Clinical trials: Cardiovascular Diseases Risk
Coronary Arterial Disease (CAD), Arterial Stiffness
SCAPIS 2 Cardio - Vibrometer Based Pulse Wave Analysis and CVD Risk Assessment
This clinical investigation will evaluate a novel contactless technology for assessing arterial stiffness and pulse wave characteristics and explore its potential in assessment of coronary artery disease, aortic stenosis and…
- Conditions
- Coronary Arterial Disease (CAD), Arterial Stiffness, Aortic Valve Disease, Heart Failure
- Trial name
- NCT07001007
- Testing
- Coronary Computer Tomography (CCTA), Laser Doppler Vibrometry and single-lead ECG, Echocardiography
- Where
- Sweden
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- HJN Sverige AB/Neko Health
Ischemic Heart Disease
Cardiovascular Risk Factors , Complications and Threputic Management Strategies in Patients With Coronary Heart Disease and COVID 19
Using INTERASPIRE model to determine patients with established CHD whether the guidelines on cardiovascular disease prevention are being followed or not with incorporation of COVID 19 as a risk factor with the other classical…
- Trial name
- NCT05092711
- Testing
- Observation
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Assiut University
Hyperlipidemia, Overweight
Pumpkin Seeds or Oil Lower Serum Triglyceride Levels in Individuals With Hyperlipidaemia
Aim of the Study: This randomized controlled experimental study aimed to evaluate the effects of cholesterol-restricted diets enriched with pumpkin seeds and pumpkin seed oil on cardiovascular risk factors-specifically serum…
- Trial name
- NCT07123844
- Testing
- low cholesterol diet
- Where
- Turkey (Türkiye)
- Volunteers
- 159 people
- Sponsor
- Kastamonu University
Metabolic Syndrome
Fertility and Cardiovascular Risk in Men With Metabolic Syndrome
Men diagnosed with metabolic syndrome (MetS) including obesity, hypertension, dyslipidemia and infertility will be assessed for cardiovascular and diabetes risk.
- Trial name
- NCT03977064
- Testing
- Life style change and weight reduction
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- University of Giessen
Atrial Fibrillation
Cohort Study for Atrial Fibrillation Risk Stratification
AFHRI is planned as a prospective, single-center cohort study in patients at high risk of AF.
- Trial name
- AFHRI (NCT05442970)
- Where
- Germany
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Cardiovascular Diseases, Hypercholesterolemia
The ZWOlle Transmural Integrated Care for CArdiovaScular Risk Management Study
Cardiovascular disease (CVD) contributes importantly to mortality and morbidity. Prevention of CVD by lifestyle change and medication is important and needs full attention.
- Conditions
- Cardiovascular Diseases, Hypercholesterolemia, Hypertension
- Trial name
- ZWOT-CASE (NCT03428061)
- Testing
- Integrated care for cardiovascular risk management
- Where
- Netherlands
- Volunteers
- 740 people
- Sponsor
- UMC Utrecht
Congenital Aortic Stenosis
Cardiac Imaging in Adults With Congenital Aortic Stenosis
The CAS study is a prospective observational cohort study investigating the effects of congenital aortic stenosis (ConAoS) on the left ventricular function and the prevalence, pattern and expanse of left ventricular hypertrophy…
- Trial name
- CAS (NCT05252351)
- Where
- Netherlands
- Volunteers
- 75 people
- Sponsor
- Erasmus Medical Center
Chronic Post-Traumatic Stress Disorder
G.R.I.T. - Goal-directed Resilience Intervention Training
This research program has addressed three reactive adaptations evident in pain, PTSD, and obesity. In this project, the focus will be on PTSD as a model of stimulus-based reactive responses to unpredictability or threat, and the…
- Trial name
- GRIT (NCT03890029)
- Testing
- Intervention Training, Control Condition
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- Morehouse School of Medicine
Chronic Coronary Syndrome
Drug-Coated Balloon Versus Drug-Eluting Stent for Treatment of De-Novo Coronary Lesions in Patients With High Bleeding Risk-2
A prospective, multi-center, open-label, randomized controlled, and superiority trial. The trial will compare clinical outcomes between discontinuation of antiplatelet agent and continuation of antiplatelet agent in HBR patients…
- Trial name
- DCB-HBR-2 (NCT06742931)
- Testing
- Discontinuation of antiplatelet agent group, Continuation of antiplatelet agent group
- Where
- 18 sites in South Korea
- Volunteers
- 1,200 people
- Sponsor
- Samsung Medical Center
Multiple Myeloma, Plasma Cell Myeloma
S0115, High-Dose Melphalan and Autologous Peripheral Stem Cell Transplantation in Treating Patients With Multiple Myeloma or Primary Systemic Amyloidosis
RATIONALE: Drugs used in chemotherapy such as melphalan work in different ways to stop cancer cells from dividing so they stop growing or die.
