Clinical trials: Cardiovascular Diseases Risk
Acute Coronary Syndromes
Multicenter Study to Develop a Risk Model for Early Major Cardiovascular Events
Through the National Registry of patients with ACS in the IMSS (RENASCA IMSS) the investigators will know the real world in terms of risk factors frequency, clinical presentation and its complications, and in the end they can…
- Trial name
- RENASCA-IMSS (NCT02255344)
- Where
- Mexico
- Volunteers
- 21,827 people
- Sponsor
- Instituto Mexicano del Seguro Social
Obesity
A Long Term Study of Sibutramine and the Role of Obesity Management in Relation to Cardiovascular Disease in Overweight and Obese Patients
The purpose of the study was to determine the long-term effect of sibutramine treatment on cardiovascular outcomes in overweight and obese patients at risk of a cardiovascular event.
- Trial name
- SCOUT (NCT00234832)
- Testing
- Sibutramine hydrochloride
- Where
- United States
- Volunteers
- 10,777 people
- Sponsor
- Abbott
Subarachnoid Hemorrhage
Antiepileptic Drugs and Vascular Risk Markers
The purpose of this study is to determine if certain seizure medications raise levels of cholesterol and other blood components which could increase the risk of heart attacks and strokes.
- Trial name
- NCT00774306
- Testing
- phenytoin, valproate, levetiracetam
- Volunteers
- 52 people
- Sponsor
- Thomas Jefferson University
Ischemic Stroke, Cognitive Decline
Austrian Polyintervention Study to Prevent Cognitive Decline After Ischemic Stroke
Aim of this randomized controlled study is to test if intensive polyintervention therapy including life style modifications targeting at reduction of modifiable risk factors of stroke can reduce the risk of post-stroke cognitive…
- Conditions
- Ischemic Stroke, Cognitive Decline, Dementia
- Trial name
- ASPIS (NCT01109836)
- Testing
- Motivation and lifestyle intervention
- Where
- 5 sites in Austria
- Volunteers
- 202 people
- Sponsor
- Danube University Krems
Cardiovascular Diseases, Personal Health Records
Mobile Cardiovascular Risk Service Trial
Risk factors for cardiovascular disease are poorly controlled even for patients who frequently visit their physician, leading to large numbers of preventable cardiovascular events such as heart attacks and strokes.
- Conditions
- Cardiovascular Diseases, Personal Health Records, Pharmaceutical Care, Mobile Apps
- Trial name
- mCVRS (NCT03081871)
- Testing
- Pharmacist-led cardiovascular risk service (CVRS), Mobile access to study Personal Health Record, Web access to study Personal Health Record
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of Iowa
Atrial Fibrillation, Stroke
AFLETES-MRI: A Cardiac and Cerebral Magnetic Resonance Imaging Study in Athletes With Atrial Fibrillation
Participation in exercise improves cardiovascular health. However, long-term endurance exercise may increase the risk of an irregular heart rhythm called atrial fibrillation (AF).
- Trial name
- AFLETES-MRI (NCT06424171)
- Testing
- Cardiac and brain magnetic resonance imaging.
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Chronic Periodontitis, Atherosclerotic Cardiovascular Disease
Short-term Changes on C-Reactive Protein (CRP) Levels After Non-surgical Periodontal Treatment
The hypotheses tested were that levels of C-Reactive Protein (CRP) would be higher in patients with chronic periodontitis in comparison with those without periodontal disease and that the non-surgical periodontal treatment would…
- Trial name
- NCT01433744
- Testing
- Non-surgical periodontal treatment
- Where
- Brazil
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- State University of Maringá
Coronary Disease, Diabetes Mellitus
A Study Examining Torcetrapib/Atorvastatin And Atorvastatin Effects On Clinical CV Events In Patients With Heart Disease
The Torcetrapib project was terminated on December 2, 2006 due to safety findings. To demonstrate if torcetrapib/atorvastatin can reduce the risk for major cardiovascular disease events, when compared to atorvastatin alone, in…
- Trial name
- ILLUMINATE (NCT00134264)
- Testing
- torcetrapib/atorvastatin, atorvastatin
- Where
- 221 sites in United States, Australia and 5 more
- Volunteers
- 15,067 people
- Sponsor
- Pfizer
Type 2 Diabetes, Sleep
My ESSENCE - A Research Study on Mindfulness for African-Americans With Type 2 Diabetes
The proposed research and training will allow Dr. Alana Biggers to obtain critical research skills and study a mindfulness meditation program designed to improve sleep and reduce stress in African-American adults with diabetes.
- Conditions
- Type 2 Diabetes, Sleep, Stress
- Trial name
- E-RCT (NCT05208164)
- Testing
- Mindfunlness Meditation
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Tobacco Use, E-Cigarette Use
E-Cigarette Effects on Markers of Cardiovascular and Pulmonary Disease
This study is designed to enhance the understanding of the possible health effects of e-cigarette use by relating the acute and long-term use of e-cigarettes and conventional cigarettes ("products") to well-validated…
- Conditions
- Tobacco Use, E-Cigarette Use, Cardiovascular Diseases, Pulmonary Disease
- Trial name
- NCT03863509
- Testing
- Cigarettes, E-Cigarettes
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Coronary Artery Disease
Efficacy Study of Hydroxychloroquine to Treat High-risk Coronary Artery Disease.
