Clinical trials: Cardiovascular Dysfunction
Congestive Heart Failure Chronic, Cognitive Impairment, Mild
Depressive Symptoms, Cognitive Impairment, and Outcomes in Hospitalized Chronic Heart Failure Patients
The goal of this observational study is to learn about the prevalence of depressive symptoms and cognitive impairment and their association with worse outcomes in a cohort of hospitalized patients between the ages of 18 ang 85…
- Conditions
- Congestive Heart Failure Chronic, Cognitive Impairment, Mild, Depressive Symptoms Mild to Moderate in Severity
- Trial name
- DSCI-CHF (NCT07284446)
- Where
- Lithuania
- Volunteers
- 300 people
- Sponsor
- Lithuanian University of Health Sciences
Ischaemic Heart Disease, Aortic Stenosis
Remifentanil/Sufentanil for CABG+/-AVR Evaluated by Recovery, Cognitive Function, Haemodynamics and Biochemical Markers.
To evaluate the effect on cognitive function, recovery, cardioprotection and haemodynamics of standard Remifentanil anaesthesia to standard Sufentanil anaesthesia in patients undergoing coronary artery bypass with or without…
- Trial name
- PRECON2 (NCT02053818)
- Testing
- Remifentanil, Sufentanil
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Aarhus University Hospital
Stroke, Cognitive Decline
Efficacy and Safety of Immersive Virtual Reality for Post-stroke Cognitive Impairment
This is a single-blind randomized controlled trial to evaluate the efficacy and safety of immersive virtual reality for post-stroke cognitive impairment.
- Trial name
- EVRPSC (NCT06704360)
- Testing
- immersive VR pathfinding training, Occupational therapy
- Volunteers
- 40 people
- Sponsor
- Dingqun Bai
Shock
Cardiovascular Metabolic Remodeling in Shock
The aim of the study is to increase our knowledge of energy dysfunction in the cardiovascular dysfunction observed during shock states by analysing the omics molecules involved.
- Trial name
- METASHOCK (NCT06285513)
- Testing
- Cardiac ultrasound
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Rouen
Stroke (Subacute)
Effect of Immersive Virtual Reality Cognitive Rehabilitation on Subacute Stroke Patients (A Pilot Study)
This pilot randomized controlled trial aims to evaluate the effectiveness of cognitive rehabilitation using an immersive Virtual Reality (VR) system compared to conventional paper-and-pencil cognitive training in subacute stroke…
- Trial name
- NCT07506486
- Testing
- Immersive Virtual Reality System, Conventional Paper-and-Pencil Cognitive Training
- Where
- Indonesia
- Volunteers
- 22 people
- Sponsor
- Universitas Padjadjaran
Cognitive Decline
Evaluating the Impact of Cerebral Ischemic And Degenerative Changes On Cognition
The purpose of this study is to evaluate whether or not cerebral atrophy scores obtained from a brain MRI can correlate with Cognitive Test results.
- Trial name
- NCT00704327
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Lahey Clinic
Parkinson Disease, Parkinsonism
Head-up Tilt Sleeping to Alleviate Orthostatic Hypotension, Supine Hypertension and Nocturia in Parkinson's Disease
Autonomic dysfunction is common and often underrecognized in Parkinson's disease (PD). Orthostatic hypotension (OH) affects up to a third of PD patients and often coincides with supine hypertension.
- Trial name
- NCT05551377
- Testing
- Head-up tilt sleeping
- Where
- 2 sites in Netherlands
- Volunteers
- 50 people
- Sponsor
- Radboud University Medical Center
Pulmonary Valve Insufficiency, Pulmonary Valve Stenosis
COMPASSION XT PAS - Post-approval Study of the SAPIEN XT THV in Patients With Pulmonary Valve Dysfunction
This study will confirm the safety and effectiveness of the Edwards Lifesciences SAPIEN XT Transcatheter Heart Valve (THV) System in patients with a dysfunctional right ventricular outflow tract (RVOT) conduit with a clinical…
- Conditions
- Pulmonary Valve Insufficiency, Pulmonary Valve Stenosis, Heart Defects, Congenital, Congenital Abnormalities
- Trial name
- NCT02987387
- Testing
- SAPIEN XT THV
- Where
- 12 sites in United States
- Volunteers
- 57 people
- Sponsor
- Edwards Lifesciences
Oncology, Cardiac Toxicity
Exercise Response After Revalidation in Cancer Patients
This study regarding oncological patients for rehabilitation after specific cancer therapy involves three aims: (1) to evaluate the predictive value of myocardial work parameters on the improvement of exercise performance after…
- Trial name
- NCT04461392
- Testing
- Cardiorespiratory exercise test
- Where
- Belgium
- Volunteers
- 191 people
- Sponsor
- Universitair Ziekenhuis Brussel
Secondary Pulmonary Arterial Hypertension
Endothelial Cell Dysfunction in Pulmonary Hypertension
This study will examine and test healthy volunteers and patients with pulmonary hypertension to try to learn more about the disease and find better ways to detect, treat, and, if possible, slow progression.