- Trial name
- NCT00064337
- Testing
- filgrastim, cyclophosphamide, dexamethasone
- Where
- 35 sites in United States
- Volunteers
- 104 people
- Sponsor
- SWOG Cancer Research Network
Acute Coronary Syndrome
Prediction of Cardiovascular Events in Vulnerable Patients Following Acute Coronary Syndrome
The purpose of this study is to determine if testing patients for endothelial dysfunction will help identify which patients are more likely at risk to have another heart attack in the future.
- Trial name
- NCT01500902
- Testing
- EndoPAT testing (non invasive device), WatchPAT testing (non-invasive device)
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Mayo Clinic
Aortic Aneurysm, Thoracic
Risk of Rupture of Aneurysms of the Thoracic Ascending Aorta (ATA) From the Dynamic Imaging
Aneurysms of the thoracic ascending aorta are a serious pathology which may threatens life by rupture or dissection. Their incidence is estimated at 10.4 per 100,000 people.
- Trial name
- NCT02538822
- Testing
- dynamic imaging, mechanical testing
- Where
- France
- Volunteers
- 31 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Heart Failure Acute, Heart Failure
Strain for Risk Assessment and Therapeutic Strategies in Patients With Acute Heart Failure (STRATS-AHF) Registry
STRATS-AHF (STrain for Risk Assessment and Therapeutic Strategies in patients with Acute Heart Failure) registry enrolled 4,312 patients hospitalized for acute HF from 3 tertiary university hospitals (Seoul National University…
- Conditions
- Heart Failure Acute, Heart Failure, Echocardiography
- Trial name
- STRATS-AHF (NCT03513653)
- Testing
- Echocardiography with speckle-tracking imaging
- Where
- 3 sites in South Korea
- Volunteers
- 4,312 people
- Sponsor
- Seoul National University Hospital
Healthy
Effect of Dietary Fat Type in Combination With High Protein on Plasma Homocysteine Levels
In this study, the investigators address the research question of whether palm olein will have a positive influence on plasma total homocysteine levels in human volunteers provided with high-protein diets formulated from common…
- Trial name
- NCT00941837
- Testing
- Olive Oil, Palm Olein Oil, Coconut Oil
- Where
- Malaysia
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Malaysia Palm Oil Board
Multiple Myeloma
Study Association of Lenalidomide, Ixazomib, Dexamethasone and Daratumumab in Newly Diagnosed Standard Risk Multiple Myeloma
The main objective of this study is to evaluate the minimal residual disease-negativity rate after administration of the combination of Lenalidomide, Ixazomib, Dexamethasone and Daratumumab as induction and consolidation therapy…
- Trial name
- IFM2018-01 (NCT03669445)
- Testing
- Ixazomib, Lenalidomide, Dexamethasone
- Where
- 12 sites in France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Toulouse
Peripheral Arterial Disease
A Non-significant Risk Clinical Study to Assess Perfusion Changes With Application of a TUS for Patients With PAD
The objective of the clinical trial is to gather evidence on the safety, performance and clinical efficacy Vibrato Sleeve TUS in people with peripheral artery disease (PAD).
- Trial name
- Concerto (NCT05100745)
- Testing
- Therapeutic Device
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Vibrato Medical, Inc.
Multiple Myeloma
MUK Nine b: OPTIMUM Treatment Protocol
To determine whether a combination of four novel agents bortezomib(Velcade), lenalidomide (Revlimid), Daratumumab (Darzalex) \& dexamethasone in combination with low-dose cyclophosphamide is sufficiently active in a high risk…
- Trial name
- MUKnineb (NCT03188172)
- Testing
- Cyclophosphamide, Bortezomib, Lenalidomide
- Where
- 21 sites in United Kingdom
- Volunteers
- 95 people
- Sponsor
- University of Leeds
Foot Ulcer, Diabetic
Reliability of a Diabetic Foot Ulcer Risk Stratification and Referral Algorithm
The main objective of this research study is to validate the St Joseph's Health Care Harmonized Foot Ulcer Assessment and Stratification tool using inter-rater reliability technique to determine if the score would consistently be…
- Trial name
- NCT03370237
- Where
- Canada
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Chronic Obstructive Pulmonary Disease (COPD)
Examining Pulmonary Rehabilitation on Discharged COPD Patients
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease primarily caused by smoking. COPD creates a tremendous burden to the healthcare system, as disease exacerbations result in frequent, prolonged…
- Trial name
- NCT02426437
- Testing
- Pulmonary Rehabilitation (PR), Usual Care
- Where
- Canada
- Volunteers
- 87 people
- Sponsor
- University of Alberta
Venous Thromboembolism, Venous Thrombosis
Intermittent Pneumatic Compression in Surgical Patients at Extremely-high Risk for Venous Thromboembolism
The aim of the study is to evaluate efficacy and safety of venous thromboembolism prophylaxis by the combination of graduated compression stockings (GCS), standard doses of low-molecular-weight heparins (LMWH) and sequential…
- Trial name
- IPCSUPER (NCT03044574)
- Testing
- SCD, GCS, LMWH
- Where
- 2 sites in Russia
- Volunteers
- 407 people
- Sponsor
- Pirogov Russian National Research Medical University
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