Clinical trials: Cardiovascular Disease (CVD)
Hypotension
Treatment of Hypotension of Prematurity (TOHOP)
Hypotension in the very preterm infant (gestational age [GA] <32 wks) is a frequently occurring clinical problem. Although no real consensus has been reached on the definition of hypotension in these infants, in clinical practice…
- Trial name
- TOHOP (NCT01434251)
- Testing
- Anti-hypotensive treatment
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- UMC Utrecht
Chronic Heart Failure, Mitral Insufficiency
Mitral Valve Reconstruction in Chronic Heart Failure (CHF): Identification of Predictors for a Successful Therapy
The aim of the study is to evaluate hemodynamic and echocardiographic parameters in patients with secondary mitral insufficiency and CHF. 1.
- Trial name
- NCT00348829
- Testing
- mitral valve repair
- Where
- Germany
- Volunteers
- 5 people
- Sponsor
- University of Leipzig
Cardiovascular Diseases
Validation of an Algorithm to Predict the Ventilatory Threshold
The aim of the current study was to develop an algorithm which has the ability to accurately predict the first and second ventilatory threshold and in cardiovascular disease patients and to guide in proper exercise intensity…
- Trial name
- NCT04929431
- Where
- Belgium
- Volunteers
- 3,000 people
- Sponsor
- Hasselt University
Hypertension, Diabetes Mellitus
MA-CEAL Community Health Ambassador Program
This research is being conducted to investigate how to increase primary care health care visits and screenings and treatment for hypertension and diabetes in residents of housing developments in Boston.
- Conditions
- Hypertension, Diabetes Mellitus, Health Care Utilization
- Trial name
- CHANGE (NCT07136402)
- Testing
- Educating participants about healthcare resources, Healthcare appointments, Workshops
- Sponsor
- Boston Medical Center
Refractory Angina
A Study to Evaluate the Safety, Tolerability, and Efficacy of IMB-1018972 in Patients With Refractory Angina
The objectives of the study are to assess the safety, tolerability, and potential efficacy of IMB-1018972 on patients with refractory angina.
- Trial name
- NCT04306237
- Testing
- IMB-1018972
- Where
- United States
- Sponsor
- Imbria Pharmaceuticals, Inc.
Diabetic Foot
Comparing the Expected Benefit of Extra-corporeal-shockwave Therapy (ESWT) Treatment to Standard Care in Treating Diabetic Foot Ulcers
The purpose of this study is to determine if Extra-corporeal-shockwave Therapy (ESWT) added to standard of care wound therapy significantly improves time to complete wound healing in diabetic foot wounds.
- Trial name
- NCT01499472
- Testing
- shock wave therapy, dermagold shockwave, standard of care
- Volunteers
- 300 people
- Sponsor
- Hadassah Medical Organization
Coronary Artery Disease, Atherosclerosis of Coronary Artery
Functional Improvement of Coronary Artery Narrowing by Cholesterol Reduction With a PCSK9 Antibody
In a large number of patients who experienced an acute coronary syndrome, multiple narrowings of the coronary arteries are identified.
- Trial name
- FITTER (NCT04141579)
- Testing
- Evolocumab 140 MG/ML [Repatha]
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- Radboud University Medical Center
Peripheral Arterial Disease
Revascularization of Total or Sub-total Occluded Peripheral Arteries With ByCross® Device. Post Market Clinical Followup
Post market clinical follow up of Bycross® device.
- Trial name
- NCT05110079
- Testing
- ByCross Atherectomy and Thrombectomy
- Where
- 3 sites in Germany
- Volunteers
- 75 people
- Sponsor
- Taryag Medical Ltd.
Hepatitis C, Chronic, Heart Failure
Hepatitis C Virus(HCV) Heart and Lung Study
This is a multicenter study in Hepatitis C Virus (HCV) infected adult patients who also have advanced cardiac disease or advanced lung disease.
- Conditions
- Hepatitis C, Chronic, Heart Failure, Pulmonary Disease, Chronic Obstructive, Lung Diseases, Interstitial
- Trial name
- NCT02858180
- Testing
- Sofosbuvir/ledipasvir fixed dose combination(SOF/LDV FDC)
- Where
- 4 sites in United States
- Volunteers
- 15 people
- Sponsor
- Duke University
Development of Standardized Assessment TAVI and MitraClip Procedures by Echocardiography, Aortic Stenosis
Examination of Valve Insufficiency Before and After MitraClip or TAVI Procedure by 3D Echocardiography Compared to MRI
Aim of the study is the definition of criteria for a standardized assessment of heart function by 3D echocardiographic procedures.
