Clinical trials: Cardiovascular Disease, Obesity
Health Problems in Pregnancy, Pregnancy Outcomes
Peking University Birth Cohort in Tongzhou
The PKUBC-T is a prospective cohort study carried out in Tongzhou district of Beijing, China. The primary aim of this study is to investigate the short-term and long-term effects of pre-pregnant and prenatal exposure on maternal…
- Conditions
- Health Problems in Pregnancy, Pregnancy Outcomes, Gestational Diabetes, Gestational Hypertension
- Trial name
- PKUBC-T (NCT03814395)
- Testing
- No intervention
- Where
- China
- Volunteers
- 5,426 people, healthy volunteers welcome
- Sponsor
- Peking University
Cardiovascular Disease, Obesity
A Small Nudge for Better Health Through Reduced Salt Intake, Increased Vegetable Intake, and Smaller Portion Size
This study will investigate whether small changes (nudges) made in a cafeteria, where participants eat for 4 weeks, can improve their food behavior and health during the 4 weeks, and 6 weeks and 6 months after their stay.
- Trial name
- NCT02808910
- Testing
- Nudged to eat less added salt and more other seasonings, Nudged to avoid foods high in salt content, and to choose foods low in salt content, Nudged to eat more vegetables
- Where
- Norway
- Volunteers
- 144 people
- Sponsor
- LHL Helse
Obesity, Cardiovascular Disease
BNP Pharmacodynamics and Effects on Metabolism in Lean and Obese Subjects
The purpose of this study is to collect data to help researchers better understand the various causes of obesity, which may lead to the development of new obesity treatment options.
- Conditions
- Obesity, Cardiovascular Disease, Hypertension, Diabetes
- Trial name
- NCT01977859
- Testing
- Nesiritide, Saline
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Obesity, Depression
The Montreal Neighbourhood Networks and Healthy Aging Panel
Social networks, social capital, i.e., network-accessed resources, and neighbourhood environments have been shown associated with a range of health behaviours and conditions, including obesity, physical activity, nutrition, and…
- Conditions
- Obesity, Depression, Physical Activity, Hypertension
- Trial name
- MoNNET-HA (NCT03369496)
- Testing
- Social capital; Neighborhood environment
- Volunteers
- 2,707 people, healthy volunteers welcome
- Sponsor
- Queen's University
Cardiovascular Diseases (CVD), Type 2 Diabetes
Epigenetics and NCD Prevention in Kazakhstan: Personalized Approaches and Biological Age Prediction
This study aims to enhance personalized and preventive care for non-communicable diseases (NCDs) in Kazakhstan by examining epigenetic factors, predicting biological age and reproductive function using machine learning, and…
- Conditions
- Cardiovascular Diseases (CVD), Type 2 Diabetes, Chronic Respiratory Diseases, Obesity (Disorder)
- Trial name
- NCT06953180
- Testing
- Genetic: DNA analysis
- Where
- Kazakhstan
- Volunteers
- 6,720 people, healthy volunteers welcome
- Sponsor
- Asfendiyarov Kazakh National Medical University
OBESITY, HYPERTENSION
The Autonomic Nervous System and Obesity
In its simplest terms, obesity is the results of a positive balance between food intake and energy expenditure (EE). I.e., we take in more energy, in the form of food, than we expend, e.g., by exercise.
- Conditions
- OBESITY, HYPERTENSION, PURE AUTONOMIC FAILURE, SHY-DRAGER SYNDROME
- Trial name
- NCT00179023
- Testing
- Trimethaphan, Pseudoephedrine
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Hypertension, Diabetes Mellitus, Type 2
Does Early Weight Loss Following Laparoscopic Sleeve Gastrectomy Affect Long-term Outcomes
A study to explore the relationship between early weight loss in the 4 weeks following laparoscopic sleeve gastrectomy and outcomes, in terms of weight loss and comorbidity improvement, 7 years following the surgery.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Gastrostomy, Morbid Obesity
- Trial name
- NCT04235829
- Testing
- Laparoscopic sleeve gastrectomy
- Where
- Israel
- Volunteers
- 156 people
- Sponsor
- Shaare Zedek Medical Center
Inflammation, Atherosclerosis
Anti-inflammatory Effects of Simvastatin
The purpose of this research study is to determine which of the two ingredients of Vytorin (Simvastatin or Ezetimibe) is responsible for the anti-inflammatory effects of Vytorin
- Conditions
- Inflammation, Atherosclerosis, Hypercholesterolemia
- Trial name
- NCT04638400
- Testing
- Simvastatin 40mg, Ezetimibe 10mg
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- paresh Dandona
Sarcopenia
Prevalence and Determinants of Sarcopenic Obesity in Taiwanese Dialysis Patients
Uraemic sarcopenia is complex, and progressive . As older persons are particularly susceptible to renal failure and this accelerates the physiological muscle wasting in this patient group.
