Clinical trials: Cardiovascular Diseases Risk
Diabetes Mellitus, Foot Ulcer
Becaplermin Use and Cancer Risk in a Patient Population of U.S. Veterans With Diabetes
The purpose of this study is to evaluate risk of cancer incidence and mortality associated with the use of REGRANEX (becaplermin) in patients with diabetes who are members of a U.S. Veterans Health Administration.
- Conditions
- Diabetes Mellitus, Foot Ulcer, Diabetic Foot, Diabetic Neuropathies
- Trial name
- NCT01235260
- Testing
- Becaplermin nonusers, Becaplermin users
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Hypertriglyceridemia, Normal
Cardiometabolic Properties of Omega-3 Functionalized With Hydroxytyrosol
The primary aim of this study is to investigate the potential cardioprotective effects of daily nutritional doses of eicosapentaenoic acid (EPA) enriched with hydroxytyrosol (HT) on cardiovascular health, as well as its…
- Trial name
- HydroxyOmega (NCT06992323)
- Testing
- EPA + HT, EPA, Sunflower Oil
- Where
- Spain
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- National Research Council, Spain
Atrial Fibrillation, Overweight and Obesity
Super-Rehab: a Novel Approach to Treat Atrial Fibrillation
This study proposes to evaluate the effectiveness of a novel lifestyle intervention (Super Rehab), in addition to standard care, for patients with symptomatic atrial fibrillation (AF) requiring rhythm control strategy who are…
- Trial name
- SuRe-AF (NCT05596175)
- Testing
- Super Rehab
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Royal United Hospitals Bath NHS Foundation Trust
Polycystic Ovary Syndrome, Hypothalamic Amenorrhea
Body Fat as Determinant of Female Gonadal Dysfunction
Reproduction requires from women enough energy depots to warrant an adequate nutritional supply to the fetus. Hence, adipose tissue is able to communicate with female hypothalamic-pituitary-ovary axis.
- Trial name
- NCT03841981
- Testing
- Anthropometric and physical examination, Indirect calorimetry, accelerometer and seven-day dietary recall, Biochemical, hormonal and metabolic phenotyping
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Hypertension, Cardiovascular Risk Factor
HIGH Altitude CArdiovascular REsearch Latin America Population Study
High blood pressure (BP) is one of the principal cardiovascular risk factors. While BP levels and hypertension prevalence are well characterized in many populations, information on BP and on cardiovascular risk profile in high…
- Conditions
- Hypertension, Cardiovascular Risk Factor, Altitude Hypoxia, Altitude Sickness
- Trial name
- HIGHCARE-LAPS (NCT04751292)
- Testing
- Exposure to high altitude
- Where
- Peru
- Volunteers
- 937 people, healthy volunteers welcome
- Sponsor
- Istituto Auxologico Italiano
Metabolic Syndrome, Diabetes Mellitus
Biomarkers Derived From Adipose Tissue Useful for Diagnosis and Prognosis of Cardiovascular Risk (CVR) in Obese Patient
This study evaluates the relationship between the adipose tissue, as an active component, which can define metabolic phenotypes linked to cardiovascular risk modification post bariatric surgery.
- Conditions
- Metabolic Syndrome, Diabetes Mellitus, Inflammatory Response
- Trial name
- CROP (NCT03561987)
- Testing
- Bariatric surgery
- Volunteers
- 70 people
- Sponsor
- Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado
Obesity
Reduction in Cardiovascular Risk Factors and Visceral Adipose Tissue in Men: Separate Effects of Diet- and Exercise-Induced Weight Loss
The purpose of the trial was to examine the independent effects of equivalent diet- or exercise-induced weight loss on obesity and related cardiovascular health risk factors.
- Trial name
- NCT00664547
- Testing
- Diet Weight Loss, Exercise Weight Loss, Exercise Without Weight Loss
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Queen's University
Essential Hypertension, Cardiovascular Disease
Prognostic Value of the Circadian Pattern of Ambulatory Blood Pressure for Multiple Risk Assessment
The HYGIA study was designed to investigate prospectively 1. the prognostic value of ambulatory blood pressure (BP) monitoring among subjects primarily evaluated at primary care settings 2.
- Conditions
- Essential Hypertension, Cardiovascular Disease, Stroke, Chronic Kidney Disease
- Trial name
- HYGIA (NCT00741585)
- Testing
- Any antihypertensive medication alone or in combination, Ambulatory blood pressure monitoring
- Where
- 20 sites in Spain
- Volunteers
- 21,983 people, healthy volunteers welcome
- Sponsor
- University of Vigo
Eligible Men or Women Considered High Risk for Atherosclerotic Cardiovascular Disease (CVD)
Outcomes Study to Assess STatin Residual Risk Reduction With EpaNova in HiGh CV Risk PatienTs With Hypertriglyceridemia
The study is a randomized, double-blind, placebo-controlled (corn oil), parallel group design that will enroll approximately 13,000 patients with hypertriglyceridemia and low HDL and high risk for CVD to be randomized 1:1 to…
- Trial name
- STRENGTH (NCT02104817)
- Testing
- Epanova® (omega-3 carboxylic acids), corn oil control
- Where
- 684 sites in United States, Australia and 20 more
- Volunteers
- 13,078 people
- Sponsor
- AstraZeneca
Cancer-associated Thrombosis, Genetic Predisposition
A New Clinic-Genetic Risk Score for Predicting Venous Thromboembolic Events in Cancer Patient
Venous thromboembolism (VTE) is a common disease in cancer patients and one of the major causes of cancer-associated mortality. Risk for developing VTE increases when cancer patients are receiving chemotherapy.
