Clinical trials: Cardiovascular Dysfunction
Behçet Disease, Physiopathology
Understanding the Role of Oral Microbiota in Behçet's Disease (BEHCETBIOT)
Behçet's disease (BD) is a systemic vasculitis that affects, especially, young people. Although its etiology remains unexplained, data suggest that the inflammatory response during BD results from a disruption of the homeostasis…
- Conditions
- Behçet Disease, Physiopathology, Microbiota, Oral Microbiota
- Trial name
- BEHCETBIOT (NCT04959435)
- Testing
- biological samples collection
- Where
- 2 sites in France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Clermont-Ferrand
Acute Coronary Syndrome
Effect of Pentoxifylline on Endothelial Dysfunction in Patients With Acute Coronary Syndrome
This study aims to investigate the effect of pentoxifylline administration on the status of endothelial function and oxidative stress biomarkers in patients with Acute Coronary Syndrome (ACS).
- Trial name
- NCT04367935
- Testing
- Pentoxifylline
- Where
- Egypt
- Volunteers
- 43 people
- Sponsor
- Ain Shams University
Bone Tumor, Cancer of Bone
Endoprosthesis Metal Toxicity Study
The purpose of this research is to investigate whether patients who previously had endoprosthesis surgery experience memory, thinking, or heart problems. It will also help determine how often these problems occur.
- Conditions
- Bone Tumor, Cancer of Bone, Heart Diseases, Cognitive Impairment
- Trial name
- NCT04755140
- Testing
- Questionnaires, Interviews, Blood Test
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Cardiovascular Diseases, Microvascular Complications
Non-invasive Microvascular Assessment in Individuals at High Risk of Cardiovascular Disease From the SCAPIS2 Study
Microvascular dysfunction, particularly endothelial dysfunction, is increasingly recognized as a key mechanism underlying various cardiovascular diseases (CVD), including heart failure, ischemic heart disease, atherosclerosis…
- Trial name
- NCT07359768
- Where
- Sweden
- Volunteers
- 900 people
- Sponsor
- HJN Sverige AB/Neko Health
Heart Failure, Mild Cognitive Impairment
Impact of Yoga on Cognitive Function
Mild cognitive impairment is highly prevalent in patients with heart failure and results in poor well-being and quality of life.
- Trial name
- NCT06434168
- Testing
- Yoga intervention, Control condition
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Auburn University
Cognitive Impairment, Depression, Anxiety
intErnet-based iNterventions FOR Cardiac arrEst suRvivors
This randomized clinical trial will test whether an internet-based lifestyle intervention administered through a web app can foster Health Related Quality of Life in patients who survived an out-of-hospital cardiac arrest and…
- Conditions
- Cognitive Impairment, Depression, Anxiety, Cardiac Arrest, Quality of Life
- Trial name
- ENFORCER (NCT06395558)
- Testing
- Lifestyle intervention
- Where
- 2 sites in Italy
- Volunteers
- 106 people
- Sponsor
- Azienda Usl di Bologna
Pulmonary Hypertension
PET/MR Pre- and Post Radiotherapy for Cardiopulmonary Dysfunction Evaluation
Radiotherapy (RT) is a well-known and established therapy or adjuvant therapy for the treatment of thoracic cancer It uses a high energy radiation from x-rays, gamma rays and other charged particles that assist in damaging the…
- Trial name
- NCT04901884
- Testing
- PET/MR with 18F-FDG
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Overweight, Obesity
Fat-Associated Cardiovascular Organ Dysfunction
This is an observational study of cardiovascular risk factors and arterial or cardiac function in subjects with overweight or obesity.
- Trial name
- FATCOR (NCT02805478)
- Testing
- There is no intervention
- Where
- Norway
- Volunteers
- 618 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Right Ventricular Dysfunction
TEE 3D RV Assessment for SAVR, Mini AVR, and TAVR
Three-dimensional echocardiography has become a gold standard to assess right ventricular (RV) function, and investigators plan to use 3D transesophageal echocardiography to assess RV function in 3 types of aortic valve…
- Trial name
- NCT05804240
- Testing
- 3D TEE RVEF
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Thomas Jefferson University
Stroke
Coughing in Infratentorial Brain Lesion Patients
To record diaphragm excursion in infratentorial brain lesions patients with dysphagia during coughing and compare them to those with supratentorial brain lesion patients with dysphasia and those with no dysphagia at a university…
- Trial name
- NCT02081040
- Testing
- Not applicable (observational study with no active intervention)
- Where
- South Korea
- Volunteers
- 42 people
- Sponsor
- The Catholic University of Korea
Lung Transplant Failure
Lung PGD Biomarkers in Organ Donors
PGD is a syndrome characterized by alveolocapillary barrier structural and functional alterations with surfactant inactivation and vascular permeability increase, which cause lung edema, parenchymal infiltrate and progressive…
- Trial name
- NCT03089489
- Testing
- lung biomarkers in organ donor for PGD in lung recipient
- Volunteers
- 50 people
- Sponsor
- University Hospital of Mont-Godinne
Embolic Stroke, Postoperative Cognitive Dysfunction
Perfusion Pressure Cerebral Infarction Trial (PPCI)
STUDY HYPOTHESIS In cardiac surgery the volume of perioperative cerebral infarctions can be reduced by increasing mean arterial pressure (MAP) during the cardiopulmonary bypass procedure.
