Clinical trials: Cardiovascular Dysfunction
Cardiopulmonary Bypass, Cardiovascular Diseases
Protective Effect of RIPC Against Negative Inflammatory Response and Organ Dysfunction After Cardiovascular Surgery (Panda VII)
Remote ischaemic pre-conditioning (RIPC) has been recognized as a low-cost, non-invasive intervention method by applying brief ischaemia and reperfusion on an arm or a leg.
- Conditions
- Cardiopulmonary Bypass, Cardiovascular Diseases, Inflammatory Response During Cardiac Surgery
- Trial name
- PANDA (NCT06707350)
- Testing
- Remote ischemic preconditioning (RIPC)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Nanjing Medical University
Chronic Cerebral Ischemia
Safety and Efficacy of Sequential Therapy With Mexidol® in Patients With Chronic Cerebral Ischemia
The purpose of this study is to evaluate safety and efficacy of sequential treatment with Mexidol® in patients with chronic cerebral ischemia (CCI).
- Trial name
- MEMO (NCT06834490)
- Testing
- Mexidol
- Where
- 14 sites in Russia, Uzbekistan
- Volunteers
- 318 people
- Sponsor
- Pharmasoft
Chronic Renal Insufficiency
Intensive Versus Standard Hemodialysis CVC Dysfunction Protocol
Central venous catheters (CVCs) are used for vascular access by approximately 56% of our 380 hemodialysis (HD) patients at the Capital Health Renal Program.
- Trial name
- NCT02474810
- Testing
- Alteplase
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- Nova Scotia Health Authority
Multiple Sclerosis
Multiple Sclerosis Produces Cardiovascular Subclinical Dysfunction
Multiple sclerosis (MS), debilitating disease involving primarily the central nervous system, may cause cardiovascular dysfunction, due to autonomous nervous system dysfunction, physical invalidity, increased oxidative stress…
- Trial name
- NCT03001284
- Testing
- NO intervention
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Carol Davila University of Medicine and Pharmacy
Mild Cognitive Impairment, Cerebrovascular Insufficiency
Efficacy and Safety of Ginkgo Biloba Extract in Mild Cognitive Impairment and Cerebrovascular Insufficiency
The purpose of the study is to determine weather Ginkgo biloba standardized extract (24% ginkoflavonoglicozides and 6% terpenes) is effective in treatment of cognitive and concentration impairment
- Trial name
- NCT00446485
- Testing
- Ginkgo biloba standardized extract 24/6
- Where
- Croatia
- Volunteers
- 90 people
- Sponsor
- Milsing d.o.o.
Obesity; Endocrine, Pregnancy in Diabetic
Female Obesity Cohort and Intervention Study Group (MOCART Study Group)
This prospective observational trial includes women with high risk pregnancies complicated with hyperglycemia in pregnancy and excessive body weight.
- Conditions
- Obesity; Endocrine, Pregnancy in Diabetic, Child Obesity, Hypertension in Pregnancy
- Trial name
- MOCART (NCT04924738)
- Testing
- Monitoring and lifestyle
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Poznan University of Medical Sciences
Alzheimer Disease, Mild Cognitive Impairment
Clinical Feasibility of Speech Phenotyping for Remote Assessment of Neurodegenerative and Psychiatric Disorders
The primary objective of the study is to evaluate the feasibility of eliciting continuous narrative speech in different neurodegenerative and psychiatric indications, using remote, self-administered speech tasks, as measured by…
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Dementia With Lewy Bodies, Dementia, Vascular
- Trial name
- RHAPSODY (NCT04939818)
- Where
- 2 sites in United Kingdom
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Novoic Limited
Nutritional and Metabolic Diseases, Gastrointestinal Dysfunction
Personalized GI Motility Responses to Diet
The goal of this randomized, crossover, clinical trial is to link: 1) gastrointestinal motility patterns induced by acute consumption of whole and refined grains, 2) enteric microbial production of bioactive metabolites, and 3)…
- Conditions
- Nutritional and Metabolic Diseases, Gastrointestinal Dysfunction, Cardiovascular Diseases, Dysbiosis
- Trial name
- NCT06386471
- Testing
- Whole grain rye bread, Refined grain rye bread
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Hypertension, Insulin Resistance
Caveolin-1 and Vascular Dysfunction
Caveolin-1 and Vascular Dysfunction Thank you for your interest in the investigators Blood Pressure Research Study. The National Institutes of Health are sponsoring us to investigate why patients develop high blood pressure…
- Trial name
- NCT01426529
- Testing
- Para-aminohippuric Acid, Angiotensin II, Norepinephrine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Brigham and Women's Hospital
Bronchogenic Carcinoma, Chronic Granulomatous Disease
Diagnostic Effectiveness of Virtual Bronchoscopy
This study will evaluate a new technique for examining the air passages of the lungs called "virtual bronchoscopy." It involves using computed tomography (CT) images of the chest to generate a 3-dimensional model of the walls of…
- Conditions
- Bronchogenic Carcinoma, Chronic Granulomatous Disease, Job's Syndrome, Mycobacterium Infection
- Trial name
- NCT00001515
- Testing
- virtual bronchoscopy
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Right Ventricular Dysfunction, Stroke Volume Index
Relationship Between Strain and Stroke Volume in Cardiac Surgery
Patients undergoing coronary artery bypass grafting up tp 30% will develop postoperative right ventricle dysfunction. Its imperative for the physician to fully understand the severity of this complication in order to perform an…
- Conditions
- Right Ventricular Dysfunction, Stroke Volume Index, Longitudinal Heart Strain
- Trial name
- NCT04694378
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Tufts Medical Center
COVID-19, Endothelial Dysfunction
The Glycocalyx in COVID-19 Patients. A Pilot Study
The damage of the endothelial glycocalyx is based on microvascular endothelial dysfunction and typical for critical clinical conditions like sepsis, trauma, bleeding, shock, as well as ARDS.
