI or stroke in patients with abdominal obesity with other cardiovascular (CV) risk factors.
- Trial name
- CRESCENDO (NCT00263042)
- Testing
- Rimonabant
- Where
- 43 sites in United States, Argentina and 41 more
- Volunteers
- 18,695 people
- Sponsor
- Sanofi
Cardiovascular Diseases, Metabolic Syndrome
Non-interventional Pre-screening Protocol Aims to Evaluate Participants for Potential Trial Eligibility in Future Clinical Trials/Studies Focusing on Metabolic and Psychiatric Health.
DOVE-MET-COME-100 is a single site prescreening survey study designed to identify adults who may be eligible for future industry-sponsored clinical trials.
- Conditions
- Cardiovascular Diseases, Metabolic Syndrome, Obesity, Prediabetes
- Trial name
- NCT07106879
- Testing
- Blood Work
- Where
- United States
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- Clindove Research LLC
Cardiovascular Risk Factor, Circadian Dysregulation
Body Weight, Sleep, and Heart Health
A multidisciplinary investigation examining the circadian mechanisms regulating cardiovascular (CV) risk, with an additional focus on obesity.
- Conditions
- Cardiovascular Risk Factor, Circadian Dysregulation, Obesity
- Trial name
- NCT03388788
- Testing
- Positron Emission Tomography (PET) scanning of cardiac function at 3 time points across the 24 hour circadian cycle
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Obesity, Hypertension
Physical Activity, Functional Capacity and Quality of Life in Older Patients With Chronic Comorbidities
The prevalence of obesity, hypertension (HT) and type 2 diabetes (T2D) is increasing. The adoption of an increasingly sedentary lifestyle is one of the main factors contributing to the increased incidence of chronic diseases such…
- Conditions
- Obesity, Hypertension, Type 2 Diabetes
- Trial name
- NCT06535295
- Where
- Turkey (Türkiye)
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Biruni University
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