Clinical trials: Cardiovascular Dysfunction
Abdominal Obesity, Metabolic Syndrome
Aldosterone, Microvascular Function and Salt-sensitivity
Currently, the incidence of obesity and obesity-related disorders is reaching epidemic proportions, which entails an increasing burden for health care systems.
- Conditions
- Abdominal Obesity, Metabolic Syndrome, Sodium-sensitivity, Insulin Resistance
- Trial name
- NCT02068781
- Testing
- Low-sodium diet, High-sodium diet
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Heart Failure, Left Ventricular Dysfunction
PARACHUTE V PercutAneous Ventricular RestorAtion in Chronic Heart FailUre Due to Ischemic HearT DiseasE.
Prospective, multi-center, post-market, non-randomized, nested-control, observational study of the CE marked CardioKinetix Parachute Implant System.
- Trial name
- P5 (NCT02543632)
- Testing
- Parachute Implant System
- Where
- 10 sites in Germany
- Volunteers
- 85 people
- Sponsor
- CardioKinetix, Inc
Obesity, Hypertension
A Randomized Clinical Trial To Study Losartan On Endothelial Dysfunction and Insulin Resistance In Obese Patients
The main purposes of this study are to find out if the study drug losartan (Cozaar) or placebo ("sugar pill") has an effect on insulin sensitivity (how your body responds to insulin) and to measure the effect of the study drug…
- Conditions
- Obesity, Hypertension, Hyperglycemia
- Trial name
- NCT00675987
- Testing
- losartan
- Where
- 9 sites in United States
- Volunteers
- 53 people
- Sponsor
- Brigham and Women's Hospital
Post-Stroke Cognitive Impairment (PSCI)
Efficacy of Vitamin D in Post-Stroke Cognitive Impairment
Post-stroke cognitive impairment (PSCI) is a prevalent and debilitating sequela of stroke, posing a significant burden on patients and healthcare systems.
- Trial name
- ViD-PSCI (NCT07767214)
- Testing
- Vitamin D2 capsules
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Suzhou Municipal Hospital of Anhui Province
Left Ventricular Dysfunction
Use of Adult Autologous Stem Cells in Treating People Who Have Had a Heart Attack (The TIME Study)
Heart attacks are a leading cause of death for both men and women in the United States. A heart attack occurs when blood flow to the heart is restricted, commonly due to a blood clot that has formed in one of the coronary…
- Trial name
- NCT00684021
- Testing
- Adult stem cells
- Where
- 5 sites in United States
- Volunteers
- 120 people
- Sponsor
- The University of Texas Health Science Center, Houston
Lung Transplant Failure and Rejection, Primary Graft Dysfunction
CLAD: Finding Biomarkers to Predict Rejection and/ or Outcome After Lung Transplantation
Lung transplantation is the ultimate treatment for end stage lung diseases. Survival after lung transplantation is limited mainly due to the development of chronic allograft dysfunction (CLAD).
- Trial name
- NCT04558333
- Testing
- blood and exhaled breath specimens
- Where
- Belgium
- Volunteers
- 24 people
- Sponsor
- University Hospital, Antwerp
Out-Of-Hospital Cardiac Arrest, Myocardial Infarction
Factors Associated With CPC 1-2 in 110 Patients Admitted in French ICU for a Myocardial Infarction Complicated by an OHCA.
This study evaluate the association of some in-ICU factors with the neurological prognosis of patients admitted for an out-of-hospital cardiac arrest due to a myocardial infarction.
- Conditions
- Out-Of-Hospital Cardiac Arrest, Myocardial Infarction, Coma, Outcome, Fatal
- Trial name
- ACR-MI (NCT04584463)
- Volunteers
- 110 people
- Sponsor
- Central Hospital, Nancy, France
Heart Failure, Congestive
Efficacy and Safety of Relaxin for the Treatment of Acute Heart Failure
Different doses of relaxin will be compared to placebo to determine efficacy and safety for the treatment of patients hospitalized with acute heart failure
- Trial name
- RELAX-AHF (NCT00520806)
- Testing
- Relaxin
- Where
- 3 sites in United States, Israel
- Volunteers
- 1,161 people
- Sponsor
- Corthera, Inc.(formerly BAS Medical, Inc.), a member of the Novartis group of companies
Cognitive Impairment, Dementia
Determinants of Cognitive Impairment Among Geriatrics
This study aims to explore the determinants of cognitive impairment among Indonesian geriatrics in an Old Age Home.
- Conditions
- Cognitive Impairment, Dementia, Hearing Impairment, Vision Impairment and Blindness
- Trial name
- NCT03669536
- Where
- Indonesia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tarumanagara University
COPD, Cognitive Impairment
Cerebral and Cardiac Blood Flow During Exercise in Patients With COPD
Heart disease and conditions related to the blood vessels are responsible for a large proportion (over a quarter) of the deaths in people with chronic obstructive pulmonary disease (COPD).
- Trial name
- REFLEX-COPD (NCT04138563)
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Stroke, Motor Activity
Altered Structural-functional Connectivity Coupling on Chronic Subcortical Stroke
The current study aims to reveal the SC-FC coupling pattern and its relationship with motor function in post-stroke survivors with motor dysfunction by multimodal MRI.
