Clinical trials: Cardiovascular Physiological Phenomena
Aging
Acute Passive Heating in Healthy Older Adults
Aging is associated with a decline in cardiovascular health, cognitive function and losses in muscle strength, with half or more of those over age 65 suffering from two or more comorbidities (e.g., heart disease, type 2…
- Trial name
- NCT05622747
- Testing
- Passive heating
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Portsmouth
Cardiovascular Physiological Phenomena, Intensive Care Unit Syndrome
Echocardiographic Measurement of Myocardial Work
Echocardiography is recommended for the hemodynamic management of patients with shock. Recently, a new echocardiographic method has been proposed that provides a non-invasive measurement of myocardial work incorporating different…
- Trial name
- MYOLOAD (NCT06422481)
- Testing
- Fluid administration, Norepinephrine administration or increase in norepinephrine dosage
- Where
- 3 sites in France
- Volunteers
- 110 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Obesity
Beige Fat, Energy, and the Natriuretic Peptide System
Obese individuals experience an increased risk of cardiovascular and metabolic diseases. Evidence from genetic studies indicate that the natriuretic peptide (NP) system may protect against these diseases.
- Trial name
- NCT04357964
- Where
- 2 sites in United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Peripheral Arterial Disease, Intermittent Claudication
Arm-crank Exercise Training on Cardiovascular Function of Patients With Peripheral Artery Disease
The aim of the study is to analyze the effect of 12 weeks of arm crank exercise (ACE) training on cardiovascular function in PAD patients, and compare it with treadmill exercise (TE), the actual recommendation for this patients.
- Conditions
- Peripheral Arterial Disease, Intermittent Claudication, Hypertension
- Trial name
- NCT03837639
- Testing
- Arm ergometer, Treadmill ergometer, Control group
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- Hospital Israelita Albert Einstein
Intubation Complication, Cardiovascular Morbidity
The Effects of Lidocaine and Magnesium Sulphate on the Attenuation of the Hemodynamic Response to Tracheal Intubation
Justification and Objectives: The hemodynamic response to stimuli of the airways is a common phenomenon and its control is important to decrease systemic repercussions.
- Trial name
- NCT02359370
- Testing
- Lidocaine, Magnesium Sulphate
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Hospital de Base
Cardiovascular Risk Factor
Comparison of Electronic Cigarettes and Tobacco Cigarettes on Cardiovascular Function and Oxidative Stress
Background: Electronic cigarettes (e-cigarettes) are battery-powered devices heating a liquid (e-liquid) composed of propylene glycol and/or vegetable glycerin, and most commonly, nicotine to form an aerosol (vapor) that is…
- Trial name
- NCT03036644
- Testing
- e-cigarette (PG+VG without nicotine; low temperature), e-cigarette (PG+VG with nicotine; low temperature), e-cigarette (PG+VG without nicotine; high temperature)
- Where
- Belgium
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Université Libre de Bruxelles
Esophageal Neoplasms
Cardiopulmonary Effects of Intrathoracic Pressure Overshoot During Carbon Dioxide Insufflation in Thoracoscopic Surgery
Video-assisted thoracoscopic surgery (VATS) has become a standard technique for addressing all types of thoracic pathology. Insufflation of carbon dioxide (CO2) into the operated chest cavity could increase lung collapse and…
- Trial name
- NCT02330536
- Testing
- Insufflation of carbon dioxide (CO2)
- Volunteers
- 232 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Prostate Cancer
Effect of Androgen Deprivation Therapy on Cardiovascular Function in Prostate Cancer
The aim of this project is to determine whether androgen deprivation therapy (ADT) decreases left ventricular function in prostate cancer patients.
- Trial name
- NCT03275181
- Testing
- Transthoracic Echocardiography, Arterial blood pressure, Submaximal Exercise
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Kansas State University
Cardiovascular Function in EMTs
Vascular Function and Oxidative Stress in Emergency Medical Responders
The goal of this clinical trial is to characterize blood vessel function and oxidative stress (a harmful condition that damages cells and tissues) in emergency medical technicians (EMTs).
- Trial name
- VF-EMT (NCT06985394)
- Testing
- Antioxidant cocktail
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Heart Function Tests, Hemodynamics
Impact of Non-invasive Positive Pressure Ventilation on Cardiac Function and Echocardiographic Parameters
Cardiologists and intensive care specialists are confronted daily with mechanically ventilated patients exhibiting cardiac failure.
