Clinical trials: Cardiovascular Disease, Obesity
Hypertension
Effect of Whole Body Vibration on Blood Pressure in Obese Postmenopausal Women.
All post-menopausal women followed an energy-restricted diet for 8 weeks. Meal plan that creates an energy deficit of 500 to 1000 Kcal per day less than the individual's average daily intake was suitable for weight reduction.Each…
- Trial name
- NCT05991050
- Testing
- energy-restricted diet, Whole body vibration
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Atherosclerosis, Obesity
Vascular Inflammation Stratified by Body Size Phenotype
Vascular Inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. 18FDG-PET is a promising novel tool for identifying and quantifying vascular inflammation within atherosclerotic plaque Recently…
- Conditions
- Atherosclerosis, Obesity, Metabolic Syndrome
- Trial name
- NCT01979068
- Where
- South Korea
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Korea University
Metabolic Syndrome, Overweight and Obesity
Pediatric Metabolic Syndrome Study
The Pediatric Metabolic Syndrome Study is an observational study being conducted at the Medical University of South Carolina to investigate cardiometabolic risk parameters in obese subjects ages 4 to 21.
- Conditions
- Metabolic Syndrome, Overweight and Obesity, Cardiovascular Risk Factor
- Trial name
- PMSS (NCT03570840)
- Where
- United States
- Volunteers
- 477 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Diabetes Mellitus, Non-insulin Dependent, Cardiovascular Diseases
Heavy Metals, Obesity and Cardiovascular Risk - Ancillary to Look AHEAD
To evaluate the relationship of baseline toenail chromium concentrations to weight loss, as well as the interaction between heavy metals and the beneficial effects of weight loss.
- Conditions
- Diabetes Mellitus, Non-insulin Dependent, Cardiovascular Diseases, Obesity, Myocardial Infarction
- Trial name
- NCT00031213
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Obesity, Intra-Abdominal Fat
Effect of a Probiotic on Visceral Fat Accumulation
The study's main objective is to investigate if an extract containing the probiotic Bifidobacterium animalis subsp. lactis BPL1 (CECT 8145) has a positive effect on the accumulation of abdominal visceral fat in people with…
- Conditions
- Obesity, Intra-Abdominal Fat, Subcutaneous Fat, Abdominal
- Trial name
- BIFFAT (NCT02921217)
- Testing
- Active Probiotic, Inactivated probiotic, Control
- Where
- Spain
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Biopolis S.L.
Obesity, Type 2 Diabetes
Youth-Onset Type 2 Diabetes and Heart Disease: The Young at Heart Prospective Cohort Study
Background: Type 2 diabetes is a disease that affects blood sugar levels. Complications can include heart and blood vessel (vascular) diseases.
- Trial name
- NCT06730113
- Where
- 2 sites in United States
- Volunteers
- 930 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Metabolic Syndrome
Dose Ranging Study of the Effects of Alpha Lipoic Acid on Oxidative Stress
Heart disease is the most common cause of death in the United States and it is commonly found in people with diabetes and high cholesterol.
- Trial name
- Alpha (NCT00857376)
- Volunteers
- 77 people
- Sponsor
- Johns Hopkins University
Aging, Hypertension
Aging, Nitrate, Endothelial Function and Muscle Oxygenation
Aging has been associated with reduced bioavailability of nitric oxide (NO) and endothelial dysfunction. Beetroot consumption, a nitrate-rich food, has been associated with increased NO bioconversion, which may promote beneficial…
- Conditions
- Aging, Hypertension, Dyslipidemia, Abdominal Obesity
- Trial name
- NCT02772900
- Testing
- Beetroot-based nutritional gel
- Volunteers
- 25 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Obesity, Cardiovascular Risk Factor
Hipoenergetic Effect of Diet Associated or Not With the Consumption of Coconut Flour in Women With Overweight
This study aimed to evaluate the effect of weight loss with diet combined coconut flour consumption improvement weight loss and reduction in glucose, cholesterol in obese women.
- Trial name
- NCT02152111
- Testing
- Coconut flour, Diet
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Suboptimal Health Status
Evaluation of Laser Acupuncture on Health Promotion of Sub-health People
Background: Suboptimal health status (SHS) is a dynamic state wherein people have not been diagnosed with a disease but tend to develop diseases. People with SHS often experience fatigue and other nonspecific symptoms.
