Clinical trials: Cardiovascular Effects
Hypertension, Pulmonary, Ventricular Dysfunction, Left
Hemodynamic and Echocardiographic Assessment of Riociguat Effects on Myocardial Wall Contractility and Relaxation Kinetics
The aim of this study is to assess whether oral Riociguat affects the left ventricular contractility and relaxation in patients with pulmonary hypertension associated with left ventricular systolic dysfunction
- Trial name
- HEARTWORK (NCT01065051)
- Testing
- Riociguat (Adempas, BAY63-2521)
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Bayer
Diabetes Mellitus, Amputation Stumps
Phototherapy in DM Amputation Ulcers.
Diabetes mellitus is a major public health problem and it is estimated that 300 million individuals will be affected by the year 2030.
- Conditions
- Diabetes Mellitus, Amputation Stumps, Diabetic Foot
- Trial name
- NCT02883751
- Testing
- LED, Control group
- Where
- Brazil
- Sponsor
- University of Nove de Julho
Cardiovascular Diseases (CVD), Drug Effect
Randomized Comparison of Morning Versus Bedtime Administration of Statins: A Cardiovascular Circadian Chronotherapy (C3) Trial
Statins inhibit hydroxy-methylglutaryl coenzyme A (HMG-CoA) reductase which catalyzes the rate-limiting step in cholesterol synthesis.
- Conditions
- Cardiovascular Diseases (CVD), Drug Effect, Atherosclerosis Cardiovascular Disease
- Trial name
- STATIN-C3 (NCT06856772)
- Testing
- Statin in the evening (such as Simvastatin, Atorvastatin, Rosuvastatin, Pravastatin), Statin in the morning (such as Simvastatin, Atorvastatin, Rosuvastatin, Pravastatin)
- Where
- Denmark
- Volunteers
- 42,000 people
- Sponsor
- Tor Biering-Sørensen
Acute Ischemic Stroke, Intracranial Atherosclerosis ICAS
Effect of Balloon Angioplasty vs Stenting Following Residual Stenosis After Endovascular Treatment of Intracranial Atherosclerotic Acute Ischemic Stroke
The ANGEL-ICAS trial is a multicenter, prospective, randomized, open-label, blinded-endpoint study designed to determine whether rescue balloon angioplasty is noninferior to rescue stenting in patients with intracranial…
- Trial name
- ANGEL-ICAS (NCT07026331)
- Testing
- balloon angioplasty, Stent
- Where
- China
- Volunteers
- 486 people
- Sponsor
- Beijing Anzhen Hospital
Stroke
NeuroReAlign Therapy for Balance and Gait Rehabilitation in Stroke Survivors
The goal of this randomized controlled trial is to investigate the effects of NeuroReAlign Therapy on balance and gait in stroke survivors in the chronic stage (>6 months).
- Trial name
- NCT06849102
- Testing
- NeuroReAlign Therapy, conventional physiotherapy interventions
- Volunteers
- 30 people
- Sponsor
- Middle East University
Metabolic X Syndrome, Overweight
Effects of a Bakery Product Enriched With Fibre and L-carnitine on Insulin Resistance in Patients With Metabolic Syndrome
The aim of this study was to evaluate the efficacy of a bakery product enriched with dietary fibre and L-carnitine on glucose homeostasis and insulin sensitivity in overweight patients with or without metabolic syndrome.
- Conditions
- Metabolic X Syndrome, Overweight, Dyslipidemias
- Trial name
- NCT02281253
- Testing
- dietary fibre plus L-carnitine bread
- Volunteers
- 54 people
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
Persistent Atrial Fibrillation
Acupuncture in Persistent Atrial Fibrillation
The aim of this trial is to evaluate the effect of acupuncture on prevention of atrial fibrillation (AF) recurrence after electrical cardioversion (EC) for persistent AF patients resistant to the antiarrhythmic drugs (AADs).
- Trial name
- NCT02110537
- Testing
- Active Acupuncture, flecainide
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Kyunghee University Medical Center
Stroke, Hemiplegia
Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) Over the Brain on the Neurotransmitter Binding
The purpose of this study is to determine whether repetitive transcranial magnetic stimulation (rTMS) over the brain can modulate the binding of neurotransmitter (GABA in this study) to its receptor using the special PET study.
- Trial name
- NCT01819675
- Testing
- Low frequency rTMS, High frequency rTMS
- Where
- South Korea
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Stroke
The Effect of Optic Flow During Treadmill Walking on the Gait Pattern in People Post-stroke
The aim of this study is to investigate the onset, magnitude and duration of the effect of manipulating the optic flow on the gait pattern during Virtual Reality (VR)-enhanced treadmill walking compared to treadmill walking…
- Trial name
- NCT03898375
- Testing
- Walking with different optic flow speeds
- Where
- Belgium
- Volunteers
- 2 people
- Sponsor
- Vrije Universiteit Brussel
Myocardial Infarction
Anti-inflammatory Effects of Intracoronary and Intravenous Abciximab Administration During Primary Percutaneous Coronary Intervention
Intracoronary abciximab administration during primary percutaneous coronary intervention (pPCI) could offer clinical advantages over the intravenous route.