- Trial name
- NCT00098072
- Testing
- Heart Catheterization
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Heart Failure, Ischemic Heart Disease
Cardiac FDG PET Viability Registry
Positron Emission Tomography (PET) is a non-invasive, unique nuclear imaging technique that allows the evaluation of blood flow in the heart and provides information about the cell activity of specific organs such as the heart…
- Conditions
- Heart Failure, Ischemic Heart Disease, Myocardial Dysfunction
- Trial name
- CADRE (NCT00766987)
- Where
- 4 sites in Canada
- Volunteers
- 2,000 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Left Ventricular Dysfunction
Use of Adult Autologous Stem Cells in Treating People Who Have Had a Heart Attack (The TIME Study)
Heart attacks are a leading cause of death for both men and women in the United States. A heart attack occurs when blood flow to the heart is restricted, commonly due to a blood clot that has formed in one of the coronary…
- Trial name
- NCT00684021
- Testing
- Adult stem cells
- Where
- 5 sites in United States
- Volunteers
- 120 people
- Sponsor
- The University of Texas Health Science Center, Houston
Coronary Artery Disease
Improvement Assessment of Coronary Flow Dysfunction Using Fundamental Fluid Dynamics
Diagnosis of relative contributions of large artery blockages and microvascular blockages is very much needed in the treatment of coronary artery disease.
- Trial name
- NCT01719016
- Testing
- Cardiac PET, Coronary catheterization
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- University of Cincinnati
Sinus Bradycardia
Cardiac Denervation Ablation Strategy for Severe Sinus Bradycardia
This is a prospective clinical observation and registration study. The investigator aimed to evaluate the efficacy and safety of cardiac denervation ablation as a treatment strategy for severe sinus bradycardia.
- Trial name
- NCT06276816
- Where
- China
- Volunteers
- 88 people
- Sponsor
- China National Center for Cardiovascular Diseases
Pulmonary Arterial Hypertension, Right Ventricular Dysfunction
Consistency of Electrical Cardiometry and Pulmonary Artery Catheter
Currently, the gold standard method to estimate CO in patients with PAH or RV dysfunction is pulmonary artery catheter (PAC), however, the invasiveness and complexity of PAC has limited its usefulness in many clinical scenarios.
- Trial name
- NCT05587400
- Testing
- passive leg raising, dobutamine test, inhaled nitric oxide
- Where
- China
- Volunteers
- 199 people
- Sponsor
- Shanghai Zhongshan Hospital
Covid19, Left Ventricular Dysfunction
Cardiac Dysfunction in Critically Ill Patients With COVID-19
Cardiac dysfunction has been reported to be common in patients infected with COVID-19. The aim of this study is to evaluate the clinical importance of cardiac dysfunction in critically ill patients infected with COVID-19.
- Conditions
- Covid19, Left Ventricular Dysfunction, Right Ventricular Dysfunction, Pulmonary Hypertension
- Trial name
- CARDYCOVID (NCT04524234)
- Testing
- Echocardiography
- Where
- 5 sites in Sweden
- Volunteers
- 132 people
- Sponsor
- Sahlgrenska University Hospital
Catheter Blockage, Catheter-Related Infections
Comparison of Effectiveness and Complications of Catheter Lock Solutions in Non-tunneled Hemodialysis Catheters
In our study, investigators will investigate the effectiveness and complications of two catheter lock solutions one of which is the standard heparin routinely used in comparison to Sodium bicarbonate.
- Conditions
- Catheter Blockage, Catheter-Related Infections, Dialysis Catheter; Thrombosis, Catheter Infection
- Trial name
- NCT04772209
- Testing
- Sodium bicarbonate, Heparin
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 441 people
- Sponsor
- Zonguldak Ataturk State Hospital
Heart Failure, Cardiotoxicity
The STOP-MED CTRCD Trial
Cancer therapy-related cardiac dysfunction (CTRCD) is when the heart's ability to pump oxygenated blood to the body is compromised. It is a side effect of cancer therapy which can occur as commonly as in 1 in 5 patients.
- Conditions
- Heart Failure, Cardiotoxicity, Cardiac Toxicity, Antineoplastics Toxicity
- Trial name
- STOP-MED CTRCD (NCT06183437)
- Testing
- Stopping Heart Failure Medication(s)
- Where
- 14 sites in United States, Australia and 4 more
- Volunteers
- 335 people
- Sponsor
- Dinesh Thavendiranathan
Stroke, Cardiovascular, Cognitive Impairment
OptiCogs: A Multicomponent Intervention to Rehabilitate Cognitive Impairment in People Post-stroke
OptiCogs Online is a complex multicomponent intervention comprising of cognitive, physical activity and educational components.
- Trial name
- NCT05414539
- Testing
- OptiCogs Online
- Where
- Ireland
- Volunteers
- 9 people
- Sponsor
- University of Limerick
Stroke, Upper Extremity Dysfunction
Comparison of the Effects of Mirror Therapy,rTMS and Robotic-assisted Hand Therapy in Stroke Patients
The aim of the study is to investigate the comparison of the effects of mirror therapy, Repetitive Transcranial Magnetic Stimulation and robot-assisted hand therapy added to conventional neurological rehabilitation on upper…
- Conditions
- Stroke, Upper Extremity Dysfunction, Neuropathic Pain, Quality of Life
- Trial name
- NCT06750692
- Testing
- Mirror Therapy, Low-Frequency Repetitive Transcranial Magnetic Stimulation, Robot-Assisted Hand Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Afyonkarahisar Health Sciences University
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