- Trial name
- PPCI (NCT02185885)
- Testing
- Increased bloodpressure during CPB.
- Where
- Denmark
- Volunteers
- 197 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Aortic Valve Stenosis, Ventricular Dysfunction, Left
Ventriculo-arterial Coupling Modification Evaluated by PRAM During TAVI Procedure
Calcified aortic stenosis is the most frequent valvulopathy in Europe and North America. Aortic stenosis is an obstacle to the ejection of blood from the left ventricle to the aorta and leads to morphological changes in the left…
- Trial name
- PRAM-TAVI (NCT03385785)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Central Hospital, Nancy, France
Behçet Disease, Behcet Syndrome
Erectile Dysfunction in Patients With Non Ocular Behçet's Disease
It was aimed to demonstrate whether erectile dysfunction is affected by BH pathogenesis and whether there is a relationship between erectile dysfunction and BD pathogenesis by assessing both sexual function and retinal…
- Conditions
- Behçet Disease, Behcet Syndrome, Erectile Dysfunction
- Trial name
- NCT04386824
- Testing
- Erectil dysfunction
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Antalya Training and Research Hospital
Sinus Node Dysfunction, Atrial Fibrillation
Atrial Fibrillation With Sinus Node Dysfunction: Intensive Device Follow-up
The study will try to access the efficacy of atrial pacing, medication and radiofrequency ablation in treating patients with paroxysmal atrial fibrillation and sinus node dysfunction; to identify the response to these treatments…
- Trial name
- SAFE PAF-SND (NCT03607123)
- Testing
- programing of pacemaker, AF ablation, Anti arryhthmic drugs
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Cognitive Impairment, Stroke
Strategy Training on Improving Executive Functions in Persons Following Acquired Brain Injury
About two-third individuals with acquired brain injury (ABI) experience cognitive impairments. Deficits in executive functions is one of the most prevalent cognitive impairments following ABI which result in decline of recovery…
- Conditions
- Cognitive Impairment, Stroke, Acquired Brain Injury
- Trial name
- NCT04033952
- Testing
- Strategy Training
- Where
- 3 sites in Taiwan
- Volunteers
- 180 people
- Sponsor
- Taipei Medical University
Takotsubo Cardiomyopathy
The Broken Heart Study II (BHS-II)
The goals of this study are as follows: 1. To rigorously establish and characterize heterogeneity in the pathophysiology of Takotsubo Syndrome (TS). 2.
- Trial name
- BHS (NCT04325321)
- Testing
- Stress reactivity test
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- The Miriam Hospital
Cognitive Decline, Dementia, Vascular
Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet in Stroke Patients Patients
To test the effects of a 2- to 3-year intervention of the MIND diet versus usual post-stroke care on cognitive decline, the characteristic feature of dementia, and on brain biomarkers of Alzheimer's Disease (AD) and vascular…
- Conditions
- Cognitive Decline, Dementia, Vascular, Alzheimer Disease, Dementia
- Trial name
- NCT04337255
- Testing
- Behavioral Dietary intervention ( MIND Diet), Behavioral Usual Care Diet Intervention
- Where
- United States
- Volunteers
- 266 people
- Sponsor
- Rush University Medical Center
Sleep Apnea, Arrhythmias, Cardiac
Sleep Apnea Diagnosis Using a Novel Pacemaker Algorithm and Link With Aldosterone Plasma Level in Patients Presenting With Diastolic Dysfunction
Little is known about potential relationships between sleep apnea, plasma aldosterone and diastolic dysfunction which is a very frequent finding among patients requiring permanent cardiac pacing.
- Conditions
- Sleep Apnea, Arrhythmias, Cardiac, Cardiac Diastolic Function, Hyperaldosteronism
- Trial name
- SAPAAD (NCT02751021)
- Testing
- pacemaker diagnostic algorithm, Attended cardiorespiratory sleep study
- Where
- France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Caen
Angioedema, Angioedemas, Hereditary
Angioedema Biomarker Research Study
This clinical trial aims to evaluate and compare novel and commercially available diagnostic assays through blood tests for the differential diagnosis and comprehensive assessment of patients experiencing recurrent angioedema…
- Conditions
- Angioedema, Angioedemas, Hereditary, Urticaria, Mastocytosis
- Trial name
- NCT06210698
- Testing
- Venipuncture
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Foundation For Rare Disease Research
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