Clinical trials: Cardiovascular Diseases Risk
Type 2 Diabetes Mellitus, Cardiovascular Disease
The Effect of a Traditional Dietary Intervention on Diabetes Mellitus and Cardiovascular Disease Risk Factors in a First Nation Community: A Pilot Study
The purpose of this study is to evaluate whether or not a traditional First Nations diet (high protein) and/or a dietary intervention based upon current Canadian dietary recommendations (high carbohydrate/high fiber) effects risk…
- Conditions
- Type 2 Diabetes Mellitus, Cardiovascular Disease, Obesity
- Trial name
- SLHDP (NCT00707460)
- Testing
- Dietary Intervention (Macronutrient composition)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Healthy People
The Effects of Freeze-Dried Whole Grape Powder on Chronic Disease and Cardiovascular Risk Factors-a Pilot Study
Cardiovascular disease (CVD) is responsible for 1 out of every 5 deaths, is the number one killer of Americans, killing about 700K US adults per year (1).
- Trial name
- NCT06006182
- Testing
- Grape Powder
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- California State Polytechnic University, Pomona
Atherosclerosis
Ramipril 10 mg/Day Prevention
The objective is to investigate the safety of ramipril 10 mg/day used in prevention of cardiovascular events in high-risk patients, including the criteria of the HOPE study.
- Trial name
- NCT01053910
- Testing
- Ramipril
- Where
- Bangladesh
- Volunteers
- 1,012 people
- Sponsor
- Sanofi
Cardiovascular Disease, Post Traumatic Stress Disorder
Cardiovascular Risk Markers in Veterans With Post Traumatic Stress Disorder
This is an observational study designed to determine whether veterans with PTSD have a higher risk of heart disease than those without PTSD.
- Trial name
- CVMarkers (NCT01650220)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- INTRuST, Post-Traumatic Stress Disorder - Traumatic Brain Injury Clinical Consortium
Severe Ischaemic Stroke, Malignant Ischaemic Stroke
Cohort Study for Severe Ischaemic Stroke
This is a multi-centre, prospective cohort study. The aim of this study is to investigate causes, risk factors, clinical course, management and outcomes of severe ischaemic stroke in a real-world setting in tertiary hospitals in…
- Trial name
- SIS (NCT03222024)
- Testing
- routine medical care
- Where
- China
- Volunteers
- 2,500 people
- Sponsor
- West China Hospital
Transfusion-associated Circulatory Overload
Transfusion-Associated Circulatory Overload Best Eliminated With Lasix
This is a pilot double-blinded placebo-controlled randomized controlled trial (RCT) to evaluate the feasibility of conducting a multicenter, randomized, placebo-controlled trial to assess the efficacy of pre-transfusion…
- Trial name
- NCT02802696
- Testing
- Furosemide, Normal Saline
- Where
- 3 sites in Canada
- Volunteers
- 80 people
- Sponsor
- Sunnybrook Health Sciences Centre
Opioid-induced Constipation
Risk of Major Adverse Cardiovascular Events for Naldemedine & Other Medications for Opioid Induced Constipation
The research objective is to characterize the risk of a major adverse cardiovascular event (MACE) among new users of naldemedine versus new users of lubiprostone and new users of naloxegol as comparator opioid induced…
- Trial name
- NCT03720613
- Testing
- Naldemedine, Lubiprostone, Naloxegol
- Where
- United States
- Volunteers
- 34,532 people
- Sponsor
- BioDelivery Sciences International
Atherosclerosis, Cardiovascular Diseases
Risk Factors for Atherogenesis in Type 1 Diabetes
To determine risk factors for atherogenesis in Type 1 diabetes.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Diabetes Mellitus, Insulin-dependent, Heart Diseases
- Trial name
- NCT00035750
- Sponsor
- University of Wisconsin, Madison
Cancer
Vaccine Therapy in Treating Patients Who Have Undergone a Donor Stem Cell Transplant and Have Cytomegalovirus Infection That Has Not Responded to Therapy
RATIONALE: Vaccines may help the body build an effective immune response to kill cytomegalovirus infections. PURPOSE: This phase I trial is studying the side effects and best dose of vaccine therapy in treating patients who have…
- Trial name
- NCT00509691
- Testing
- cytomegalovirus pp65-specific cytotoxic T lymphocytes, polymerase chain reaction, diagnostic laboratory biomarker analysis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Louisville
Atherosclerosis, Cardiovascular Diseases
Beijing Hospital Atherosclerosis Study
The Beijing Hospital Atherosclerosis Study (BHAS) is a prospective, single-center, observational cohort study performed at the Beijing Hospital in Beijing, China.
