Clinical trials: Cardiovascular Event
MASLD, Cardiovascular (CV) Risk
Integrated Ultrasound-Derived Fat Fraction and 2D/4D HeartAI for Cardiovascular Risk Management in Patients With MASLD
This prospective observational cohort study aims to evaluate the association between liver fat fraction measured by ultrasound-derived fat fraction (UDFF) and cardiac functional parameters assessed by 2D and 4D HeartAI in adult…
- Conditions
- MASLD, Cardiovascular (CV) Risk, Subclinical Cardiovascular Impairments
- Trial name
- MUCHAI (NCT07545343)
- Where
- China
- Volunteers
- 700 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Monoclonal Gammopathy of Undetermined Significance (MGUS), Myelodysplastic Syndromes
Study of MGUS, Smoldering Myeloma, Early MDS and CLL to Assess Molecular Events of Progression and Clinical Outcome
Blood cancers occur when the molecules that control normal cell growth are damaged. Many of these changes can be detected by directly examining parts of the cancer or cells in blood.
- Conditions
- Monoclonal Gammopathy of Undetermined Significance (MGUS), Myelodysplastic Syndromes, Hematological Malignancies, B-cell Malignancy, Low-grade
- Trial name
- NCT02269592
- Where
- 7 sites in United States
- Volunteers
- 10,000 people
- Sponsor
- Dana-Farber Cancer Institute
Prostate Cancer
Randomized Study to Evaluate MACE in Patients With Prostate Cancer Treated With Relugolix or Leuprolide Acetate
This was a randomized study to evaluate the risk of major adverse cardiovascular events (MACE) for relugolix compared with leuprolide acetate. Enrollment in this study was discontinued by the Sponsor on 01 Dec 2023.
- Trial name
- NCT05605964
- Testing
- Relugolix, Leuprolide Acetate
- Where
- 108 sites in United States
- Volunteers
- 387 people
- Sponsor
- Sumitomo Pharma America, Inc.
Ischemic Heart Disease, Coronary Artery Disease
Electronic Letters to Improve Patient Activation in IHD: The NUDGE-IHD Trial
The goal of this clinical trial is to learn whether simple electronic information letters can increase patient activation and improve risk-factor monitoring in adults in Denmark with ischemic heart disease (IHD) who have LDL…
- Conditions
- Ischemic Heart Disease, Coronary Artery Disease, Hypercholesterolemia, Lipoprotein(a)
- Trial name
- NUDGE-IHD (NCT07382414)
- Testing
- LDL-C information letter, Lp(a) information letter
- Where
- Denmark
- Volunteers
- 123,000 people
- Sponsor
- Tor Biering-Sørensen
Myocarditis, Ventricular Arrhythmia
Image-Based Prediction of Ventricular Tachycardias in Post-Myocarditis Patients: an International Multicenter Case-control Study
Ventricular arrhythmias (VAs) are frequently associated with structural heart diseases (SHD) such as myocardial infarction, myocarditis, and non-ischemic cardiomyopathies.
