Clinical trials: Cardiovascular Diseases, completed
Multiple Myeloma
Revlimid And Prednisone Followed By Revlimid, Melphalan And Prednisone In Multiple Myeloma Patients
This study will determine whether the association of Revlimid and Prednisone (RP) as induction treatment followed by Revlimid, Melphalan and Prednisone (MPR) as consolidation treatment is safe and induce a significant rate of PR…
- Trial name
- RP_MPR (NCT01160107)
- Testing
- RP followed by MPR
- Volunteers
- 46 people
- Sponsor
- Fondazione EMN Italy Onlus
Hypertension, Blood Pressure
Long-term Accuracy and Stability of Blood Pressure Measurements From a Smartwatch: Prospective Validation Study
The aim of the study is to perform an experimental validation of the long-term accuracy of blood pressure measurement using the Samsung Galaxy Smartwatch
- Trial name
- BPLONG (NCT06098092)
- Testing
- Long-term non-invasive Blood pressure monitoring
- Where
- 2 sites in Czechia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Czech Technical University in Prague
Pulmonary Hypertension
Phase 2 Study of Ambrisentan for Liver Function Test Rescue in Pulmonary Arterial Hypertension
This Phase 2 study was to determine the incidence of increased serum aminotransferase concentrations (alanine aminotransferase [ALT] and/or aspartate aminotransferase [AST]), as well as the overall safety and tolerability of…
- Trial name
- NCT00423592
- Testing
- ambrisentan
- Volunteers
- 36 people
- Sponsor
- Gilead Sciences
Branch Retinal Vein Occlusion, Macular Edema
Navigated Laser In Branch Retinal Vein Occlusion Study
Branch retinal vein occlusion (BRVO) is often complicated by macular edema, possibly leading to severe visual loss or blindness.
- Trial name
- NIRVANA (NCT03651011)
- Testing
- Aflibercept Injection [Eylea], Navigated laser photocoagulation
- Where
- 2 sites in Denmark
- Volunteers
- 47 people
- Sponsor
- Odense University Hospital
Hypotension, Ischemia
Phase III Study of Hemospan® for Treating Hypotension in Hip Arthroplasty
The purpose of this study is to determine whether Hemospan is superior to Voluven for treatment of hypotensive episodes during the perioperative period (from induction of spinal anesthesia until 6 hours after skin closure), and…
- Trial name
- NCT00420277
- Testing
- Hemospan (MP4OX), Voluven (HES 130/0.4)
- Where
- 22 sites in Belgium, Czechia and 3 more
- Volunteers
- 462 people
- Sponsor
- Sangart
Coronary Artery Disease, Atrial Fibrillation
Rivaroxaban - Percutaneous Coronary Intervention
We investigated in-vitro the management of intraprocedural anticoagulation in patients requiring immediate percutaneous coronary intervention(PCI) while using regular direct oral anticoagulants(DOACs).
- Trial name
- NCT05541757
- Testing
- In vitro heparin
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Bursa Postgraduate Hospital
Ventricular Arrhythmias
Antiarrhythmic Effects of Spironolactone in Patients With ICDs
This study will test whether spironolactone, an approved drug for among other things hypertension, will reduce the risk of severe arrhythmias in patients with implanted defibrillators.
- Trial name
- SPIRIT (NCT04495712)
- Testing
- spironolactone
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- VA Office of Research and Development
Hyperhomocysteinemia, Thrombotic, Cbs-Related, Ischemic Stroke
Methylenetetrahydrofolate Reductase Deficiency in Ischemic Stroke
Adult onset epileptic seizures is rare and often associated with metabolic disorders, drugs and intracranial pathologies such as ischemia, hemorrhage or space-occupying lesions.
- Conditions
- Hyperhomocysteinemia, Thrombotic, Cbs-Related, Ischemic Stroke, Epilepsy
- Trial name
- NCT04287881
- Testing
- Methylenetetrahydrofolate reductase (MTHFR) deficiency
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Istanbul Medeniyet University
Peripheral Arterial Disease, Peripheral Artery Disease
Study of BD Sirolimus Drug Coated Catheter for Treatment of Femoropopliteal Arteries
The objective of this early feasibility study is to assess the safety and performance of the BD™ Sirolimus Drug Coated Balloon Catheter.
- Conditions
- Peripheral Arterial Disease, Peripheral Artery Disease, Stenosis Artery
- Trial name
- PREVISION (NCT05556681)
- Testing
- BD™ Sirolimus Drug Coated Balloon Catheter percutaneous transluminal angioplasty
- Where
- 10 sites in Australia, New Zealand and 1 more
- Volunteers
- 34 people
- Sponsor
- C. R. Bard
Hypotension, Hypoxemia
Point of Care Ultrasound Evaluation in the Post-Anesthesia Unit
The purpose of this observational research study is to examine how point-of care ultrasound affects the workup and management of perioperative complications for specific clinical scenarios of low blood pressure (hypotension), low…
- Conditions
- Hypotension, Hypoxemia, Altered Mental Status, Urine Output Low
- Trial name
- NCT04410757
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Loma Linda University
Diabetic Foot Ulcers
Evaluating the Ease of Use of a VAC GranuFoam Bridge Dressing on Diabetic Foot Ulcers Receiving VAC Negative Pressure Wound Therapy
The study is aimed at evaluating the clinician's perceived ease of using the V.A.C. GranuForm bride dressing and the patients perceived level of comfort during the dressing wear.
