Clinical trials: Cardiovascular Disease (CVD), open to volunteers
Non-communicable Diseases (NCD), Neoplams
Health for Hungary (H4H) - Longitudinal Collection of Blood Samples and Corresponding Data
The Health for Hungary (H4H) study collects blood samples and corresponding health data to investigate healthy aging and health-to-disease transitions in middle-aged and elderly participants.
- Conditions
- Non-communicable Diseases (NCD), Neoplams, Cancer, Lung Cancer (NSCLC)
- Trial name
- H4H (NCT07743021)
- Where
- 33 sites in Hungary
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Center for Molecular Fingerprinting Research Nonprofit LLC
Cardiovascular Diseases (CVD), Postoperative
Evaluate the Value of Modified Shock Index in Predicting the Incidence of Cardiovascular Events After Non-cardiac Surgery in Cardiac Patients
The objective of this study is to evaluate the efficacy of the modified shock index (MSI) in predicting the incidence of postoperative cardiovascular events (PCEs) in patients with pre-existing cardiac disease undergoing…
- Trial name
- NCT07735689
- Volunteers
- 1,500 people
- Sponsor
- Fujian Medical University Union Hospital
HIV Infection, Cardiovascular Diseases (CVD)
Colchicine to Reduce Coronary Artery Inflammation in People With HIV
The purpose of this study is to evaluate whether colchicine can reduce coronary artery inflammation in people living with HIV and high cardiovascular risk.
- Trial name
- COLCOHIV (NCT07704164)
- Testing
- Colchicine 0.5 mg
- Where
- 4 sites in Spain
- Volunteers
- 90 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Cardiovascular Diseases (CVD), Cardiovascular Surgery
The Effects of a 6-week Pre-operative Administration of a Microbiome Modulator "WellBiome" Versus Placebo on Cardiac Surgical Outcomes and NHS Cost Savings.
More than 7.4 million people in the UK are currently waiting for surgery. Behind that number are real people-patients preparing mentally and physically for procedures ranging from joint replacements to major heart and abdominal…
- Trial name
- NCT07483502
- Testing
- 5g of prebiotic fibre and 300mg of magnesium (WellBiome), 5g of maltodextrin
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Refractory Heart Failure, Cardiovascular Diseases (CVD)
European Study of the BrioVAD Heart Pump for Advanced Heart Failure
This clinical investigation evaluates the safety and clinical performance of the BrioVAD Left Ventricular Assist System in patients with advanced, refractory left ventricular heart failure who require mechanical circulatory…
- Trial name
- BRIOLIFE (NCT07252531)
- Testing
- LVAD implantation
- Where
- 2 sites in Netherlands
- Volunteers
- 60 people
- Sponsor
- BrioHealth BV
Cardiovascular Disease (CVD) Risk Factors
Empowering Cardiovascular Health in Custodial Grandparents
In this study, the investigators will tailor an existing intervention (Rural Caregiver Heart Health Education (RICHH)) protocol and test its feasibility, acceptability, and initial effect with grandparent caregivers.
- Trial name
- ECG (NCT07083895)
- Testing
- Modified RICHH, Standard of Care (SOC)
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Hypertension, Cardiovascular Diseases (CVD)
Royal Jelly as a Strategy to Modulate Inflammation and Oxidative Stress in Patients With Systemic Arterial Hypertension
The study aims to evaluate the effect of the royal jelly on inflammation and oxidative stress in participants with systemic arterial hypertension.
- Conditions
- Hypertension, Cardiovascular Diseases (CVD), Inflammation
- Trial name
- NCT06917131
- Testing
- Royal Jelly
- Where
- Brazil
- Volunteers
- 34 people
- Sponsor
- Universidade Federal Fluminense
Pulmonary Arterial Hypertension (PAH), Comorbidities
COMMODITIES Trial: Initial Dual Oral Therapy vs Monotherapy in PAH With Cardiovascular Comorbidities
Pulmonary arterial hypertension (PAH) is a rare, progressive disease associated with poor prognosis, especially in patients with cardiovascular comorbidities.
- Conditions
- Pulmonary Arterial Hypertension (PAH), Comorbidities, Cardiovascular Disease (CVD)
- Trial name
- COMMODITIES (NCT07245680)
- Testing
- Tadalafil, Ambrisentan
- Where
- France
- Volunteers
- 186 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Microvascular Dysfunction, Microvasculature
Palmitic Acid and Human Microvascular Function
The goal of this study is to learn how a supplement Quercetin can affect microvascular function. Participants will: give two blood draws of 5 mL each have a camera placed under the tongue to take pictures of blood vessels have 2…
- Conditions
- Microvascular Dysfunction, Microvasculature, Cardiovascular Diseases, Cardiovascular Diseases (CVD)
- Trial name
- NCT06683534
- Testing
- Quercetin (dietary supplement)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Medical College of Wisconsin
Cardiovascular Diseases (CVD), Cerebro Vascular Disease
Identifying Risk Factors and Predicting Future Health Outcomes for Korean Patients With Heart and Blood Vessel Diseases: A Long-term Follow-up Study
This study aims to establish a comprehensive, long-term clinical registry infrastructure for heart and brain vascular diseases (cardiovascular diseases and stroke) at Samsung Medical Center.