- Trial name
- NCT01757457
- Testing
- Intracoronary administration of an abciximab bolus during primary PCI, Intravenous administration of an abciximab bolus during primary PCI
- Where
- Italy
- Volunteers
- 89 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Peripheral Arterial Disease, Intermittent Claudication
The Effects of Metformin on Functional Capacity in Individuals With Peripheral Artery Disease-Related Intermittent Claudication
The purpose of this study is to determine the effects of metformin on functional capacity (pain-free and maximum walking times) in individuals with peripheral artery disease (PAD)-related intermittent claudication.
- Trial name
- NCT01799057
- Testing
- Metformin
- Where
- Australia
- Volunteers
- 2 people
- Sponsor
- Baker Heart and Diabetes Institute
Ischemic Mitral Regurgitation
Serotonin Receptor Blockers in Ischemic Mitral Regurgitation
This study is intended to investigate the effect of cyproheptadine (a 5HT2B receptor blocker) on mitral regurgitation severity.
- Trial name
- CYPRO-MR (NCT05469165)
- Testing
- Cyproheptadine 4 Mg Oral Tablet
- Where
- Canada
- Volunteers
- 214 people
- Sponsor
- Laval University
Cardiovascular Disease
The Effects of Peanuts and Peanut Products on Glucose Control and Vascular Function
Pilot study data have demonstrated that peanuts ameliorate the postprandial glucose and insulin response when incorporated into an acute high fat/high glucose meal.
- Trial name
- NCT01405300
- Testing
- Control, Peanut
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Penn State University
Peripheral Arterial Disease(PAD)
Effect of Anticoagulant and Antiplatelet Drug Intervention on Postoperative Major Adverse Events in Patients with PAD：Phase II
This study is a multicenter, prospective, observational research project. It is anticipated to enroll a total of 6,000 patients between February 1, 2025, and January 31, 2028 (with completion of one-year postoperative follow-up…
- Trial name
- NCT06850207
- Volunteers
- 6,000 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Ischemic Stroke, Stroke Rehabilitaion
Neurological Rehabilitation and Neuroplasticity After Ischemic Stroke
This observational study evaluates the effects of neurological rehabilitation on biological markers associated with neuroplasticity and neurotransmitter profiles in patients after ischemic stroke.
- Trial name
- NCT07899710
- Volunteers
- 60 people
- Sponsor
- Medical University of Lodz
Obstructive Sleep Apnea of Adult
Effect of Continuous Positive Airway Pressure on Chronotype, Dietary Intake, and Cardiovascular Risk Markers
In this study the investigators will evaluate chronotype, food intake pattern, and cardiovascular risk markers of elder individuals with OSA, in use of CPAP, when submitted to two weeks of CPAP withdrawal.
- Trial name
- NCT04262960
- Testing
- Device: active CPAP
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Cardiovascular Mortality, Cardiac Function
Intervention With Selenium and Q10 on Cardiovascular Mortality and Cardiac Function in the Elderly Population in Sweden
The dietary supplements selenium and Q10 has been evaluated in a double blind placebo-controlled study in an elderly Swedish population.
- Trial name
- KiSel-10 (NCT01443780)
- Testing
- Selenium and ubiquinon (Q10) combined
- Where
- Sweden
- Volunteers
- 443 people, healthy volunteers welcome
- Sponsor
- University Hospital, Linkoeping
Coronary Artery Disease (CAD)
Caffeine's Effect on Regadenoson Administration With Single Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging (MPI)
Observe whether the administration of caffeine prior to regadenoson will affect the interpretation of test results in subjects with coronary artery disease (CAD) undergoing SPECT MPI
- Trial name
- NCT00826280
- Testing
- regadenoson, overencapsulated caffeine, technetium
- Where
- 25 sites in United States
- Volunteers
- 347 people
- Sponsor
- Astellas Pharma Inc
Chronic Obstructive Pulmonary Disease, Pulmonary Hypertension
Sildenafil Effects on Pulmonary Haemodynamics and Gas Exchange in Chronic Obstructive Pulmonary Disease (COPD)
Sildenafil is a phosphodiesterase-5 inhibitor that has been approved for the treatment of pulmonary arterial hypertension with orphan drug designation. Sildenafil modulates the nitric oxide (NO) pathway in the vessel wall.
- Trial name
- SIL-COPD-01 (NCT00491803)
- Testing
- Sildenafil
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Hospital Clinic of Barcelona
Hypertension, Laughter Yoga
The Effect of Laughter Yoga Practice in Hypertension Patients
Hypertension (HT), which is defined as an arterial blood pressure higher than 140/90 mmHg, is an important health problem because it causes serious complications and is commonly seen in the community.
- Trial name
- HT-Laughter (NCT07148869)
- Testing
- LAUGHTER YOGA, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kilis 7 Aralik University