Clinical trials: Cardiovascular Diseases, completed
Hereditary Blood Disorders, Cardiovascular Diseases
Effect of mHealth Intervention on Oral Health-Related Quality of Life Among Adult Patients With Chronic Systemic Diseases
This study evaluated whether an mHealth oral health education intervention could improve oral health-related quality of life among adults with chronic systemic diseases registered in specialized disease centers in Al-Ahsa, Saudi…
- Conditions
- Hereditary Blood Disorders, Cardiovascular Diseases, Chronic Kidney Disease, Diabete Mellitus
- Trial name
- NCT07839429
- Testing
- mHealth Oral Health Education Intervention, Printed Oral Health Education Leaflet
- Where
- 4 sites in Saudi Arabia
- Volunteers
- 206 people
- Sponsor
- King Faisal University
Elranatamab, Myeloma
A Study of Elranatamab (PF-06863135) in Chinese Participants With Refractory Multiple Myeloma.
The purpose of this study is to understand the study medicine (called Elranatamab, or PF-06863135) as potential treatment for refractory multiple myeloma.
- Conditions
- Elranatamab, Myeloma, Multiple Myeloma, Relapsed Multiple Myeloma
- Trial name
- NCT05228470
- Testing
- Elranatamab
- Where
- 15 sites in China
- Volunteers
- 39 people
- Sponsor
- Pfizer
Infant, Low Birth Weight
Household Air Pollution and Health: A Multi-country LPG Intervention Trial
This study is a randomized controlled trial of liquefied petroleum gas (LPG) stove and fuel distribution in 3,200 households in four countries (India, Guatemala, Peru, and Rwanda).
- Trial name
- HAPIN (NCT02944682)
- Testing
- Liquefied petroleum gas (LPG) cookstove
- Where
- 4 sites in Guatemala, India and 2 more
- Volunteers
- 6,704 people
- Sponsor
- Emory University
Stroke, Brain Diseases
Spinal Cord Stimulation for Restoration of Arm and Hand Function in People With Subcortical Stroke
The goal of this study is to verify whether electrical stimulation of the cervical spinal cord can activate muscles of the arm and hand in people with hemiplegia following stroke.
- Conditions
- Stroke, Brain Diseases, Central Nervous System Diseases, Nervous System Diseases
- Trial name
- NCT04512690
- Testing
- Epidural electrical stimulation (EES) of the cervical spinal cord
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Lee Fisher, PhD
Cardiovascular Risk, Chronic Kidney Disease
ZEUS - A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Cardiovascular Disease, Chronic Kidney Disease and Inflammation
This study is conducted to see if ziltivekimab reduces the risk of having cardiovascular events (for example heart attack and stroke) in people with cardiovascular disease, chronic kidney disease and inflammation.
- Conditions
- Cardiovascular Risk, Chronic Kidney Disease, Inflammation
- Trial name
- ZEUS (NCT05021835)
- Testing
- Ziltivekimab B, Ziltivekimab C
- Where
- 1,073 sites in United States, Argentina and 36 more
- Volunteers
- 6,385 people
- Sponsor
- Novo Nordisk A/S
Cardiovascular Diseases, Endothelial Dysfunction
Investigation of the Effects of Dietary Nitrate and Sex on COVID-19 Vaccine Induced Vascular Dysfunction in Healthy Men and Women (DiNOVasc-COVID-19)
Inorganic nitrate can protect blood vessels from the damage that occurs during cardiovascular disease. Early experimental work suggests that nitrate-induced improvements in vascular function relate to the suppression of…
- Trial name
- NCT04889274
- Testing
- COVID-19 vaccine, Concentrate beetroot Juice, Nitrate-deplete beetroot juice
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Cardiovascular Diseases
Re-thinking the Role of Peers And Training Patients [RePeAT]
This study, Re-thinking the role of Peers And Training Patients [RePeAT], is designed to test the feasibility of training peer-coaches to prepare limited health literacy (LHL) patients to engage in shared-decision making (SDM)…
- Trial name
- RePeAT (NCT05933655)
- Testing
- Peer Coach
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Rochester
Cardiovascular Diseases, Self Efficacy
CommunityRx-Cardiovascular Disease
The goal of this single arm pre-test post-test design study is to test the impact of providing patients with information about community-based resources to address health-related social needs and cardiometabolic health in rural…
- Trial name
- CRx-CVD (NCT06264726)
- Testing
- HealtheRx
- Where
- 2 sites in United States
- Volunteers
- 308 people
- Sponsor
- University of North Carolina, Chapel Hill
Cardiovascular Diseases, Type 2 Diabetes Mellitus in Obese
Implementation of a Peer Leader-facilitated Dyadic Intervention
This Pilot Study Large Application builds upon the results of our prior work to 1) Implement and pilot test a peer leader-facilitated 12-week dyadic intervention (Community Health among Asian Indian immigrants (CHAI) Dyad study)…
- Conditions
- Cardiovascular Diseases, Type 2 Diabetes Mellitus in Obese, Hyperlipidemias
- Trial name
- NCT06643806
- Testing
- CHAI dyad study
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Atherosclerotic Cardiovascular Diseases, Cerebrovascular Diseases
Phase 1 Study of the Safety and Pharmacokinetics of YN001 With Rosuvastatin in Healthy Chinese Subjects
The primary objective of this study is to investigate the safety and tolerability of YN001 in combination with rosuvastatin, so as to provide evidence for the feasibility of YN001 combined with statins in subsequent clinical…
- Trial name
- NCT07309042
- Testing
- YN001, Rosuvastatin calcium Tablets
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Beijing Inno Medicine Co., Ltd.
