Clinical trials: Cardiovascular Disease (CVD)
Heart Failure
The PURI-HF (Air Purifiers on Heart Failure) Trial
Indoor air pollution and fine mode particulate matter with an aerodynamic diameter smaller than 2.5 micrometers (PM2.5) is a major contributor to global morbidity and mortality, particularly due to cardiovascular disease.
- Trial name
- NCT05230784
- Testing
- AirOk Air Purifier
- Where
- 3 sites in India
- Volunteers
- 255 people
- Sponsor
- NYU Langone Health
Ischemic Stroke, Alteplase Adverse Reaction
Predictors of AIS Unfavorable Outcomes
The investigators evaluated whether the characteristics of ischemic stroke patients, door-to-needle time, and stroke risk factors were predictive variables for unfavourable outcomes.
- Trial name
- NCT06058884
- Testing
- Alteplase
- Where
- Egypt
- Volunteers
- 592 people
- Sponsor
- Kafrelsheikh University
Partial Thickness Wound, Pressure Ulcer
The RESPOND Registry
The RESPOND Registry is an observational study to assess the impact of PuraPly™ AM on the management of wounds in real world clinical settings; no experimental intervention is involved.
- Conditions
- Partial Thickness Wound, Pressure Ulcer, Venous Ulcer, Diabetic Ulcer
- Trial name
- RESPOND (NCT03286452)
- Testing
- PuraPly™ Antimicrobial Wound Matrix
- Where
- 15 sites in United States
- Volunteers
- 310 people
- Sponsor
- Organogenesis
Physical Activity, Life Style
Cardiovascular Disease Prevention Strategies for High-risk Urban Sedentary Employees in Karachi, Pakistan
Heart diseases and other non-communicable diseases are serious health issues in countries like Pakistan. Many people who work in offices, like bank employees, sit for more than 8 hours a day.
- Conditions
- Physical Activity, Life Style, Dietary Habits, Cardiovascular Diseases
- Trial name
- m-LIfE (NCT06981247)
- Testing
- m-LIfE: mobile based lifestyle intervention for employees to increase their physical activity and promote healthy diet., Routine care arm
- Where
- Pakistan
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Acute Decompensated Heart Failure
Mobile Education System to Improve Disease Knowledge, Self-efficacy and Quality of Life in Patients With Heart Failure
Heart failure (HF) is an incurable and complex disease syndrome with sophisticated disease trajectories. The guideline for HF management suggests that treatment should include adequate education to help patients have better…
- Trial name
- NCT06161649
- Testing
- accepting the operation process of automated intelligent education software system
- Where
- Taiwan
- Volunteers
- 138 people
- Sponsor
- Chang Gung Memorial Hospital
Heart Failure, Acute Kidney Injury
Sodium-Glucose Cotransporter-2 Inhibitor for Patients With Acute Cardiorenal Syndrome
The overall objective of this study is to determine whether the addition of SGLT2 inhibitors to usual care in hospitalized patients with heart failure associated acute kidney injury is safe and efficacious.
- Trial name
- NCT07273838
- Testing
- Dapagliflozin 10mg Tab
- Where
- 2 sites in United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Yale University
Antiphospholipid Syndrome
Prevalence and Consequences of Antiphospholipid Syndrome in Patients Aged 65 and Over With Ischemic Strokes (IS)
Stroke represents a major cause of morbidity and mortality despite significant progress in recent decades. In individuals under the age of 65, the etiologies of ischemic stroke (IS) are diverse, and management is…
- Trial name
- SAPLAGE (NCT07163338)
- Testing
- Collectio nof blood
- Where
- France
- Volunteers
- 400 people
- Sponsor
- CHU de Reims
Hypertension
Calibration of a Wrist Cuff Blood Pressure Device, According to the AAMI/ESH/ISO Universal Standard
The objective of this study is to calibrate the blood pressure measurements of the Pulsewave Health Monitor (PAD-2A) device to be within 5±8 mmHg of the average of the dual-observer measurements via an aneroid sphygmomanometer…
- Trial name
- NCT04869826
- Testing
- Pulsewave Health Monitor (PAD-2A) Device
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cardiovascular Research New Brunswick
Brugada Syndrome
Brugada Ablation of VF Substrate Ongoing MultiCenter Registry
Current treatment of high-risk Brugada Syndrome (BrS) patients (pts) with recurrent VF is limited. Catheter ablation (CA) has been performed for BrS but a large study with long-term outcomes of CA in BrS ablation are lacking.
- Trial name
- BRAVO (NCT04420078)
- Testing
- Catheter Ablation
- Where
- Thailand
- Volunteers
- 159 people
- Sponsor
- Pacific Rim Electrophysiology Research Institute
Atrial Fibrillation
Improvement in Endothelial Dysfunction After Initiation of Anti-arrhythmic Therapy in Atrial Fibrillation Patients
This is a prospective, observational study that will examine endothelial dysfunction in atrial fibrillation before and after treatment with anti-arrhythmic agents and the extent to which baseline endothelial dysfunction improves…
- Trial name
- NCT04128878
- Testing
- Sotalol, Dofetilide
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Samir Saba
Coronary Artery Disease
Assessment of Coronary Artery Lesion Using Optical Coherence Tomography Versus IntraVascular Ultrasound for BiorEsorbable Vascular Scaffold Implantation
The primary objective is to determine whether IVUS- (vs. OCT-) guided BVS implantation is non-inferior to achieve a large in-scaffold minimal lumen area (primary endpoint) measured by OCT at 1-year follow-up.
