Clinical trials: Cardiovascular Disease (CVD)
Hypertension, Aortic Stenosis, Calcific
Pressure Assessment to Improve Outcomes After TAVR: a Registry
At the Malcom Randall Veterans Affairs Medical Center (MRVAMC), invasive cardiac pressures are routinely recorded after transcatheter aortic valve replacement (TAVR) procedures.
- Conditions
- Hypertension, Aortic Stenosis, Calcific, Quality of Life, Heart Failure With Preserved Ejection Fraction
- Trial name
- NCT03923530
- Testing
- Eplerenone
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- North Florida Foundation for Research and Education
Heart Failure, Telemedicine
Evaluating Telehealth Home Care for Elderly Veterans With Congestive Heart Failure
Congestive heart failure (CHF) is one of the most common reasons for hospitalization in patients aged 65 years and older. Many hospitalizations for CHF are potentially preventable if the warning signs of decompensation are…
- Trial name
- NCT00057200
- Testing
- Telephone, videophone care
- Where
- United States
- Volunteers
- 198 people
- Sponsor
- US Department of Veterans Affairs
Coronary Artery Disease, Systemic Inflammation
MIECC vs Conventional Cardiopulmonary Bypass and Systemic Inflammation in CABG
This prospective observational study evaluates the effects of minimally invasive extracorporeal circulation (MIECC) and conventional cardiopulmonary bypass on systemic inflammatory response in patients undergoing coronary artery…
- Trial name
- MIECC-CABG (NCT07823400)
- Testing
- Minimally Invasive Extracorporeal Circulation, Conventional Cardiopulmonary Bypass
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Cardiovascular Disease
Study of the Cardiovascular Vitamin, CardioLife
Evaluation of the metabolic and physiological characteristics of patients with diagnosed Cardiovascular Disease following administration of the Cardiovascular vitamin, CardioLife.
- Trial name
- NCT02088307
- Testing
- CardioLife
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Utah
Cardiovascular Disease
Growth Hormone's Effect on Endothelial Progenitor Cells
To assess the effect of short-term low-dose growth hormone therapy on the mobilization of endothelial progenitor cells from the bone marrow within a group of healthy adults.
- Trial name
- NCT00397592
- Testing
- Growth Hormone
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Pulmonary Embolism
Effect of a Global Simplified Strategy on Thromboembolic Events in Emergency Department Patients with Suspected Pulmonary Embolism
Pulmonary embolism (PE) is frequently suspected in emergency departments (ED) patients which often leads to the prescription of DDimer testing and irradiative chest imaging (Computed Tomographic Pulmonary Angiogram CTPA in most…
- Trial name
- MODS STRATEGY (NCT06190392)
- Testing
- MODS Modified simplified diagnostic strategy
- Where
- France
- Volunteers
- 1,223 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Heart Diseases
Regional Cerebral Oxygenation and Brain Blood Volume During Cardiac Surgery Using the NeurOS System
Study of Regional Cerebral Oxygenation and Brain Blood Volume changes during Cardiac Surgery using the NeurOS system
- Trial name
- COBBV-CS (NCT03969836)
- Testing
- NeurOS system
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- University of Louisville
Acromegaly Cardiomyopathy
Endocrine Cardiomyopathy: Response to Cyclic GMP PDE5 Inhibitors in Acromegaly Cardiomyopathy
Pathophysiology of acromegaly cardiomyopathy is yet unclear and a specific treatment have not been indicated. It was already demonstrated the positive impact of phosphodiesterase type 5A (PDE5A) inhibition in several models of…
- Trial name
- SUM (NCT02611336)
- Testing
- Tadalafil
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Andrea M. Isidori
Venous Thromboembolism
Explicit Assessment of Thromboembolic Risk and Prophylaxis for Medical Patients in Switzerland
Until now, no risk assessment model informing about the need of thromboprophylaxis in patients admitted for an acute medical event has been validated.
- Trial name
- NCT01277536
- Where
- 7 sites in Switzerland
- Volunteers
- 1,478 people
- Sponsor
- University Hospital, Geneva
Hypercholesterolemia, Hypertension
Effects of Rosiglitazone on Blood Vessels in Patients With High Blood Pressure and High Cholesterol
Cells in the lining of blood vessels produce various substances that cause the vessels to dilate (relax) and constrict (tighten), thereby regulating blood flow.
- Trial name
- NCT00006071
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Takayasu Arteritis, Methotrexate
Efficiency of Methotrexate and Tofacitinib in Mild and Moderate Patients
Takayasu arteritis (TAK) is a rare chronic inflammatory arteritis, which lacks an effective well-accepted intervention strategy.