- Conditions
- Heart Function Tests, Hemodynamics, Noninvasive Ventilation, Circulatory and Respiratory Physiological Phenomena
- Trial name
- NCT02267291
- Testing
- Non-invasive positive pressure ventilation
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Normal and Abnormal Cardiovascular Physiology
Technical and Translational Development of Cardiovascular Magnetic Resonance (CMR) Imaging
Background: Magnetic resonance imaging (MRI) is an important non-invasive tool to study and diagnose cardiovascular disease. MRI scanners use strong magnetic fields and radio waves to create pictures of body organs.
- Trial name
- NCT03581318
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Long COVID Symptoms
Using Enhanced External Counterpulsation to Recover Cardiovascular Function for Patient of Chronic Diseases
The goal of this clinical trial is to learn whether enhanced external counterpulsation (EECP) therapy can improve cardiopulmonary function and symptoms in adults with long COVID.
- Trial name
- NCT07492953
- Testing
- enhanced external counterpulsation
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- National Defense Medical Center, Taiwan
Early Menopause, Menopause
Influence of Early Menopause on Sympathetic Activation and Cardiovascular Function in Older Women
Women who enter menopause early are at a greater risk for developing cardiovascular disease later in life as compared to women with normal onset of menopause.
- Trial name
- NCT03692572
- Testing
- Nitrate supplementation
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Severe Obesity, Cardiovascular Function
Use of Liraglutide in Children Aged 6 to 12 Years With Severe Obesity
This randomized controlled trial evaluates the efficacy, safety, metabolic, and cardiovascular effects of liraglutide in children aged 6 to 12 years with severe obesity.
- Conditions
- Severe Obesity, Cardiovascular Function, Liraglutide, Childhood Obesity
- Trial name
- NCT07590219
- Testing
- Liraglutide (Saxenda) 6Mg/Ml Inj Pen 3Ml
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo General Hospital
Smoking Cessation, Cardiovascular Diseases
E-cigarettes and Cardiovascular Function
The large current uptake of e-cigarettes (2.8 million U.K. users in 2016; 26), the continuous involvement of e-cigarettes (which potentially affects their contents as well), the uncertainty about their medium- and longer-term…
- Conditions
- Smoking Cessation, Cardiovascular Diseases, Microcirculation, Macrocirculation
- Trial name
- ISME-NRT (NCT03061253)
- Testing
- Electronic Cigarette and behavioural change support., Nicotine-Free Electronic Cigarette and behavioural change support., Nicotine Replacement Therapy and behavioural change support.
- Where
- United Kingdom
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- Sheffield Hallam University
Cardiovascular Physiology
Effects of Tart Cherry and Aronia Extract Supplementation on Selected Physiological Parameters in Endurance-Trained Men
This study will evaluate the effects of four weeks of oral supplementation with a double-standardized tart cherry (Prunus cerasus) and aronia (Aronia melanocarpa) extract on cardiovascular regulation and exercise performance in…
- Trial name
- NCT07885098
- Testing
- Standardized Tart Cherry and Aronia Extract
- Where
- Poland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Pre-Eclampsia; Complicating Pregnancy, Antiphospholipid Syndrome in Pregnancy
Antiphospholipid Syndrome and Postpartum Pulmonary Artery Pressure
The primary goal of this observational study is to learn about postpartum pulmonary artery pressure in women who suffered from Preeclampsia and Antiphospholipid Syndrome.
- Conditions
- Pre-Eclampsia; Complicating Pregnancy, Antiphospholipid Syndrome in Pregnancy, Pulmonary Hypertension
- Trial name
- NCT05679206
- Testing
- Echocardiography images, 24-hour ambulatory blood pressure monitoring
- Where
- Switzerland
- Volunteers
- 900 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cardiovascular Diseases
Exploring the Effects of Aquatic Exercise on Cardiovascular Function in Older Adults
Cardiovascular ageing is implicated in the development of cardiovascular disease (CVD). Aquatic exercise is being considered as a co-adjuvant form of rehabilitation, but there is limited evidence for its cardiovascular…
- Trial name
- ACELA (NCT04308057)
- Testing
- Aquatic exercise
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sheffield Hallam University
Parasympathetic Cardiovascular Function Disorder
Heart Rate Variability and Cardiorespiratory Complications During Ophthalmic Arterial Chemotherapy for Retinoblastoma
A patient undergoing ophthalmic arterial chemosurgery may experience a sudden, profound decrease in lung compliance when the microcatheter is in the ICA or ophthalmic artery.
- Trial name
- NCT03450590
- Where
- South Korea
- Volunteers
- 38 people
- Sponsor
- Seoul National University Hospital