Clinical trials: Caries, Dental
Caries Infiltration, Fluorosis
Resin Infiltration and Resin Infiltration With Bleaching in Improving the Esthetics for Fluorosis Stains
Dental fluorosis is a clinical manifestation of chronic exposure to high intakes of fluoride during the tooth development. The present study is planned to evaluate the efficacy of Resin Infiltration technique in improving the…
- Conditions
- Caries Infiltration, Fluorosis, Dental Care
- Trial name
- NCT01733888
- Testing
- Office Bleaching, Resin Infiltration, Resin Infiltration twice
- Where
- 2 sites in India
- Volunteers
- 80 people
- Sponsor
- DMG Dental Material Gesellschaft mbH
Dental Caries
Pharmacokinetics of Advantage Arrest in Children
The purpose of this study is to characterize basic PK parameters (Cmax, t1/2, AUC) in healthy children to contribute to evidence for the safety of Advantage Arrest, consistent with Guidance for Industry--Exposure--Response…
- Trial name
- NCT04186663
- Testing
- Silver Diamine Fluoride
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Advantage Silver Dental Arrest, LLC
Dental Caries
Phase 2, Safety & Microbiology Study of C16G2 in Multiple Oral Gel &/or Mouth Rinse Doses to Healthy Adults
The focus of the study is to evaluate the safety of multiple study drug administrations and the study drug selectively reducing or eliminating a specific bacteria in the mouth.
- Trial name
- NCT02044081
- Testing
- C16G2 Rinse, C16G2 Gel
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Armata Pharmaceuticals, Inc.
Dental Caries
Clinical Performance of Incremental and Bulk Fill Composites in Class II Restorations
This study will examine the clinical performance of Class II restorations over a three year period with 3 composite resins - a conventional composite resin, a flowable composite resin and a bulk placed and cured composite resin.
- Trial name
- NCT02889835
- Testing
- Supreme Universal Restorative, Supreme Flowable Restorative, Bulk Fill Flowable Restorative
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Solventum US LLC
Disintegration, Healthy
Scintigraphy Study to Evaluate the Gastrointestinal Behavior of EDP1815 Oral Dosage Forms
This study is to find out how different types of capsules or tablets containing EDP1815 move through the GI tract and release the drug after being swallowed.
- Trial name
- NCT05066373
- Testing
- EDP1815 capsule A, EDP1815 capsule B, EDP1815 tablet
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Evelo Biosciences, Inc.
Dental Caries
Assessment of Prevident Sodium Fluoride 1.1% Toothpaste Using an Intra-oral Remineralization-demineralization Model
This is a double blind, cross-over, controlled clinical trial utilizing thirty (30) adults to evaluate remineralization of early caries lesions.
- Trial name
- NCT02708160
- Testing
- Fluoride Free toothpaste, 1.1% Fluoride toothpaste, 0.243% Fluoride toothpaste
- Volunteers
- healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dental Caries in Children
Comparison of Early Caries Detection in Children Utilizing an Electrical Conductance Device and the Gold Standard of Visual-tactile Technique.
The purpose of this study is to evaluate a methodology for detecting early forming cavities in children that is more accurate and reliable than the gold standard used by dentists around the world.
- Trial name
- NCT02002728
- Where
- Venezuela
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Ortek Therapeutics, Inc.
Dental Caries
Intra Oral Appliance (IOA) Model Evaluating the Efficacy of Sensitive Toothpaste
This single-center, randomized, double-blind, three-period crossover in situ study evaluated the enamel remineralization potential and fluoride bioavailability of three dentifrices: a fluoride-free negative control, a positive…
- Trial name
- NCT07419763
- Testing
- Negative Control Toothpaste, Active Comparator, Test toothpaste
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Church & Dwight Company, Inc.
Dental Caries
Effect of Curodont Repair or Placebo on the Remineralisation in Patients With Class 5 Carious Lesions
The purpose of this study is to evaluate the therapeutic benefit of Curodont Repair for the treatment of early buccal carious lesions compared to placebo.
- Trial name
- NCT02020681
- Testing
- Curodont Repair, Fluoride
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Credentis AG
Dental Caries
Phase 2, Open-Label Study for Safety, Microbiology and PK of Single or Multiple Oral C16G2 Gel Doses
Part A: Open-label, multiple arm, safety, microbiology and pharmacokinetic (PK) study in healthy adult male and female subjects 18-75 years of age. All subjects will be assessed for safety and microbiology parameters.
- Trial name
- NCT02254993
- Testing
- C16G2
- Where
- 2 sites in United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Armata Pharmaceuticals, Inc.