- Conditions
- Takayasu Arteritis, Methotrexate, Inhibition, Treatment
- Trial name
- NCT04299971
- Testing
- Methotrexate Tablets, Tofacitinib tablet
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Shanghai Zhongshan Hospital
Coronary Artery Disease, Atrial Fibrillation (AF)
Medical Large Language Model-Assisted Diagnosis and Treatment in Primary Care Chronic Disease Management
This study aims to explore the feasibility of using medical large language models to assist in chronic disease management. By setting up experimental and control group interventions and having experts blindly evaluate anonymized…
- Conditions
- Coronary Artery Disease, Atrial Fibrillation (AF), Heart Failure, Stroke
- Trial name
- NCT07740044
- Testing
- Medical large language model
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Jiangsu Taizhou People's Hospital
Atrial Fibrillation
Use of a High Density Mapping System to Complete Wide Area Circumferential Ablation of the Pulmonary Veins and Avoid Ostial Segmental Ablation
This is a prospective, multicentre, randomized single blind, parallel group study to be conducted in the UK (2 sites).Approximately 48 patients will be recruited aiming for 40 eligible for randomization.
- Trial name
- HD-WACA (NCT02917044)
- Testing
- Atrial Fibrillation Ablation, Catheters used to isolate pulmonary veins, Atrial Fibrillation Ablation with HD mapping to isolate PVs
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- Imperial College Healthcare NHS Trust
Hypertension
A Study of the Efficacy and Safety of Nebivolol Added to Existing Antihypertensive Treatment in Patients With Hypertension
The purpose of this study was to contrast the efficacy and safety of 3 dose levels of nebivolol vs. placebo, when added to a patient's existing antihypertensive medication(s) for 3 months, in patients with mild to moderate…
- Trial name
- NCT00200434
- Testing
- Nebivolol
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Mylan Bertek Pharmaceuticals
Hypertension
Reducing Disparities in the Treatment of Hypertension Using the OWL mHealth Tool
This is a one-year study. The study's primary outcome is successful improvement of the Our Whole Lives for Hypertension (OWL-H) online patient education platform, based upon participant use and focus group feedback, to deliver…
- Trial name
- OWL-H (NCT03974334)
- Testing
- OWL-Hypertension 8 Wk Trial
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Paula Gardiner
Ischemic Stroke, Atherosclerosis
Preventive Effects of Ginseng Against Atherosclerosis
This study is a 12-month, double-blind, randomized, placebo-controlled trial. The purpose of this study is to determine whether ginseng is effective in the prevention of atherosclerosis and subsequent ischemic stroke.
- Trial name
- PEGASUS (NCT02796664)
- Testing
- Ginseng
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Dae Chul Suh
Atrial Fibrillation
Safety and Feasibility of Atrial Deganglionation as Adjunctive Therapy for AF
A prospective, single arm, multi-center exploratory study of safety and feasibility in the treatment of patients undergoing cardiothoracic surgery.
- Trial name
- Neural-AF (NCT04775264)
- Testing
- Pulsed Electric Field Ablation
- Where
- 2 sites in Czechia, Georgia
- Volunteers
- 24 people
- Sponsor
- Atrian Medical Ltd.
Depression, Hypertension
Biological CVD Risk Factors in Older Depressed Patients
The purpose of this study is to determine if improvements in mood will ameliorate autonomic dysregulation, HPA dysfunction and typical (e.g.
- Conditions
- Depression, Hypertension, Hypercholesterolemia
- Trial name
- NCT00318864
- Testing
- Cognitive behavioral therapy
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Stanford University
Aphasia
LEXURE for Post-Stroke Aphasia
This study evaluates the efficacy of digital language rehabilitation using LEXURE for the treatment of post-stroke aphasia. Half of participants will receive structured language training using the LEXURE application, while the…
- Trial name
- NCT07570264
- Testing
- LEXURE, Workbook
- Where
- 12 sites in South Korea
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Nunaps Inc
Atherosclerosis, Hypercholesterolemia
Investigating the Effects of Lipid-therapy Intensification With Alirocumab on Endothelial Function, Carotid Arteries, Lipoprotein Particle Subfractions, Inflammation and Post-prandial Lipemia
A prospective, open-label, pilot study with 24 cardiovascular high risk patients (N=24) having insufficient Low density lipoprotein cholesterin (LDL-C) reduction despite standard of care lipid-modifying therapies (LMTs), to…
- Conditions
- Atherosclerosis, Hypercholesterolemia, Post Prandial Lipemia, Cardiovascular Diseases
- Trial name
- ALIROCKS (NCT03559309)
- Testing
- Magnet Resonance Tomography, Carotid Arteries Sonography, Flow-mediated Dilation, Fat-tolerance Test, Laboratory Testing
- Where
- Austria
- Volunteers
- 24 people
- Sponsor
- Medical University of Graz
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