Clinical trials: Cardiovascular Diseases Risk
Anticoagulants Causing Adverse Effects in Therapeutic Use, Atrial Fibrillation
Atrial Fibrillation: Risk and Benefits of Anti-coagulation in the Elderly
This study was designed to assess the effectiveness of oral anticoagulants in elderly patients (>=75 years) with atrial fibrillation.
- Conditions
- Anticoagulants Causing Adverse Effects in Therapeutic Use, Atrial Fibrillation, Frail Elderly Syndrome
- Trial name
- Carebbean-e (NCT03828162)
- Testing
- Anticoagulants
- Volunteers
- 2,943 people
- Sponsor
- Karolinska Institutet
Frailty, Acute Coronary Syndrome
Role of Frailty in Bleeding Risk Prediction in Acute Coronary Syndrome
Studying the incremental role of frailty in predicting in-hospital, short-term (30 days), and mid-term (6 months) bleeding in ACS patients.
- Conditions
- Frailty, Acute Coronary Syndrome, Bleeding
- Trial name
- NCT07158788
- Volunteers
- 850 people
- Sponsor
- Assiut University
Type 2 Diabetes, High Blood Pressure
Polypill for Prevention of Cardiomyopathy
This study will investigate the utility of a polypill-based strategy for patients with type 2 diabetes mellitus and high risk of heart failure (HF), as assessed via the WATCH-DM risk score.
- Trial name
- PolyPreventHF (NCT06143566)
- Testing
- Polypill, Combined prescription of the individual medications
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Texas Southwestern Medical Center
Long QT Syndrome, Sudden Cardiac Death
Electromechanical Profiling of the Long-QT Syndrome (LQTS)
High-resolution, non-invasive electromechanical mapping in genotyped long-QT syndrome patients and healthy controls at baseline and during smart provocation.
- Conditions
- Long QT Syndrome, Sudden Cardiac Death, Ventricular Tachycardia
- Trial name
- EMLoQ (NCT04074122)
- Testing
- Adenosine and epinephrine, isoprenaline provocation
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Healthy Subjects (HS), Obese Adult Participants at Risk of Cardiovascular Disease
A Phase 1, Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ISM8969
This is a single center, phase 1, randomized, double-blind, placebo-controlled sequential study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple ascending oral doses of ISM8969…
- Trial name
- NCT07581431
- Where
- Australia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- InSilico Medicine Hong Kong Limited
Metabolic Syndrome
A Mediterranean Diet-Based Culinary Intervention in Adults With Metabolic Syndrome
Metabolic syndrome is a major public health concern associated with an increased risk of cardiovascular disease, type 2 diabetes, and premature mortality.
- Trial name
- CUINAMET (NCT07702695)
- Testing
- Mediterranean diet-based culinary intervention, Standard nutritional counseling
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Hypercholesterolemia
Study of Efficacy and Safety of Inclisiran in Asian Participants With Atherosclerotic Cardiovascular Disease (ASCVD) or ASCVD High Risk and Elevated Low Density Lipoprotein Cholesterol (LDL-C)
A multicenter study to evaluate safety and efficacy of inclisiran in Asian patients with ASCVD or ASCVD high risk and elevated LDL-C
- Trial name
- NCT04765657
- Testing
- inclisiran sodium
- Where
- 45 sites in China, Singapore and 2 more
- Volunteers
- 345 people
- Sponsor
- Novartis Pharmaceuticals
Venous Thromboembolism
Comparison of Bleeding Risk Between Rivaroxaban and Apixaban: The Pilot Study
This vanguard pilot study compares rivaroxaban and apixaban, two of the new oral blood thinners for the treatment of blood clots. Half of the patients will receive apixaban and half will receive rivaroxaban.
- Trial name
- COBRRA Pilot (NCT02559856)
- Testing
- Apixaban, Rivaroxaban
- Where
- 4 sites in Canada
- Volunteers
- 71 people
- Sponsor
- Ottawa Hospital Research Institute
Multiple Myeloma
MUK Nine b: OPTIMUM Treatment Protocol
To determine whether a combination of four novel agents bortezomib(Velcade), lenalidomide (Revlimid), Daratumumab (Darzalex) \& dexamethasone in combination with low-dose cyclophosphamide is sufficiently active in a high risk…
- Trial name
- MUKnineb (NCT03188172)
- Testing
- Cyclophosphamide, Bortezomib, Lenalidomide
- Where
- 21 sites in United Kingdom
- Volunteers
- 95 people
- Sponsor
- University of Leeds
Sudden Cardiac Arrest
The Jewel IDE Study
The Jewel IDE Study: A Clinical Evaluation of the Jewel P-WCD in Subjects at High Risk for Sudden Cardiac Arrest. ("JEWEL")
- Trial name
- NCT05201495
- Testing
- Jewel Patch Wearable Cardioverter Defibrillator (P-WCD)
- Where
- 30 sites in United States
- Volunteers
- 322 people
- Sponsor
- Element Science, Inc.
