Clinical trials: Cardiovascular Disease (CVD)
COPD (Chronic Obstructive Pulmonary Disease), CHF (Congestive Heart Failure)
A Pilot Observation and Feasibility Study of Prevora, Integrated Into Homecare Visits of High-risk Adults
Prevora is an antiseptic medication and dental treatment approved by Health Canada for reducing root decay (cavities) in adults at high risk of dental decay. An antiseptic kills germs and harmful bacteria.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), CHF (Congestive Heart Failure), Dialysis, Chronic Metabolic Disorder
- Trial name
- NCT06158633
- Testing
- Prevora
- Volunteers
- 30 people
- Sponsor
- CHX Technologies Inc.
Essential Hypertension
Study of the Product QGC001 as a Single Dose and Multiple Doses Administered Orally to Healthy Adult Subjects
1QG2 is a Phase 1 study aiming to assess the safety and tolerability of ascending single/multiple oral doses (SAD \& MAD) in healthy young subjects, the preliminary food interaction and the effect of QGC001 on blood pressure and…
- Trial name
- NCT01900184
- Testing
- QGC001 [(3S,3'S)-4,4'-dithiobis (3-aminobutane-1-sulfonic acid)]
- Where
- France
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Quantum Genomics SA
Hypertension
Compare the Effects of Telemedicine Approach With Usual Care in Hypertension Management in China
This three arm study is to compare the effects of a coordinated PCP-Cardiologist Telemedicine Model (PCTM) with usual care and self-care in community hypertension management in China.
- Trial name
- NCT02919033
- Testing
- Usual care, Self-management, PCTM intervention
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Xu Lei
Heart Failure, Congestive, Renal Insufficiency, Chronic
Mechanisms of Erythropoietin Action in the Cardiorenal Syndrome
Erythropoietin (EPO) treatment in patients with the severe cardiorenal syndrome increases cardiac performance and decreases progression of renal failure by dampening the main driving forces of the cardiorenal syndrome in part via…
- Trial name
- NCT00356733
- Testing
- Erythropoietin administration
- Where
- 2 sites in Netherlands
- Volunteers
- 62 people
- Sponsor
- UMC Utrecht
Hypercholesterolemia, Hypertension
Evaluating "Health at Every Size"(HAES) as an Alternative Obesity Treatment Model
Increasingly more individuals are trying to lose weight. Indeed, many women, regardless of their size, experience a life-long battle and preoccupation with their weight.
- Conditions
- Hypercholesterolemia, Hypertension, Depression, Diabetes Mellitus, Type 2
- Trial name
- NCT00074633
- Testing
- Health at Every Size (HAES), Diet (Traditional, moderate energy restriction)
- Where
- 2 sites in United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Congenital Heart Disease (CHD), Postoperative Respiratory Dysfunction
Effect of Coughing Exercises Versus Incentive Spirometry on Respiratory Function and Recovery in Children After Cardiac Surgery.
This study examines the effects of coughing exercises and incentive spirometry (IS) on lung function and recovery in children who undergo heart surgery.
- Conditions
- Congenital Heart Disease (CHD), Postoperative Respiratory Dysfunction, Postoperative Recovery After Cardiac Surgery
- Trial name
- CEXIS (NCT07405333)
- Testing
- Coughing Exercises, Incentive Spirometry, Standard Postoperative Care
- Where
- 4 sites in Iraq
- Volunteers
- 99 people
- Sponsor
- University of Baghdad
Systemic Lupus Erythematosus (SLE), Systemic Sclerosis (SSc)
A Clinical Study of YTS109 Cell in R/R Autoimmune Diseases
This study evaluates the safety and efficacy of YTS109 cells in adults with relapsed/refractory autoimmune diseases, such as Systemic Lupus Erythematosus (SLE), Systemic Sclerosis (SSc), etc.
- Conditions
- Systemic Lupus Erythematosus (SLE), Systemic Sclerosis (SSc), Inflammatory Myopathy, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
- Trial name
- NCT06978647
- Testing
- YTS109 cell
- Where
- China
- Volunteers
- 12 people
- Sponsor
- China Immunotech (Beijing) Biotechnology Co., Ltd.
Fibromuscular Dysplasia, Renal Artery Stenosis
Renal Arteries Dysplastic Aneurysms: Anatomopathological and Genetic Study
Fibromuscular dysplasia (FMD) is localized structural defects in the arterial wall, whose innate or acquired character is still unknown.
- Trial name
- NCT02528149
- Testing
- tissue of adjacent part and aneurysm of renal aneurysm, blood sample
- Where
- 17 sites in France
- Volunteers
- 34 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Atrial Fibrillation
Comparison of Two Doses of Edoxaban Using Different Tests (Assays) and Clinical Outcomes
Atrial fibrillation is when the heart's two upper chambers (called atria) beat chaotically and irregularly, out of coordination with the two lower chambers (called ventricles) of the heart.
- Trial name
- NCT02964949
- Testing
- Edoxaban
- Where
- 233 sites in Belgium, Bulgaria and 13 more
- Volunteers
- 607 people
- Sponsor
- Daiichi Sankyo
Hemiparesis
Music Therapy for The Rehabilitation of Upper Limb With Stroke Patients
Impairment of arm function is more common than lower limb impairment in stroke patients and is also more resistant to treatment.
