Clinical trials: Cardiovascular Diseases Risk
Multiple Myeloma, Fall Risk Factors
Fall Risk Assessment and an Exercise Intervention for Prevention of Falls in Multiple Myeloma Patients
Approximately one third of the population over the age of 65 falls at least once a year. The risk of falling is in increased in older patients with tumor diseases.
- Conditions
- Multiple Myeloma, Fall Risk Factors, Strength Training Effects, Balance Training Effects
- Trial name
- Myfall (NCT07044427)
- Testing
- Strength and balance training in combination with a treadmill-based pertubation intervention
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital Heidelberg
Atrial Fibrillation, Stroke
Computerized Decision Support to Prevent Stroke in Atrial Fibrillation
Atrial fibrillation (AF) is the most preventable cause of stroke. However, despite widely available risk stratification tools, numerous options for oral anticoagulation, and evidence-based practice guidelines, anticoagulation for…
- Trial name
- AF-ALERT3 (NCT06355986)
- Testing
- Alert-based computerized decision support
- Where
- 2 sites in United States
- Volunteers
- 2,500 people
- Sponsor
- Brigham and Women's Hospital
Symptomatic Severe Aortic Stenosis
PARTNER II Trial: Placement of AoRTic TraNscathetER Valves II - High Risk and Nested Registry 7
The purpose of this trial is to determine the safety and effectiveness of the Edwards SAPIEN 3 transcatheter heart valve and delivery systems which are intended for use in patients with symptomatic, calcific, severe aortic…
- Trial name
- PII S3HR/NR7 (NCT03222141)
- Testing
- TAVR Implantation of the THV Prosthesis
- Where
- 40 sites in United States, Canada
- Volunteers
- 583 people
- Sponsor
- Edwards Lifesciences
Transplant; Failure, Heart, Heart Failure, Congestive
Utilizing Technology for Optimization of Pain Management and Mobilization in High Risk Cardiac Surgical ICU Patients
The purpose of this project is to improve mobility in the perioperative period using activity trackers to augment current practice.
- Conditions
- Transplant; Failure, Heart, Heart Failure, Congestive, Lung Transplant Failure
- Trial name
- NCT04146727
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- Cedars-Sinai Medical Center
Hypertension
Preventing Outcomes Through Effective Cardiovascular Risk Reduction After Transplant II
Background and Rationale Cardiovascular disease is highly prevalent in the kidney transplant population, accounting for approximately 40% of all deaths and significant morbidity.
- Trial name
- PROTECTII (NCT02003469)
- Testing
- Ambulatory Blood Pressure Monitoring
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- University of Michigan
Systemic Lupus Erythematosus, Cardiovascular Disease
The Role of Anifrolumab in Improving Markers of Vascular Risk in Patients With Systemic Lupus Erythematosus (SLE) - IFN-CVD
Background: People with systemic lupus erythematosus (SLE) are at risk of developing complications in their blood vessels. This can increase the risk of heart attacks or stroke.
- Conditions
- Systemic Lupus Erythematosus, Cardiovascular Disease, Premature Atherosclerosis
- Trial name
- NCT05440422
- Testing
- anifrolumab
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Hypercholesterolemia, Dyslipidemia
Atorvastatin Study in Cardiovascular Disease Risk
Treatment of hypercholesterolemia is based on the guidelines of ESC-EAS 2011 (European Heart Journal (2011) 32, 1769-1818, ESC / EAS Guidelines for the management of dyslipidaemias) These calculate the 10 year risk based on SCORE…
- Trial name
- ANTLER (NCT02392416)
- Where
- 2 sites in Greece
- Volunteers
- 900 people
- Sponsor
- Elpen Pharmaceutical Co. Inc.
Atrial Fibrillation/Flutter in Patients With High Risk of Stroke
A Clinical Trial to Evaluate the Detection of Atrial Fibrillation for an One Day Versus More Than or Equal to Eight Days Using MEMO Patch PLUS in Individuals Aged ≥ 75 Years, or Those at High Risk of Stroke
The purpose of this study is to evaluate the benefits in the atrial fibrillation detection rate of the continuous ECG monitoring group for more than 8 days by contrasting with one-day ECG monitoring using MEMO Patch PLUS in 1000…
- Trial name
- MEMO-DAF8 (NCT05355948)
- Testing
- MEMO Patch PLUS for 1 day, MEMO Patch PLUS for More than 8-days
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Yonsei University
Obesity
On-Line Intervention For Promoting Healthy Habits And Weight Loss In Hypertensive Patients
Efficacy of an Internet-based self-guided intervention for promoting healthy habits and weight loss in hypertensive people with overweight and obesity: A Randomized Controlled Trial
- Trial name
- VIVIR-MEJOR (NCT02445833)
- Testing
- Lifestyle on-line intervention
- Volunteers
- 106 people
- Sponsor
- Universitat Jaume I
Stigma, Social, Obesity
Weight Stigma in Women Who Are Obese: Assessing How an Acute Exposure to Stigma Negatively Impacts Cardiovascular Health
The current study examined the influence of an acute weight stigma exposure on cardiovascular reactivity among women with obesity and high blood pressure and women with obesity and normal blood pressure.
- Conditions
- Stigma, Social, Obesity, Cardiovascular Disease Risk Factor, Blood Pressure
- Trial name
- NCT04161638
- Testing
- Stigma Video Exposure, Neutral video exposure
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Vascular Cognitive Impairment, Post-stroke Depression
Cognition and Affect After Stroke: a Prospective Evaluation of Risks
Stroke is a leading cause of disability, affecting about 34,000 to 41,000 individuals in the Netherlands of middle and old age every year.