- Conditions
- COVID-19, Endothelial Dysfunction, Coagulation Disorder
- Trial name
- Glycovid-19 (NCT05137249)
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Cardiomyopathy
Budapest Upgrade CRT Study (Version 009-4.1)
Effect of biventricular upgrade on left ventricular reverse remodeling and clinical outcomes in patient in left ventricular dysfunction and intermittent or permanent apical/septal right ventricular pacing (Budapest CRT upgrade…
- Trial name
- NCT02270840
- Testing
- CRT-D
- Where
- 17 sites in Germany, Hungary and 5 more
- Volunteers
- 360 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Coronary Artery Disease, Atherosclerosis
Rilonacept to Improve Artery Function in Patients With Atherosclerosis
This study will determine whether an experimental drug called Rilonacept can improve artery function in patients with atherosclerosis, a disease in which fatty deposits in arteries cause the vessels to stiffen, impeding blood…
- Conditions
- Coronary Artery Disease, Atherosclerosis, Inflammation, Endothelial Dysfunction
- Trial name
- NCT00417417
- Testing
- Rilonacept
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease, Angina
Ivabradine and Post-revascularisation Microcirculatory Dysfunction
The aim of the study is to test whether, in patients with angina and flow limiting epicardial coronary artery disease, pre-treatment with Ivabradine, as opposed to beta blockers, will reduce post percutaneous coronary…
- Trial name
- MICRO-PCI (NCT02507050)
- Testing
- Ivabradine
- Where
- United Kingdom
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust
Varicose Veins, Varicose Veins of Lower Limb
The Evaluation of the Pathophysiology of Varicose Veins in Pregnancy
Varicose veins (VV) are the early sign of Chronic venous insufficiency (CVI) which are characterised by abnormal tortuosity and dilatation of superficial veins of lower limb extremities.
- Conditions
- Varicose Veins, Varicose Veins of Lower Limb, Chronic Venous Insufficiency, Varicose; Vessel
- Trial name
- NCT05058989
- Testing
- Advanced ultrasound measurements (Duplex ultrasound (DUS) and Vector flow imaging (VFI), Clinical interventions and procedures
- Where
- United Kingdom
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Carotid Artery Diseases, Neurocognitive Dysfunction
Assessing Neurocognition After Cerebrovascular Intervention
Decreased blood flow to the brain can cause decreased cognitive function. Carotid disease can result in decreased blood flow to the brain.
- Trial name
- NCT03344276
- Testing
- Neurocognitive Assessments, Measurements of inflammatory biomarkers, Carotid Artery Stenting
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Diego
Ranolazine, Diastolic Heart Failure
Effect of Ranolazine on Echocardiographic Indices of Diastolic Dysfunction
The purpose of this study is to evaluate the effects of ranolazine, an FDA-approved medication for the treatment of angina, on heart function by using echocardiography.
- Conditions
- Ranolazine, Diastolic Heart Failure, Tissue Doppler Ultrasound, Echocardiography
- Trial name
- NCT00574756
- Testing
- ranolazine
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of California, San Diego
Renal Failure, Multiple Myeloma
Lenalidomide & High Dose Dexamethasone for Untreated Multiple Myeloma Renal Failure Patients
Primary: To validate the initial dosing recommendations for newly diagnosed MM (Mutiple Myeloma) patients with various degrees of renal failure using pharmacokinetic studies Secondary: To evaluate the safety of lenalidomide and…
- Trial name
- NCT01270932
- Testing
- Lenalidomide and Dexamethasone
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- University Health Network, Toronto
Atherosclerosis, Endothelial Dysfunction
Apoptosis Proteins and Endothelial Dysfunction in Patients With Atherosclerosis of Peripheral Arteries
Modern vascular surgery has various options for open and endovascular surgical methods aimed at treating patients with peripheral arterial diseases.
- Trial name
- NCT04502849
- Testing
- Bypass surgery, Endovascular angioplasty/stenting, Hybrid surgery
- Where
- Russia
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Ryazan State Medical University