- Trial name
- ONCOTHROMB (NCT03114618)
- Where
- 9 sites in Spain
- Volunteers
- 416 people
- Sponsor
- Andres muñoz
Shift-Work Sleep Disorder
Shift Work and Risk of Cardio-vascular Disease
The purpose of this research is to test the hypothesis that those with non-traditional work schedules (e.g. shift workers) have a higher cardio-metabolic risk than those with traditional work schedules (e.g.
- Trial name
- NCT02901860
- Testing
- Sleep, Dietary and Cardio-metabolic Measurements
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Obesity
Efficacy of a Web-based Lifestyle Modification Program in Obese Patients With Cardiovascular Risk Factors
To evaluate the effect of a 6-month web-based lifestyle modification program with and without telephone counseling versus usual care in obese patients with cardiovascular risk factors on: Weight Loss Waist circumference; blood…
- Trial name
- NCT01664026
- Testing
- Web-based lifestyle modification, Web-based lifestyle modification +
- Where
- Argentina
- Sponsor
- Clínica Bazterrica
Hypertension, Cardiovascular Diseases
Effects of Cured Pork Peptides on Blood Pressure & Cardiovascular Risk Factors
Spanish dry-cured ham has been shown a source of antihypertensive peptides in mice. To date, no clinical study has been performed in humans to check the effects of bioactive peptides produced naturally during the processing of…
- Trial name
- PocPep-CVD (NCT02585089)
- Testing
- Spanish cured-pork ham, Cooked pork ham
- Where
- Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Acute Myocardial Infarction, Acute Coronary Syndrome
MERITnI - Mindray-hs-cTnI Assay: Analytical and Clinical Evaluation for the Diagnosis and RIsk AssessmenT of Myocardial InfarctIon.
The Mindray High Sensitivity Troponin-I Measurement System is an in vitro diagnostic test for the quantitative determination of high sensitivity cardiac troponin I (hs-cTnI) in human serum or plasma.
- Trial name
- MERITnI (NCT05853042)
- Testing
- high-sensitivity cardiac troponin testing
- Where
- United States
- Volunteers
- 1,559 people
- Sponsor
- Fred Apple
HIV-1-infection, Inflammation
The MISTRAL Study: Gut Microbiome Correlates of Serious AIDS and Non-AIDS Events
MISTRAL (Microbiome-based stratification of individuals at risk of HIV-1 acquisition, chronic clinical complications, antimicrobial drug resistance, and unresponsiveness to therapeutic HIV-1 vaccination) is a 5-year EU Horizon…
- Conditions
- HIV-1-infection, Inflammation, AIDS
- Trial name
- MISTRAL (NCT05421286)
- Where
- 22 sites in Belgium, Croatia and 9 more
- Volunteers
- 991 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Type 2 Diabetes
Evaluation of Myocardial Perfusion Heterogeneity Imaging in Diabetes Patients (EVADIAB)
Long-term additive prognostic value of heterogeneity myocardial perfusion imaging of SPECT over clinical and ischemia in high-risk diabetic patients
- Trial name
- EVADIAB (NCT02316054)
- Testing
- MPHI
- Where
- France
- Volunteers
- 170 people
- Sponsor
- University Hospital, Grenoble
Overweight and Obesity, Cardiometabolic Risk Factors
Effect of Vitamin K2 Over Osteocalcin, Leptin, Cytokines, and Cardiovascular Risk in Young Adults With Overweight and Obesity
The goal of this clinical trial is to compare de effect of vitamin K2 in young adults with overweight or obesity. The main questions to answer are: What is the effect of Vitamin K2 supplementation on methylation, serum…
- Trial name
- NCT05995522
- Testing
- Vitamin K2, Cornstarch
- Where
- Mexico
- Volunteers
- 51 people
- Sponsor
- University of Guadalajara
Coronary Artery Disease Progression
Intensive Lipid-lowering for Plaque and Major Adverse Cardiovascular Events in Low to Intermediate 10-year ASCVD Risk Population
Current guidelines recommend moderate-intensity lipid-lowering therapy (goal for LDL-C <2.6 mmol/L or 30%-50% reduction from baseline) for patients with intermediate 10-year ASCVD risk.
- Trial name
- ILLUMINATION (NCT05462262)
- Testing
- Intensive lipid-lowering control, Moderate-intensity lipid-lowering control
- Where
- China
- Volunteers
- 2,900 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Atherosclerotic Cardiovascular Disease, Familial Hypercholesterolemia
Trial to Evaluate the Effect of ALN-PCSSC Treatment on Low Density Lipoprotein Cholesterol (LDL-C)
This study is a Phase II, placebo-controlled, double-blind, randomized trial in 480 participants with atherosclerotic cardiovascular disease (ASCVD) or ASCVD-risk equivalents (for example, diabetes and familial…
- Conditions
- Atherosclerotic Cardiovascular Disease, Familial Hypercholesterolemia, Diabetes
- Trial name
- ORION-1 (NCT02597127)
- Testing
- ALN-PCSSC, Normal Saline
- Where
- 54 sites in United States, Canada and 3 more
- Volunteers
- 501 people
- Sponsor
- The Medicines Company
Heart Failure Risk Factors in Healthy Individuals
Cleveland Heart and Metabolic Prevention Study
The purpose of this research study is to investigate the role of chemical reactions, such as inflammation and oxidation, in the cause of cardiac dysfunction (the heart does not function properly).
- Trial name
- CHAMPS (NCT03012022)
- Where
- United States
- Volunteers
- 1,208 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.