- Conditions
- Vascular Cognitive Impairment, Post-stroke Depression, Post-stroke Apathy, Post-stroke Dementia
- Trial name
- CASPER (NCT02585349)
- Where
- Netherlands
- Volunteers
- 250 people
- Sponsor
- Maastricht University Medical Center
Hypertension, Vascular Diseases
SPYRAL GEMINI Pilot Study
The purpose of the SPYRAL GEMINI Pilot Study is to evaluate that multi-organ denervation with the Gemini System is safe and provide evidence of blood pressure reduction when studied in an uncontrolled hypertensive population with…
- Conditions
- Hypertension, Vascular Diseases, Cardiovascular Diseases, Chronic Kidney Diseases
- Trial name
- SPYRAL GEMINI (NCT06907147)
- Testing
- Multi-Organ Denervation Gemini System
- Where
- 18 sites in United States, Australia and 4 more
- Volunteers
- 175 people
- Sponsor
- Medtronic Vascular
Impaired Glucose Tolerance, Prediabetic State
Cardiovascular Disease (CVD) Risk and Prevention in Early Glucose Intolerance
The purpose of this study is to determine whether cardiovascular disease (CVD) risk markers, β-cell function, and insulin sensitivity can be improved by targeting mechanisms of both diabetes and CVD - using an antioxidant, an…
- Trial name
- NCT00122447
- Testing
- Aspirin, Alpha lipoic acid, Olmesartan
- Where
- 2 sites in United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Emory University
Acute Coronary Syndrome, Cardiovascular Diseases
Aggressive Smoking Cessation Trial (ASAP)
The ASAP Trial is a 5-year, multi-centre, randomized controlled trial that will assess the efficacy, safety, and tolerability of aggressive smoking cessation therapy among people at elevated cardiovascular risk.
- Trial name
- ASAP (NCT05257629)
- Testing
- Combination Therapy Arm (Varenicline and Nicotine E-Cigarettes Plus Counseling), Varenicline Plus Counseling
- Where
- 13 sites in Canada
- Volunteers
- 798 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Epilepsy
Impact of Eslicarbazepine Acetate on Lipid Metabolism and Cardiovascular Risk Factors
Knowing the impact that the use of ESL as adjunctive treatment of partial epilepsy has on cardiovascular risk factors measured by biochemical and ultrasound parameters compared with enzyme-inducing AEDs.
- Trial name
- NCT02573272
- Testing
- eslicarbacepine
- Where
- Spain
- Volunteers
- 204 people
- Sponsor
- Andalusian Initiative for Advanced Therapies - Fundación Pública Andaluza Progreso y Salud
Coronary Arteriosclerosis, Diabetes Mellitus, Type 2
Establish The Benefits Of Using Various Starting Doses Of Atorvastatin On Achievement Of Cholesterol Targets (ACTFAST)
Physicians tend to always use the lowest dose of statins to initiate therapy even in subjects who require large reductions in cholesterol.
- Conditions
- Coronary Arteriosclerosis, Diabetes Mellitus, Type 2, Cerebrovascular Accident, Dyslipidemia
- Trial name
- ACTFAST (NCT00442845)
- Testing
- Atorvastatin (Lipitor)
- Where
- 121 sites in Cameroon, Canada and 3 more
- Volunteers
- 2,080 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Adenocarcinoma
Cancer-related Thromboembolic Disease
Patients with cancer are at particularly high risk of venous thromboembolism (VTE). The guidelines therefore strongly recommend thromboprophylaxis but recent surveys clearly show that oncologists are reluctant to use it because…
- Trial name
- PROSPECT (NCT02785757)
- Testing
- Thrombin Generation Assay
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Hospices Civils de Lyon
Coronary Artery Disease, Renal Impairment
Renal Effects of Two Iodinated Contrast Media in Patients at Risk Undergoing Coronary Angiography
The main purpose of this study is to evaluate and compare the effects on kidney function of two contrast media, the iso-osmolar iodixanol and the low-osmolar iopamidol in patients at risk of kidney damage associated with the…
- Trial name
- NCT00209430
- Testing
- Iodixanol 320 mgI/mL
- Where
- Sweden
- Volunteers
- 408 people
- Sponsor
- GE Healthcare
Diabetes Mellitus, Type 2, Cardiovascular Diseases
Heart of the Family: A Cardiovascular Disease and Type 2 Diabetes Risk Reduction Intervention in High-Risk Rural Families
Rural populations in the U.S. are disproportionately burdened by cardiovascular disease and type 2 diabetes. Lifestyle modification interventions are needed that support long-term engagement in risk-reducing health behaviors.
- Trial name
- NCT04891575
- Testing
- Active Control Intervention educational sessions, Family Dyad Intervention
- Where
- United States
- Volunteers
- 504 people, healthy volunteers welcome
- Sponsor
- Gia Mudd
Heart Disease
A Clinical Trial in Higher Risk Geriatric Patients Undergoing OHSP
To provide information on parameters needed to design a subsequent Phase III confirmatory trial and to assess the safety and efficacy of the acute use of CMI X-11S in high-risk geriatric patients undergoing open-heart surgical…
- Trial name
- MiniMetrxics (NCT00500929)
- Testing
- CMI X-11S
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Cardiometabolics
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