Atherosclerotic Cardiovascular Disease
YN001 in Healthy Subjects and Patients With Coronary Atherosclerosis
This study consists of two parts. The SAD and MAD of part I are a randomized, double-blind, placebo-controlled, single and multiple ascending dose study in healthy adult subjects.
- Trial name
- NCT06048588
- Testing
- YN001, rosuvastatin calcium tablets
- Where
- 6 sites in China
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Beijing Inno Medicine Co., Ltd.
Type 2 Diabetes
Comparative Study of Tirzepatide Versus Dulaglutide (SURPASS CVOT) or Semaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes
This cohort study was initiated to emulate the design of the SURPASS-CVOT trial using observational analogues of the trial design components in a study based on insurance claims data.
- Trial name
- NCT06779929
- Testing
- Tirzepatide, Dulaglutide, Semaglutide
- Where
- United States
- Volunteers
- 70,000 people
- Sponsor
- Brigham and Women's Hospital
Cardiovascular Diseases, Arteriosclerosis
Simplified Pulse Wave Velocity Measurement, Validation Study of the pOpmètre in Children
Arterial stiffness is an important marker of cardiovascular risk. It is measured by pulse wave velocity. The reference device to measure pulse wave velocity is the Sphygmocor which uses applanation tonometry.
- Conditions
- Cardiovascular Diseases, Arteriosclerosis, Atherosclerosis
- Trial name
- EPIPOP (NCT02991703)
- Testing
- pOpmètre®, Sphygmocor
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Nantes University Hospital
Cardiovascular Disease
Vivo Heart: Home-Based Virtual Exercise Program for Older Adults With Cardiovascular Disease
This pilot study will assess the feasibility and generate preliminary efficacy data of a novel, synchronous, home-based exercise training program for rural older adults with cardiovascular disease (CVD) using Vivo, an online…
- Trial name
- NCT05972850
- Testing
- Vivo Heart
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Wake Forest University Health Sciences
Cardiovascular Diseases
Adherence to Pharmacotherapy in Patients Admitted for Inpatient Treatment at the Scientific Medical Center (PRIMULA)
This cross-sectional observational study will assess adherence to previously prescribed medication in patients admitted to inpatient treatment at the scientific medical center.
- Trial name
- NCT07040800
- Where
- Russia
- Volunteers
- 5,463 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Atherosclerotic Cardiovascular Disease Without Prior Ischemic Events
Impact of Alirocumab on Cardiovascular Events in Participants With Atherosclerotic Cardiovascular Disease But Without Prior Ischemic Events
To estimate ischemic event rates in individuals with established atherosclerotic cardiovascular disease (ASCVD) and no prior acute ischemic events, comparing alirocumab with no Proprotein Convertase Subtilisin/Kexin type 9…
- Trial name
- OPTIMUS-EPIC (NCT07734753)
- Testing
- Alirocumab, Comparator: No PCSK9i Therapy (monoclonal antibodies or small interfering RNA agents)
- Where
- Netherlands
- Volunteers
- 4,006 people
- Sponsor
- Sanofi
Cardiovascular Diseases (CVD), Cardiovascular Diseases Risk
Cardiovascular Health and Nursing Interventions in 6th Grade Middle School Children
Interventions that can improve cardiovascular health behaviors in children are of critical importance for reducing the burden of cardiovascular disease in the future.
- Conditions
- Cardiovascular Diseases (CVD), Cardiovascular Diseases Risk, Health Behavior, School Health Services
- Trial name
- NCT06812156
- Testing
- Cardiovascular Health Education
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ankara University
Psoriasis, Atherosclerotic Cardiovascular Disease
Pilot Study to Evaluate the Effect of Nicotinamide Riboside on Immune Activation in Psoriasis
Background: Psoriasis causes chronic inflammation in the body. Researchers want to see if a kind of vitamin B3 dietary supplement can help. This might lead to more treatment options.
- Conditions
- Psoriasis, Atherosclerotic Cardiovascular Disease, Obesity, Dyslipidemia
- Trial name
- NCT04271735
- Testing
- Niagen
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Obesity, Body Weight
Metabolic and Bio-behavioral Effects of Following Recommendations in the Dietary Guidelines for Americans
This study, at the Western Human Nutrition Research Center (WHNRC), will focus on whether or not achieving and maintaining a healthy body weight is the most important health promoting recommendation of the Dietary Guidelines for…
- Trial name
- DGA4ME (NCT04293224)
- Testing
- DGA Mediterranean diet pattern, energy balance, DGA Mediterranean diet pattern, negative energy balance, TAD diet pattern, negative energy balance
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Atherosclerotic Cardiovascular Disease Without Prior Ischemic Events
Alirocumab and Ischemic Risk in Atherosclerotic Cardiovascular Disease (ASCVD)
The objective of this study is to evaluate ischemic event rates among individuals with established atherosclerotic cardiovascular disease without prior acute ischemic events, comparing those treated with alirocumab versus those…
- Trial name
- OPTIMUS-IMPACT (NCT07615179)
- Testing
- Alirocumab, Comparator: No PCSK9i Therapy (either mAb or siRNA)
- Where
- United States
- Volunteers
- 4,545 people
- Sponsor
- Sanofi