The purpose of this study is to evaluate whether treated with hydroxychloroquine could improve therapeutic effect for patients with high-risk coronary artery disease.
- Trial name
- CHANGAN (NCT02874287)
- Testing
- Hydroxychloroquine Sulfate Tablets
- Where
- China
- Volunteers
- 35 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Aortic Valve Disease, Pulmonary Valve Disease
Artificial Intelligence in New Cardiac MR Markers for Congenital Heart Disease
The goal of this study is to investigate children with aortic and pulmonary valve disease treated or untreated longitudinally. Established CMR measures with additional newly developped, promising, highly refined and clinically…
- Conditions
- Aortic Valve Disease, Pulmonary Valve Disease, Child, Only, Magnetic Resonance Imaging
- Trial name
- AI-CMR (NCT05979870)
- Testing
- Valvuloplasty,
- Where
- Sweden
- Volunteers
- 45 people
- Sponsor
- Sahlgrenska University Hospital
Inpatients and Outpatients With Routine 12-lead ECG
Personalized Risk Identification and Management for Arrhythmias and Heart Failure by ECG and MRI
Prevention of myocardial functional deterioration and sudden cardiac death among individuals of intermediate risk remains one of the most elusive frontiers of contemporary medicine.
- Trial name
- PRIMERI (NCT01353131)
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- Johns Hopkins University
Diabetes Mellitus, Type 1
Effect of Metformin in Patients With Type-1 Diabetes With Inadequate Glycaemic Control by Insulin and Diet
Ninety percent of patients with type-1-diabetes will develop late-diabetic complications in the eyes, kidneys, nervous- or cardiovascular-system.
- Trial name
- NCT00118937
- Testing
- Metformin
- Volunteers
- 100 people
- Sponsor
- Steno Diabetes Center Copenhagen
Metabolic Syndrome
Evaluating the Effectiveness of a Community Exercise Program to Reduce the Risk of Metabolic Syndrome Among Black Americans
Black Americans with a family history of early heart disease tend to have a group of risk factors that can contribute to heart disease.
- Trial name
- NCT00783445
- Testing
- Community-Based Exercise Program (C-FIT), Self-Help Exercise Program (HOME)
- Where
- United States
- Volunteers
- 204 people
- Sponsor
- Johns Hopkins University
Cerebral Hemorrhage
REstart or STop Antithrombotic Randomised Trial in France
RESTART- fr is a randomised controlled trial for adults surviving spontaneous intracerebral haemorrhage who had taken an antithrombotic drug (i.e.
- Trial name
- RESTART-Fr (NCT02966119)
- Testing
- Clopidogrel or Aspirin and/or Dypyridamole
- Where
- France
- Volunteers
- 23 people
- Sponsor
- University Hospital, Lille
Aortic Valve Stenosis
ExCEED: CENTERA THV System in Intermediate Risk Patients Who Have Symptomatic, Severe, Calcific, Aortic Stenosis
This study will monitor the safety and valve performance of the Edwards CENTERA Transcatheter Heart Valve (THV) System in patients with symptomatic, severe, calcific aortic stenosis who are at intermediate operative risk for…
- Trial name
- NCT03517436
- Testing
- TAVR with CENTERA THV
- Where
- 23 sites in United States
- Volunteers
- 101 people
- Sponsor
- Edwards Lifesciences
Cardiovascular Diseases, Cardiovascular Risk Factor
Digital Cardiac Counseling Trial: DCC Trial
Most patients undergoing a cardiovascular procedure need an ICU-bed during the hospitalization and therefore it is possible that for the unforeseen future, because of the Covid-19 crisis, many patients will stay on the waiting…
- Trial name
- DCC (NCT04393636)
- Testing
- Digital cardiac Counseling
- Where
- Netherlands
- Volunteers
- 394 people
- Sponsor
- Academisch Ziekenhuis Maastricht
Type 2 Diabetes, Cardiovascular Risk
Different Insulin Regimens and Postprandial Coagulation Activation
The purpose of this study in patients with type 2 diabetes was to investigate the acute effect of postprandial blood glucose levels modified by two different insulin treatment regimens on coagulation activation, inflammation and…
- Conditions
- Type 2 Diabetes, Cardiovascular Risk, Hemostasis, Inflammation
- Trial name
- NCT01053234
- Testing
- Standardised meals
- Where
- Denmark
- Volunteers
- 78 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Vascular Death, Myocardial Infarction
Vascular Events In Noncardiac Surgery Patients Cohort Evaluation Study (VISION)
The investigators' study has 4 primary objectives. Among patients undergoing noncardiac surgery the investigators will determine: (1) the incidence of major perioperative vascular events; (2) the optimal clinical model to predict…
- Conditions
- Vascular Death, Myocardial Infarction, Cardiac Arrest, Stroke
- Trial name
- VISION (NCT00512109)
- Where
- 8 sites in Brazil, Canada and 5 more
- Volunteers
- 40,060 people
- Sponsor
- McMaster University
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