Clinical trials: Cardiovascular Disease (CVD)
Diabetic Retinopathy
A Blinded, Self-control Trial to Evaluate an Artificial Intelligence Based CAD System for Diabetic Retinography
To evaluate the safety and performance of an innovative artificial intelligence based Computer-Aided Diagnosis(CAD) system for diabetic retinography, Retinal images of patients with diabetes mellitus or diabetic retinopathy(DR)…
- Trial name
- NCT03973762
- Testing
- DR Grading with CAD, DR Grading by expert panel
- Where
- China
- Volunteers
- 1,081 people
- Sponsor
- Peking Union Medical College Hospital
Chronic Kidney Disease, Fistula
Hemodialysis Vascular Access Imaging Study
The goal of this study is to find the best techniques to take non-invasive images of the arteriovenous fistula (AVF) in hemodialysis patients.
- Conditions
- Chronic Kidney Disease, Fistula, Hemodialysis Fistula Thrombosis
- Trial name
- NCT02374762
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Renal Research Institute
Cardiac Disease, Extracorporeal Circulation; Complications
PErfusion QUality ODds
Cardiac surgery-associated acute kidney injury (CSA-AKI) is a frequent complication after cardiac operations with cardiopulmonary bypass (CPB) use. Its frequency varies depending on the severity grade.
- Conditions
- Cardiac Disease, Extracorporeal Circulation; Complications, Perfusion; Complications, Acute Kidney Injury
- Trial name
- PEQUOD (NCT06019546)
- Testing
- PEQUOD
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- IRCCS Policlinico S. Donato
Heart Failure
Evaluation of Circulating Levels of Adult Stem Cells in the Peripheral Blood of Patients With Acute Decompensated Heart Failure and Following Stabilization, in Comparison With Healthy Volunteers
Despite advances in medical technology, heart failure remains a major cause of illness on a global scale. Medical research, over recent years, has shown that adult stem cells (as opposed to embryonic stem cells) are present in…
- Trial name
- CIRCSTEM-HF (NCT01027403)
- Where
- Australia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Monash University
Acute Ischemic Stroke
Citicoline in Ischemic Stroke
There is evidence that citicoline is the only neuroprotectant able to improve the functional status of the patients after an acute ischemic stroke.
- Trial name
- NCT05154903
- Testing
- Citicoline 500 MG
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Ain Shams University
Out-of-Hospital Cardiac Arrest, Pulmonary Ventilation
CAvent-Ventilation During Advanced Cardiopulmonary Resuscitation in Out-of-hospital Cardiac Arrest- an Observational Study
The aim of this observational study is to investigate how ventilations is given during cardiopulmonary resuscitation (CPR) given by advanced life support providers (ALS).
- Trial name
- CAvent (NCT04237727)
- Testing
- Fluxmed GrH portable pneumotachograph
- Where
- 5 sites in Netherlands, Sweden
- Volunteers
- 241 people
- Sponsor
- Uppsala University
Neurological Rehabilitation, Stroke
Effects of Repetitive Transcranial Magnetic Stimulation Therapy on Lower Extremity Motor Development in Stroke Patients
The aim of our study is to investigate the effects of rTMS applications at different current frequencies (low frequency / intermittent (intermittent) theta burst (iTBS)) in stroke patients on lower extremity motor development…
- Conditions
- Neurological Rehabilitation, Stroke, Lower Extremity Problem, Quality of Life
- Trial name
- NCT05554861
- Testing
- Low Frequency rTMS Protocol, Intermittent Theta Burst Stimulation (iTBS) Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Afyonkarahisar Health Sciences University
Congenital Heart Disease
Effectiveness of a Transition Program for Adolescents With Congenital Heart Disease in the Transition to Adulthood
This study is part of a larger research project known as Swedish Transition Effects Project Supporting Teenagers with chrONic mEdical conditionS (STEPSTONES).
- Trial name
- NCT02675361
- Testing
- Transition program
- Where
- 7 sites in Sweden
- Volunteers
- 189 people
- Sponsor
- Göteborg University
Coronary Artery Disease
Prognosis and Antiplatelet Strategies for Patients With PCI and High Bleeding Risk:A Study Protocol
Percutaneous coronary intervention (PCI) is an important treatment strategy for patients with coronary artery disease. Combined bleeding after PCI significantly increases the risk of death in patients.
- Trial name
- NCT05369442
- Where
- China
- Volunteers
- 1,300 people
- Sponsor
- West China Hospital
Heart Failure, Congestive, Chronic Heart Failure
Antidepressant Medication Treatment for Depression in Individuals With Chronic Heart Failure
This study will examine the effect of antidepressant medication on rates of death and disease in depressed people with chronic heart failure.