- Trial name
- NCT00847730
- Testing
- V.A.C. Negative Pressure Wound Therapy System
- Where
- 6 sites in United States
- Volunteers
- 33 people
- Sponsor
- KCI USA, Inc
Stroke
Stroke Therapy, Education, Prevention: Telemedicine Outpatient Initiative Trial
This study aims to determine whether patients who have had a stroke caused by a blockage of blood flow to the brain can have medical follow up after they leave the hospital in their home using a camera connected to a computer…
- Trial name
- STEP TO IT (NCT01875328)
- Testing
- Telemedicine, Clinic
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Oregon Health and Science University
Hypertension
Kanagawa Combination Anti-hypertensive Therapy (K-CAT)
The purpose of this study is to compare the effect and safety of the antihypertensive combination therapies between losartan/amlodipine and fixed dose drug of losartan/hydrochlorothiazide.
- Trial name
- NCT00492128
- Testing
- Losartan/amlodipine or losartan/hydrochlorothiazide
- Where
- Japan
- Volunteers
- 196 people
- Sponsor
- Yokohama City University Medical Center
Multiple Myeloma
Neurocognitive and Neuroimaging Outcomes in Older Patients With Multiple Myeloma Treated With Autologous Stem Cell Transplantation
The purpose of this study is to learn about possible changes in thinking (cognitive) abilities, such as memory skills, and in brain anatomy and function, in adults with multiple myeloma who are treated with high-dose chemotherapy…
- Trial name
- NCT03508765
- Testing
- Structural Image, Functional Image, Digit Span subtest
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Prevention, Venous Thromboembolism
A Study of DU-176b, Prevention of Venous Thromboembolism in Patients After Total Hip Arthroplasty
The objective of this study is to assess the efficacy and safety of DU-176b compared with enoxaparin sodium for the prevention of venous thromboembolism in patients after elective total hip arthroplasty.
- Trial name
- NCT01181167
- Testing
- edoxaban, enoxaparin sodium
- Where
- 2 sites in Japan
- Volunteers
- 610 people
- Sponsor
- Daiichi Sankyo Co., Ltd.
Coronary Artery Disease, Radial Artery
Korean Prospective Registry for Evaluating the Safety and Efficacy of Distal Radial Approach (KODRA)
The left distal radial approach (DRA) has been introduced as a feasible and safe alternative route of the radial artery. However, there is still lack of evidence for DRA regarding the feasibility, safety, effective time for…
- Conditions
- Coronary Artery Disease, Radial Artery, Puncture
- Trial name
- NCT04080700
- Testing
- Distal radial approach
- Where
- 14 sites in South Korea
- Volunteers
- 5,000 people
- Sponsor
- Wonju Severance Christian Hospital
Atrial Fibrillation
Outcome of Atrial Fibrillation Ablation After Permanent Pulmonary Vein Antrum Isolation With or Without Proven Left Atrial Posterior Wall Isolation
Objective: This prospective study aims to examine the outcome of atrial fibrillation (AF) ablation after permanent pulmonary vein antrum isolation or pulmonary vein antrum isolation plus left atrial posterior wall isolation is…
- Trial name
- NCT01660100
- Testing
- Pulmonary vein antrum isolation (PVAI), PVAI plus left atrial posterior wall (LAPW) isolation
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation
Atrial Fibrillation (AF)
Cardiac Rehabilitation Needs Among Individuals With Atrial Fibrillation
The goal of this survey- and registry-based study is to learn about the cardiac rehabilitation needs of individuals with atrial fibrillation (AF). The main objectives of the study is to: 1.
- Trial name
- PRIME-AF (NCT06772207)
- Where
- Denmark
- Volunteers
- 30,882 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Atrial Fibrillation
Cognitive Impairment Related to Atrial Fibrillation Prevention Trial
Cognitive and functional decline observed in atrial fibrillation (AF) patients are related to thrombotic and/or cardioembolic events.
- Trial name
- GIRAF (NCT01994265)
- Testing
- Warfarin, Dabigatran
- Where
- 2 sites in Brazil
- Volunteers
- 200 people
- Sponsor
- University of Sao Paulo
Stroke, Paresis
What do Stroke Survivors Actually Learn When Regaining Walking Ability After Stroke? The TARGET Phase I Study
Phase I: Exploring what stroke survivors exactly learn when recovering the ability to stand and walk.
- Conditions
- Stroke, Paresis, Gait, Hemiplegic
- Trial name
- TARGET (NCT03728036)
- Testing
- conventional rehabilitation
- Where
- 3 sites in Belgium
- Volunteers
- 66 people
- Sponsor
- Universiteit Antwerpen
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