Clinical trials: Cardiovascular Disease Risk Factor
Coronary Heart Disease, Periodontitis
Changes in the Risk Factors of Coronary Heart Disease Observed After Scaling and Root Planing
The purpose of this study is to determine whether scaling and root planing as a periodontal intervention helps in improving the overall health of patients suffering from coronary heart disease.
- Trial name
- NCT02417376
- Testing
- piezoelectric ultrasonic scaler (frequency of 28-36 KHz), Gracey curettes
- Volunteers
- 70 people
- Sponsor
- Government College of Dentistry, Indore
Heart Failure, Type 2 Diabetes Mellitus
Effect of Sotagliflozin on Cardiovascular and Renal Events in Participants With Type 2 Diabetes and Moderate Renal Impairment Who Are at Cardiovascular Risk
The primary objective of the study was to compare the effect of sotagliflozin to placebo on total occurrences of cardiovascular (CV) death, hospitalization for heart failure [HHF], and urgent visit for heart failure [HF] in…
- Conditions
- Heart Failure, Type 2 Diabetes Mellitus, Chronic Kidney Diseases
- Trial name
- SCORED (NCT03315143)
- Testing
- Sotagliflozin
- Where
- 754 sites in United States, Argentina and 43 more
- Volunteers
- 10,584 people
- Sponsor
- Lexicon Pharmaceuticals
Cardiovascular Disease, Coronary Disease
Effects of Cardiac Rehabilitation (CR) on Functional Capacity and Cardiovascular Risk Factors
The purpose of this trial are to pragmatically investigate whether participation in a comprehensive CR (i.e., exercise with education) program in a Latin American MIC results in better functional capacity, cardiovascular risk…
- Trial name
- NCT02575976
- Testing
- comprehensive CR, exercise-based CR, wait list control
- Where
- Brazil
- Volunteers
- 115 people
- Sponsor
- Federal University of Minas Gerais
Hypertension, Hypercholesterolemia
Caduet vs Usual Care in Subjects With Hypertension and Additional Risk Factors
To investigate whether a Caduet based treatment strategy might result in greater reduction in total cardiovascular risk as compared to usual care in subjects with hypertension and additional risk factors.
- Trial name
- CRUCIAL (NCT00407537)
- Testing
- Amlodipine besylate/atorvastatin calcium single pill combination
- Where
- 125 sites in Costa Rica, Croatia and 18 more
- Volunteers
- 1,531 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Pregnancy Related, Cardiovascular Risk Factor
Promoting Stretching Exercise to Reduce Cardiovascular Health Risk in Late Pregnant Women With Obesity
The purpose of this trial is to determine whether a stretching intervention is superior to a usual care control condition (moderate/vigorous activity 30 minutes daily, 5 days per week) for pregnant women from 27 to 37 gestational…
- Conditions
- Pregnancy Related, Cardiovascular Risk Factor, Obesity
- Trial name
- NCT04291560
- Testing
- Stretching Exercise Intervention
- Where
- United States
- Volunteers
- 224 people
- Sponsor
- University of North Carolina, Chapel Hill
Insulin Sensitivity, Cardiovascular Risk
Oral Contraceptives, Insulin Resistance and Cardiovascular Risk Profile in Pre-Menopausal Women
Birth control pills are the most commonly used method of birth control. The purpose of this research study is to examine whether birth control pills change heart disease risk and how the body handles blood sugar when given to…
- Conditions
- Insulin Sensitivity, Cardiovascular Risk, Perimenopausal Disorder
- Trial name
- NCT01475513
- Testing
- Ortho Cyclen®
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cardiovascular Disease, High Cardiovascular Risk
A Study to Evaluate the Effect of Long-term Treatment With BELVIQ (Lorcaserin HCl) on the Incidence of Major Adverse Cardiovascular Events and Conversion to Type 2 Diabetes Mellitus in Obese and Overweight Subjects With Cardiovascular Disease or Multiple Cardiovascular Risk Factors
This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group study in overweight and obese subjects with cardiovascular (CV) disease and/or multiple CV risk factors.
- Conditions
- Cardiovascular Disease, High Cardiovascular Risk, Obesity, Overweight
- Trial name
- CAMELLIA-TIMI (NCT02019264)
- Testing
- Lorcaserin hydrochloride
- Where
- 499 sites in United States, Australia and 6 more
- Volunteers
- 14,673 people
- Sponsor
- Eisai Inc.
Cardiovascular Risk Factors, Serious Mental Illness
Intervention Trial to Decrease Cardiovascular Risk in Persons With Serious Mental Illness
This study will determine whether a program where a health coach works with participants on heart healthy behaviors and treatment of risk factors is coordinated with primary care can reduce overall heart disease risk in people…
- Trial name
- IDEAL (NCT02127671)
- Testing
- IDEAL intervention, Control
- Where
- United States
- Volunteers
- 269 people
- Sponsor
- Johns Hopkins University
Cardiovascular Risk Factor, Cardiovascular Diseases
Substituting Sitting With Standing and Walking in Free-living Conditions Improves Daily Glucose Profile in South Asians
The purpose of this study is to investigate the effects of substituting sitting under free-living conditions in South Asian adults with overweight and obesity on continuous glucose profiles.