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Coronary Artery Disease, Myocardial Ischemia
- Trial name
- BHAS (NCT03072797)
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Beijing Hospital
Cardiovascular Diseases, Mental Disorder
Association Between Cardiovascular Diseases and Mental Illness
Cardiovascular diseases (CVD) are important public health concerns around the world and closely associated with the development and progression of mental illness, which in turn increases the risk of developing cardiovascular…
- Trial name
- NCT06239246
- Testing
- Behavioral
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Ningbo No. 1 Hospital
Cardiovascular Disease, High Blood Pressure
Using Practice Facilitation in Primary Care Settings to Reduce Risk Factors for Cardiovascular Disease
The primary purpose of this study is to evaluate the effectiveness of practice facilitation as a quality improvement strategy for implementing the Million Hearts' ABCS treatment guidelines for reducing cardiovascular disease…
- Trial name
- NCT02646488
- Testing
- Million Hearts ABCS 6 Months, Million Hearts ABCS 9 Months, Million Hearts ABCS 12 Months
- Where
- United States
- Volunteers
- 276 people
- Sponsor
- NYU Langone Health
Myeloproliferative Neoplasm, Right Ventricular Dysfunction
Pulmonary Hypertension and RV Dysfunction in Myeloproliferative Neoplasms
This cross-sectional study aims to determine the prevalence of pulmonary hypertension and right ventricular dysfunction in patients with myeloproliferative neoplasms and to identify associated clinical and hematologic factors.
- Conditions
- Myeloproliferative Neoplasm, Right Ventricular Dysfunction, Pulmonary Hypertension
- Trial name
- NCT07834918
- Volunteers
- 145 people
- Sponsor
- Assiut University
Lipid Metabolism Disorders, Lipid Metabolism, Inborn Errors
Screening for Disorders of Lipid Metabolism and Familial Hyperlipidemia in Children and Adolescents With Increased Cardiovascular Risk Due to Chronic Diseases Such as Congenital Heart Disease, Chronic Inflammatory Bowel Disease, Celiac Disease and Rheumatic Disorders
Preventive measures are increasingly coming to the forefront of medicine. Many of these measures can be implemented as early as childhood and adolescence.
- Conditions
- Lipid Metabolism Disorders, Lipid Metabolism, Inborn Errors, Congenital Heart Disease, Inflammatory Bowel Disease (IBD)
- Trial name
- FAMELIPIDCHILD (NCT07716488)
- Testing
- blood test, questionaire
- Where
- Germany
- Volunteers
- 600 people
- Sponsor
- Alexandra Miriam Kiess
Ischemic Stroke
Study of Tiprogrel in the Treatment of High-risk Patients with Acute Ischemic Cerebrovascular Events (THRIVE).
This study is designed to evaluate efficacy and safety of tiprogrel in the treatment of patients with acute ischemic cerebrovascular events.
- Trial name
- NCT06601127
- Testing
- Tiprogrel, Clopidogrel
- Where
- 2 sites in China
- Volunteers
- 600 people
- Sponsor
- Tianjin Institute of Pharmaceutical Research Co., Ltd
Cardiovascular Disease, HIV Infection
Human Immunodeficiency Virus (HIV), Arterial Dysfunction, Lipids, Lovaza (HALO) Trial
The purpose of this study is to determine whether fish oil supplementation with Lovaza, formally known as Omacor will result in a significant reduction in serum triglyceride (TG), an increase in high density lipoproteins(HDL)…
- Trial name
- HALO (NCT00795717)
- Testing
- Lovaza
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Tufts University
Intracranial Aneurysm, Cerebral Ischemia
The Clinical Benefit and Risk of Oral Aspirin for Unruptured Intracranial Aneurysm Combined With Cerebral Ischemia
The first purpose of this study is to find out the clinical benefit and risk of oral aspirin for unruptured intracranial aneurysm (small than 7mm) combined with cerebral ischemia in patients in the real world.
- Trial name
- CBROAUNACCI (NCT02846259)
- Where
- China
- Volunteers
- 2,135 people
- Sponsor
- Beijing Tiantan Hospital
Multiple Myeloma
Up-front CART-BCMA With or Without huCART19 in High-risk Multiple Myeloma
This is an open-label, phase 1 study to assess the safety, pharmacodynamics, and anti-myeloma effects of autologous T cells expressing BCMA (B-cell maturation antigen)-specific chimeric antigen receptors with tandem TCRζ and…
- Trial name
- NCT03549442
- Testing
- BCMA CART + huCART19, CART BCMA or CART BCMA + huCART19, Single-dose infusion of CART BCMA or CART BCMA + huCART19
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Pennsylvania
Venous Thromboembolism
Determination of Venous Thromboembolism Risk and Nursing Practices in Patients Hospitalized in Medical Services
Together with individual predisposition to form vascular clots and clinical conditions that further increase this risk, venous thromboembolism (VTE) poses a significant additional morbidity and mortality risk for the majority of…
- Trial name
- NCT06445283
- Testing
- Determination of VTE risk levels
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 157 people
- Sponsor
- Hacettepe University
Diet, Cooking
Dietary Behavior Intervention in African Americans at Risk for Cardiovascular Disease
Background: The risk of heart disease among African Americans is still common despite a greater understanding of the disease and better approaches to managing it.
- Trial name
- NCT04305431
- Testing
- Cooking Intervention
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
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