- Trial name
- MYOCARDITIS-VT (NCT06730607)
- Where
- 3 sites in Italy, Spain
- Volunteers
- 150 people
- Sponsor
- Centro Medico Teknon
Liver Cirrhosis, Metabolic Syndrome
Precision Medicine to Predict the Trajectory of Liver Cirrhosis: Prospective Cohort Study
Preventing decompensation is a key endpoint in the management of compensate cirrhosis patients. The known factors that increases the risk of decompensation include the presence of clinically significant portal hypertension (CSPH)…
- Conditions
- Liver Cirrhosis, Metabolic Syndrome, Spleen; Fibrosis, Frailty
- Trial name
- NCT05899309
- Testing
- liver and spleen stiffness test and laboratory test
- Where
- Singapore
- Volunteers
- 80 people
- Sponsor
- Changi General Hospital
Chronic Kidney Disease Stage 5, Dialysis
An Evaluation of the KCCQ Score in Predicting Cardiovascular Risk in Dialysis Patients
Cardiovascular Disease (CVD) is the main complication and the most important cause of death in CKD patients. As the disease progresses, the incidence of cardiovascular disease in CKD patients gradually increases, especially in…
- Conditions
- Chronic Kidney Disease Stage 5, Dialysis, Heart Failure
- Trial name
- NCT06542016
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Shenzhen Second People's Hospital
Heart Failure, Congestive
PREVENT-HF: Prevention of Heart Failure Events With Impedance Cardiography Testing
The purpose of this study is to determine whether outpatient therapeutic management guided by impedance cardiography (ICG), in addition to standard clinical assessment, will result in a longer time in days to the first heart…
- Trial name
- NCT00409916
- Testing
- BioZ Dx
- Where
- 3 sites in United States
- Volunteers
- 500 people
- Sponsor
- CardioDynamics
Obstructive Sleep Apnea, Pulmonary Edema Cardiac Cause
Obstructive Sleep Apnea Treatment on Cardiovascular Events in Patients With Acute Cardiogenic Pulmonary Edema: CPAP-CARE STUDY.
Despite the advances in the treatment of acute cardiogenic pulmonary edema (ACPE), the readmissions rates and cardiovascular events remain very high.
- Trial name
- CPAP-CARE (NCT03936751)
- Testing
- CPAP, Nasal Strips
- Where
- 4 sites in Brazil
- Volunteers
- 150 people
- Sponsor
- University of Sao Paulo
Rheumatoid Arthritis, Cardiovascular Disease
Cardiovascular Outcomes in the VA's Rheumatoid Arthritis(VARA) Population
Rheumatoid arthritis (RA) is a symmetric, peripheral polyarthritis of uncertain etiology that can lead to joint deformity and destruction. However, the effects of RA are not confined simply to joint involvement.
- Conditions
- Rheumatoid Arthritis, Cardiovascular Disease, Coronary Disease
- Trial name
- NCT00431405
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- Dallas VA Medical Center
Ischemic Heart Disease, Stenotic Coronary Lesion
China Resolute Integrity 34/38 mm Study
To evaluate the clinical safety and efficacy in Chinese subjects, eligible for percutaneous transluminal coronary angioplasty (PTCA) in lesions amenable to treatment with a 34/38 mm Medtronic Resolute Integrity™…
- Conditions
- Ischemic Heart Disease, Stenotic Coronary Lesion, Cardiovascular Diseases, Arteriosclerosis
- Trial name
- NCT03118531
- Testing
- Resolute Integrity™ Zotarolimus-Eluting Coronary Stent System(34/38 mm)
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- Medtronic Vascular
ACS, Clonal Hematopoiesis of Indeterminate Potential
CHIP and Residual Cardiovascular Event Tendency After Smoking Cessation
In order to identify the association between clonal hematopoiesis of indeterminate potential (CHIP) and cardiovascular risks after smoking cessation, this study intends to recruit ACS patients undergoing complete…
- Conditions
- ACS, Clonal Hematopoiesis of Indeterminate Potential, Smoking Cessation
- Trial name
- CHIP-RETENTION (NCT04987268)
- Testing
- clonal hematopoiesis of indeterminate potential
- Where
- China
- Volunteers
- 1,029 people
- Sponsor
- Shenyang Northern Hospital
Intracranial Aneurysm
Guided Antiplatelet Therapy in Interventional Treatment of Intracranial Aneurysms
The use of intracranial stents expands the possibilities for endovascular treatment of intracranial aneurysms and improves the success rate. However, it also increases the risk of ischemic complications in patients.
- Trial name
- GATITIA (NCT05825391)
- Testing
- Adjustment of Antiplatelet Drugs
- Where
- 2 sites in China
- Volunteers
- 590 people
- Sponsor
- Beijing Tiantan Hospital
Heart; Dysfunction Postoperative, Cardiac Surgery, Genetic Predisposition to Disease
Identification of Genomic Predictors of Adverse Events After Cardiac Surgery
This study aims to identify genetic causes of adverse events after cardiac surgery, such as atrial fibrillation, myocardial infarction, renal dysfunction and heart failure.
