Clinical trials: Cardiovascular Dysfunction
Symptomatic Congestive Heart Failure
The Predictive Value of Dobutamine Echo-stress in the Clinical Response to CCM Therapy in Advanced HF
The goal of this observational cohort study, which is both retrospective and prospective, is to evaluate the long-term clinical and instrumental response to Cardiac Contractility Modulation (CCM) treatment in adult subjects…
- Trial name
- PREDICT-CCM (NCT06973902)
- Testing
- Cardiac Contractility Modulation (CCM) implant
- Where
- 13 sites in Italy
- Volunteers
- 120 people
- Sponsor
- Quovadis Associazione
Preeclampsia, Severe Preeclampsia
Diastolic Dysfunction 2025
This is a prospective observational study conducted at the Maternity and Neonatology Center of Tunis to evaluate cardiac diastolic function in women with preeclampsia compared with normotensive pregnant women.
- Trial name
- NCT07190846
- Testing
- No Intervention (Observational Echocardiographic Evaluation)
- Where
- Tunisia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Tunis El Manar
Heart Failure, Renal Dysfunction
Low Dose Intravenous (IV) Infusion of BNP in the Presence and Absence of Acute Type V Phosphodiesterase (PDE V) in Improving Renal Function in Hospitalized Chronic Heart Failure (CHF) Patients With Renal Dysfunction
The purpose of the study is to determine if low doses of BNP can improve renal function in people with chronic heart failure with renal dysfunction, also to determine whether Sildenafil assists with improvement.
- Trial name
- Aim 3 BNP/PDEV (NCT00972569)
- Testing
- BNP and PDE-V, BNP
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Heart Failure, Cardiotoxicity
The STOP-MED CTRCD Trial
Cancer therapy-related cardiac dysfunction (CTRCD) is when the heart's ability to pump oxygenated blood to the body is compromised. It is a side effect of cancer therapy which can occur as commonly as in 1 in 5 patients.
- Conditions
- Heart Failure, Cardiotoxicity, Cardiac Toxicity, Antineoplastics Toxicity
- Trial name
- STOP-MED CTRCD (NCT06183437)
- Testing
- Stopping Heart Failure Medication(s)
- Where
- 14 sites in United States, Australia and 4 more
- Volunteers
- 335 people
- Sponsor
- Dinesh Thavendiranathan
Stroke ( 3 Months After Onset), Cognitive Dysfunction ( MMSE < 24 )
The Effects of Virtual Reality-based Training for the Treatment of Neglect Syndrome in Stroke: a Randomized Controlled Trial
This study aims to investigate the effectiveness and underlying recovery mechanisms of a virtual reality-based training program for the treatment of neglect syndrome in stroke patients in the chronic phase (more than three months…
- Conditions
- Stroke ( 3 Months After Onset), Cognitive Dysfunction ( MMSE < 24 ), Unilateral Neglect Syndrome
- Trial name
- NCT07102927
- Testing
- Virtual reality-based training for the treatment of neglect syndrom in stroke, Conventional occupational therapy
- Where
- South Korea
- Volunteers
- 28 people
- Sponsor
- Yonsei University
Carotid Artery Disease, Carotid Artery Stenosis
Effect of Raised CBF During CEA on Cognition in DM Patients
The purpose of this study is to determine if we can reduce the incidence of cognitive dysfunction - difficulty in performing certain pencil-paper, memory, finger dexterity and thinking type of tasks called neuropsychometric tests…
- Conditions
- Carotid Artery Disease, Carotid Artery Stenosis, Diabetes, Cognitive Dysfunction
- Trial name
- NCT00597545
- Testing
- Carotid endarterectomy, Shunt
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Columbia University
Carotid Stenosis, Postoperative Cognitive Dysfunction
Neurocognitive Function After Carotid Thrombendarterectomy
Previous studies did not reach a consensus on the influence of the type of anesthesiologic procedure and monitoring, during carotid thrombendarterectomy, on perioperative complications and cognitive outcomes.
- Conditions
- Carotid Stenosis, Postoperative Cognitive Dysfunction, Neurological Impairment
- Trial name
- NCT05739357
- Testing
- NIRS, EEG
- Where
- Croatia
- Volunteers
- 60 people
- Sponsor
- Clinical Hospital Centre Zagreb
Angina, Non-obstructive Coronary Artery Disease
Imaging Coronary Microvascular Dysfunction (CMD) Study
Angina is a common clinical symptom of ischemic heart disease, affecting up to 11 million people in the United States alone, and 112 million people globally.
- Trial name
- NCT05634031
- Testing
- PET imaging, Coronary CT angiogram, Functional Angiography
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Covid19, Cardiac Disease
COvid-19 LongitUdinal Multiethnic BioImaging Assessment of CARDiovascular Sequelae Registry
COLUMBIA CARDS is a pilot study to understand how COVID-19 affects the heart. It is known that COVID-19 can affect the heart in different ways.
- Conditions
- Covid19, Cardiac Disease, Cardiac Arrhythmia, Myocarditis
- Trial name
- NCT04661657
- Testing
- Transthoracic echocardiogram (TTE), Cardiovascular Magnetic Resonance (CMR) Imaging
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Columbia University
Cardio-pulmonary Bypass, Cardiovascular Surgery
Protective Effect of Angong Niuhuang Against Negative Inflammatory Response and Neurologic Dysfunction After Cardiovascular Surgery
Neurologic Dysfunction is one of the main factors contributing to poor outcomes in cardiac surgery patients, except for heart failure.
- Conditions
- Cardio-pulmonary Bypass, Cardiovascular Surgery, Cerebral Protection, Brain Injury
- Trial name
- NCT06723366
- Testing
- Angong Niuhuang Pill (ANP), Control (Standard treatment)
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Nanjing Medical University
Mild Cognitive Impairment, Alzheimer Disease
A Double-Blind, Placebo-Controlled Safety and Efficacy Study of NA-831
This study seeks to evaluate the efficacy and safety of NA-83 in subjects with mild cognitive impairment due to Alzheimer's Disease
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Alzheimer Dementia, Dementia, Vascular
- Trial name
- NCT03538522
- Testing
- N-831(Traneurocin) 10 mg QD, NA-831 (Traneurocin) 20 mg QD, NA-831 (Traneurocin) 40 mg QD
- Where
- 2 sites in New Zealand
- Volunteers
- 126 people
- Sponsor
- Biomed Industries, Inc.
Rheumatoid Arthritis, Stiffness, Aortic
Methotrexate, Blood Pressure and Arterial Function in Rheumatoid Arthritis
The investigators will study the effects of methotrexate on blood pressure, arterial stiffness and endothelial function in patients with rheumatoid arthritis.
- Conditions
- Rheumatoid Arthritis, Stiffness, Aortic, Endothelial Dysfunction, Cardiovascular Risk Factor
- Trial name
- NCT03254589
- Testing
- Methotrexate, Sulfasalazine, Other DMARDs
- Where
- Australia
- Volunteers
- 124 people
- Sponsor
- Flinders University
Myocardial Viability in Ischemic Left Ventricular Dysfunction, Prediction for Improvement in Cardiac Function After Revascularization Therapy
The Use of Myocardial Deformation Imaging
Myocardial deformation imaging allows analysis of myocardial viability in ischemic left ventricular dysfunction. This study will evaluate the predictive value of myocardial deformation imaging for improvement in cardiac function…
- Trial name
- NCT00476320
- Testing
- Magnetic Resonance Imaging, Revascularization, Echocardiography with myocardial deformation imaging
- Where
- Germany
- Sponsor
- RWTH Aachen University
Heart Failure
Efficacy of Candesartan on Symptomatic Heart Failure in Treating Diabetic and Hypertensive Patients.
The purpose of this study is to determine the effects of candesartan, once daily (QD), on the N-terminal pro-B-type Natriuretic Peptide laboratory marker in subjects with symptomatic heart failure with diastolic dysfunction.
- Trial name
- NCT00775840
- Testing
- Candesartan
- Where
- 37 sites in Germany
- Volunteers
- 22 people
- Sponsor
- Takeda
Mitral Insufficiency
Assessing the Relationship Between Symptoms and Mitral Regurgitnant. Severity
The current American College of Cardiology/American Heart Association (ACC/AHA) guidelines recommend surgery in patient with mitral regurgitation (MR) based on 1) the severity of MR and 2) the presence or absence of symptoms.
- Trial name
- NCT06738615
- Testing
- Pressure volume loop evaluation, cardiovascular magnetic resonance imaging, Cardiopulmonary exercise testing (CPET)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Atlantic Health System
Aortic Aneurysm of the Proximal Arch, Aortic Aneurysms Arch
Effects of Remimazolam on Postoperative Cognitive Dysfunction and Neuroinflammatory Biomarkers in Patients Undergoing Aortic Arch Surgery
The purpose of this study is to compare remimazolam- and propofol-based anesthesia for their effects on postoperative cognitive dysfunction in patients undergoing aortic arch surgery.
- Conditions
- Aortic Aneurysm of the Proximal Arch, Aortic Aneurysms Arch, Aortic Arch Disease, Postoperative Delirium (POD)
- Trial name
- NCT07816068
- Testing
- Remimazolam Besylate, propofol
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Seoul National University Hospital
Dementia, Alzheimer Disease
Effects of Remote-based Resistance Training on Cardiometabolic Risk Factors, Cognitive Function, and Quality of Life in Adults Living With Alzheimer's Disease and/or Related Dementias
The investigators aim to study the effects of a 24-week remote-based resistance exercise training program on cardiovascular disease risk factors, cognitive function, and quality of life in older adults living with mild cognitive…
- Conditions
- Dementia, Alzheimer Disease, Dementia, Vascular, Lewy Body Disease
- Trial name
- NCT05004558
- Testing
- Remote-based Resistance Exercise Training
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Drexel University
Cerebrovascular Disease
Multi-Modality Imaging Standard Cohort Of Cerebrovascular Disease
The aim of this study is to establish a multi-center and multi-modality imaging standard cohort of cerebrovascular disease, analyze the potential mechanisms affecting the prognosis of cerebrovascular disease based on a variety of…
- Trial name
- NCT06925178
- Where
- China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Infective Endocarditis
Evaluation of Systemic Microvascular Endothelial Dysfunction in Patients Presenting With Infective Endocarditis
Infective endocarditis (IE) is a severe clinical condition with a high in-hospital and 5-year mortality. It has a growing incidence, both related to healthcare and possibly to changes in prophylaxis recommendations regarding oral…
- Trial name
- NCT02940340
- Where
- Brazil
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
Hypertension
Effect of the Angiotensin II Receptor Antagonist Irbesartan on Biochemical and Functional Markers of Endothelial Dysfunction in Patients With Hypertension
Primary: To evaluate the impact of irbesartan on endothelial function in hypertensive patients with metabolic syndrome. Secondary: To evaluate the oxidative stress status in patients with hypertension with metabolic syndrome.
- Trial name
- NCT00529750
- Testing
- IRBESARTAN, Atenolol
- Volunteers
- 108 people
- Sponsor
- Sanofi