Clinical trials: Cardiovascular Dysfunction
Antiphospholipid Syndrome, Endothelial Dysfunction
The Influence of Antiphospholipid Antibodies on the Relationship Between Hyperurecemia, Gout and Metabolic Syndrome
Patients with hyperuricemia were confirmed to have higher risks of cardiovascular disease, but the exact mechanism remained to be elucidated.
- Conditions
- Antiphospholipid Syndrome, Endothelial Dysfunction, Hyperuricemia, Gout
- Trial name
- URIC (NCT01818505)
- Where
- Taiwan
- Volunteers
- 210 people
- Sponsor
- National Taiwan University Hospital
Refractory Angina, Microvascular Angina
Coronary Sinus Reducer Implantation in Patients With Ischaemia and Non-obstructed Coronary Arteries and Coronary Microvascular Dysfunction.
To demonstrate the feasibility and efficacy of the CS Reducer for the treatment of patients with ischaemia and non-obstructed coronary arteries (INOCA) and coronary microvascular dysfunction (CMD) and through a nested mechanistic…
- Conditions
- Refractory Angina, Microvascular Angina, Microvascular Coronary Artery Disease, Coronary Disease
- Trial name
- REMEDY-PILOT (NCT05492110)
- Testing
- Coronary sinus reducer, Invasive coronary physiology
- Where
- United Kingdom
- Volunteers
- 54 people
- Sponsor
- Imperial College London
Mild Dementia, Mild Cognitive Impairment
The Swedish BioFINDER - Primary Care Study
The overall aim of the study is to improve the diagnostic accuracy of AD and cognitive impairment in primary care settings to ensure better care and treatment as well as facilitate correct referrals to specialized memory clinics.
- Conditions
- Mild Dementia, Mild Cognitive Impairment, SCD, Alzheimer Disease
- Trial name
- ADetect (NCT06120361)
- Testing
- Plasma APS 2 score, Plasma p-tau217/np-tau217, Plasma p-tau217
- Where
- Sweden
- Volunteers
- 1,200 people
- Sponsor
- Skane University Hospital
Left Ventricular Systolic Dysfunction
The SMART-LV Pilot Study
The goal of this pilot study is to evaluate the prospective performance of an image-based, smartphone-adaptable artificial intelligence electrocardiogram (AI-ECG) strategy to predict and detect left ventricular systolic…
- Trial name
- NCT05630170
- Testing
- AI-ECG
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University
Tachyarrhythmias, Heart Failure
Safety and Clinical Performance of the Protecta ICD and CRT-D
The purpose of the study is two-fold. In Phase I (Protecta Clinical Study), system performance will be evaluated. In Phase II (PainFree SST), the inappropriate shock-free rate at one year of subjects implanted with a Medtronic…
- Conditions
- Tachyarrhythmias, Heart Failure, Ventricular Dysfunction
- Trial name
- NCT00982397
- Testing
- Protecta VR-ICD, Protecta DR-ICD or CRT-D
- Where
- 122 sites in United States, Austria and 19 more
- Volunteers
- 2,770 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Congenital Heart Disease, Executive Dysfunction
Learning by Heart: The Effectiveness of an EF Training Program for Pre-schoolers With Critical CHD
Advances in prenatal and neonatal care have improved outcomes in children with critical congenital heart disease (CCHD). With the increase in survival, neurocognitive problems such as executive functioning (EF) impairments have…
- Trial name
- LbH (NCT06267430)
- Testing
- Kleuter Extra training program
- Where
- 3 sites in Netherlands
- Volunteers
- 103 people
- Sponsor
- Erasmus Medical Center
Mild Cognitive Impairment, Hypertension
Hypertension, Brain Clearance, and Markers of Neurodegeneration
The purpose of this research study is to measure cerebrospinal fluid (CSF) clearance in subjects with and without high blood pressure.
- Trial name
- NCT05785871
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Peripheral Arterial Disease, Endothelial Dysfunction
Effects of Combined Aerobic and Resistance Training in Patients With Intermittent Claudication
Exercise training improves walking capacity and regional perfusion in patients with Intermittent Claudication (IC). Endothelial Progenitor Cells (EPCs) and Endothelial Microparticles (EMPs) could play an important role in this…
- Trial name
- NCT04302571
- Testing
- combined aerobic and resistance physical activity
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Of Perugia
Atrial Fibrillation
Swiss Atrial Fibrillation Cohort Study
Swiss-AF is a prospective observational, multicentric cohort study in Switzerland. Overall, 2600 patients with documented atrial fibrillation aged >65 years will be included and followed on a yearly basis.
- Trial name
- SWISS-AF (NCT02105844)
- Where
- Switzerland
- Volunteers
- 2,415 people
- Sponsor
- University Hospital, Basel, Switzerland
Extracorporeal Circulation; Complications, Extracorporeal Membrane Oxygenation Complication
Definition and Management of Right Ventricular Injury in Adult Patients Receiving Extracorporeal Membrane Oxygenation
The aim of this study is to identify existing definitions and therapeutic approaches for acute right ventricular injury (RVI) in patients receiving extracorporeal membrane oxygenation (ECMO) for respiratory support.
