Clinical trials: Cardiovascular Surgery
Cardiovascular Diseases
Effects of the Low-level Laser Therapy on Inflammatory Profile of the Patients With Coronary Artery Bypass Surgery
Cardiovascular diseases are the leading causes of morbidity and mortality in Brazil and surgical procedures to treat these disorders have grown dramatically in recent years.
- Trial name
- NCT02709499
- Testing
- 0J LLLT, 6J LLLT
- Volunteers
- 38 people
- Sponsor
- Federal University of Health Science of Porto Alegre
Cardiac Output, Low, Surgery
Validation of Automated Cardiac Output Measurement
Automated software analysis now allows for quick estimation of cardiac output from the echocardiographic 5-chamber view. This study will validate the automated software method against pulmonary artery thermodilution and against…
- Trial name
- NCT03372863
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- University of Aarhus
Atrial Fibrillation
Concomitant Treatment of Permanent Atrial Fibrillation
RESTORE-SR study is a multi-center, prospective, nonrandomized study with case matched concurrent controls to evaluate the safety and efficacy of the AtriCure Bipolar System
- Trial name
- RESTORE SR (NCT00566787)
- Testing
- Surgical bipolar radiofrequency ablation using the AtriCure Bipolar System
- Where
- 10 sites in United States
- Volunteers
- 39 people
- Sponsor
- AtriCure, Inc.
Carotid Artery Stenosis
GORE® Embolic Filter in Carotid Stenting for High Risk Surgical Subjects (EMBOLDEN)
Compare the 30-day safety and efficacy of the GORE® Embolic Filter used in conjunction with FDA-approved carotid stents to a performance goal obtained from carotid stent studies utilizing distal embolic protection.
- Trial name
- EMBOLDEN (NCT00766493)
- Testing
- GORE® Embolic Filter
- Volunteers
- 250 people
- Sponsor
- W.L.Gore & Associates
Venous Thromboembolism, Deep Venous Thrombosis
Twice Daily Enoxaparin Prophylaxis in Reconstructive Surgery Patients
Blood clots that form in the extremities (deep venous thrombosis) and lungs (pulmonary embolus) are feared complications of reconstructive surgery.
- Conditions
- Venous Thromboembolism, Deep Venous Thrombosis, Pulmonary Embolus
- Trial name
- NCT02687204
- Testing
- Twice daily enoxaparin prophylaxis, Real time dose adjustment
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- University of Utah
Pulmonary Regurgitation, Tetralogy of Fallot
Multi-center Trial of Percutaneous Pulmonary Valve Implantation With Venus-p
Venus-P Valve (Venus Medtech, Shanghai, China) is the first self-expandable interventional Pulmonary Valve, which is composed of a Nitinol multilevel support frame with a tri-leaflet porcine pericardial tissue valve, and a 14-22…
- Trial name
- Venus-P (NCT02590679)
- Testing
- Venues-P Valve
- Where
- 3 sites in China
- Volunteers
- 44 people
- Sponsor
- Shanghai Zhongshan Hospital
Peripheral Arterial Disease (PAD), Amputation
Personalizing Thromboprophylaxis for Patients With Peripheral Artery Disease
The goal of this clinical trial is to determine whether a personalised blood clot prevention plan is more effective than standard treatment in adults with peripheral artery disease (PAD) who have undergone a procedure to restore…
- Conditions
- Peripheral Arterial Disease (PAD), Amputation, Thrombosis, Thrombosis (Stent Thrombosis)
- Trial name
- NCT07613840
- Testing
- Aspirin, Clopidogrel, Ticagrelor
- Where
- 2 sites in United States
- Volunteers
- 484 people
- Sponsor
- Massachusetts General Hospital
Coronary Artery Disease
Clinical Trial of Kryptonite for Prevention of Sternal Complications in High Risk Patients Undergoing Cardiac Surgery
Kryptonite is a non-toxic biologic polymer, that has previously been used in orthopedic surgery. The objective of our study is to demonstrate the benefits of Kryptonite in cardiac surgery patients at high risk for sternal wound…
- Trial name
- Kryptonite (NCT01368991)
- Testing
- Kryptonite, Conventional closure
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Cardiology Research UBC
Peripheral Arterial Disease, Chronic Limb-Threatening Ischemia
Spectroscopic Assessment of Tissue Oxygenation Changes During Vascular Surgery
This study is a single-center, observational study designed to collect tissue spectrometric data related to tissue oxygenation.
- Conditions
- Peripheral Arterial Disease, Chronic Limb-Threatening Ischemia, Ischemia Vascular, Tissue Ischemia
- Trial name
- NCT07786623
- Volunteers
- 30 people
- Sponsor
- Spectrocor
Heart Disease, Mitral Regurgitation
Using Beta Blockers to Treat Mitral Regurgitation
The purpose of this study tests whether beta-blocker will benefit asymptomatic patients with chronic primary mitral regurgitation.