- Conditions
- Development of Standardized Assessment TAVI and MitraClip Procedures by Echocardiography, Aortic Stenosis, Mitral Valve Insufficiency
- Trial name
- 3D_TTE_TAVI (NCT01966146)
- Testing
- Echography GE Healthcare Vivid E9
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- RWTH Aachen University
ANGIOEDEMA
CLOUD-R HAE REGISTRY
Angioedema is a disease characterized by the appearance of self-limiting edema that last 1-5 days and affect the subcutaneous tissue and/or gastrointestinal and oropharyngeal mucosa.
- Trial name
- CloudRHAE (NCT03845946)
- Testing
- angioedema
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Grenoble
Stroke
Comparison of Effects of Activity Base Therapy vs Strength Training on Gait Performance in Chronic Stroke
Stroke is a leading cause of disability worldwide affecting both male and female especially in older people. Functional independence and locomotion are hampered in stroke, therefore, affecting their quality of life.
- Trial name
- NCT04823546
- Testing
- activity based therapy, Strength Training
- Where
- Pakistan
- Volunteers
- 16 people
- Sponsor
- Riphah International University
Venous Insufficiency
Open Label Safety Investigation of Solutio™ Tumescent Catheter
The goal of this clinical investigation is to evaluate safety of the Solutio™ catheter when administering tumescent anesthesia before treatment with endothermal ablation in adults above the age of 18, who suffer from unilateral…
- Trial name
- NCT07823088
- Testing
- Administration of local anesthesia
- Where
- 2 sites in Sweden
- Volunteers
- 30 people
- Sponsor
- MedVasc AB
Intracranial Aneurysms
Evaluation of DeltaMaxx® Microcoil System in Intracranial Aneurysms
The primary objective of this registry is to assess the safety and angiographic outcomes of endovascular treatment of intracranial aneurysms using the DeltaMaxx Microcoil System.
- Trial name
- NCT01945827
- Testing
- DeltaMaxx Microcoil System
- Sponsor
- Codman & Shurtleff
Atherosclerosis, Subclinical Atherosclerosis
DETECTion of the Prevalence of Silent Atherosclerosis Across Adult Life - Phase I of REACT
Atherosclerosis is preventable, yet it continues to significantly contribute to global morbidity and mortality. Atherosclerosis may occur early in life and may present in all vascular territories.
- Conditions
- Atherosclerosis, Subclinical Atherosclerosis, Cardiovascular Diseases
- Trial name
- DETECT (NCT06692127)
- Where
- 5 sites in Denmark, Spain
- Volunteers
- 16,808 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cardiovascular Disease
Effect of Soy on HDL-C Function, Central Blood Pressure, and Arterial Stiffness
The purpose of the proposed pilot study is to evaluate the effects of a soy protein isolate with naturally occurring isoflavones on the properties of HDL-C (total HDL-C, HDL particle size and HDL function), central blood…
- Trial name
- SOY (NCT02180841)
- Testing
- Soy Protein Powder (25g/d), Soy Protein Powder (50g/d)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Penn State University
Angina (Stable), Coronary Microvascular Disease
Coronary Sinus Reducer in Coronary Microvascular Disease
Coronary microvascular dysfunction (CMD) is a common cause of treatment- resistant angina that lacks evidence-based treatment options.
- Trial name
- REDUCE CMD (NCT06898541)
- Testing
- Coronary sinus reducer
- Where
- 2 sites in Netherlands
- Volunteers
- 50 people
- Sponsor
- UMC Utrecht
AKI - Acute Kidney Injury, PAI-1 4G/5G Polymorphism
Correlation Study of PAI-1 4G/5G Polymorphism and Postoperative AKI in Patients With Aortic Dissection
To explore the association between PAI-1 4G5G polymorphism and the risk of CSA-AKI in Stanford type A dissection patients undergoing open-heart repair surgery.
- Conditions
- AKI - Acute Kidney Injury, PAI-1 4G/5G Polymorphism, Aortic Dissection
- Trial name
- NCT05490394
- Where
- China
- Volunteers
- 283 people
- Sponsor
- Xijing Hospital
Acute Ischemic Stroke
NeVa ONE Registry Study
A prospective, open label study designed to assess the safety, performance and efficacy of thrombus removal in subjects presenting with acute ischemic stroke with the NeVa stent retrievers.
- Trial name
- NCT04562194
- Testing
- NeVa Stent Retriever
- Where
- 3 sites in Argentina, Italy and 1 more
- Volunteers
- 600 people
- Sponsor
- Vesalio
Hypertension
The Impact of Mobile Application-Supported Monitoring on Treatment Compliance and Success in Lifestyle Changes in Hypertensive Patients
Hypertension (HT) is defined as an arterial blood pressure persistently exceeding 140/90 mmHg in repeated measurements. It is a systemic disease characterized by chronically elevated blood pressure, which can lead to severe…
- Trial name
- NCT07299266
- Testing
- Mobile App-Supported Blood Pressure Monitoring
- Volunteers
- 40 people
- Sponsor
- University of Gaziantep
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