Clinical trials: Cardiovascular Dysfunction
Pregnancy Related, Pelvic Floor Disorders
Effects of Reformer Pilates in Pregnant Women
Pregnancy is known as a period associated with important physiological and psychological changes in women's lives. There is moderately sufficient evidence in the literature to recommend supplementing prenatal physical activity…
- Conditions
- Pregnancy Related, Pelvic Floor Disorders, Pain, Back, Pain, Neck
- Trial name
- NCT06777771
- Testing
- Reformer pilates exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Izmir Democracy University
Hypertension, Cognitive Decline
The Influence of Tai Chi Practice on Blood Pressure and Brain Health Among Older Adults With Hypertension (ACTION)
High blood pressure and poor cognitive function are two common health problems among older adults in the United States. They are also closely related because high blood pressure may lead to negative changes in brain structure and…
- Trial name
- ACTION (NCT04384263)
- Testing
- Tai Chi
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Connecticut
Coronary Artery Disease
Improvement Assessment of Coronary Flow Dysfunction Using Fundamental Fluid Dynamics
Diagnosis of relative contributions of large artery blockages and microvascular blockages is very much needed in the treatment of coronary artery disease.
- Trial name
- NCT01719016
- Testing
- Cardiac PET, Coronary catheterization
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Cincinnati
Central Line-associated Bloodstream Infection (CLABSI), Central Venous Catheter Associated Bloodstream Infection
Central Venous Catheter Insertion Site and Colonization in Pediatric Cardiac Surgery
Randomized controlled trial comparing femoral vs internal jugular insertion site of central venous catheters (CVC) in newborns and infants undergoing cardiac surgery.
- Conditions
- Central Line-associated Bloodstream Infection (CLABSI), Central Venous Catheter Associated Bloodstream Infection, Heart; Surgery, Heart, Functional Disturbance as Result, Congenital Heart Disease
- Trial name
- PRECiSE (NCT03282292)
- Testing
- Internal jugular vein CVC insertion
- Where
- Italy
- Sponsor
- IRCCS Policlinico S. Donato
Cardiomyopathy, Hypertrophic
The Role of Heart Stiff and Weak Atrium on Exercise Capacity in Patients With Hypertrophic Cardiomyopathy
This study will examine how heart stiffness and a weak atrium affect exercise capacity and symptoms in patients with hypertrophic cardiomyopathy (HCM).
- Trial name
- NCT00074880
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Bronchiolitis, Viral
Etude PROTECT : Prognostic Role of Tapse Evaluation in Children's bronchioliTis
In this prospective study, we aim to evaluate the association between an echocardiographic marker of right ventricular systolic function, the TAPSE (Tricuspid Annular Plane Systolic Excursion), and poor outcome in patients…
- Trial name
- PROTECT (NCT07209956)
- Testing
- Echocardiographic assessment of TAPSE
- Where
- France
- Volunteers
- 46 people
- Sponsor
- University Hospital, Bordeaux
Hypertension
A Study of the Effects of 6R-BH4 on Blood Pressure in Subjects With Poorly Controlled Systemic Hypertension
The purpose of this study is to determine whether 6R-BH4 (sapropterin dihydrochloride) is safe and effective in the treatment of poorly controlled hypertension in the presence or absence of type 2 diabetes.
- Trial name
- NCT00325962
- Testing
- 6R-BH4 (sapropterin dihydrochloride)
- Where
- 24 sites in United States
- Volunteers
- 84 people
- Sponsor
- BioMarin Pharmaceutical
Peripheral Vascular Diseases
Examining the Impact of Exercise Training on Vascular Dysfunction in Individuals With Mental Health Disorders - Study 1
The purpose of this research study is to examine the role oxidants, substances produced in the blood that can damage blood vessel function, may play in blood vessel function in healthy individuals as well as individuals with…
- Trial name
- NCT04916327
- Testing
- Antioxidant
- Where
- United States
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Non-hodgkin Lymphoma,B Cell, Multiple Myeloma
CAR T-cell Therapy in Patients With Renal Dysfunction
This is a prospective, descriptive study designed to assess the feasibility of administering CAR T therapy among patients with moderate to severe renal impairment using dose adjusted lymphodepleting chemotherapy.
- Conditions
- Non-hodgkin Lymphoma,B Cell, Multiple Myeloma, Acute Lymphoblastic Leukemia, Adult
- Trial name
- NCT05909059
- Testing
- Fludarabine, Cyclophosphamide
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Northside Hospital, Inc.
Hypertension, Endothelial Dysfunction
Effects of Magnesium Supplementation on Vascular Structure and Function in Hypertensive Patients
Introduction: Magnesium has been the target for many experimental and clinical studies due to the negative correlation between its serum and intracellular levels and the prevalence of hypertension and other cardiovascular…
- Trial name
- MG600 (NCT01151683)
- Testing
- magnesium
- Where
- Brazil
- Volunteers
- 52 people
- Sponsor
- Rio de Janeiro State University
Parkinson Disease, Stroke
COMPuter-assisted Self-training to Improve EXecutive Function
This project explores the effects of specialized computer-based cognitive rehabilitation (CBCR) targeting executive functions in three groups of patients: Stroke, Cardiac Arrest and Parkinson's Disease.
