Clinical trials: Cardiovascular Risks
Pulmonary Embolism
Ultrasound-assisted, Catheter-directed Thrombolysis for Acute Intermediate-high-risk Pulmonary Embolism
The purpose of this retrospective and prospective multicenter study is to evaluate the incidence of pulmonary hypertension (PH) within 6 months from ultrasound-assisted, Catheter-directed Thrombolysis for acute intermediate…
- Trial name
- USAT IH-PE (NCT06143969)
- Testing
- ultrasound-assisted, catheter-directed thrombolysis
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- Niguarda Hospital
Cardiovascular Risk Factor, Hypertension
A Web-based Platform to Conduct Trials of mHealth Apps for Hypertension
Self-management of cardiovascular (CV) risk factors is a recommended form of secondary disease prevention. There are thousands of consumer-facing mobile health (mHealth) applications (apps) intended for tracking, monitoring, and…
- Trial name
- NCT04528654
- Testing
- Mobile Health Application
- Where
- 2 sites in Canada
- Volunteers
- 5 people
- Sponsor
- McMaster University
Obesity
Effect of Wholegrain Wheat on Body Weight and Composition and Cardiovascular Risk
The aim of this study is to investigate the potential beneficial effect of wholegrain on body weight and composition as well as cardiovascular risk in overweight women.
- Trial name
- HEALTHGRAIN (NCT00869531)
- Testing
- wholegrain, refined wheat
- Where
- Denmark
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Fabry Disease
Study Based on Electronic Health RecOrds to Identify Patients at High-risk of Fabry DiseasE (HOPE Fabry)
Primary objective: To estimate the prevalence of patients who are at high-risk for Fabry Disease (FD) in the Cleveland Clinic, Abu Dhabi (CCAD) United Arab Emirates (EMR) database from May 2016 to May 2022, according to the…
- Trial name
- NCT05671770
- Where
- United Arab Emirates
- Volunteers
- 15 people
- Sponsor
- Sanofi
Prostate Cancer
Investigation of GLP1-Receptor Agonists in Men With Prostate Cancer Taking Androgen Deprivation Therapy
GAIN PC CONTROL is a study investigating Glucagon-Like Peptide-1 Receptor Agonists in men with prostate cancer who are being treated with androgen deprivation therapy.
- Trial name
- GAINPCCONTROL (NCT06908694)
- Testing
- Semaglutide Pen Injector
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Hamilton Health Sciences Corporation
Stroke, Aging Problems
Innovative Models in the Rehabilitation of the Elderly With Stroke Through Technological Innovation
The final goal of the present study is to propose a new approach and an innovative therapeutic plan in the post-stroke rehabilitation of elderly patients, focused on the use of robotic device, in order to obtain the beneficial…
- Conditions
- Stroke, Aging Problems, Innovative Rehabilitation Treatment Based on Robotics
- Trial name
- NCT04087083
- Testing
- Technological intervention arm, Control arm
- Where
- 2 sites in Italy
- Volunteers
- 150 people
- Sponsor
- Istituto Nazionale di Ricovero e Cura per Anziani
Cardiovascular Risk Score
10 Years Cardiovascular Risk Score Among Primary Health Care Centre Attendees, Assiut Governorate.
The study aim to assess cardiovascular risk score among patients of AlHadary primary health care centre in Waldeya, Assiut governorate. And to determine the awareness about cardiovascular risk among these patients as well.
- Trial name
- NCT05330962
- Testing
- Framingham study cardiovascular disease 10-years risk assessment score
- Volunteers
- 383 people, healthy volunteers welcome
- Sponsor
- Assiut University
Coronary Heart Disease
A Study of the Effect of RO4607381 on Atherosclerotic Plaque in Patients With Coronary Heart Disease
This study will assess the effect of RO4607381, compared to placebo, on atherosclerotic plaque in patients with coronary heart disease (CHD) including patients with other CHD risk factors.
- Trial name
- NCT00655473
- Testing
- Dalcetrapib (RO4607381)
- Where
- 12 sites in United States, Canada
- Volunteers
- 130 people
- Sponsor
- Hoffmann-La Roche
Pregnancy, Preconception Education
Lifestyle, Education, Activity, Nutrition (LEAN) Into Pregnancy
The goal of this randomized controlled clinical trial is to determine if healthy lifestyle education can help improve cardiovascular health and reduce pregnancy complications in women during the preconception period or early…
- Conditions
- Pregnancy, Preconception Education, Preconception Care, Preconception Risk, Adverse Pregnancy Outcomes
- Trial name
- LEAN (NCT06879054)
- Testing
- Healthy lifestyle education
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Medical College of Wisconsin
Mitral Valve Insufficiency
Determinants of the Progression and Outcome of Mitral Regurgitation
Mitral regurgitation (MR) is one of the most frequent valve lesions, both in North America and in Europe, and its prevalence is increasing with the aging of the population.