- Trial name
- TIMPStro (NCT02310438)
- Testing
- Therapeutic Instrumental Music Performance
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Anglia Ruskin University
ST Segment Elevation Myocardial Infarction, Percutaneous Coronary Intervention
Platelet Inhibition With Cangrelor and Crushed Ticagrelor in STEMI
In STEMI patients undergoing PPCI there is a delayed onset of action of oral P2Y12 receptor inhibitors, including prasugrel and ticagrelor.
- Trial name
- CANTIC (NCT03247738)
- Testing
- Cangrelor
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Florida
Obesity, Cardiovascular Disease
The Effect of Oral Alpha-Cyclodextrin on Fecal Fat Excretion
Saturated fat leading to elevated low density lipoprotein (LDL) cholesterol is considered a cardiovascular risk factor. The properties associated with α- cyclodextrin, allow it to selectively reduce saturated fat and calories…
- Trial name
- FAT ABSORBER (NCT01910558)
- Testing
- Alpha-cyclodextrin and digestible starch, Alpha-cyclodextrin, Digestible starch
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Traumatic Brain Injury, Stroke
Long-term Brain Stimulation of the Motor Ventral Thalamus (VOP/VIM) to Improve Motor Function
This study aims to recruit patients already implanted with Deep Brain Stimulation (DBS) for movement disorders to complete tasks assessing parameters of motor output, speech, and swallowing functions, both with and without…
- Conditions
- Traumatic Brain Injury, Stroke, Brain Disease, Movement Disorders (Incl Parkinsonism)
- Trial name
- NCT07056348
- Testing
- Deep Brain Stimulation (DBS) of the Motor Thalamus
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jorge Gonzalez-Martinez
Hypertension
HARMONY Study (Hypertension Analysis of Stress Reduction Using Mindfulness Meditation and Yoga)
The purpose of this study is to determine if Mindfulness Based Stress Reduction (MBSR) is an effective intervention for lowering blood pressure in early unmedicated hypertensives.
- Trial name
- HARMONY (NCT00825526)
- Testing
- Mindfulness Based Stress Reduction (MBSR) Therapy
- Where
- 2 sites in Canada
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Dyspnea, Respiratory Insufficiency
Cognitive and Behavioral Intervention for the Management of Episodic Breathlessness in Patients With Advanced Disease
Episodic breathlessness is a common and distressing symptom in patients with advanced disease such as cancer, chronic obstructive pulmonary disease (COPD) and chronic heart failure.
- Conditions
- Dyspnea, Respiratory Insufficiency, Neoplasms, Pulmonary Disease, Chronic Obstructive
- Trial name
- CoBeMEB (NCT04630743)
- Testing
- Cognitive and Behavioral intervention for the Management of Episodic Breathlessness
- Where
- Germany
- Volunteers
- 49 people
- Sponsor
- University of Cologne
Ventricular Tachycardia, Ventricular Arrhythmia
Anti-arrhythmic Therapy vs Catheter Ablation as First Line Treatment for AICD Shock Prevention
The purpose of this study is to determine whether catheter based ablation is better than conventional anti-arrhythmic drug (AAD) therapy for reducing recurrent shocks in patients with an implantable cardioverter defibrillator…
- Trial name
- AVATAR (NCT02114528)
- Testing
- Antiarrhythmic Drug Therapy, Catheter ablation
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Hypotension, Bradycardia
Effects of Ondansetron on Hemodynamic Changes After Spinal Anesthesia in Geriatric Urologic Surgery
Spinal anesthesia is frequently used in urologic surgery in geriatric patients; however, it may cause significant hemodynamic changes such as hypotension and bradycardia.
- Conditions
- Hypotension, Bradycardia, Hypotension During Surgery, Spinal Anesthesia Induced Hemodynamic Change
- Trial name
- NCT07551219
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Ankara City Hospital Bilkent
Atherosclerosis
Evaluation of the Neointimal Healing by OCT of the Tapered DES Biomime Morph (TAPER-I Study)
The long and very long stents, although they represent a greater navigability challenge, especially in tortuous and calcified coronary arteries, they have the advantage of providing shorter procedural time, with less contrast…
- Trial name
- TAPER-I (NCT04805619)
- Testing
- Biomime Morph, a tapered drug eluting stent (DES) with hybrid design
- Where
- Brazil
- Volunteers
- 35 people
- Sponsor
- University of Sao Paulo General Hospital
Cerebral Vasospasm, Subarachnoid Hemorrhage
Safety Study of Sildenafil in Treatment of Cerebral Aneurysm Vasospasm
Rupture of a cerebral aneurysm is a serious medical condition that may result in permanent disability or even death just related to the aneurysm rupture itself.
- Trial name
- NCT00871065
- Testing
- Sildenafil citrate
- Sponsor
- University of Nebraska
Atrial Fibrillation, Marker of Inflammation
Change in Inflammatory State in Patients Undergoing Transcatheter Ablation of Atrial Fibrillation
It is a non-pharmacological (biological), spontaneous observational study. The main objective is to evaluate the correlation between inflammation markers and local adiposity, clinical risk factors and their possible variation…
- Conditions
- Atrial Fibrillation, Marker of Inflammation, Inflammation, Arrhythmia
- Trial name
- POLICARDIOFA (NCT05961865)
- Testing
- Markers of inflammation and fibrosis
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico