Clinical trials: Cardiovascular Event
Cardiovascular Disease
Comprehensive Rimonabant Evaluation Study of Cardiovascular ENDpoints and Outcomes
The primary objective is to show whether rimonabant reduces the risk of a heart attack (MI), stroke, or death from an MI or stroke in patients with abdominal obesity with other cardiovascular (CV) risk factors.
- Trial name
- CRESCENDO (NCT00263042)
- Testing
- Rimonabant
- Where
- 43 sites in United States, Argentina and 41 more
- Volunteers
- 18,695 people
- Sponsor
- Sanofi
Coronary Artery Disease, ST-segment Elevation Myocardial Infarction
Post-Marketing Safety Study in ST-Segment Elevation Myocardial Infarction (STEMI) Participants Undergoing Primary Percutaneous Coronary Intervention (PCI) Procedure With VISIPAQUE® as the Contrast Medium
The purpose of this study is to prospectively observe the incidence rate of acute kidney injury (AKI), major adverse renal and cardiovascular events (MARCE) in participants who were diagnosed with ST-segment elevation myocardial…
- Trial name
- NCT03671603
- Testing
- Iodixanol
- Where
- 36 sites in China, South Korea
- Volunteers
- 2,755 people
- Sponsor
- GE Healthcare
Cardiovascular Diseases, Heart Diseases
Epidemiology of Insulin Growth Factor (IGF) and Cardiovascular Events
To explore the role of insulin growth factor in cardiovascular disease in older men and women.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Myocardial Infarction
- Trial name
- NCT00086424
- Volunteers
- 5,888 people
- Sponsor
- Albert Einstein College of Medicine
Major Adverse Cardiovascular Events (MACE), Prevention
Serial Coronary CTA-based Plaque Progression Detection for Management of Coronary Heart Disease
The primary objective of this study is to evaluate whether a management strategy based on coronary computed tomography angiography (CCTA) for patients with non-obstructive coronary artery disease can improve the LDL-C target…
- Conditions
- Major Adverse Cardiovascular Events (MACE), Prevention, Coronary Artery Disease(CAD), CT Angiography
- Trial name
- SUCCESS (NCT06843005)
- Testing
- Coronary Computed Tomography Angiography, Current clinical guidelines
- Where
- China
- Volunteers
- 3,100 people
- Sponsor
- Zhang longjiang,MD
Glucose Metabolism Disorders, Coronary Artery Disease
Acarbose and Secondary Prevention After Coronary Stenting
The purpose of this study is to determine whether the intervention for newly diagnosed abnormal glucose tolerance after coronary stenting will improve the long-term clinical outcome.
- Trial name
- NCT00221156
- Testing
- Acarbose
- Where
- 3 sites in Japan
- Volunteers
- 300 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Coronary Artery Disease, In-stent Restenosis
CT-FFR-guided Strategy for In-stent Restenosis
This study will be a prospective, randomized clinical trial to compare standard practice guided by usual care testing to CT-FFR-guided management in patients with in-stent restenosis.
- Trial name
- NCT05611190
- Testing
- CT-FFR, Usual Care
- Volunteers
- 294 people
- Sponsor
- Yan'an Affiliated Hospital of Kunming Medical University
Ischemic Stroke, Acute
Emergency Stroke Unit for Acute Cerebrovascular Events ( ESU-ACE-A )
To compare the door-to-needle time of patients with hyperacute ischemic stroke (within 4.5 hours after the onset of symptoms) managed in a standard stroke unit adherent to guidelines versus managed in Emergency Stroke Unit (a new…
- Trial name
- NCT06492239
- Testing
- Emergency Stroke Unit based on 0.23-T MRI, Standard stroke unit adherent to guidelines
- Where
- China
- Volunteers
- 218 people
- Sponsor
- Beijing Tiantan Hospital
Cardiovascular Disease, Peripheral Artery Disease
Platelet Activity in Vascular Surgery and Cardiovascular Events
Pathological and clinical studies have consistently demonstrated that abnormalities in thrombosis and hemostasis play a major role in the pathogenesis of atherosclerosis and atherothrombosis.
- Conditions
- Cardiovascular Disease, Peripheral Artery Disease, Critical Limb Ischemia
- Trial name
- PACE (NCT02106429)
- Where
- United States
- Volunteers
- 246 people
- Sponsor
- NYU Langone Health
Cardiovascular Diseases
ASpirin Use and stAtin Strategy for Primary Prevention in Severe Coronary Calcium Score on Computed Tomography
The primary objective of the ASA-3C trial is to evaluate the role of aspirin and high-intensity statin therapy, respectively, in individuals with severe coronary calcification (coronary calcium score ≥300) to prevent…
- Trial name
- ASA-3C (NCT06676280)
- Testing
- Aspirin, High-intensity statin, Guideline-directed statin therapy
- Where
- 32 sites in South Korea
- Volunteers
- 5,000 people
- Sponsor
- Jung-min Ahn
Ischemic Attack, Transient, Stroke
Systematic Follow up of Drug Treatment by Pharmacists in Secondary Prevention After Transient Ischemic Attack
Use of drugs is an important factor in secondary prophylaxis after transient ischemic attack (TIA), but studies show that adherence to the prescribed drugs is often poor.