Pulmonary Embolism Acute Massive
Early Catheter-directed Treatment of High Risk Pulmonary Embolism
Prospective, multicenter, open label, randomized controlled clinical trial to compare the effects of an early catheter-directed treatment plus conventional care with conventional care in patients with high-risk pulmonary embolism
- Trial name
- CATCH-PE II (NCT06672081)
- Testing
- Early Catheter-Interventional Treatment, Conventional care
- Where
- 18 sites in Germany
- Volunteers
- 210 people
- Sponsor
- Leipzig Heart Science gGmbH
Diabetes Mellitus (DM), Dyslipidemia
Impact of Golden Rice-Piper Crocatum Cookies on Lipid Control in Diabetes Mellitus Patients
People with diabetes often experience abnormal blood fat levels, known as dyslipidemia, which increase the risk of heart disease and stroke.
- Conditions
- Diabetes Mellitus (DM), Dyslipidemia, Lipid Profile, Functional Food
- Trial name
- GRPC-DM (NCT07268781)
- Testing
- Golden Rice cookies with Piper crocatum Extract
- Where
- 2 sites in Indonesia
- Volunteers
- 102 people
- Sponsor
- Hasanuddin University
Coronary Heart Disease
Stress Management and Biomarkers of Risk in Cardiac Rehabilitation
The purpose of this study is to assess the extent to which combining exercise and stress management training (SMT) is more effective at improving biomarkers in vulnerable cardiac patients compared to exercise-based cardiac…
- Trial name
- ENHANCED (NCT00981253)
- Testing
- SMT-enhanced Cardiac Rehabilitation, Standard Cardiac Rehabilitation
- Where
- 2 sites in United States
- Volunteers
- 164 people
- Sponsor
- Duke University
Cardiac Disease, PCI
Comparison of the Supraflex Cruz 60 Micron Versus the Ultimaster Tansei 80 Micron in HBR PCI Population
The study compares the outcome of the ultrathin stent strut Supraflex Cruz stent to the thin stent strut Ultimaster Tansei stent in a PCI population at high risk for bleeding (HBR).
- Conditions
- Cardiac Disease, PCI, High Bleeding Risk
- Trial name
- NCT04500912
- Testing
- Supraflex Cruz 60 Micron, Ultimaster Tansei 80 Micron
- Where
- 11 sites in Netherlands
- Volunteers
- 736 people
- Sponsor
- Pieter C.Smits
Cardiovascular Diseases, Coronary Disease
20 Year Changes in Fitness & Cardiovascular Disease Risk - Ancillary to CARDIA
To understand the complex, longitudinal relations between physical fitness, physical activity, body mass and composition and fat distribution, and genetic factors and their independent or interactive effects on the development of…
- Conditions
- Cardiovascular Diseases, Coronary Disease, Diabetes Mellitus, Metabolic Syndrome X
- Trial name
- NCT00106457
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Heart Failure, Quality of Life
Focused Palliative Care Intervention in Advanced Heart Failure
This small pilot study will be assessing the the impact of a standardized, social-worker led, longitudinal palliative care intervention on alignment of patient and physician understanding of prognosis and goals of care.
- Trial name
- NCT02805712
- Testing
- Verbal Information and Discussion, Control
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Brigham and Women's Hospital
Schizophrenia, Cardiovascular Risk Factor
Effectiveness of a Cardiovascular Risk Intervention Program in Patients With Schizophrenia (PRISCA)
The main objective is to determine the effectiveness of a program which consists of multidisciplinary, intensive and individualized interventions, carried out by a group of health professionals (psychiatrist, psychologist, mental…
- Trial name
- PRISCA (NCT04276012)
- Testing
- Multifactorial intervention
- Where
- Spain
- Volunteers
- 130 people
- Sponsor
- Dr. Pere Roura-Poch
Coronary Artery Disease
ESCALATion of Medical Therapy Following Multimodality Plaque Evaluation in High-risk Chronic Coronary Syndromes
ESCALATE will provide a thorough investigation of how anti-inflammatory therapy, with low-dose colchicine, affects patients with stable coronary artery disease.
- Trial name
- ESCALATE (NCT06469528)
- Testing
- Colchicine 0.5 MG
- Volunteers
- 50 people
- Sponsor
- King's College Hospital NHS Trust
Hypertension, Cardiovascular Diseases
Cardiovascular Disease Risk Factors in Chinese American Immigrants
The Chinese population is currently the fastest growing ethnic group in New York City (NYC). Research has shown that Chinese immigrants living in NYC have higher rates of cardiovascular disease (CVD) than individuals in China.
- Conditions
- Hypertension, Cardiovascular Diseases, Diabetes Mellitus, Metabolic Syndrome X
- Trial name
- CHA-CHA (NCT00362128)
- Where
- United States
- Volunteers
- 2,072 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Hypertension, Diabetes Mellitus
Community Based Multiple Risk Factors Intervention Strategy
Randomized controlled trial of CORFIS Programme. The study objectives are as follows: 1. To determine the efficacy of a community based multiple risk factors interventional strategy (CORFIS) for a treatment period of 6 months in…
- Conditions
- Hypertension, Diabetes Mellitus, Hyperlipidemia
- Trial name
- CORFIS (NCT00490672)
- Testing
- No Active Intervention., Community Based Multiple Risk Factor Intervention Strategies
- Where
- 78 sites in Malaysia
- Volunteers
- 770 people
- Sponsor
- Ministry of Health, Malaysia
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