Clinical trials: Cardiovascular Effects
Stroke
Vibroacoustic Therap in Patients With Stroke
PURPOSE: to investigate the effect of vibroacoustic therapy device with laser motion guidance affect balance sensory integration in patients with stroke BACKGROUND: Following stroke, motor recovery can be dictated by the degree…
- Trial name
- NCT07206485
- Testing
- vibro-acoustic therapy, Motion Guidance Laser, selected physical therapy exercises program
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- October 6 University
Rheumatoid Arthritis
Clinical Study Evaluating the Effect of Carvedilol in Patients With Active Rheumatoid Arthritis
This study aims at investigating the possible efficacy and safety of carvedilol as an adjunctive therapy in patients with active rheumatoid arthritis and hypertension.
- Trial name
- NCT06108518
- Testing
- Carvedilol
- Volunteers
- 70 people
- Sponsor
- Tanta University
Congestive Heart Failure
Study of Sildenafil in Advanced Heart Failure.
Despite advances in medical therapy for patients with heart failure, one-third of patients remain limited by fatigue and shortness of breath.
- Trial name
- NCT00309790
- Testing
- sildenafil
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Stroke
Cognitive Training After Stroke : Effects and Mechanisms
Stroke is a major cause of severe cognitive and physical disability. Despite the high and increasing incidence, and large health, economic, social and personal consequences, studies designed to remedy cognitive impairments and…
- Trial name
- NCT04932304
- Testing
- Transcranial direct current stimulation (tDCS)
- Where
- 2 sites in Norway
- Volunteers
- 54 people
- Sponsor
- Oslo University Hospital
Abdominal Aortic Aneurysm
Endoprosthesis Treatment Effects on Human Abdominal Aorta Aneurysms (AAA) Metabolic Activity
The purpose of this study is to determine whether Positron Emission Tomography imaging can help to predict the evolutivity of AAA treated with endovascular prosthesis.
- Trial name
- AAAendo (NCT01253252)
- Testing
- [18F] Fluorodeoxyglucose PET Scan Imaging, CT scan, Blood sampling for biological investigations
- Where
- 7 sites in France
- Volunteers
- 45 people
- Sponsor
- Central Hospital, Nancy, France
Hypertension
H-Type Hypertension Precision Medicine Trial
This is a multicenter, randomized, double-blind, controlled clinical trial. It aims to investigate the effects of different doses of folic acid on lowering homocysteine (Hcy) in patients with hypertension with different genotypes…
- Trial name
- NCT03472508
- Testing
- Folic Acid, Enalapril Maleate and Folic Acid Tablets (Yiye), Enalapril
- Where
- 5 sites in China
- Volunteers
- 3,600 people
- Sponsor
- Shenzhen Ausa Pharmed Co.,Ltd
Genetics Disease, Type2 Diabetes
Effects of Sitagliptin in Individuals With Genetically Decreased DPP4
This is a pilot clinical trial to test the hypothesis that during sitagliptin (DPP4 inhibitor), individuals heterozygous for DPP4 loss of function variants will have a reduction in DPP4 activity and antigen, lower glucose after a…
- Conditions
- Genetics Disease, Type2 Diabetes, Heart Failure
- Trial name
- NCT04323189
- Testing
- Sitagliptin 100mg
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Coronary Artery Disease, Optical Coherence Tomography
Effect of PCSK9 Inhibitors on Coronary Atherosclerotic Plaques Derived From Optical Coherence Tomography
The presence of coronary atherosclerotic vulnerable plaque significantly impacts the clinical outcomes of patients diagnosed with coronary artery disease (CAD).
- Trial name
- NCT06520904
- Testing
- PCSK9 inhibitor, Statin
- Where
- China
- Volunteers
- 396 people
- Sponsor
- First Affiliated Hospital of Xinjiang Medical University
Diabetes Mellitus - Type 1, Diabetes Mellitus - Type 2
Diabetes Visual Function Supplement Study
This study will evaluate the effects of a novel multi-component dietary supplement on the visual function and retinal structure of patients with diabetes with both no diabetic retinopathy and mild to moderate diabetic…
- Conditions
- Diabetes Mellitus - Type 1, Diabetes Mellitus - Type 2, Non-proliferative Diabetic Retinopathy
- Trial name
- DiVFuSS (NCT01646047)
- Testing
- multi-component nutritional supplement capsules, multi-component dietary supplement
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- ZeaVision, LLC
Hypertension
Effect of Lacidipine and Losartan on 24 Hour Systolic Blood Pressure Variability in Elderly Hypertensive Patients
The aim of this study is to evaluate the effect of lacidipine and losartan in elderly hypertensive patients on reducing the 24 hour systolic BP variability, which is one of the potential parameter to consider in treating elderly…
- Trial name
- NCT00533858
- Testing
- lacidipine (4 mg) or losartan (50 mg)
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Seoul National University Hospital
COVID-19 Pandemic, Diabetes
Study on the Effect of Incentive Spirometer-based Respiratory Training on the Long COVID-19
The COVID-19 pandemic has emerged as the most significant public health crisis of the 21st century. As of the end of January 2023, global confirmed cases have exceeded 670 million, with a domestic cumulative total of 10.24…
- Conditions
- COVID-19 Pandemic, Diabetes, Hypertension, Cardiac Disease
- Trial name
- NCT06231225
- Testing
- Incentive Spirometer respiratory training
- Volunteers
- 100 people
- Sponsor
- National Taipei University of Nursing and Health Sciences
Hemorrhoids
Ligasure Hemorrhoidectomy Versus Open Hemorrhoidectomy
This is a single center randomized clinical trial comparing Ligasure Hemorrhoidectomy and Open Hemorrhoidectomy for the treatment of prolapsing haemorrhoids.