- Conditions
- Heart; Dysfunction Postoperative, Cardiac Surgery, Genetic Predisposition to Disease, Atrial Fibrillation, Myocardial Infarction
- Trial name
- CABGGenomics (NCT01258231)
- Where
- 3 sites in United States
- Volunteers
- 4,000 people
- Sponsor
- Brigham and Women's Hospital
Heart Failure With Preserved Ejection Fraction
CHIP in Endothelial Dysfunction Associated With HEpEF
This study aims at identifying processes that are deregulated in blood cells by Clonal Hematopoiesis of Indeterminate Potential (CHIP) which are involved in the development of heart failure with preserved ejection fraction…
- Trial name
- CHiEF (NCT05828888)
- Volunteers
- 80 people
- Sponsor
- University Hospital, Bordeaux
Elevated Lipoprotein(a)
A Phase II, Randomized, Double-Blind, Placebo-Controlled Study of Oral SAL0137 in Adults With Elevated Lp(a) and Increased Risk of Cardiovascular Events
This is a randomized, double-blind, placebo-controlled Phase II trial evaluating the efficacy and safety of oral SAL0137 in adults with elevated Lp(a) and high cardiovascular risk.
- Trial name
- NCT07729475
- Testing
- SAL0137 Dose 1, SAL0137 Dose 2, SAL0137 Dose 3
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shenzhen Salubris Pharmaceuticals Co., Ltd.
Coronary Heart Disease, Diabetes
The Effect of Autonomic Neuropathy Status on the Endpoint Events in Diabetes Patients With Coronary Heart Disease and Sleep Apnea.
Background: diabetes combined with cardiac autonomic neuropathy (CAN) can denervate the heart, which may prevent patients with sleep apnea syndrome from bradycardia in the early stage, and directly show an increased risk of…
- Conditions
- Coronary Heart Disease, Diabetes, Sleep Apnea Syndrome, Cardiovascular Autonomic Neuropathy (CAN)
- Trial name
- NCT07723222
- Testing
- The total score of Ewing test (i.e. cardiovascular autonomic reflex test and heart rate variability) was ≥1, which was divided into cardiac autonomic neuropathy group (CAN grou
- Volunteers
- 326 people
- Sponsor
- Xiangtan Central Hospital
Migraine
TRiptan Use and Serious Vascular Events in Elderly Over 65 Years
This study will be conducted as a retrospective study of exposed and unexposed cohort of the French population included all beneficiaries aged 65 and older.
- Trial name
- TRUE (NCT02838537)
- Testing
- Exposure to Triptan, Exposure to Ergot
- Where
- France
- Volunteers
- 25,000 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Acute Myocardial Infarction (AMI), Percutaneous Coronary Intervention (PCI)
Trends and Risk Factors of Adverse Cardiovascular and Cerebrovascular Events After Primary PCI
This single-center, ambispective cohort study will use real-world data from Zhongshan Hospital, Fudan University. About 8,000 patients aged 18 years or older with acute myocardial infarction (AMI) who underwent primary…
- Trial name
- TRACE-pPCI (NCT07833995)
- Testing
- Collection of baseline characteristics
- Where
- China
- Volunteers
- 8,000 people
- Sponsor
- Shanghai Zhongshan Hospital
Myocardial Infarction, Stroke
Women's Health Initiative Strong and Healthy Study
The WHISH trial applies state-of-the science behavioral principles and currently available technologies to deliver a physical activity intervention without face-to-face contact to ~25,000 older U.S. women expected to consent.
- Conditions
- Myocardial Infarction, Stroke, Cardiovascular Mortality, Hip Fractures
- Trial name
- WHISH (NCT02425345)
- Testing
- Physical Activity
- Volunteers
- 49,331 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
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