Clinical trials: Cardiovascular Disease, Obesity
Mediterranean Diet, Overweight or Obese Adults
ENERGY2MOB STUDY: OBESITY MANAGEMENT IN BERGUEDÀ
Background: Obesity is a prevalent multifactorial disease worldwide and has become a significant public health concern. The latest data from the 2022 Catalonia Health Survey show that 56.2% of men and 43.7% of women are…
- Conditions
- Mediterranean Diet, Overweight or Obese Adults, Exercise Therapy, Cardiovascular Diseases
- Trial name
- ENERGY2MOB (NCT06988904)
- Testing
- Energy2MOB
- Where
- Spain
- Volunteers
- 136 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Obesity
Low Carb Diets & Exercise for Cardiovascular Disease (CVD) Reduction
The purposes of this study are: To investigate the effects of a 6 month low carbohydrate diet in obese men on markers of heart health including blood fats, blood clotting factors, inflammatory markers and levels of body fat.
- Trial name
- NCT01176084
- Testing
- low carbohydrate diet, low carbohydrate diet and exercise
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Surrey
Atrial Fibrillation
Single vs. Dual-DCCV in Obese Patients
Currently, the usual initial strategy for direct current cardioversion (DCCV) typically involves delivering 200J of electricity between two pads placed in the anterior and posterior positions (i.e., one on the chest and one on…
- Trial name
- NCT04539158
- Testing
- Direct Current Cardioversion
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Dr. Daniel P Morin, MD MPH FHRS
Cardiovascular Diseases, Coronary Disease
Framingham Cycle V Offspring-Spouse Nutrition Studies
To examine the associations between diet, nutrition and coronary heart disease (CHD) incidence over seven years using the Cycle V Framingham Offspring/Spouse examination ; to examine the cross-sectional associations between…
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Hypertension
- Trial name
- NCT00005347
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Obesity, Hypertension
The Effect of Phentermine and B12 on Weight Loss Among Obese Patients
This is a pilot study designed to test the hypothesis that the combination of phentermine and B12 will result in significantly greater weight loss among obese patients compared to phentermine alone.
- Trial name
- NCT01719185
- Testing
- Phentermine and B12, Phentermine
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Dr. Michael Lang
Cardiovascular Diseases, Heart Diseases
Study of Children's Activity and Nutrition (SCAN)
In the first study, to identify children at high and low risk for cardiovascular disease and study their nutritional and physical activity behaviors as they relate to cardiovascular disease.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Hypertension
- Trial name
- NCT00005178
- Sponsor
- Augusta University
Obesity, Overweight
Tirzepatide vs Semaglutide in Individuals at Cardiovascular Risk But Without Diabetes.
Investigators are building an empirical evidence base for real world data through large-scale emulation of randomized controlled trials.
- Trial name
- NCT07619508
- Testing
- Tirzepatide, Semaglutide
- Where
- United States
- Volunteers
- 100,000 people
- Sponsor
- Brigham and Women's Hospital
Periodontal Diseases
Effect of Non-chirurgical Periodontal Treatment on the Immune System From a Gender Perspective
The goal of this observational study is to evaluate non-surgical periodontal treatment in women and men with periodontitis with and without obesity.
- Trial name
- NCT06261723
- Testing
- non-chirurgical periodontal treatment
- Where
- 2 sites in Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Milagros Rocha Barajas
Non-Alcoholic Fatty Liver Disease, Obesity
Growth Hormone Releasing Hormone Analog to Improve Nonalcoholic Fatty Liver Disease and Associated Cardiovascular Risk
Nonalcoholic fatty liver disease (NAFLD) is common in individuals with obesity and is a significant threat to public health, because it can lead to impaired liver function and liver failure.
- Conditions
- Non-Alcoholic Fatty Liver Disease, Obesity, Obesity, Abdominal, Liver Fat
- Trial name
- NCT03375788
- Testing
- Tesamorelin
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Massachusetts General Hospital
Obesity, Insulin Resistance
Nicotinamide Riboside and Metabolic Health
This study will investigate the effects of 6 week Nicotinamide Riboside supplementation (1000 mg/day) on metabolic health in healthy (pre)obese humans. The primary objective will be hepatic and whole body insulin sensitivity.
- Trial name
- NCT02835664
- Testing
- Nicotinamide Riboside (Niagen)
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Diabetic Foot Ulcer
Effect of Adiposity and Associated Local Microbial Factors on Healing and Progression of Diabetic Foot Ulcers
Diabetic foot ulcers (DFUs) and their associated complications like amputations are increasingly becoming a problem in low and middle income (LMI) countries.
- Trial name
- NCT03960255
- Testing
- Normal standard care
- Where
- 4 sites in Tanzania
- Volunteers
- 300 people
- Sponsor
- Muhimbili University of Health and Allied Sciences
Morbid Obesity, Hypertension
Prevention of Coronary Heart Disease in Morbidly Obese Patients
The changes in risks of developing coronary heart disease in patients with morbid obesity after different weight loss interventions have not been extensively studied.
