Clinical trials: Cardiovascular Disease (CKD)
Arterial Hypertension, Chronic Renal Insufficiency
Renal Protection Using Sympathetic Denervation in Patients With Chronic Kidney Disease
Kidney protection study (KPS 1) is a prospective randomized clinical study comparing the use of renal denervation (RDN) and optimal medical therapy in subjects with chronic kidney disease stage 3-4 and resistant arterial…
- Trial name
- KPS (NCT02002585)
- Testing
- Renal denervation
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- Charles University, Czech Republic
Chronic Kidney Diseases, Eye Diseases
Smarter Care Virginia, Examining Low-Value Care in Virginia
Low-value care is defined as patient care that provides no net benefit to patients in specific clinical scenarios, and can cause patient harm.
- Conditions
- Chronic Kidney Diseases, Eye Diseases, Cardiac Disease, Surgery
- Trial name
- NCT04053335
- Testing
- Multicomponent Physician Performance Peer-Comparison Feedback Intervention
- Where
- United States
- Volunteers
- 5,000,000 people
- Sponsor
- University of California, Los Angeles
Chronic Kidney Disease
A Study of PRT-201 Administered Immediately After Radiocephalic Arteriovenous Fistula(AVF) Creation in Patients With Chronic Kidney Disease (CKD) (PATENCY-1)
This research study is designed to assess the safety and effectiveness of an experimental drug called PRT-201 in patients both receiving or expecting to receive dialysis who have chronic kidney disease and who are undergoing…
- Trial name
- NCT02110901
- Testing
- PRT-201
- Where
- 35 sites in United States
- Volunteers
- 349 people
- Sponsor
- Proteon Therapeutics
Renal Insufficiency, Chronic, Cardio-Renal Syndrome
Comparing the Effects of Spironolactone With Chlortalidone on LV Mass in Patients With CKD
In stage 3 chronic kidney disease (CKD) the risk of death due to cardiovascular causes is high and greatly exceeds the risk of progression to end stage renal failure.
- Trial name
- SPIRO-CKD (NCT02502981)
- Testing
- Spironolactone, Chlortalidone
- Where
- 4 sites in United Kingdom
- Volunteers
- 154 people
- Sponsor
- University Hospital Birmingham
End Stage Kidney Disease, Chronic Kidney Diseases
The WavelinQ™ Arterio-Venous Endovascular Fistula: A Global, Post-Market Investigation
This is a global, multi-center, prospective, post-market, confirmatory, interventional, non-randomized, single-arm clinical investigation evaluating arteriovenous fistula (AVF) creation by means of the WavelinQ™ EndoAVF System in…
- Conditions
- End Stage Kidney Disease, Chronic Kidney Diseases, Kidney Failure, Kidney Insufficiency
- Trial name
- WAVE-Global (NCT04626427)
- Testing
- WavelinQ™ EndoAVF System
- Where
- 3 sites in Belgium, Greece and 1 more
- Volunteers
- 21 people
- Sponsor
- C. R. Bard
Anemia, Dialysis-Dependent Chronic Kidney Disease
Efficacy and Safety Study to Evaluate Vadadustat for the Correction or Maintenance Treatment of Anemia in Participants With Incident Dialysis-dependent Chronic Kidney Disease (DD-CKD)
A multicenter, randomized, open-label, active-controlled Phase 3 study for the correction or maintenance treatment of anemia in participants with incident dialysis-dependent chronic kidney disease (DD-CKD).
- Trial name
- NCT02865850
- Testing
- Vadadustat, Darbepoetin alfa
- Where
- 118 sites in United States, Argentina and 9 more
- Volunteers
- 369 people
- Sponsor
- Akebia Therapeutics
Chronic Kidney Diseases, Hypertension
Nephrospec Switzerland
This is a randomized, double-blind sham-controlled monocentric trial. 30 patients that are diagnosed with hypertension and with moderate to severe chronic kidney disease are included in this trial.
