Clinical trials: Cardiovascular Events, active
Interstitial Lung Disease, Venous Thromboembolism
Risk Factors of Venous Thrombotic Event in Interstitial Lung Disease
This study aims to determine the incidence of venous thromboembolic events (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), among hospitalized patients with interstitial lung disease (ILD).
- Conditions
- Interstitial Lung Disease, Venous Thromboembolism, Pulmonary Embolism, Deep Venous Thrombosis
- Trial name
- NCT07833254
- Volunteers
- 100 people
- Sponsor
- Sohag University
Tetralogy of Fallot, Cardiac Death, Sudden
Repaired Tetralogy of Fallot Italian Registry
The CMR/CT WG of the Italian pediatric cardiology society set up a multi-center observational clinical database of repaired-TOF evaluated.
- Conditions
- Tetralogy of Fallot, Cardiac Death, Sudden, Cardiac Arrhythmia, Cardiac Event
- Trial name
- RETE-Fallot (NCT05288894)
- Testing
- Cardiac magnetic resonance imaging
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero, Universitaria Ospedali Riuniti
Nitric Oxide, Cardiac Surgery
Nitric Oxide for Reduced Intensive Support in Cardiac Surgery With Cardiopulmonary Bypass
Cardiac surgery is a procedure that is commonly performed worldwide. Despite these technological advances, cardiac surgery remains a high-risk surgery.
- Conditions
- Nitric Oxide, Cardiac Surgery, Cardiopulmonary Bypass, Adult Patients Undergoing Cardiovascular Surgery With Cardiopulmonary Bypass
- Trial name
- NORISC (NCT06702553)
- Testing
- Nitric Oxide Gas, Standard Care Arm
- Where
- 3 sites in United States, China and 1 more
- Volunteers
- 3,650 people
- Sponsor
- Xijing Hospital
Acute Myocardial Infarction, Cardiac Rehabilitation
Effect of Digital Therapeutics for Cardiac Rehabilitation in Patients With Acute Myocardial Infarction
This study adopts a multicenter, open-label, randomized controlled clinical study, with Jiangsu Provincial People's Hospital as the leading unit, and the other 13 hospitals as cooperative units.
- Trial name
- NCT06772337
- Testing
- digital cardiac rehabilitation, Regular Treatment
- Where
- China
- Volunteers
- 160 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Cardiovascular Disease, Dementia
Recombinant Herpes Zoster Vaccine for Prevention of Cardiovascular Events and Dementia
DAN-ZOSTER is a nationwide randomized study investigating whether vaccination against herpes zoster (shingles) can reduce the risk of cardiovascular disease and dementia in older adults.
- Trial name
- DAN-ZOSTER (NCT07485283)
- Testing
- Recombinant Herpes Zoster Vaccine (Shingrix)
- Where
- 2 sites in Denmark
- Volunteers
- 168,460 people, healthy volunteers welcome
- Sponsor
- Tor Biering-Sørensen
Hip Fracture, MACE
AI-Based Risk Factor Analysis and Prediction Model of MACE in Elderly Hip Fracture Patients Postoperatively
This is a multicenter ambispective observational cohort study led by Beijing Anzhen Hospital, Capital Medical University, with China-Japan Friendship Hospital serving as the external validation center.
- Conditions
- Hip Fracture, MACE, Elderly, Perioperative Complications
- Trial name
- NCT07709377
- Where
- 2 sites in China
- Volunteers
- 600 people
- Sponsor
- Beijing Anzhen Hospital
Acute Myocardial Infarction (AMI), Percutaneous Coronary Intervention (PCI)
Trends and Risk Factors of Adverse Cardiovascular and Cerebrovascular Events After Primary PCI
This single-center, ambispective cohort study will use real-world data from Zhongshan Hospital, Fudan University. About 8,000 patients aged 18 years or older with acute myocardial infarction (AMI) who underwent primary…
- Trial name
- TRACE-pPCI (NCT07833995)
- Testing
- Collection of baseline characteristics
- Where
- China
- Volunteers
- 8,000 people
- Sponsor
- Shanghai Zhongshan Hospital
Cardiac Disease
Predicting Cerebrovascular Adverse Events Post Cardiac Surgery
The aims of this study are: i) to assess cerebral autoregulation and autonomic control within the different phases of cardiac surgery with cardiopulmonary bypass; ii) to compare cerebral autoregulation measures derived via…
- Trial name
- PASCAL (NCT05786274)
- Testing
- Cerebral autoregulation monitoring
- Where
- Italy
- Volunteers
- 104 people
- Sponsor
- IRCCS Policlinico S. Donato
Cerebrovascular Event, Acute Ischemic Stroke
Prospective Italian Validation of SMS in Patients With Suspected Acute Stroke
The overall objective of the study is to prospectively validate the diagnostic accuracy of the Stroke Mimics Score (SMS). This score is calculated using information collected at the time of the patient's arrival in the Emergency…
- Conditions
- Cerebrovascular Event, Acute Ischemic Stroke, Intracerebral Hemorrhage, TIA (Transient Ischemic Attack)
- Trial name
- PIVA-SMS (NCT07601659)
- Volunteers
- 1,000 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Coronary Artery Disease, Coronary Artery Bypass Grafting
Total Arterial vs. Mixed Grafting in Left Coronary CABG
This is a prospective, randomized, double-blind controlled trial comparing the clinical efficacy of total arterial grafting (internal thoracic artery and radial artery) versus conventional mixed grafting (internal thoracic artery…
- Conditions
- Coronary Artery Disease, Coronary Artery Bypass Grafting, Arterial Graft, Graft Patency
- Trial name
- NCT07057713
- Testing
- Total Arterial Grafting, Conventional Mixed Grafting
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Second Hospital of Jilin University
GVHD - Graft-Versus-Host Disease, Infections After HSCT
Cell Free DNA Profiling As a Tool to Monitor Clinically-Relevant Events in Allogeneic Hematopoietic Stem Cell Transplantation
Allogeneic hematopoietic stem cell transplantation (HSCT) is a life-saving treatment for people with severe blood-related diseases.