- Trial name
- NCT02718612
- Volunteers
- 70 people
- Sponsor
- Tungs' Taichung Metroharbour Hospital
Obesity
A Study on Efficacy and Safety of Topiramate in the Treatment of Patients With Obesity
The purpose of this study is to compare the efficacy and safety of topiramate (96, 192, and 256mg daily) with placebo in long-term treatment of obesity.
- Trial name
- NCT00236639
- Testing
- topiramate
- Volunteers
- 1,293 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Cardiovascular Risk Factor, Obesity
Essential Amino Acids and High Intensity Interval Training
Purpose: The primary purpose is to determine the combined effects of essential amino acids (EAA) supplementation and high intensity interval training (HIIT) on body composition, muscle characteristics, and muscle architecture in…
- Trial name
- NCT04080102
- Testing
- High Intensity Interval Training, Essential Amino Acid, High intensity interval training and essential amino acid supplement
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Cardiovascular Diseases, Heart Diseases
Epidemiology of Stress and the Metabolic Syndrome
To examine the effects of psychological stress on the metabolic syndrome.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Obesity, Hypertension
- Trial name
- NCT00073775
- Volunteers
- 3,075 people
- Sponsor
- University of Florida
Obesity
High Fat Diet: Oxidative and Cardiovascular Effects
To test the effects of a modified Atkins high fat diet on endothelial function, insulin resistance and energy balance.
- Trial name
- AFN (NCT00696228)
- Testing
- MUFA, PUFA, SFA
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Cardiovascular Diseases, Obesity
Association Between Abdominal Body Composition, Inflammation, and Risk for Cardiovascular Disease (The MESA ABD Study)
Obesity is a growing public health concern, with approximately 31% of Americans considered obese. The link between abdominal obesity and cardiovascular disease (CVD) has been well established, but the effect of distinct types of…
- Trial name
- MESA ABD (NCT00612365)
- Where
- United States
- Volunteers
- 1,975 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Obesity
Gut Microbiota as a Therapeutic Target for CVD
Background: The Mediterranean Diet (MD) is considered an healthy diet useful in the prevention of cardiovascular disease (CVD). High quality extra virgin olive oil (HQ-EVOO, [1]), an essential component of this diet, exerts a…
- Trial name
- oliomicroFDG (NCT03441802)
- Testing
- High quality extra virgin olive oil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Obesity, Depression
Study of a Holistic Health Program for United Methodist Clergy
This study seeks to test a two-year intervention designed for United Methodist clergy. The intervention consists of: the stress reduction program Williams LifeSkills, adapted for clergy; the 10-session online weight loss program…
- Conditions
- Obesity, Depression, Diabetes, Hypertension
- Trial name
- SpiritedLife (NCT01564719)
- Testing
- Holistic health
- Where
- United States
- Volunteers
- 1,114 people, healthy volunteers welcome
- Sponsor
- Duke Clergy Health Initiative
Obesity
The Autonomic Nervous System and the Metabolic Syndrome
The overall goal of this proposal is to determine the role of the autonomic nervous system in the insulin resistant state associated with obesity and the metabolic syndrome.
- Trial name
- NCT00580957
- Testing
- Blocked, Intact
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Obesity
Methods of Weight Loss in Overweight Coronary Patients
We hypothesize that a combination of high-caloric expenditure exercise and behavioral weight loss counseling would lead to a greater loss of fat mass and a greater improvement in cardiometabolic risk factors that standard (lower…
- Trial name
- NCT00628277
- Testing
- high caloric expenditure exercise, low caloric expenditure exercise plus dietary counseling
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of Vermont
Chronic Kidney Disease, Obesity
Weight Loss Interventions in Obese Patients With Stages 3-4 Chronic Kidney Disease: a Randomised Controlled Trial
Weight loss surgery is the most effective weight loss treatment available, but the direct effect on chronic kidney disease is less widely understood.
- Trial name
- NCT01053130
- Testing
- laparoscopic sleeve gastrectomy, weight management program
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- King's College Hospital NHS Trust
Gestational Diabetes Mellitus in Pregnancy, Gestational Hypertension
No-worry Baby Project
The Huizhou mother-infant cohort was set up to investigate the effect of dietary factors and environmental exposures during pregnancy on health consequences of mothers and offsprings in Huizhou, China.
- Conditions
- Gestational Diabetes Mellitus in Pregnancy, Gestational Hypertension, Thyroid Disease Pregnancy, Obesity
- Trial name
- NCT03922087
- Testing
- No intervention
- Where
- China
- Volunteers
- 5,216 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
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