- Trial name
- NCT04325945
- Testing
- Low level laser therapy
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Cardiovascular Diseases, Obesity
Evaluation of a Novel Technology to Support Tailored Health Behavior Counseling in Rural Primary Care Clinics
This project will conduct a pilot hybrid study that examines the implementation (Aims 1 \& 2) and preliminary effectiveness (Aim 3) of PREVENT, a digital health intervention, among patients with overweight/obesity (N=100) using a…
- Trial name
- Rural PREVENT (NCT06397729)
- Testing
- Wait-List Control, PREVENT Tool
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Washington University School of Medicine
Hypertension (HTN)
Finerenone and Empagliflozin Combination in Obesity With Hypertension: A 12-Week Prospective, Parallel-design, Double-blind, Randomized, Placebo-controlled Trial
The EFFORT Study (Empagliflozin and Finerenone Combination in Obesity with Hypertension) is a 12-week, randomized, double-blind, placebo-controlled trial that aims to test whether combining empagliflozin (10 mg/day) with…
- Trial name
- NCT07678151
- Testing
- Empagliflozin and Finerenone
- Where
- 2 sites in China
- Volunteers
- 260 people
- Sponsor
- Heart Health Research Center
Cardiovascular Diseases, Natriuretic Peptides
GENESIS: Genotype Guided - Natriuretic Peptides - Cardiometabolic Health Study
Natriuretic Peptides (NP) are hormones produced by the heart, and they have a wide range of favorable metabolic benefits. Lower levels of these hormones are associated with an increased likelihood of the development of diabetes…
- Conditions
- Cardiovascular Diseases, Natriuretic Peptides, Cardiometabolic Diseases, Energy Expenditure
- Trial name
- NCT05216042
- Testing
- Study diet, Exercise capacity VO2 max determination, Exercise Challenge
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Coronary Heart Disease, Obesity
Alternate Day Fasting for Weight Loss, Weight Maintenance and Cardio-protection
The proposed research will demonstrate that alternate day modified fasting (ADMF) is a suitable alternative to daily calorie restriction (CR) for weight loss, weight maintenance, and heart disease prevention.
- Conditions
- Coronary Heart Disease, Obesity, Weight Loss
- Trial name
- NCT00960505
- Testing
- Alternate day fasting, Calorie restriction, Control diet
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Hypertension, Diabetes Mellitus, Type 2
Use and Acceptability of an AI-Assisted Health Application for Individuals Living With a Chronic Condition
The SOFIA study evaluates a web-based health application for people living with one or more chronic conditions. The study aims to find out whether the SOFIA application is useful, easy to use, and used over time by participants.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Obesity
- Trial name
- SOFIA (NCT07916753)
- Testing
- SOFIA application
- Where
- Switzerland
- Volunteers
- 1,600 people
- Sponsor
- Fondation Net-Care.ch
Atherosclerosis, Congestive Heart Failure
Dallas Heart Study 2: Return Clinic Visit for the Dallas Heart Study Cohort
The Dallas Heart Study (DHS-1) is a large, multi-ethnic, population-based epidemiological study designed to identify determinants of atherosclerotic heart disease (ASHD) in a representative United States (US) urban environment.
- Conditions
- Atherosclerosis, Congestive Heart Failure, Left Ventricular Hypertrophy, Diabetes Mellitus
- Trial name
- NCT00344903
- Where
- United States
- Volunteers
- 3,400 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Sleep, Cardiovascular Disease
Impact of Sleep Restriction in Women
The overall goal of this project is to test the hypothesis that long-term, sustained sleep restriction (SR), in women, will lead to increased cardio-metabolic risk.
- Conditions
- Sleep, Cardiovascular Disease, Obesity
- Trial name
- NCT02835261
- Testing
- Sleep Restriction
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Columbia University
Covid19
Comorbidities and Risk Score in COVID-19 Patients
Retrospective multi-center cohort study. Consecutive patients hospitalized for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) up to October 2020 will be included.
- Trial name
- Comorbidities (NCT04670094)
- Where
- 5 sites in Italy
- Volunteers
- 4,555 people
- Sponsor
- University of Milano Bicocca
Obesity, Cardiovascular Risk Factors
Planned CORR: Planned Care for Obesity and Risk Reduction
The researchers propose a randomized controlled trial to evaluate how well an intervention, Planned Care for Obesity \& Risk Reduction (Planned CORR), supports primary care treatment of obesity in adults with at least one…
- Trial name
- Planned CORR (NCT01134029)
- Testing
- Stepped Care
- Where
- United States
- Volunteers
- 262 people
- Sponsor
- University of California, San Diego
Metabolic Syndrome (MetS), Obesity & Overweight
Validating Integrative Multi-omics Approaches in Metabolic Syndrome-related Diseases
This study aims to validate integrative multi-omics approaches for understanding complications related to metabolic syndrome. By combining genetic, transcriptomic, metabolomic, and microbiome data from participants with and…
- Conditions
- Metabolic Syndrome (MetS), Obesity & Overweight, Cardiovascular Diseases (CVD), Chronic Kidney Disease
- Trial name
- NCT07248371
- Testing
- No intervention
- Where
- Taiwan
- Volunteers
- 6,266 people
- Sponsor
- Chang Gung Memorial Hospital
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