- Trial name
- NCT07393412
- Testing
- Standard Medical Therapy, Revascularization Procedures, Lifestyle Modification
- Where
- South Korea
- Volunteers
- 800,000 people
- Sponsor
- Samsung Medical Center
Cardiovascular Diseases (CVD), Chronic Kidney Disease
Study on Construction of Whole Lifecycle Cohort, Big Data Management and Clinical Prognosis of Cardio-Renal-Metabolic (CKM) Syndrome
This is a single-center observational registry study aiming to establish a structured clinical and multimodal imaging database for cardiovascular-kidney-metabolic (CKM) populations and to support lifecycle follow-up and outcome…
- Conditions
- Cardiovascular Diseases (CVD), Chronic Kidney Disease, Metabolic Diseases, Cardiovascular-kidney-metabolic Syndrome
- Trial name
- CKM-LCBP (NCT07547098)
- Where
- China
- Volunteers
- 8,000 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Cardiovascular Diseases (CVD)
Heart Institute BioRepository (HIBR) for Pediatric Heart Disease
The purpose of this protocol is to redefine the Heart Institute BioRepository (HIBR) to facilitate Investigator-initiated and programmatic basic, translational, clinical and outcomes research.
- Trial name
- HIBR (NCT07478354)
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Depression and CVD
A Patient Activation Approach to Implementing Depression Treatment in Cardiac Patients
This study, which is being conducted as part of a Quality Improvement (QI) Initiative at Columbia University Irving Medical Center, will test whether delivering the iHeart DepCare tool increases real world reach and adoption of…
- Trial name
- iHeart_2 (NCT07390331)
- Testing
- iHeart Depcare tool
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Columbia University
CVD - Cardiovascular Disease
Community Health Worker-Led Intervention to Increase Cardiac Rehabilitation Participation
This study is being done to evaluate whether a program called Heart to Heart, that helps patients make a more informed decision about cardiac rehab (CR), is interesting, acceptable to participants, and whether participants would…
- Trial name
- H2H (NCT06908590)
- Testing
- Education, Providing and Engaging Social Support and Assistance with Health System Navigation
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- Johns Hopkins University
Cardiovascular Diseases (CVD), Cardiovascular Disease Prevention
Assessment and Prediction of Cardiovascular Health and Disease Risk Using Wearable Biometrics.
This prospective, observational cohort study will evaluate the associations between wearable-derived biometrics and cardiovascular health, quantified by the American Heart Association's Life's Essential 8 framework, as well as…
- Conditions
- Cardiovascular Diseases (CVD), Cardiovascular Disease Prevention, Cardiovascular Disease Risk Factor, Coronary Artery Disease (CAD)
- Trial name
- BEACON-HEART (NCT07401550)
- Where
- Ireland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Rheumatoid Arthritis, Atherosclerotic Ischemic Disease
Coronary Computed Tomography Angiography In Rheumatoid Arthritis Study
The Coronary Computed Tomography Angiography in Rheumatoid Arthritis study is part of the multinational, prospective, observational Autoimmunity and Atherosclerosis in Rheumatic Diseases cohort (https://atacc-rd.com) that…
- Conditions
- Rheumatoid Arthritis, Atherosclerotic Ischemic Disease, Pulmonary Disease, Depressive Disorder
- Trial name
- COTIRA (NCT07363980)
- Where
- 4 sites in Denmark
- Volunteers
- 4,000 people
- Sponsor
- Ellen Margrethe Hauge
Prediabetic State, Metabolic Syndrome
Effects of Sweetener Consumption on Risk Factors for Heart Disease in Prediabetic Subjects
The aim of this prospective interventional study is to investigate the metabolic effects of consuming artificial and natural sweeteners in persons with prediabetes.
- Conditions
- Prediabetic State, Metabolic Syndrome, Insulin Resistance, Thrombosis
- Trial name
- Sweetheart (NCT07377097)
- Testing
- Saccharin, Sucralose, Erythritol
- Volunteers
- 80 people
- Sponsor
- Charite University, Berlin, Germany
Wearable Electronic Devices, Polygenic Risk Score
DELphi Procedure for Developing Recommendations for the Implementation of Wearable Devices and Polygenic Risk Scores
DEL-DIP is a prospective observational study employing a Delphi methodology (at least two online rounds) to elicit and consolidate the views of an expert panel within the INNOPREV project.
- Conditions
- Wearable Electronic Devices, Polygenic Risk Score, CVD - Cardiovascular Disease, Primary Prevention
- Trial name
- DEL-DIP (NCT07358481)
- Where
- Italy
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Gender Incongruence, Cardiovascular Disease (CVD) Risk Factors
Cardiomodulatory Effects of Gender-Affirming Hormone Therapy
Gender-affirming hormone therapy is today a well-established treatment for individuals experiencing gender-incongruence. However, little is known about the long-term effects of gender-affirming hormone therapy on the…
- Trial name
- CARMEN (NCT07128771)
- Where
- Norway
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- University Hospital, Akershus
CVD - Cardiovascular Disease, MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease
Corazones Unidos Study
CVD is the leading cause of death among individuals with MASLD, a risk factor for liver cancer. In Southern Arizona, CVD and cancer (including liver and gastric cancer) are among the leading causes of death for Mexican-origin…
- Trial name
- NCT07298213
- Testing
- Your Heart, Your Health
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Arizona