Dental Caries
Effect of Dentifrice Usage Regime on Delivery and Efficacy of Fluoride
This study will evaluate and compare the effect of the amount of toothpaste used and brushing time on enamel strengthening (percent of surface microhardness recovery, % SMHR) and enamel fluoride uptake (EFU).
- Trial name
- NCT01563172
- Testing
- Sodium fluoride / silica and carbopol, 0.5g, Sodium fluoride / silica and carbopol, 1.5g, Fluoride free dentifrice
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dental Caries, Oral Disease
Fluoride Varnish Community Trial
This cluster-randomized controlled community trial aimed to assess the efficacy and costs of fluoride varnish application for caries prevention in a high-risk population in South Africa.
- Conditions
- Dental Caries, Oral Disease, Costs
- Trial name
- NCT03429829
- Testing
- Flairesse varnish
- Where
- 2 sites in South Africa
- Volunteers
- 513 people, healthy volunteers welcome
- Sponsor
- DMG Dental Material Gesellschaft mbH
Dental Caries
Evaluation of Oral Hygiene Products in an In Situ Caries Model
The study will evaluate and compare the potential anti-caries efficacy of a test regimen: placebo (fluoride free) toothpaste (twice daily use) plus fluoride mouthwash (once daily use), in comparison with brushing with a placebo…
- Trial name
- NCT02399163
- Testing
- Fluoride free toothpaste, Fluoride toothpaste, Fluoride mouthwash
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dental Caries
In-situ Clinical Trial Assessing Ability to Detect and Monitor Active Caries and Their Remineralization
The goal of this clinical trial is to evaluate whether BlueCheck® can accurately detect and monitor early-stage dental caries (tooth decay) and their remineralization in adults.
- Trial name
- NCT07100626
- Testing
- BlueCheck
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Incisive Technologies Pty Ltd
Dental Caries in Children
Silver Diamine Fluoride Gel: Single Group Observational Study
A single group observational study to determine the clinical response of dental caries lesions in primary teeth where 38% silver diamine fluoride gel is applied and cover with 2.5% sodium fluoride varnish.
- Trial name
- KiruPoderoso (NCT05395065)
- Testing
- Silver Diamine Fluoride/Sodium Fluoride Varnish
- Where
- 5 sites in Peru
- Volunteers
- 237 people
- Sponsor
- Advantage Silver Dental Arrest, LLC
Dental Caries, Pulp Exposure, Dental
Clinical Study Evaluating Solventum™ Vitrebond™ Pulp Protect Liner/Base for Direct Capping of Pulpal Exposure
This research study is looking at the safety and effectiveness of Solventum™ Vitrebond™ Pulp Protect Liner/Base for direct pulp capping (DPC) on permanent teeth that have pulp exposure due either to deep cavities, trauma, or…
- Conditions
- Dental Caries, Pulp Exposure, Dental, Tooth Decay, Dental Decay
- Trial name
- NCT07231237
- Testing
- Vitrebond™ Pulp Protect Liner/Base
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Solventum US LLC
Dental Caries
A Clinical Study to Evaluate Experimental Children's Toothpastes in an In-Situ Caries Model
An in situ model will be used to evaluate and compare enamel remineralization of human enamel specimens after single use of experimental children's toothpastes.
- Trial name
- NCT01607411
- Testing
- Fluoride
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Dental Caries
Population-centered Risk- and Evidence-based Dental Inter-professional Care Team
The main goal of the payment and delivery system reform is to reduce disparities in oral health and dental care access of low-income mothers and children living in rural Oregon counties.
- Trial name
- PREDICT (NCT02312921)
- Testing
- PREDICT
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Advantage Dental Services, LLC
Dental Caries
To Determine the Ability of a New Product Formulation to Remineralize an Early Caries Lesion by an In-situ Study
This is a double blind, cross-over, controlled clinical trial utilizing thirty (30) adults to evaluate remineralization of early caries lesions.
- Trial name
- NCT02388178
- Testing
- Control toothpaste containing no anti-cavity ingredients, Experimental toothpaste containing fluoride and amino acid (arginine), Fluoride toothpaste containing fluoride as the anti-cavity ingredient
- Volunteers
- healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dental White Spots
Enamel Damages Following De-bracketing From Infiltrated Surfaces
Demineralisation and white-spot caries often occures during MB treatment. While resin infiltration has been proved to stop progression of enamel demineralisation, there is still a paucity of information in the literature…
- Trial name
- NCT02359318
- Testing
- Resin infiltration, Bonding and debonding of brackets.
- Where
- Chile
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- DMG Dental Material Gesellschaft mbH