- Trial name
- NCT02089074
- Testing
- Drug use counselling
- Where
- 6 sites in Norway
- Volunteers
- 265 people
- Sponsor
- Norwegian University of Science and Technology
Diabetic Foot Ulcers
Clinical Efficacy of Platelet Gel From Cord Blood for the Treatment of Diabetic Foot Ulcers
A novel method (PCT n. WO 2010/007502 A2, 2010) has been developed to obtain platelet gel from umbilical cord blood (CBPG). The main advantages so far identified in CBPG as compared to platelet gel derived from adult platelets…
- Trial name
- CBPG-DFU (NCT02389010)
- Testing
- Allogeneic cord blood platelet gel-CBPG, Standard Local Medications-SLM
- Where
- 9 sites in Italy, Spain
- Volunteers
- 50 people
- Sponsor
- Centro Nazionale Sangue
Severe Obstructive Sleep Apnea (Apnea Hypopnea Index > 30 Events/Hour), Hypertension
Study of Cardiovascular Disease and Obstructive Sleep Apnea
The purpose of this study is to determine if two medicines (allopurinol and losartan) can influence heart and blood vessel health compared to placebo in patients with sleep apnea who are using continuous positive airway pressure…
- Trial name
- CVD/OSA (NCT01637623)
- Testing
- Losartan, Allopurinol
- Where
- 4 sites in United States
- Volunteers
- 87 people
- Sponsor
- University of Wisconsin, Madison
Cardiovascular Disease
Impact of Text Messages to Promote Secondary Prevention After Acute Coronary Syndrome
The study is a two-arm, parallel, randomized clinical trial. The purpose of the study is to evaluate the effectiveness of automated mobile phone text message-based intervention for secondary prevention after acute coronary…
- Trial name
- IMPACS (NCT03414190)
- Testing
- Mobile phone text message
- Where
- Brazil
- Volunteers
- 160 people
- Sponsor
- Federal University of Minas Gerais
Atrial Fibrillation
Comparison of External Event Recorders for Atrial Fibrillation Monitoring
Ablation of atrial fibrillation is a well established treatment method to restore normal sinus rhythm and eliminate the need for continued antiarrhythmic therapy and anticoagulation.
- Trial name
- NCT00863382
- Testing
- Standard Event Monitor, Sleuth Monitor
- Where
- United States
- Sponsor
- Dhanunjaya Lakkireddy, MD, FACC
Hemodialysis Complication
Alpha Lipoic Acid Against Cardiovascular Events in Patients With Haemodialysis
Evaluate the association between possible benefit effects of oral administration of alpha lipoic acid by patients with hemodialysis and the possible reduction in cardiovascular events (CVEs); using Advanced glycation end products…
- Trial name
- NCT03912727
- Testing
- Alpha-Lipoic acid plus renal replacement therapy, renal replacement therapy
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Rehab Werida
Coronary Computed Tomography Angiography, Stable Chest Pain
CCTA Improves Clinical Management of Stable Chest Pain
The investigator aims to prospectively enroll patients who were referred for coronary computed tomography angiography (CCTA) for the assessment of stable chest pain (SCP) suspected of obstructive coronary artery disease (CAD).
- Conditions
- Coronary Computed Tomography Angiography, Stable Chest Pain, Optimal Medical Therapy, Invasive Coronary Angiography
- Trial name
- CICM-SCP (NCT04691037)
- Testing
- CCTA
- Where
- 4 sites in China
- Volunteers
- 50,000 people
- Sponsor
- Tianjin Chest Hospital
Posttraumatic Stress Disorder, Myocardial Infarction
EMDR Treatment in PTSD Following Cardiac Events
Cardiac events can often result in debilitating and persistent psychological symptoms. A key question involves whether optimal treatment of cardiac-induced posttraumatic stress disorder (PTSD) reduces PTSD symptoms and thereby…
- Conditions
- Posttraumatic Stress Disorder, Myocardial Infarction, Eye Movement Desensitization and Reprocessing
- Trial name
- EMDR_PTSD_MI (NCT04672551)
- Testing
- EMDR Treatment
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- University of Zurich
Deep Vein Thrombosis, Pulmonary Embolus, Colon Cancer
VTE Incidence After Curative Colon Cancer Surgery in an ERAS Program
Based on data on a cohort of 2,141 patients undergoing elective colonic cancer resection in an ERAS program, the incidence of postoperative thromboembolic events is estimated in patients no receiving prolonged thromboembolic…
- Trial name
- NCT06009484
- Testing
- Colon resection
- Volunteers
- 2,141 people
- Sponsor
- Nordsjaellands Hospital
Peripheral Arterial Disease(PAD)
Effect of Anticoagulant and Antiplatelet Drug Intervention on Postoperative Major Adverse Events in Patients with PAD：Phase II
This study is a multicenter, prospective, observational research project. It is anticipated to enroll a total of 6,000 patients between February 1, 2025, and January 31, 2028 (with completion of one-year postoperative follow-up…
- Trial name
- NCT06850207
- Volunteers
- 6,000 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Intracranial Hemorrhages
Colchicine for the Prevention of Vascular Events After an Acute Intracerebral Hemorrhage
The overall goal is to establish the safety and efficacy of colchicine in ICH patients for the prevention of major cardiovascular events and brain injury.
- Trial name
- CoVasc-ICH (NCT05159219)
- Testing
- Colchicine Pill
- Where
- 11 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Population Health Research Institute
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