- Conditions
- Extracorporeal Circulation; Complications, Extracorporeal Membrane Oxygenation Complication, Right Heart Failure, Right Ventricular Dysfunction
- Trial name
- NCT05948332
- Testing
- Delphi Rounds to generate consensus opinions among Experts
- Where
- United Arab Emirates
- Volunteers
- 52 people
- Sponsor
- Prashant Nasa
Inferior Wall; Transmural Myocardial Infarction, Right Ventricular Dysfunction
Acute Right Ventricular Infarction Registry
This Study aims to provide an assessment of clinical presentation, management, hospital course, and prognosis of acute right ventricular infarction presenting with or without Inferior or infero-posterior wall Myocardial…
- Trial name
- NCT06424028
- Testing
- Right Ventricular Infarct
- Where
- Pakistan
- Volunteers
- 1,000 people
- Sponsor
- National Institute of Cardiovascular Diseases, Pakistan
Hypertension, Pulmonary, Pulmonary Arterial Hypertension
Endothelial Function in Patients With Pulmonary Arterial Hypertension
The objectives of the current study are to identify and evaluate new prognostic non-invasive and serological markers in patients with pulmonary hypertension.
- Conditions
- Hypertension, Pulmonary, Pulmonary Arterial Hypertension, Pathophysiology, Genetics
- Trial name
- NCT01317134
- Testing
- EndoPAT measurement, Blood Test
- Where
- Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Pulmonary Artery Hypertension, Right Ventricular Dysfunction
Right Ventricular Pacing in Pulmonary Arterial Hypertension
In pulmonary arterial hypertension (PAH), progressive pulmonary vascular remodeling leads to supraphysiologic right ventricular (RV) afterload.
- Trial name
- NCT04194632
- Testing
- Temporary right ventricular pacing
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of California, San Francisco
MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease, Cirrhosis
MASLD in Type 2 Diabetes in Primary Care - a Follow-up Study
The goal of this observational study is to understand how metabolic dysfunction-associated steatotic liver disease (MASLD) changes over time in individuals with type 2 diabetes who previously participated in the EPSONIP study.
- Conditions
- MASLD - Metabolic Dysfunction-Associated Steatotic Liver Disease, Cirrhosis, Advanced Fibrosis, Sarcopenia
- Trial name
- EPSOMIP2 (NCT07312136)
- Where
- Sweden
- Volunteers
- 317 people
- Sponsor
- Linkoeping University
Stroke
Sexual Nursing Care in Stroke Patients
The study aims to assess the impact of "sexual nursing care" on sexual dysfunctions in Italian stroke patients. The method involves a randomized clinical trial with two groups: one receiving specific sexual care and the other…
- Trial name
- StrokeSex_23 (NCT06278363)
- Testing
- Sexual Nursing care, Standard Nursing Care
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Takotsubo Cardiomyopathy
The Role of Emotional Stress in Patients With Stress-induced Cardiomyopathy
The event-related potentials may be different in patients with Takotsubo cardiomyopathy than in patients without Takotsubo.
- Trial name
- NCT02361073
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Magdeburg
Hypertensive Heart Disease Without (Congestive) Heart Failure
The Influence of Beetroot Powder at a Dose of 20 g on Blood Pressure, Microcirculation, and Biochemical Markers in Men With Arterial Hypertension.SVEKLA2025.
Objective: to evaluate the effectiveness of using a food product, dry finely dispersed beetroot powder in a dose of 20 g, containing 800 mg of nitrate (NO3-), in relation to the regulation of blood pressure in men with…
- Trial name
- NCT07270718
- Testing
- Plus SVEKLA
- Where
- Russia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Lower Extremity Dysfunction, Stroke
Sensitivity to Change of the Lower Extremity Functional Scale in Patients With Stroke
The purpose of this study was to investigate the reliability, construct validity, and sensitivity to change of the Lower Extremity Functional Scale (LEFS) in individuals affected by stroke.
- Trial name
- NCT01536990
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Mayo Clinic
Cardio-pulmonary Bypass, Cardiovascular Surgery
Protective Effect of Angong Niuhuang Against Negative Inflammatory Response and Neurologic Dysfunction After Cardiovascular Surgery
Neurologic Dysfunction is one of the main factors contributing to poor outcomes in cardiac surgery patients, except for heart failure.
- Conditions
- Cardio-pulmonary Bypass, Cardiovascular Surgery, Cerebral Protection, Brain Injury
- Trial name
- NCT06723366
- Testing
- Angong Niuhuang Pill (ANP), Control (Standard treatment)
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Nanjing Medical University
Microvascular Coronary Dysfunction, Microvascular Angina
Microvascular Coronary Rehabilitation For Improving Treatment - Feasibility Study
The goal of this clinical trial is to assess the feasibility of undertaking a randomized controlled trial assessing the impact of a personalised, intense cardiac rehabilitation programme involving high intensity interval exercise…
- Conditions
- Microvascular Coronary Dysfunction, Microvascular Angina, Coronary Microvascular Dysfunction (CMD)
- Trial name
- MICROFIT (NCT06681896)
- Testing
- MICROFIT - personalised high intensity interval training exercise rehabilitation and dietary advice
- Where
- 2 sites in United Kingdom
- Volunteers
- 40 people
- Sponsor
- Royal United Hospitals Bath NHS Foundation Trust
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