- Conditions
- GVHD - Graft-Versus-Host Disease, Infections After HSCT, Transplant Associated Microangiopathy TAM, Sinusoidal Obstruction Syndrome (SOS)
- Trial name
- NCT06715046
- Testing
- Sample collation for cfDNA methylation analysis, Sample collection for EV phenotype analysis
- Where
- 2 sites in Italy
- Volunteers
- 30 people
- Sponsor
- University of Turin, Italy
Thrombosis, Cancer
Safety of Perioperative Anticoagulation Management in People With Active Cancer Undergoing Cancer-Related Surgery or Procedures (ACE-HIGH Study)
The purpose of this study is to help find how safe current practices are when managing blood thinners in people with cancer who are having surgery or medical procedures.
- Conditions
- Thrombosis, Cancer, Thrombosis, Deep Vein, Atrial Fibrillation (AF)
- Trial name
- ACE-HIGH (NCT07372716)
- Testing
- standardized perioperative anticoagulation management Guideline
- Where
- Canada
- Volunteers
- 700 people
- Sponsor
- Ottawa Hospital Research Institute
Myocardial Infarction (MI)
Optimize Risk Prediction After Myocardial Infarction: The ORACLE Study
Background. Myocardial infarction (MI) is a leading cause of death worldwide. After MI, longterm antithrombotic therapy is crucial to prevent recurrent events, but increases bleeding, that also impacts morbidity and mortality.
- Trial name
- ORACLE (NCT06993415)
- Testing
- data collection
- Where
- Spain
- Volunteers
- 750 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Coronary Artery Disease, Subclinical Atherosclerotic Cardiovascular Disease
Aspirin in Subclinical Coronary Artery Disease: A Pilot Randomised Controlled Trial
In patients with subclinical coronary artery disease, the ASCAD-P study aims to assess the feasibility of a larger phase 3 pragmatic randomized controlled trial comparing prescription versus no prescription of low-dose aspirin in…
- Trial name
- ASCAD-P (NCT07524335)
- Testing
- Prescription of Aspirin, No prescription
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Montreal Heart Institute
Coronary Artery Disease
Digital Monitoring for Patients Post Coronary Interventions to Reduce Risk for Recurrent Adverse Cardiovascular Events
The study aims to support patients immediately after percutaneous coronary intervention (PCI) by implementing a telemonitoring program. Eligible patients have coronary heart disease and undergo PCI.
- Trial name
- NCT06114615
- Testing
- LiveCare, Text Messages, Conventional Care
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of California, Davis
COVID-19, Hemostasis
Thrombo Embolic Events in Hospitalized Patients With Covid-19 Serious Acute Pneumopathy
The understanding of haemostasis and inflammation cross-talk has gained considerable knowledge during the past decade in the field of arterial and venous thrombosis.
- Conditions
- COVID-19, Hemostasis, Coagulation
- Trial name
- THROMBCOVID2 (NCT04377490)
- Testing
- venous ultrasound, blood sample
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Critical Illness, Brain Injury
Adverse Events During Physical Therapy in Neurocritical ICU Patients
The goal of this observational study is to identify the clinical, neurological, hemodynamic, and respiratory variables associated with the occurrence of adverse events during physical therapy interventions in adult neurocritical…
- Conditions
- Critical Illness, Brain Injury, Stroke, Subarachnoid Hemorrhage
- Trial name
- NCT07901140
- Testing
- Physical Therapy Intervention
- Where
- 2 sites in Mexico
- Volunteers
- 47 people
- Sponsor
- Hospital H+ Queretaro
Type2diabetes, Heart Failure
N-terminal Pro-B-type Natriuretic Peptide (NT-proBNP) in Type 2 Diabetes Mellitus
More than 400 million people have type 2 diabetes (T2D) globally, and the burden of diabetes-related cardiovascular complications is increasing.
- Conditions
- Type2diabetes, Heart Failure, Cardiovascular Complication
- Trial name
- PISCES (NCT05745090)
- Where
- Singapore
- Volunteers
- 1,200 people
- Sponsor
- Singapore General Hospital
ESRD (End-Stage Renal Disease), Maintenance Hemodialysis
Efficacy of pHA130 Hemoadsorption on Protein-Bound Uremic Toxins and Quality of Life in Kidney Failure
Patients on maintenance hemodialysis (MHD) face a high risk of cardiovascular mortality and reduced quality of life. Conventional high-flux hemodialysis (HD) is the standard of care but has limited efficacy in clearing…
- Trial name
- PHOENIX (NCT07656168)
- Testing
- pHA130 Hemoadsorption Cartridge, High-flux Hemodialyzer
- Where
- China
- Volunteers
- 100 people
- Sponsor
- China-Japan Friendship Hospital
Aortic Stenosis
Identifying Biological Markers of Cardiovascular Events in Patients With Aortic Stenosis or TAVI
Aortic stenosis, a common cardiovascular disease, is pathophysiologically associated with a chronic inflammatory myocardial reaction and fibrosis leading to cardiac dysfunction and impaired coronary perfusion.
- Trial name
- Bio-TAVI (NCT06713889)
- Testing
- Biocollection, Quality of life questionnaires
- Where
- 2 sites in France
- Volunteers
- 125 people
- Sponsor
- Hospices Civils de Lyon