- Trial name
- ACTIV-BVS (NCT02814578)
- Testing
- Optical coherent tomography, IntraVascular UltraSound
- Where
- 3 sites in South Korea
- Volunteers
- 9 people
- Sponsor
- Young-Hak Kim, MD, PhD
Stroke, Hemiplegia
Functional Electrical Stimulation for Footdrop in Hemiparesis
The objective of this research is to determine if electrical stimulation can improve the strength and coordination of the lower limb muscles, and the walking ability of stroke survivors.
- Trial name
- NCT00148343
- Testing
- Odstock Dropped-Foot Stimulator (ODFS), Conventional Standard of Care, Traditional Physical Therapy Treatment
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- MetroHealth Medical Center
Hypertension
Telmisartan With or Without Hydrochlorothiazide in Patients With Mild-to-moderate Hypertension
Study to demonstrate that a fixed dose combination of telmisartan 80 mg plus hydrochlorothiazide (HCTZ) 12.5 mg (FDC 80/12.5) is superior to telmisartan 80 mg (Telm 80) alone in patients who failed to respond adequately to Telm…
- Trial name
- NCT02177435
- Testing
- Telmisartan, Telmisartan/Hydrochlorothiazide
- Volunteers
- 491 people
- Sponsor
- Boehringer Ingelheim
Heart Failure, Photoplethysmography
Seerlinq: Non-invasive LVFP Monitoring in HF
Left ventricular filling pressure (LVFP) monitoring has been associated with improved quality of life, survival and reduced hospitalization rates.
- Conditions
- Heart Failure, Photoplethysmography, Right Heart Catheterization
- Trial name
- PPG-HF (NCT06649435)
- Testing
- PPG measurement
- Where
- Slovakia
- Volunteers
- 131 people
- Sponsor
- Seerlinq s. r. o.
Coronary Artery Disease
TAXUS PERSEUS Workhorse
The purpose of the TAXUS PERSEUS Workhorse trial is to evaluate the safety and efficacy of the next-generation Boston Scientific TAXUS paclitaxel-eluting coronary stent system (TAXUS® ElementTM) for the treatment of de novo…
- Trial name
- PERSEUS WH (NCT00484315)
- Testing
- Percutaneous coronary intervention (PCI) with paclitaxel-eluting stent (TAXUS Element) implantation, Percutaneous coronary intervention (PCI) with paclitaxel-eluting stent (TAXUS Express) placement
- Where
- 90 sites in United States, Australia and 2 more
- Volunteers
- 1,264 people
- Sponsor
- Boston Scientific Corporation
Primary Ciliary Dyskinesia
A Study to Assess the Safety, Tolerability, Ciliary Rescue, and Pharmacodynamics of RCT1100 in Adults With PCD
This is the second in-human study with RCT1100 and is designed to provide safety, tolerability and preliminary efficacy data for future clinical studies.
- Trial name
- NCT06600425
- Testing
- RCT1100
- Where
- 2 sites in United Kingdom
- Volunteers
- 7 people
- Sponsor
- ReCode Therapeutics
Cataract Surgery
Music Listening for Cataract Surgery
The purpose of the study is to assess the effect of music therapy on anxiety and hypertension during cataract surgery procedures performed under topical anaesthesia.
- Trial name
- MUSICATOP (NCT02892825)
- Testing
- Music, No Music
- Where
- France
- Volunteers
- 313 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Coronary Artery Bypass, Atherosclerosis
Study of the Xience V Everolimus-eluting Stent in Saphenous Vein Graft Lesions
The specific aim of the SOS-Xience V study is to examine the 12-month incidence of binary angiographic in-stent restenosis after implantation of the Xience V stent in aortocoronary saphenous vein bypass graft lesions.
- Trial name
- SOS-Xience V (NCT00911976)
- Testing
- Xience V coronary stent
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- North Texas Veterans Healthcare System
Atherosclerosis
A Study Investigating the Concentrations of Darapladib in Blood and the Safety of This Compound in Healthy Japanese Men
This study is being conducted to provide initial safety, tolerability, PK and PD data that will allow further studies with darapladib in Japanese patients
- Trial name
- NCT00551317
- Testing
- Darapladib (SB480848)
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Acute Coronary Syndrome
Deciphering the Salutogenic Effects of Close Relationships: Psycho-physiological Coregulation Processes and Their Outcomes in Couples Coping With Cardiovascular Disease
The established attachment theory elucidates how early human bonds bring about functional neurophysiological alterations influencing the lifelong capacity for self and co- regulation within relationships.
- Trial name
- NCT05341440
- Where
- Israel
- Volunteers
- 81 people
- Sponsor
- Bar-Ilan University, Israel
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