- Conditions
- Heart Disease, Mitral Regurgitation, Heart Valve Disease, Mitral Valve Insufficiency
- Trial name
- REGURG (NCT00700947)
- Testing
- Beta-blocker therapy (TOPROL-XL® )
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Patients Who Underwent Surgery for Congenital Heart Disease
Influence of Tidal Volume During Mechanical Ventilation on Postoperative Clinical Outcome in Pediatric Patients Undergoing Congenital Heart Surgery
High tidal volume during mechanical ventilation has been reported to increase mortality in patients with acute lung injury or acute respiratory distress syndrome.
- Trial name
- NCT02081274
- Testing
- Surgery for congenital heart disease
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Samsung Medical Center
Post-cardiac Surgery, Inflammation
Cytokine Adsorption During Complex Cardiac Surgery: a Controlled Randomized Trial
This prospective single-centre randomized controlled trial aims at evaluating the safety and efficacy of hemoadsorption with HA-380® during cardio-pulmonary bypass in 40 patients undergoing complex cardiac surgery.
- Conditions
- Post-cardiac Surgery, Inflammation, Organ Dysfunction Syndrome, Cardiac Disease
- Trial name
- JACCS (NCT06512623)
- Testing
- Hemoadsoprtion
- Where
- Switzerland
- Volunteers
- 41 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Valvular Disease, Coronary Stenosis
The Scanner in the Coronary Evaluation
Conventional coronary angiography is the recommended procedure in detection of coronary stenosis in patients with heart valve disease referred for surgery.The aim of this prospective study is to assess diagnostic accuracy of…
- Trial name
- NCT00484380
- Testing
- Coronary scanner
- Where
- France
- Volunteers
- 66 people
- Sponsor
- French Cardiology Society
Infection, Surgical Site
Use of Real-time Fluorescence Imaging in Diabetic Foot Ulcers: the Impact of Colonization
The study evaluates the efficacy of fluorescence-guided de-colonization in patients with non-infected diabetic foot ulcers. The efficacy will also be compared between those who used artificial dermis and split-thickness skin…
- Trial name
- NCT05873049
- Testing
- MolecuLight
- Where
- Taiwan
- Volunteers
- 210 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Hypotension Drug-Induced
A Prospective Study of Vasopressor on Cerebral Oxygenation During General Anesthesia
The purpose of this study is to investigate whether norepinephrine(N), phenylephrine(P) or ephedrine(E) have different effect on cerebral oxygenation in abdominal surgery with propofol or sevoflurane.
- Trial name
- NCT06334549
- Testing
- Ephedrine-P, Phenylephrine-P, Norepinephrine-P
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Dalian Municipal Central Hospital
Aortic Stenosis
TAVI Without On-Site Cardiac Surgery in Poland: A Randomized Multicenter Trial Protocol
Aortic stenosis (AS) represents the most prevalent acquired valvular heart disease in European populations, and transcatheter aortic valve implantation (TAVI) has become the dominant treatment modality for patients with…
- Trial name
- NOSCAR-TAVI (NCT07515768)
- Testing
- transcathter aortic valve implantation
- Volunteers
- 404 people
- Sponsor
- Medical University of Warsaw
Cardiovascular Diseases, Coronary Disease
Program on Surgical Control of Hyperlipidemias (POSCH)
To determine whether a profound reduction in serum cholesterol level, induced and maintained by partial ileal bypass, would prevent a second heart attack among men and women who had one myocardial infarction and whose blood…
- Conditions
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Myocardial Infarction
- Trial name
- NCT00000490
- Testing
- jejunoileal bypass, diet, fat-restricted
- Sponsor
- University of Minnesota
Vascular Disease
Transferability and Cost-effectiveness of PROSPECT in Surgical Trainees
To design, validate and prove cost-effectiveness of a comprehensive endovascular simulation curriculum consisting of cognitive and psychomotor skills training for endovascular management of symptomatic vascular disease in the…
- Trial name
- PROSPECT (NCT01965860)
- Testing
- additional curriculum (E-learning + simulation), additional E-learning
- Where
- Belgium
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University Ghent
Aortic Stenosis
The Effects of High Spinal Anesthesia on Heart Function, Stress Response and Pain Control in Aortic Valve Surgery
This study is looking at the effects of high spinal anesthesia (also known as total spinal anesthesia) combined with general anesthesia versus general anesthesia alone on the following: Stress response: Patients undergoing aortic…
- Trial name
- NCT00348920
- Testing
- High Spinal and General Anesthesia
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- University of Manitoba
Cardiac Surgery, Extracorporeal Circulation; Complications
Evaluation of Blood and Cardiac Protein O-GlcNAcylation Levels in Cardiac Surgery in Children
Cardiac surgery requires the use of extracorporeal circulation (ECC). Age-related differences in inflammatory response, the greater susceptibility of immature organ systems to injury and the larger ratio of extracorporeal…
- Conditions
- Cardiac Surgery, Extracorporeal Circulation; Complications, Metabolism, Low Cardiac Output
- Trial name
- CardiOGlcNAc (NCT06754709)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Nantes University Hospital