- Trial name
- PROGRAM (NCT01835054)
- Testing
- Blood biomarkers, DNA collection, Echocardiography
- Where
- 4 sites in Belgium, Canada and 1 more
- Volunteers
- 440 people
- Sponsor
- Laval University
Metabolic Syndrome, Vascular Disorders
Optimal Timing of Physical Activity in Cancer Treatment
The number of long-term cancer survivors is growing. As a result, treatment-related morbidity - such as cardiovascular disease, metabolic syndrome, functional decline and fatigue - is impacting quality of life and impairing…
- Conditions
- Metabolic Syndrome, Vascular Disorders, Cardiovascular Risk Factors, Fatigue
- Trial name
- ACT (NCT01642680)
- Testing
- A tailored physical activity program during chemotherapy, A tailored physical activity program after chemotherapy
- Where
- Netherlands
- Volunteers
- 266 people
- Sponsor
- University Medical Center Groningen
Diabetes
Impact of Decision Aids to Enhance Shared Decision Making for Diabetes
The proposed trial seeks to determine the impact of patient decision aids versus usual care on measures of patient involvement in decision-making, diabetes care processes, medication adherence, glycemic and cardiovascular risk…
- Trial name
- DAD (NCT01029288)
- Testing
- Diabetes Medication Choice Decision Aid, Statin Choice Decision Aid, Usual care for lipid therapy medication
- Where
- 5 sites in United States
- Volunteers
- 110 people
- Sponsor
- Mayo Clinic
Hypertension, Ischemic Heart Disease
Add-on Effects of Valsartan on Morbi- Mortality (KYOTO HEART Study)
The KYOTO HEART Study is to assess the add-on effect of valsartan, an Angiotensin-Receptor Blocker, on top of the conventional treatment in high risk patients in Japan with hypertension in terms of the morbidity and mortality.
- Conditions
- Hypertension, Ischemic Heart Disease, Congestive Heart Failure, Stroke
- Trial name
- NCT00149227
- Testing
- Valsartan, Non-ARB
- Where
- Japan
- Volunteers
- 3,031 people
- Sponsor
- Kyoto Prefectural University of Medicine
Hypercholesterolemia
Observation of the Effects of Guideline-driven Lifestyle Interventions, Including Use of a Red-yeast Based Nutraceutical
The objective of the present multinational, multicentre, prospective, scientific study is to confirm that prescription of a low-dose red yeast-based nutraceutical.
- Trial name
- NCT05000541
- Where
- 7 sites in Austria, Germany
- Volunteers
- 259 people
- Sponsor
- Mylan Inc.
Cardiovascular Diseases
PLATELET TISSUE FACTOR AS BIOMARKER OF THROMBOTIC RISK IN CORONARY ARTERY DISEASE PATIENTS (TRIT-ONE)
Enhancing thrombotic risk stratification in patients with coronary artery disease (CAD) is crucial for the prevention and management of cardiovascular disease.
- Trial name
- TRIT-ONE (NCT06919731)
- Testing
- whole blood flow cytometry analisys
- Volunteers
- 600 people
- Sponsor
- Centro Cardiologico Monzino
Intracranial Aneurysm
Surgical Management of Complex Intracranial Aneurysms With Hybrid Operating Techniques
To evaluate the clinical benefits and risks of hybrid operating techniques in management of complex intracranial aneurysms, which could coexists with multiple risk factors.
- Trial name
- CIA-HOTs (NCT03206853)
- Testing
- Hybrid Operating Techniques
- Where
- China
- Volunteers
- 258 people
- Sponsor
- liuxingju
Cardiovascular Diseases, Obesity Prevention
Team-based Learning Intervention to Prevent Risk Factors for Chronic Diseases - a Cluster Randomized Trial
Background: Chronic diseases, such as cardiovascular diseases, diabetes, and cancer, are a major global health issue. Their modifiable risk factors, including poor diet, physical inactivity, irregular sleep, tobacco use, and…
- Conditions
- Cardiovascular Diseases, Obesity Prevention, Sedentary Behaviors, Sleep Perception
- Trial name
- NCT06894134
- Testing
- Team-based learning
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Professor Fernando Figueira Integral Medicine Institute
Arrhythmias, Cardiac, Tachycardia, Ventricular
Cardiac Arrhythmias at Extreme Altitude
Background: Exposure to high altitudes has been associated with an increased risk of cardiac arrhythmias in healthy subjects and an increased risk of sudden cardiac death.
- Conditions
- Arrhythmias, Cardiac, Tachycardia, Ventricular, Tachycardia, Supraventricular, Bradycardia
- Trial name
- SUMMIT (NCT05676398)
- Testing
- Ambulatory rhythm recording
- Where
- Nepal
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
High Bleeding Risk Patients, Cardiology
Dual Anti-Platelet Optimized Stent for High Bleeding Risk Patient
High risk of bleeding (HBR) is a determining factor for the duration of dual antiplatelet therapy (DAPT). Recent studies have shown that the use of one-month DAPT is beneficial in terms of ischemic as well as hemorrhagic events…
- Conditions
- High Bleeding Risk Patients, Cardiology, Stent Implantation, DAPT(Dual Antiplatelet Therapy)
- Trial name
- DIOHR (NCT07140133)
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- University Hospital, Grenoble
Chronic Obstructive Pulmonary Disease, Asthma
Evaluation of ST2 and IL-33 in Patients Presenting to the Emergency Department With Trouble Breathing
Trouble breathing (dyspnea) is a nonspecific symptom associated with many diseases such as chronic obstructive pulmonary disease (lung disorder in which the flow of air to the lungs is blocked), asthma, pneumonia, pulmonary…
- Conditions
- Chronic Obstructive Pulmonary Disease, Asthma, Pulmonary Embolism, Pneumonia
- Trial name
- NCT00707811
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- The Cleveland Clinic