Clinical trials: Cardiovascular Diseases, completed
Cardiac Disease, Cancer
Electronic Medical Records and Genomics (eMERGE) Phase III
The Electronic Medical Records and Genomics (eMERGE) Network is in its third phase and during this time is enrolling and sequencing 25,000 individuals on a custom sequencing panel of clinically relevant, actionable genes.
- Conditions
- Cardiac Disease, Cancer, Hypercholesterolemia, Diabetes
- Trial name
- eMERGE (NCT03394859)
- Volunteers
- 25,380 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Paroxysmal Atrial Fibrillation, Pulmonary Vein Isolation
ADenosine Following Pulmonary Vein Isolation to Target Dormant Conduction Elimination: the ADVICE Trial
Atrial fibrillation (AF) is the most common heart rhythm disorder, impairs quality of life and increases stroke risk and mortality. Despite advances in medical treatment, AF remains uncontrolled in many patients.
- Conditions
- Paroxysmal Atrial Fibrillation, Pulmonary Vein Isolation, Dormant Pulmonary Vein Conduction
- Trial name
- ADVICE (NCT01058980)
- Testing
- Additional ablation until elimination of dormant conduction, No additional ablation, Registry group
- Where
- 18 sites in Australia, Austria and 4 more
- Volunteers
- 550 people
- Sponsor
- Montreal Heart Institute
Mitral Regurgitation
Prognosis in Asymptomatic Mitral Regurgitation (PAMIR) Study
The purpose of this study is to determine if the use of BNP/NT-proBNP levels in the detection of early left ventricular dysfunction and damage may improve the timing of cardiac surgery and therefore the long-term management of…
- Trial name
- NCT00509080
- Where
- 6 sites in Germany, Switzerland
- Volunteers
- 200 people
- Sponsor
- University Hospital, Basel, Switzerland
Coronary Artery Disease
Evaluation of Coronary Artery Calcification Using Gated Stationary Chest Tomosynthesis
The purpose of this study is to propose a new method for evaluating coronary artery calcium scores (CACS) in individuals with coronary artery disease.
- Trial name
- NCT03169062
- Testing
- Gated Stationary Chest Tomosynthesis
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of North Carolina, Chapel Hill
Diabetic Retinopathy
A Blinded, Self-control Trial to Evaluate an Artificial Intelligence Based CAD System for Diabetic Retinography
To evaluate the safety and performance of an innovative artificial intelligence based Computer-Aided Diagnosis(CAD) system for diabetic retinography, Retinal images of patients with diabetes mellitus or diabetic retinopathy(DR)…
- Trial name
- NCT03973762
- Testing
- DR Grading with CAD, DR Grading by expert panel
- Where
- China
- Volunteers
- 1,081 people
- Sponsor
- Peking Union Medical College Hospital
Chronic Kidney Disease, Fistula
Hemodialysis Vascular Access Imaging Study
The goal of this study is to find the best techniques to take non-invasive images of the arteriovenous fistula (AVF) in hemodialysis patients.
- Conditions
- Chronic Kidney Disease, Fistula, Hemodialysis Fistula Thrombosis
- Trial name
- NCT02374762
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Renal Research Institute
Heart Failure
Evaluation of Circulating Levels of Adult Stem Cells in the Peripheral Blood of Patients With Acute Decompensated Heart Failure and Following Stabilization, in Comparison With Healthy Volunteers
Despite advances in medical technology, heart failure remains a major cause of illness on a global scale. Medical research, over recent years, has shown that adult stem cells (as opposed to embryonic stem cells) are present in…
- Trial name
- CIRCSTEM-HF (NCT01027403)
- Where
- Australia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Monash University
Out-of-Hospital Cardiac Arrest, Pulmonary Ventilation
CAvent-Ventilation During Advanced Cardiopulmonary Resuscitation in Out-of-hospital Cardiac Arrest- an Observational Study
The aim of this observational study is to investigate how ventilations is given during cardiopulmonary resuscitation (CPR) given by advanced life support providers (ALS).
- Trial name
- CAvent (NCT04237727)
- Testing
- Fluxmed GrH portable pneumotachograph
- Where
- 5 sites in Netherlands, Sweden
- Volunteers
- 241 people
- Sponsor
- Uppsala University
Neurological Rehabilitation, Stroke
Effects of Repetitive Transcranial Magnetic Stimulation Therapy on Lower Extremity Motor Development in Stroke Patients
The aim of our study is to investigate the effects of rTMS applications at different current frequencies (low frequency / intermittent (intermittent) theta burst (iTBS)) in stroke patients on lower extremity motor development…
- Conditions
- Neurological Rehabilitation, Stroke, Lower Extremity Problem, Quality of Life
- Trial name
- NCT05554861
- Testing
- Low Frequency rTMS Protocol, Intermittent Theta Burst Stimulation (iTBS) Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Afyonkarahisar Health Sciences University
Congenital Heart Disease
Effectiveness of a Transition Program for Adolescents With Congenital Heart Disease in the Transition to Adulthood
This study is part of a larger research project known as Swedish Transition Effects Project Supporting Teenagers with chrONic mEdical conditionS (STEPSTONES).