- Conditions
- Morbid Obesity, Hypertension, Type 2 DM, Obstructive Sleep Apnea
- Trial name
- SphCor (NCT00626964)
- Testing
- Bariatric Surgery, Conservative Treatment:
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- The Hospital of Vestfold
Hypertension (HTN), Diabetes (DM)
Team-Based Shared Decision-Making Program in Cardiovascular-Kidney-Metabolic Health (Healthy Heart - CKM)
The investigators are proposing a new team-based shared decision-making (SDM) program. The goal of this study is to see whether this program is practical and whether it may help adults with cardiometabolic risk factors and…
- Conditions
- Hypertension (HTN), Diabetes (DM), Hyperlipidaemia, Kidney Disease
- Trial name
- SDM in CKM (NCT07662616)
- Testing
- Team-based shared decision-making
- Volunteers
- 94 people
- Sponsor
- Johns Hopkins University
Type2diabetes, Heart Failure
Understanding and Addressing Risks of Low Socioeconomic Status and Diabetes for Heart Failure
This study aims to determine whether a 6-month multilevel intervention involving problem-solving training, exercise training and support from community health workers is more effective in improving outcomes for individuals with…
- Conditions
- Type2diabetes, Heart Failure, Obesity
- Trial name
- UNLOAD-HF (NCT06364644)
- Testing
- Community Champions, Homegrown Heroes
- Where
- 2 sites in United States
- Volunteers
- 156 people
- Sponsor
- Johns Hopkins University
Overweight and Obesity, Cardiovascular Risk Factor
The Emirates Heart Health Project: A Family-based Diet and Exercise Intervention in Obese and Overweight Patients
Data from Abu Dhabi's Department of Health document that the leading cause of death among the population of the emirate of Abu Dhabi is cardiovascular disease (CVD).
- Trial name
- EHHP (NCT04688684)
- Testing
- Family-based diet and exercise intervention
- Where
- United Arab Emirates
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- United Arab Emirates University
Obesity, Hyperlipidemia
Translating a Heart Disease Lifestyle Intervention Into the Community
Translating a Heart Disease Lifestyle Intervention in the Community study will evaluate the feasibility and initial effectiveness of a community-based, culturally-targeted, lifestyle intervention to improve the cardiovascular…
- Conditions
- Obesity, Hyperlipidemia, Hypertension, Pre-diabetes
- Trial name
- NCT01647438
- Testing
- Lifestyle Intervention, Print Health Education
- Where
- 2 sites in United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Hypertension, Diabetes Mellitus, Type 2
Effects of SGLT2 Inhibitor on Hemodynamic Parameters in Resistant Hypertensive Subjects
New strategies trying to achieve blood pressure control and consequently reduce cardiovascular risk in resistant hypertensive subjects are promising.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Blood Pressure, Obesity
- Trial name
- NCT03089333
- Testing
- Dapagliflozin 10mg, Glibenclamide 5Mg Tablet
- Where
- Brazil
- Volunteers
- 16 people
- Sponsor
- University of Campinas, Brazil
Psoriasis, Atherosclerotic Cardiovascular Disease
Pilot Study to Evaluate the Effect of Nicotinamide Riboside on Immune Activation in Psoriasis
Background: Psoriasis causes chronic inflammation in the body. Researchers want to see if a kind of vitamin B3 dietary supplement can help. This might lead to more treatment options.
- Conditions
- Psoriasis, Atherosclerotic Cardiovascular Disease, Obesity, Dyslipidemia
- Trial name
- NCT04271735
- Testing
- Niagen
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Atherosclerosis, Cardiovascular Risk Factor
Early Vascular Ageing in the YOUth
This is a single-center observational study on adolescents to determine predictors of the early steps of the formation of atherosclerosis and to quantify their influence on Intima-Media-Thickness of the carotid artery and the…
- Conditions
- Atherosclerosis, Cardiovascular Risk Factor, Cardiovascular Diseases, Cardiovascular Pathology
- Trial name
- EVA4YOU (NCT04598685)
- Where
- Austria
- Volunteers
- 1,517 people, healthy volunteers welcome
- Sponsor
- VASCage GmbH
Abdominal Obesity
INNUPREC (Nutrigenetic Intervention for the Prevention of Cardiovascular Disease)
Background: Abdominal obesity (AO) is a multifactorial disease that affects 81.6% of the Mexican population; it is characterized by the excessive accumulation of adipose tissue in abdominal region.
- Trial name
- INNUPREC (NCT06847243)
- Testing
- Nutrigenetic diet according the genetic test, Control intervention group
- Where
- Mexico
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Guadalajara
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