- Trial name
- NCT04139876
- Testing
- Open Haemorrhoidectomy, LigaSure Hemorrhoidectomy
- Where
- Denmark
- Volunteers
- 70 people
- Sponsor
- Holbaek Sygehus
Cardiovascular Diseases
Prehabilitation's Effect on Skeletal Muscle Mass in Cardiac Patients
The study will investigate the effect prehabilitation on skeletal muscle mass via a scanner.
- Trial name
- NCT06624774
- Testing
- Prehabilitation
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Manchester Metropolitan University
Coronary Artery Disease
Effect of Rotablator on Balloon Resistant Calcified Coronary Lesion
The optimal treatment of calcified coronary lesion remained to be elucidated. A Prospective, randomized controlled trial was perform to explore the immediate effect and long-term outcome of rotational atherectomy in patients with…
- Trial name
- NCT01887704
- Testing
- Rotablator, conventional angioplasty, stenting
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Capital Medical University
Hypertension, Pulmonary
Multidisciplinary Collaboration Care in Pulmonary Arterial Hypertension (PAH)
Pulmonary arterial hypertension (PAH) is a severe pulmonary vascular affection, which treatment has evolved in the last few years, improving quality of life. However, adherence to treatment has not been assessed in such patients.
- Trial name
- ETHAP (NCT01038284)
- Testing
- Patient education, Data collection
- Where
- 11 sites in France
- Volunteers
- 101 people
- Sponsor
- University Hospital, Grenoble
Children, Haemodialysis
Haemodiafiltration vs Conventional Haemodialysis in Children
Children on conventional haemodialysis (HD) die of heart disease. Also, they can be malnourished and short. Haemodiafiltration (HDF) is a newer type of dialysis that achieves better removal of toxins and excess fluid than HD.
- Conditions
- Children, Haemodialysis, Haemodiafiltration
- Trial name
- 3H (NCT02063776)
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Myocardial Infarction
GLP-1 on Non-ST-Segment Elevation Myocardial Infarction
The investigators planned to evaluate the effects of liraglutide on left ventricular function in patients with non-ST-segment elevation myocardial infarction (NSTEMI).
- Trial name
- NCT02577848
- Testing
- GLP-1
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Chinese PLA General Hospital
Wilms Tumor, Neuroblastoma
Pharmacokinetic Study of Doxorubicin in Children With Cancer
Analyze pharmacokinetics of doxorubicin in children with cancer. Furthermore investigate the predictive role of troponin and natriuretic peptides for anthracycline-induced cardiotoxicity .
- Conditions
- Wilms Tumor, Neuroblastoma, Soft Tissue Sarcoma, Acute Lymphoblastic Leukemia
- Trial name
- Doxo (NCT01095926)
- Testing
- doxorubicin
- Where
- 23 sites in France, Germany and 2 more
- Volunteers
- 101 people
- Sponsor
- University Hospital Muenster
Atrial Fibrillation
Landiolol in Postoperative Atrial Fibrillation
Postoperative atrial fibrillation is a common complication after cardiac surgery and is associated with an elevation of morbidity and mortality. The recommended treatment includes heart rate control with a beta blocker.
- Trial name
- MMELPOAF (NCT03779178)
- Testing
- Landiolol
- Where
- France
- Volunteers
- 58 people
- Sponsor
- Hospices Civils de Lyon
Central Retinal Vein Occlusion
Retinal Ischemia in Central Retinal Vein Occlusion, and the Effects of Treatment With Intravitreal Ranibizumab
Recent studies have shown a remarkably positive effect of 6 monthly injections of Ranibizumab on eyes with CRVO. The disease may cause severe sight threatening complications, partly due to restrictions in blood flow and…
- Trial name
- LuRVO (NCT01360385)
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- Glostrup University Hospital, Copenhagen