- Conditions
- Cardiovascular Risk Factor, Cardiovascular Diseases, Diabetes, Type 2 Diabetes
- Trial name
- NCT04645875
- Testing
- SIT regimen, SITless regimen
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Bedfordshire
Diabetes, Depression
INtegrating DEPrEssioN and Diabetes treatmENT (INDEPENDENT) Study
To provide better care and preventive services for people with both depression and diabetes, the investigators propose to develop and test whether interventions to reduce depressive symptoms can be integrated into routine…
- Conditions
- Diabetes, Depression, Cardiovascular Risk Factor
- Trial name
- INDEPENDENT (NCT02022111)
- Testing
- Patient Education and Behavioral Activation, Supporting Self-Care (care coordinators), Psychiatrist and Diabetologist Reviews
- Where
- 4 sites in India
- Volunteers
- 404 people
- Sponsor
- Emory University
Diabetic Retinopathy, Diabetic Macular Edema
Anti-VEGF Treatment for Prevention of PDR/DME
Multiple studies have implicated vascular endothelial growth factor VEGF as a major causative factor in human eye diseases characterized by neovascularization including proliferative diabetic retinopathy (PDR) and vascular…
- Trial name
- NCT02634333
- Testing
- Prompt aflibercept, Deferred laser, Deferred aflibercept
- Where
- 85 sites in United States, Canada
- Volunteers
- 399 people
- Sponsor
- Jaeb Center for Health Research
Occupational Diseases, Cardiovascular Diseases
Heart at Work Study
This is an observational study to examine the cardiovascular mechanisms of increased cardiovascular mortality in those with high activity occupations.
- Conditions
- Occupational Diseases, Cardiovascular Diseases, Cardiovascular Risk Factor, Occupational Exposure
- Trial name
- NCT04075279
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Pittsburgh
Osteoarthritis, Cardiovascular Disease
Risk Factor Control Before Orthopedic Surgery
This trial is designed to determine the best preoperative management strategy for patients undergoing orthopedic surgery.
- Trial name
- OPTMIZE-OS (NCT01837069)
- Testing
- Metoprolol, Lisinopril, Atorvastatin
- Where
- United States
- Volunteers
- 198 people
- Sponsor
- NYU Langone Health
Bipolar Disorder, Cardiovascular Disease
Self-Management Addressing Heart Disease Risk Trial
The purpose of this research study is to learn whether or not people with bipolar disorder can reduce their risk of heart disease and related conditions by having a Care Manager provide self management and care management.
- Trial name
- SMAHRT (NCT00499096)
- Testing
- Chronic care model for Bipolar Disorder
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- US Department of Veterans Affairs
Type 2 Diabetes, Cardiovascular Disease
Study of TAK-875 in Adults With Type 2 Diabetes and Cardiovascular Disease or Risk Factors for Cardiovascular Disease
The purpose of this study is to demonstrate no excess risk of cardiovascular (CV) composite events exists following long term treatment with TAK-875 compared with placebo.
- Trial name
- NCT01609582
- Testing
- TAK-875
- Where
- 584 sites in United States, Argentina and 30 more
- Volunteers
- 3,207 people
- Sponsor
- Takeda
Cardiovascular Risk Factor, Lipaemia
Effect of Lactose on Blood Lipids
This study aims to determine to what extent ingestion of free sugars influence postprandial triglyceridaemia in men and women.
- Conditions
- Cardiovascular Risk Factor, Lipaemia, Metabolic Disease
- Trial name
- NCT04924530
- Testing
- Maltodextrin, Sucrose, Lactose
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Bath
Depression
Omega-3 for Depression and Other Cardiac Risk Factors - 2
The purpose of this 10 week randomized, placebo-controlled, double-blind clinical trial is to determine whether antidepressant augmentation with two grams of EPA omega-3 per day is superior to antidepressant therapy alone for…
- Trial name
- Omega-3(2) (NCT02021669)
- Testing
- Omega-3 supplement
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Washington University School of Medicine
Diabetes Mellitus, Hypertension
A Quality Improvement Process to Support Delivery of Cardiovascular Care in Community Mental Health Organizations
This pilot study will examine whether an implementation strategy will improve delivery of evidence-based care for cardiovascular risk factors for people with serious mental illness.
- Conditions
- Diabetes Mellitus, Hypertension, Dyslipidemias
- Trial name
- NCT04696653
- Testing
- Comprehensive Unit Based Safety Program (CUSP)
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Sub-optimal Vitamin D Status, Pre-diabetes
Effect of Vitamin D3 Supplementation on Insulin Resistance- The DIR Study
Insulin resistance is a state where the body does not respond as it should to the insulin it produces. Individuals who are insulin resistant are at increased risk of both heart disease and type 2 diabetes; importantly, diabetes…
- Conditions
- Sub-optimal Vitamin D Status, Pre-diabetes, Insulin Resistance
- Trial name
- NCT01889810
- Testing
- Vitamin D3 supplementation
- Where
- United Kingdom
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Hyperlipidemia
Effect Of Capros Supplementation On Cardiovascular Disease Risk Factors In Humans
The hypothesis of this study is that the natural supplement Capros will decrease LDL levels, platelet aggregation, and serum concentrations of high sensitivity C-reactive protein in humans at risk for cardiovascular disease.
- Trial name
- Capros (NCT01858376)
- Testing
- Capros dietary supplement
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Chandan K Sen