- Trial name
- NCT06194591
- Testing
- NephrospecTM, low-intensity extracorporal shockwave therapy device
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Menno Pruijm
Hemodialysis
Cardiovascular Protective Effect of Spironolactone in Hemodialysis
The purpose of the present study is to determine if spironolactone is safe and effective in the treatment of cardiovascular complications in hemodialysis patients.
- Trial name
- NCT00277693
- Testing
- Spironolactone (drug)
- Where
- Chile
- Sponsor
- Universidad de los Andes, Chile
Hypertension, Chronic Kidney Disease
Renal Nerve Ablation in Chronic Kidney Disease Patients
In patients with treatment resistent hypertension renal nerve ablation emerged as an effective interventional approach of treating hypertensive disease with a progressively increasing fall in blood pressure.
- Trial name
- NCT01442883
- Testing
- Simplicity Catheter
- Where
- 2 sites in Germany
- Volunteers
- 27 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Chronic Kidney Disease
Evaluation of Cardiovascular Risk Factors in Incident Dialysis Patients
To evaluate the relationships between bone mineral markers levels at dialysis start and vascular calcification progression during a 2 year follow up
- Trial name
- NCT02813642
- Testing
- Plasma osteoprotegerin level, Plasma fibroblast growth factor 23 level, Vascular calcification score
- Where
- 5 sites in France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Montpellier
Chronic Kidney Disease, Stable Angina
Effect of Platelet Inhibition According to Clopidogrel Dose in Patients With Chronic Kidney Disease
Impaired renal function is associated with reduced responsiveness to clopidogrel. There are no studies which have shown a means by which to overcome platelet hyporesponsiveness in patients with chronic kidney disease (CKD).
- Trial name
- CKD (NCT01328470)
- Testing
- Clopidogrel, cilostazol
- Where
- South Korea
- Volunteers
- 85 people
- Sponsor
- Kyunghee University Medical Center
Kidney Failure, Chronic, Peritoneal Dialysis Complication
International (Pediatric) Peritoneal Biobank
Within few years the peritoneal membrane of adult peritoneal dialysis (PD) patients undergoes substantial morphological transformation, including progressive fibrosis, vasculopathy and neoangiogenesis.
- Conditions
- Kidney Failure, Chronic, Peritoneal Dialysis Complication, Transplantation, Healthy
- Trial name
- NCT01893710
- Testing
- biopsy sampling
- Where
- 26 sites in United States, Austria and 13 more
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Heidelberg University
Haemodialysis
Efficacy and Local Tolerability of Topically Applied Heparin on the Suitability of Newly Constructed Primary Arteriovenous Fistulas in Patients Planned for Haemodialysis
The primary objective of this study is to evaluate the effect of topically applied heparin in comparison to placebo on suitability of newly constructed primary arteriovenous fistulas in patients planned for haemodialysis at 7th…
- Trial name
- NCT01382888
- Testing
- Heparin 2,400 IU /ml Cutaneous Spray
- Where
- 3 sites in Austria
- Volunteers
- 30 people
- Sponsor
- Cyathus Exquirere Pharmaforschungsgmbh
Acute Kidney Injury, Kidney Transplant
MEMRI and Kidney Disease
Acute kidney injury (AKI) is common and costly.1 Although patients who suffer an episode of AKI may recover, many will go on to develop cardiovascular disease and chronic kidney disease (CKD).
- Conditions
- Acute Kidney Injury, Kidney Transplant, Vasculitis, Chronic Kidney Disease(CKD)
- Trial name
- NCT06698614
- Testing
- MRI, Blood tests, Urine tests
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of Edinburgh
Chronic Kidney Diseases, Hypertension
Green Propolis Extract and Royal Jelly in Hypertensive Patients and/or With Chronic Kidney Disease
This work aims to evaluate the effects of the association of green propolis extract with royal jelly on inflammation and oxidative stress in participants with chronic kidney diseases (CKD) and Systemic arterial hypertension…
- Conditions
- Chronic Kidney Diseases, Hypertension, Cardiovascular Diseases
- Trial name
- NCT06288204
- Testing
- Propolis associated with Royal Jelly, Royal Jelly
- Where
- 2 sites in Brazil
- Volunteers
- 153 people
- Sponsor
- Universidade Federal Fluminense