- Conditions
- Parkinson Disease, Stroke, Cardiac Arrest, Cognitive Dysfunction
- Trial name
- COMPEX (NCT04229056)
- Testing
- Computer-based cognitive rehabilitation (CBCR), General computer-based cognitive stimulation
- Where
- 2 sites in Denmark
- Volunteers
- 307 people
- Sponsor
- Bispebjerg Hospital
Liver Failure, Liver Failure, Acute
Use of N-Acetylcysteine During Liver Procurement
Randomized prospective study on the impact on the post-LT outcome by the infusion of N-acetylcysteine (NAC) during the liver procurement procedure, as an anti-oxidant agent to reduce the ischemia-reperfusion damage of organs for…
- Conditions
- Liver Failure, Liver Failure, Acute, Liver Diseases, Carcinoma, Hepatocellular
- Trial name
- NCT01394497
- Testing
- N-acetylcystein
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Azienda Ospedaliera di Padova
Coronary Artery Disease, Mild Cognitive Impairment
Genomic Outcomes of Metformin
Medical scientists have found that people with diabetes who take the drug Metformin have less age-related disease than those taking other treatments and researchers believe it may prevent numerous diseases and conditions that…
- Conditions
- Coronary Artery Disease, Mild Cognitive Impairment, Obesity, Abdominal, Hypertension
- Trial name
- GOMET (NCT02986659)
- Testing
- Metformin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Wake Forest University Health Sciences
Proteinuria, Kidney Dysfunction
Azilsartan in Patients With Diabetic Kidney Disease and Hypertension
Hypertension is the most common complication in patients with diabetes nephropathy. Strengthening blood pressure and blood sugar control is the basic treatment for patients with diabetes nephropathy.
- Conditions
- Proteinuria, Kidney Dysfunction, Blood Pressure, Diabetic Kidney Disease
- Trial name
- NCT05753696
- Testing
- Azilsartan, Losartan
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Diabetes Mellitus Type 2 (T2DM), Left Ventricular Diastolic Dysfunction
Diastolic Dysfunction in Patients With Type 2 Diabetes Mellitus
Examination of the effect of Linagliptin versus placebo on diastolic function in patients with type 2 diabetes mellitus and diastolic dysfunction as assessed by transthoracic echocardiography.
- Trial name
- Diast Dysfkt (NCT01888796)
- Testing
- Linagliptin
- Where
- Germany
- Volunteers
- 8 people
- Sponsor
- RWTH Aachen University
Hypertrophic Cardiomyopathy, Endothelial Dysfunction
Assessment of the Relations Between Endothelial and Venous Dysfunctions and Left Ventricular Obstruction in Genetic Hypertrophic Cardiomyopathies
Left ventricular obstruction is an invalidating complication of hypertrophic cardiomyopathies (HCM), and endothelial dysfunction has also been observed in these pathologies.
- Trial name
- HCM-Vein (NCT04129905)
- Testing
- BNP blood sample test, Electrocardiogram, Holter ECG
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Takotsubo Cardiomyopathy
The Cedars-Sinai Smidt Heart Institute Takotsubo Registry & Proteomic Study
The Cedars-Sinai SHI Takotsubo Registry and Proteomic Study is an observational registry that will collect retrospective and prospective demographic, clinical, hemodynamic, laboratory and other diagnostic parameters, therapy and…
- Trial name
- NCT03910569
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Cedars-Sinai Medical Center
Coronary Disease, Inflammation
Metabolic, Vascular and Cognitive Effects of Treatment With Anthocyanins
The purpose of this study is to examine weather treatment with anthocyanins will affect lipid profile, markers of inflammation and oxidative stress in addition to antioxidative level in serum to the better in persons with…
- Conditions
- Coronary Disease, Inflammation, Cognitive Impairment
- Trial name
- NCT02409446
- Testing
- Anthocyanin
- Where
- Norway
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Helse Stavanger HF
Hypertension, Pulmonary, Ventricular Dysfunction, Left
A Study to Test the Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Left Ventricular Diastolic Dysfunction
The aim of this study is to assess whether single oral doses of Riociguat safely improve the cardiovascular function in patients with pulmonary hypertension associated with left ventricular diastolic dysfunction
- Trial name
- DILATE (NCT01172756)
- Testing
- Riociguat (BAY63-2521)
- Where
- 7 sites in Austria, Czechia and 1 more
- Volunteers
- 39 people
- Sponsor
- Bayer
Traumatic Brain Injury, Cognitive Decline
Cognitive and Vascular Functioning Following TBI
This observational study will examine the association of chronic traumatic cerebrovascular injury and cardiovascular risk factors with TBI-related cognitive impairment and vascular dementia.
- Conditions
- Traumatic Brain Injury, Cognitive Decline, Vascular Dementia
- Trial name
- NCT06034509
- Testing
- No intervention. This is an observational study.
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Walter Reed National Military Medical Center
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