- Trial name
- NCT05648552
- Where
- China
- Volunteers
- 70 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Subarachnoid Hemorrhage, Delayed Cerebral Ischemia
MicroRNA Diagnostics in Subarachnoid Hemorrhage 2
The purpose of this study is to validate results from a related trial (NCT01791257) and to compare the profile of microRNA in blood from patients suffering subarachnoid hemorrhage with and without systemic complications.
- Conditions
- Subarachnoid Hemorrhage, Delayed Cerebral Ischemia, Acute Lung Injury, Cardiac Dysfunction
- Trial name
- NCT02320539
- Where
- Denmark
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Obstructive Sleep Apnea
Ambulatory Blood Pressure Control and Cognition in Patients With Obstructive Sleep Apnea (AMPLE)
To compare the blood pressure control and cognitive responses of three groups of patients: those diagnosed with Obstructive Sleep Apnea (OSA) and treated with Continuous Positive Airway Pressure (CPAP) for at least six months…
- Trial name
- AMPLE (NCT06463002)
- Testing
- Ambulatory blood pressure monitoring and Montreal Cognitive Assessment
- Where
- Singapore
- Volunteers
- 150 people
- Sponsor
- National University Hospital, Singapore
Liver Cirrhosis, Portal Hypertension
Exploration of Systemic and Portal Hemostasis in Patients Undergoing Transjugular Intrahepatic Portosystemic Shunt Placement
Portal vein thrombosis is defined as non-tumoural obstruction of the portal vein or one of its branches. Its incidence is 0.7 to 2.7 per 100,000 patient-years in the general population, and 4.6 per 100 patient-years in patients…
- Trial name
- PORTHEMOST (NCT07439939)
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Kidney Disease, Chronic, Ischemic Heart Disease
Prevention of Contrast Induced Nephropathy in Patients With Advanced Renal Dysfunction Undergoing Coronary Interventions
There is a pressing need to find effective strategies for the prevention of contrast induced nephropathy in patients with advanced renal dysfunction.
- Trial name
- NCT02468401
- Testing
- Percutaneous coronary intervention
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Meir Medical Center
Dementia, Mild Cognitive Impairment
Norwegian COgnitive Impairment After STroke (NorCOAST) Study
A prospective observational multicenter study aiming to describe incidence, and identify predictors for development of poststroke dementia (PSD) and mild cognitive impairment (MCI) after stroke
- Conditions
- Dementia, Mild Cognitive Impairment, Stroke
- Trial name
- Nor-Coast (NCT02650531)
- Where
- Norway
- Volunteers
- 816 people
- Sponsor
- Norwegian University of Science and Technology
Hypotension, Cognitive Impairment
Comparing Fluid Responsiveness Assessment Methods in Patients With Impaired Consciousness
Hypotension is a significant precursor to unfavorable clinical outcomes. To determine whether infusion therapy can positively impact the management of hypotension, several evaluative tests can be utilized.
- Trial name
- NCT06180902
- Testing
- Inferior vena cava's diameter ratio, Central venous pressure, Passive leg raising test
- Where
- Russia
- Volunteers
- 222 people
- Sponsor
- Federal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology
Coronary Artery Disease, Diastolic Dysfunction
The MyoVista Angiography Angioplasty Percutaneous Coronary Intervention Trial
Purpose of this clinical investigation: clinical evaluation/accuracy of HeartSciences MyoVista High-Sensitivity (hsECG) 12 lead Electrocardiogram device, for patients presenting with cardiac related chest pain and/or Non…
- Trial name
- MAAP (NCT03635801)
- Testing
- MyoVista 12 lead Electrocardiogram (ECG)
- Where
- United Kingdom
- Volunteers
- 126 people
- Sponsor
- Royal Cornwall Hospitals Trust
Mild Cognitive Impairment, Ischemic Stroke
Clinical Trial of Efficacy and Safety of MMH-MAP in the Treatment of Mild Cognitive Impairment in Early Recovery Stage After Ischemic Stroke
The purpose of this study is: to evaluate efficacy of MMH-MAP in the treatment of mild cognitive impairment in subjects in early rehabilitation period of ischemic stroke to evaluate safety of MMH-MAP in the treatment of mild…
- Trial name
- NCT03815292
- Testing
- MMH-MAP
- Where
- 28 sites in Russia
- Volunteers
- 276 people
- Sponsor
- Materia Medica Holding
Heart; Surgery, Heart, Functional Disturbance as Result
FAPO-X: Assisted Digital Telemonitoring With Wearables in Patients After Cardiovascular Surgery
This study aims to develop a digitally assisted telemonitoring platform using the Samsung TM Galaxy Watch5 smartwatch, validating the applicability of the solution in patients with POAF (Postoperative Atrial Fibrillation), along…
- Trial name
- FAPO-X (NCT05966857)
- Testing
- Wearable: Smartwatch
- Where
- Brazil
- Volunteers
- 108 people
- Sponsor
- University of Sao Paulo
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