- Conditions
- Heart Failure, Congestive, Chronic Heart Failure, Depression
- Trial name
- SADHART-CHF (NCT00078286)
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 469 people
- Sponsor
- Duke University
Peripheral Vascular Disease
Comparison of the SUpera® PERipheral System in the Superficial Femoral Artery
This is a prospective, multicenter, non-randomized, single arm, pivotal trial. The main objective of this study is to demonstrate the safety and effectiveness of the IDev SUPERA® Nitinol Stent System in treating subjects with…
- Trial name
- SUPERB (NCT00933270)
- Testing
- SUPERA® Nitinol Stent System
- Where
- 49 sites in United States
- Volunteers
- 325 people
- Sponsor
- Abbott Medical Devices
Stroke
Effects of Priming Intermittent Theta Burst Stimulation on Upper Limb Motor Recovery After Stroke: A Randomized Controlled Trial
The aim of this study is to investigate the effects of intermittent theta burst stimulation primed with continous theta burst stimulation (cTBS), on top of a standard robot-assisted training (RAT) on improving the upper limb…
- Trial name
- NCT04034069
- Testing
- Theta burst stimulation (TBS), Robot-assisted training
- Where
- Hong Kong
- Volunteers
- 42 people
- Sponsor
- The Hong Kong Polytechnic University
Heart Failure, Chronic Heart Failure
Pre-Symptomatic Detection of Impending Decompensation in Heart Failure Through Voice Data
PRE-DETECT-HF is a prospective, single-arm observational study evaluating a voice-based machine learning algorithm for early detection of heart failure decompensation.
- Conditions
- Heart Failure, Chronic Heart Failure, Chronic Heart Disease
- Trial name
- PRE-DETECT-HF (NCT07443969)
- Testing
- Daily Voice Recording and Symptom Monitoring
- Where
- 3 sites in Netherlands, Spain
- Volunteers
- 123 people
- Sponsor
- Noah Labs
Cardiovascular Disease, Dementia
Recombinant Herpes Zoster Vaccine for Prevention of Cardiovascular Events and Dementia
DAN-ZOSTER is a nationwide randomized study investigating whether vaccination against herpes zoster (shingles) can reduce the risk of cardiovascular disease and dementia in older adults.
- Trial name
- DAN-ZOSTER (NCT07485283)
- Testing
- Recombinant Herpes Zoster Vaccine (Shingrix)
- Where
- 2 sites in Denmark
- Volunteers
- 168,460 people, healthy volunteers welcome
- Sponsor
- Tor Biering-Sørensen
Epilepsy, Tumor
High-density EEG in Neurological Disorders
The purpose of the study is to use a new method of high-density electroencephalogram (HD-EEG) recording to map brain areas important for movement, sensation, language, emotion, and cognition.
- Conditions
- Epilepsy, Tumor, Healthy
- Trial name
- NCT04266041
- Testing
- High-density electroencephalogram (HD-EEG)
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Heart Failure
Heart Failure Self-care With the Aid of a Smartphone Application
The purpose of this study was the development, and testing of a HF application that was used to provide self-care support to HF patients through a smartphone device.
- Trial name
- HFSC (NCT03194841)
- Testing
- Heart failure application
- Volunteers
- 10 people
- Sponsor
- University of Massachusetts, Worcester
Cardiac Arrhythmia
Validation of a Smartphone-based Recorder for Detection of Cardiac Arrhythmias
The investigators will evaluate the diagnostic yield of the new AliveCor device versus a 12 lead ECG when used simultaneously to detect cardiac arrhythmia
- Trial name
- NCT03996954
- Testing
- Alivecor recording
- Where
- United Kingdom
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Blackpool Teaching Hospitals NHS Foundation Trust
Stroke, Balance
The Validity and Reliability of an Improved Paper Grasping Test for Stroke
The study included volunteer patients diagnosed with stroke who applied to the Neurology Outpatient Clinic at SANKO University Sani Konukoğlu Application and Research Hospital.
- Conditions
- Stroke, Balance, Validity and Safety
- Trial name
- NCT07181005
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Sanko University
Peripheral Artery Disease
AMS INSIGHT 1 Study - Bioabsorbable Metal Stent Investigation in Chronic Limb Ischemia Treatment
Prospective, multicenter, randomized clinical trial, Follow-up at 1-, 6- and 12 months This clinical investigation is first of all designed to demonstrate the safety and effectiveness of the MAGIC EXPLORER stent system.
- Trial name
- AMS-INSIGHT1 (NCT00572494)
- Testing
- MAGIC EXPLORER (Biotronik AG), PLEON EXPLORER (Biotronik AG)
- Where
- 12 sites in Austria, Belgium and 2 more
- Volunteers
- 117 people
- Sponsor
- Flanders Medical Research Program
Atrial Fibrillation, Anticoagulants
Application of "I-Anticoagulation"in Patients With Atrial Fibrillation
The goal of this prospective, multicenter, cluster randomized controlled trial is to assess the effectiveness of a shared decision-making tool, "I-Anticoagulation", for anticoagulation management in AF patients.
- Trial name
- NCT06137794
- Testing
- Use of "I-Anticoagulation" to make the decision and manage patients
- Volunteers
- 440 people
- Sponsor
- RenJi Hospital
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