- Trial name
- NCT02675361
- Testing
- Transition program
- Where
- 7 sites in Sweden
- Volunteers
- 189 people
- Sponsor
- Göteborg University
Heart Failure, Congestive, Chronic Heart Failure
Antidepressant Medication Treatment for Depression in Individuals With Chronic Heart Failure
This study will examine the effect of antidepressant medication on rates of death and disease in depressed people with chronic heart failure.
- Conditions
- Heart Failure, Congestive, Chronic Heart Failure, Depression
- Trial name
- SADHART-CHF (NCT00078286)
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 469 people
- Sponsor
- Duke University
Peripheral Vascular Disease
Comparison of the SUpera® PERipheral System in the Superficial Femoral Artery
This is a prospective, multicenter, non-randomized, single arm, pivotal trial. The main objective of this study is to demonstrate the safety and effectiveness of the IDev SUPERA® Nitinol Stent System in treating subjects with…
- Trial name
- SUPERB (NCT00933270)
- Testing
- SUPERA® Nitinol Stent System
- Where
- 49 sites in United States
- Volunteers
- 325 people
- Sponsor
- Abbott Medical Devices
Stroke
Effects of Priming Intermittent Theta Burst Stimulation on Upper Limb Motor Recovery After Stroke: A Randomized Controlled Trial
The aim of this study is to investigate the effects of intermittent theta burst stimulation primed with continous theta burst stimulation (cTBS), on top of a standard robot-assisted training (RAT) on improving the upper limb…
- Trial name
- NCT04034069
- Testing
- Theta burst stimulation (TBS), Robot-assisted training
- Where
- Hong Kong
- Volunteers
- 42 people
- Sponsor
- The Hong Kong Polytechnic University
Epilepsy, Tumor
High-density EEG in Neurological Disorders
The purpose of the study is to use a new method of high-density electroencephalogram (HD-EEG) recording to map brain areas important for movement, sensation, language, emotion, and cognition.
- Conditions
- Epilepsy, Tumor, Healthy
- Trial name
- NCT04266041
- Testing
- High-density electroencephalogram (HD-EEG)
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Heart Failure
Heart Failure Self-care With the Aid of a Smartphone Application
The purpose of this study was the development, and testing of a HF application that was used to provide self-care support to HF patients through a smartphone device.
- Trial name
- HFSC (NCT03194841)
- Testing
- Heart failure application
- Volunteers
- 10 people
- Sponsor
- University of Massachusetts, Worcester
Stroke, Balance
The Validity and Reliability of an Improved Paper Grasping Test for Stroke
The study included volunteer patients diagnosed with stroke who applied to the Neurology Outpatient Clinic at SANKO University Sani Konukoğlu Application and Research Hospital.
- Conditions
- Stroke, Balance, Validity and Safety
- Trial name
- NCT07181005
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Sanko University
Peripheral Artery Disease
AMS INSIGHT 1 Study - Bioabsorbable Metal Stent Investigation in Chronic Limb Ischemia Treatment
Prospective, multicenter, randomized clinical trial, Follow-up at 1-, 6- and 12 months This clinical investigation is first of all designed to demonstrate the safety and effectiveness of the MAGIC EXPLORER stent system.
- Trial name
- AMS-INSIGHT1 (NCT00572494)
- Testing
- MAGIC EXPLORER (Biotronik AG), PLEON EXPLORER (Biotronik AG)
- Where
- 12 sites in Austria, Belgium and 2 more
- Volunteers
- 117 people
- Sponsor
- Flanders Medical Research Program
Inflammation, Macrophage Infiltration
Effectiveness of Sitagliptin for HIV Insulin Resistance and Inflammation
People living with human immunodeficiency virus infection (HIV) have 2-4fold greater risk for developing diabetes and heart disease than the general population.
- Conditions
- Inflammation, Macrophage Infiltration, Cardiovascular Disease
- Trial name
- NCT01552694
- Testing
- Sitagliptin
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Washington University School of Medicine
Arrhythmia
Prevention of Arrhythmia Device Infection Trial (PADIT)
The goal of the study is to compare whether a center-wide policy of incremental antibiotic therapy will reduce CIED infection rate compared to a policy of conventional antibiotic prophylaxis in high-risk patients undergoing…
- Trial name
- NCT01628666
- Testing
- Incremental, Conventional
- Where
- Canada
- Volunteers
- 12,814 people, healthy volunteers welcome
- Sponsor
- Population Health Research Institute
Stroke
The Experiences of Family Caregivers of Stroke Patients: A Cross-sectional Study of a French Cohort
Stroke is the most common cause of non-traumatic disability in adults and ranks second among causes of dementia and third among causes of death.
- Trial name
- AVCAIDE (NCT04741451)
- Where
- 2 sites in France
- Volunteers
- 16 people
- Sponsor
- Fondation Hôpital Saint-Joseph
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